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研究生:黃珮庭
研究生(外文):HUANG, PEI-TING
論文名稱:半枝蓮之成分及其抗酪胺酸酶活性研究
論文名稱(外文):Anti-Tyrosinase Principles and Constituents of Scutellaria Barbata
指導教授:李佳穎李佳穎引用關係
指導教授(外文):LI, CHIA-YING
口試委員:詹于誼張雯惠
口試委員(外文):CHAN, YU-YICHANG, WEN-HUEI
口試日期:2020-06-18
學位類別:碩士
校院名稱:國立屏東大學
系所名稱:應用化學系碩士班
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2020
畢業學年度:108
語文別:中文
論文頁數:95
中文關鍵詞:半枝蓮酪胺酸酶美白協同作用
外文關鍵詞:Scutellaria barbatatyrosinasewhiteningsynergy
相關次數:
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  本研究利用半枝蓮 (Scutellaria barbata) 進行活性初步測試,顯示半枝蓮甲醇萃取之氯仿層具有良好的酪胺酸酶抑制活性。將半枝蓮甲醇萃取之氯仿層分離後,共得到23個化合物,其中包含9個單苯環化合物、6個黃酮類化合物、3個生物鹼類化合物、1個ionone衍生物、4個clerodane萜類化合物。
  針對化合物活性顯示,在抑制酪胺酸酶活性上,6-Methoxynaringenin (11)、Scutebata J (30)、Scutebarbatine A (44)、Barbatin C (122)及6-Hydroxy-2(H)-quinolinone (151)有抑制活性,其中,6-Methoxynaringenin (11)及Scutebata J (30)的IC50分別為0.19 mg/mL以及0.20 mg/mL;另在各劃分之化合物間協同活性上,將SB C4、SB C5、SB C6以及SB C7中活性較佳的化合物與各劃分中其他化合物混合,分別有某些組合顯示出具有協同效果;此外,在與Kojic acid混合的協同活性上,Kojic acid與Apigenin (5)、5,7,4’-Trihydroxy-8-methoxyflavon (9)、4-Hydroxy-benzaldehyde (139)、4-Hydroxyacetophenone (140)、Methyl ferulate (142)、Methyl 4-hydroxy-3-methoxybenzoate (145)、Indole-3-carboxaldehyde (150)及Loliolide (152)混合後顯示出具有協同作用;且在最佳配比測試上,Kojic acid與5,7,4'-Trihydroxy-8-methoxyflavon (9)混合時,即使Kojic acid的劑量減少,仍然可以維持抑制效果;Kojic acid與Apigenin (5) 以及Indole-3-carboxaldehyde (150)以適當比例混合時可以發揮最佳的抑制效果。
  以上活性結果,可提供後續美白化粧保養產品開發以及配方設計參考。
  The preliminary activity testing of Scutellaria barbata showed that the CHCl3 layer of MeOH extracts had good activity in tyrosinase inhibition assay. Twenty-three constituents, including nine benzenoids, six flavones, three alkaloids, one ionone and foue clerodanes were isolated from the CHCl3 layer of Scutellaria barbata MeOH extracts.
  The results of the activity test indicated that 6-Methoxynaringenin (11)、Scutebata J (30)、Scutebarbatine A (44)、Barbatin C (122)、6-Hydroxy-2(H)-quinolinone (151) showed significant activity on tyrosinase inhibition. Among them, the IC50 of 6-Methoxynaringenin (11) and Scutebata J (30) are 0.19 mg/mL and 0.20 mg/mL. Besides, the results of synergistic assays in each fraction showed the synergistic effect in formulation. In addition, the results of the synergistic assays with Kojic acid and choosed compounds showed the synergistic effect at the mix of Apigenin (5), 5,7,4’-Trihydroxy-8-methoxyflavon (9), 4-Hydroxybenzaldehyde (139), 4-Hydroxy-acetophenone (140), Methyl ferulate (142), Methyl 4-hydroxy-3-methoxybenzoate (145), Indole-3-carboxaldehyde (150) and Loliolide (152) with Kojic acid. Moreover, even though the weight of Kojic acid was reduced, the inhibitory still can be maintained in high activity when mixed with 5,7,4'-Trihydroxy-8-methoxyflavon (9) and Indole-3-carboxaldehyde (150) in optimal proportion respectively. It could achieve the best synergistic effect in Apigenin (5) mixed with Kojic acid in 4:3.
  The present study points out the potential of Scutellaria barbata extracting components as functional ingredients for cosmetic formulation.
誌謝 I
摘要 II
Abstract III
目錄 IV

第一章 緒論 1
 第一節 研究背景與目的 1
 第二節 植物介紹 4
第二章 文獻探討 5
 第一節 半枝蓮之成分回顧 5
 第二節 半枝蓮之活性回顧 28
第三章 方法與材料 29
 第一節 實驗架構 29
 第二節 活性測試 30
 第三節 儀器與材料 31
第四章 半枝蓮之萃取與分離 33
第五章 半枝蓮化合物之構造解析 38
 第一節 Indole-3-carboxylic acid (149) 之構造研究 38
 第二節 Indole-3-carboxaldehyde (150) 之構造研究 40
 第三節 6-Hydroxy-2(H)-quinolinone (151) 之構造研究 42
 第四節 Loliolide (152) 之構造研究 44
 第五節 4-Hydroxy-3’-methoxy-chalcone (147) 之構造研究 46
 第六節 Scutebata J (30) 之構造研究 48
 第七節 Scutebarbatine A (44) 之構造研究 50
 第八節 Barbatin C (122) 之構造研究 52
 第九節 Scutelinquanine E (153) 之構造研究 54
第六章 半枝蓮之活性測試研究 56
第七章 結論 71
參考文獻 73
附錄 84
 附錄一 光譜數據 84
 附錄二 植物的萃取與分離 94
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