臺灣博碩士論文加值系統

Abstract…………………………………………….…………………..………………I
中文摘要……………………………………………………….……………………..II
誌謝辭………………………………………………………………………………..III
壹、 Synthesis of halogenated indolo[3,2-c]quinolinones…………………………….1
一、前言…………………………………………………..………..………..………..1
1. Indolo[3,2-c]quinolinone之簡介…….…………………..………..……….…...1
2. 銅金屬催化串聯反應用於合成indolo[2,3-c]quinolinones之前期研究成果..2
二、結果與討論………………………………………………………………….….....4
1. 2-(2-Bromophenyl)-N-(2-cyanophenyl)acetamides 8a–h之合成………...…....4
2. 3-Chloro-5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one (9a)之合成探討.........5
3. 含F、Cl、I取代基之5,11-dihydro-6H-indolo[3,2-c]quinolin-6-one合成……...6
三、結論………………………………………………………………..…………..…..7
貳、 Deamination of methylated aminobenzamide by hydrogen peroxide under alkaline conditions..................................................................................................8
一、 前言........................................................................................................................8
1. 回顧deamination反應之發現及2-aminobenzonitrile與2-aminobenzamide之deamination........................................................................................................8
二、 結果與討論..........................................................................................................11
1. 2-(Methylamino)benzamide (16)及2-amino-N-methybenzamide (17)之合成..........................................................................................................................11
2. 2-(Methylamino)benzamide (16)在hydrogen peroxide或urea hydrogen peroxide條件下反應...........................................................................................11
3. 2-Amino-N-methybenzamide (17)在hydrogen peroxide或urea hydrogen peroxide條件下反應...........................................................................................12
4. 1-Methyl-1,2-dihydro-3H-indazol-3-one (21)之結構鑑定............................. 14
5. Deamination之反應機構推測.........................................................................17
三、 結論......................................................................................................................19
參、 Experiment Section……………………………………………....………....…..20
1. Synthesis of halogenated indolo[3,2-c]quinolinones…….…………..……......20
2. Deamination of methylated aminobenzamide by hydrogen peroxide under alkaline conditions …………………………………………………………….....26
肆、 參考文獻……………………………..……………..………………...….……..28
伍、 光譜數據……………..………………………………………..………………..31

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