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研究生:賴冠宏
研究生(外文):Kuan-Hung Lai
論文名稱:評估顱底小腦橋腦角手術後遺症的針刺療效
論文名稱(外文):Evaluation of Acupuncture effects for Complications after Surgery of Cerebellopontine Angle Tumor in Skull Base
指導教授:陳方佩陳方佩引用關係
指導教授(外文):Fang-Pey Chen
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:傳統醫藥研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2020
畢業學年度:108
語文別:英文
論文頁數:152
中文關鍵詞:顱底腫瘤小腦橋腦角腫瘤神經外科手術後遺症中醫學針灸顏面神經麻痺疼痛緩解生活品質
外文關鍵詞:skull base tumorcerebellopontine angle tumorcomplicationsTCMacupuncturefacial paralysispainquality of life
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Contents
Signature Page.....................................iii
Thesis Approval Form …..........................iv
Acknowledgments …................................v
Chinese
Abstract………………………………………………………………………….....………………………vii
English Abstract…………………………………………………………………………………………………………….…ix
Contents………………………………………………………………………………………………………………xiii
List of Figures………………………………………………………………………………………………………………...xv
List of Tables………………………………………………………………………………………………………………..….xvi
List of Appendices………………………………………………………………………………………………………...xviii
Chapter 1 Introduction…………………………………………………………………………….1
1-1 Complementary Alternative Medicine (CAM) and Traditional Chinese Medicine(TCM)……………………………………………………………………………………....……… …1
1-1-1 Complementary Alternative Medicine (CAM)…………………………………………....................1
1-1-2 Traditional Chinese Medicine(TCM)……………………………………………………………………..…..1
1-2 Skull base tumor, cerebellopontine angle tumor and complications…………………...5
1-3 Acupuncture……………………………………………………………………………………………………...9
1-3-1 Origin and basic principles of acupuncture…………………………………………………………………9
1-3-2 Acupuncture and tumor……………………………………………………………………………………….…….12
1-3-3 Acupuncture for complications of surgery……………………………………………………….……… 13
1-4 The aim of study…………………………………………………………………………………....15

Chapter 2 Method………………………………………………………………………………….……..16

2-1 Study design……………………………………………………………………………………………………..16
2-2 Inclusion and exclusion condition……………………………………………………………..….…..17
2-3 Materials……………..…………………………………………………………………………………………...19
2-4 Flow Chart…………………………………………………………………………………………….…………..29
2-5 Research outcome measurement and measurement procedure…………………..…..31
2-6 Statistics..……………………………………………………………………………………………………..…..39
2-7 Research authorization certificate…………………………………………………………..….…….42

Chapter 3 Result and Analysis……………………………………………………………………….43

3-1 The study population at baseline……………………………………………………………….……43
3-2 The result of House-Brackmann Grading Scale…………………………………………….….44
3-3 The result of Visual Analogue Scale……………………………………………………..45
3-4 The result of WHOQOL-BREF Taiwan version……………………………………….47
3-5 The result of Functional Assessment of Cancer Therapy: General………..53
3-6 The analysis of the two groups…………………………………………………………….58
3-7 The analysis of facial function………………………………………………………………63
3-8 The analysis of pain……………………………………………………………………………..66
3-9 The analysis of quality of life………………………………………………………………..69
Chapter 4 Discussion…………………………………………………………………………76
4-1 Facial paralysis,, the recovery and evaluation of facial function in management…………………………………………………………………………………………76
4-1-1 Facial paralysis…………………………………………………………………………………76
4-1-2 Research design, acupuncture intervention and results…………………..78

4-2 Pain in management…………………………………..............................82

4-2-1 Headache after brain tumor surgery…………………………………………….82
4-2-2 Study design, acupuncture treatment and results………………………..84
4-3 Quality of life in management…………………..………………………………………...87
4-3-1 TCM for quality of life…………………………………………………………………..87
4-3-2 Study design, acupuncture intervention and results…………………….89
4-4 Limitations of this research.…………………………………………………………………94
4-5 Perspectives…………………………………………………………………………………………95

Chapter 5 Conclusion…………………………………………………………………...……..96

References……………………………………………………………………………………...…......97
Figures…………………………………………………………………………………………........….107
Figure 1 Skull base………………………………………………………………………..…….107
Figure 2 Acupoints map………………………………………………………………..……108
Figure 3 Study Design………………………………………………………………….…….109
Figure 4 Study flow chart……………………………………………………………….…..110
Figure 5 Comparison with experimental group and control group in House-Brackman Grading Scale…………………………………………………………………………….…..……111
Figure 6 Comparison with experimental group and control group in VAS……………………………………………………………………………………………..…..…..112
Figure 7 Comparison with experimental group and control group in WHOQOL-BREF Taiwan Version…………………………………………………………………………..…………………....113
Figure 8 Comparison with experimental group and control group in FACT-G……………………………………………………………………….……..………………...114

Tables……………………………………………………………………………………………..115
Table 1 Demographic and Characteristics of the study Population at Baseline………………………………………………………………………………………….….115
Table 2.1 Functional Assessment of Cancer Therapy: General: the 0th week to the 3rd week and the 3rd week to the 4th week……………………………………………………………………………………………..….....116
Table 2.2 Functional Assessment of Cancer Therapy: General:
the 0th week to the 4th week, the 4th week to the 8th week and the 0th week to the 8th week.
…………………………………………………………………………………………………………...117
Table 3.1 WHOQOL BREF Taiwan version, the 0th week to the 3rd week…………………….……………………………………………………………………………..118
Table 3.2 WHOQOL BREF Taiwan version, the 0th week to the 4th week…………………………….……………………………………………………………………..119
Table 3.3 WHOQOL BREF Taiwan version, the 3rd week to the 4th week…………………………….…………………………………………………………..…………120
Table 3.4 WHOQOL BREF Taiwan version, the 4th week to the 8th week…………………………….………………………………………………………….………….121
Table 3.5 WHOQOL BREF Taiwan version, the 0th week to the 8th week…………………………….………………………………………………………..……………122
Table 4.1 Pain analysis scale: the 0th week to the 3rd week and the 3rd week to the 4th week.…………………………….…………………..……….…123
Table 4.2 Pain analysis scale: the 0th week to the 4th week, the 4th week to the 8th week and the 0th week to the 8th week.
……………………………………………………………………….……………………..………….…124
Table 5.1 Facial function analysis : the 0th week to the 3rd week and the 3rd week to the 4th week.
…………………………….……………………………………………………………………..………125
Table 5.2 Facial function analysis: the 0th week to the 4th week, the 4th week to the 8th week and the 0th week to the 8th week.
…………………………….………………………………………………………………………………126

Appendix…………………………………………………………………………………....……..127
Appendix 1………………………………………………………………………………………..……127
Appendix 2…………………………………………………………………………………………..…130
Appendix 3…………………………………………………………………………………..…………131
Appendix 4……………………………………………………………………………..………………132
Appendix 5……………………………………………………………………………………..………134
Appendix 6…………………………………………………………………………………………..…135
Appendix 7………………………………………………………………………………………..……137
Appendix 8…………………………………………………………………………………………..…139
Appendix 9 ………………………………………………………………………………..…………140
Appendix 10…………………………………………………………………………………………….151
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