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研究生:張志豪
研究生(外文):Chih-Hao Chang
論文名稱:影響早產兒脫離經鼻連續正壓通氣因子:台灣單一醫學中心之回溯性研究
論文名稱(外文):Factors affecting the weaning from Nasal Continuous Positive Airway Pressure in Preterm Neonates: a single center, retrospective study in Taiwan.
指導教授:陳秀玲陳秀玲引用關係
指導教授(外文):HSIU-LIN CHEN
口試委員:楊志仁,鍾美勇
口試委員(外文):Chih-Jen Yang,Mei-Yung Chung
口試日期:2020-01-17
學位類別:碩士
校院名稱:高雄醫學大學
系所名稱:醫學研究所碩士班
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2020
畢業學年度:108
論文頁數:98
中文關鍵詞:早產兒NCPAP脫離影響因子
外文關鍵詞:PrematureNCPAPWeaningaffecting factors
相關次數:
  • 被引用被引用:0
  • 點閱點閱:125
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目錄
中文摘要 I
Abstract III
致謝 VI
目錄 VII
表目錄: X
圖目錄: XII
第一章 緒論 1
第一節 研究背景 1
第二節 研究目的 2
第二章 文獻探討 3
第一節 早產兒及肺部發展學 3
第二節 早產兒常見肺部疾病 6
第三節 經鼻連續正壓呼吸道支持設備作用機制、與併發症 10
第四節 經鼻連續正壓的脫離 14
第五節 脫離經鼻連續正壓裝置失敗的危險因子 19
第三章 研究方法 21
第一節 研究假設 21
第二節 倫理揭露 21
第三節 研究對象 22
第四節 研究流程及架構 24
第五節 NCPAP脫離流程 27
第六節 研究資料分析 29
第四章 資料分析與結果 31
第一節 樣本特性 31
第二節 體重與懷孕週數影響脫離NCPAP之PMA比較 40
第三節 出生體重及週數與非侵襲性呼吸支持使用天數及成功脫離NCPAP之PMA的關聯 43
第四節 影響非侵襲性呼吸支持使用天數及成功脫離NCPAP之PMA的臨床因子分析 47
第五節 影響非侵襲性呼吸支持使用天數及成功脫離NCPAP之PMA因子單變量分析 56
第六節 影響非侵襲性呼吸支持天數及成功脫離NCPAP 之PMA因子多變量分析 64
第五章 討論 68
第一節 NCPAP使用及脫離現況與分析 69
第二節 影響成功脫離NCPAP之PMA因子分析 71
第三節 研究限制及未來展望 77
第六章 結論 78
參考文獻 79
附錄一、IRB同意證明書 85

表目錄:
表 二 1 Definition of Bronchopulmonary dysplasia 8
表 二 2 NCPAP脫離方法與成功脫離週數、體重比較表 16
表 二 3 文獻上NCPAP脫離失敗及成功定義比較表[43, 48-50] 18
表 二 4 影響NCPAP脫離危險因子[40] 20
表 四 1 Demographic and clinical data of the study population 33
表 四 2 Demographic and clinical data of the study population: Non-intubation vs. Intubation. 38
表 四 3 Body weight and PMA at various NCPAP time points, for the entire cohort and for subgroups stratified by intubation. 42
表 四 4 Effect of clinical factors on Total days of non-invasive ventilation in study infants. 52
表 四 5 Effect of clinical factors on PMA in weeks at successfully NCPAP weaning. 54
表 四 6 Univariate analysis for Total days of non-invasive ventilation and significant predictor variables. 60
表 四 7 Univariate analysis for PMA successful NCPAP weaning and significant predictor variables. 62
表 四 8 Multivariate analysis for Total days of non-invasive ventilation and significant predictor variables 66
表 四 9 Multivariate analysis for PMA successful NCPAP weaning and significant predictor variables. 67

圖目錄:
圖 二 1 高雄長庚醫院使用Hudson nasal prong的早產兒 10
圖 三 1 收案流程圖 26
圖 四 1 Correlation between Gestational age and Total days of 45
圖 四 2 Correlation between BW(Birth weight) and Total days of 45
圖 四 3 Correlation between GA(Gestational age) and 46
圖 四 4 Correlation between BW(Birth weight) and PMA 46
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