臺灣博碩士論文加值系統

目錄
誌謝 ...........................................................i
中文摘要 .........................................................iii
英文摘要 ..........................................................vi
圖目錄 ........................................................xiii
表目錄 .........................................................xiv
第一章 緒論 ...........................................................1
第一節 研究背景與動機 ...........................................................1
第二節 研究的重要性 ...........................................................3
第三節 研究假設 ...........................................................4
第二章 文獻回顧 ...........................................................5
第一節 經皮吸收與參數計算算
...........................................................5
2.1.1 皮膚構造 ...........................................................5
2.1.2 皮膚吸收途徑 ...........................................................7
2.1.3 經皮吸收參數計算
...........................................................8
第二節 體外經皮吸收試驗系統 ..........................................................8
2.2.1 流動式經皮擴散槽 (Flow- through diffusion cell)
...........................................................9
2.2.2 靜態式經皮擴散槽 (Static diffusion cell)
..........................................................10
第三節 單一暴露 (Single exposure) 與混合暴露 (Mixture exposure)
..........................................................11
2.3.1 連續暴露 (Sequential exposure) ..........................................................12
2.3.2 共同暴露 (Concurrent exposure) ..........................................................13
第四節 皮膚滲透增強劑 ..........................................................14
第五節 Linalool 簡介與分類 ..........................................................15
2.5.1 Linalool的辨識資料與化學特性 ..........................................................15
2.5.2 Linalool的來源與應用 ..........................................................17
2.5.3 Linalool的皮膚吸收 ..........................................................18
2.5.4 Linalool的毒性 ..........................................................18
2.5.5 Linalool的使用劑量規範 ..........................................................19
第六節 Salicylic acid 簡介與分類 ..........................................................20
2.6.1 Salicylic acid的辨識資料與化學特性 ..........................................................20
2.6.2 Salicylic acid的來源與應用 ..........................................................21
2.6.3 Salicylic acid的皮膚吸收 ..........................................................22
2.6.4 Salicylic acid的毒性 ..........................................................22
2.6.5 Salicylic acid的使用劑量規範 ..........................................................23
第七節 Caffeine簡介與分類 ..........................................................24
2.7.1 Caffeine的辨識資料與化學特性 ..........................................................24
2.7.2 Caffeine的來源與應用 ..........................................................25
2.7.3 Caffeine的皮膚吸收 ..........................................................25
2.7.4 Caffeine的毒性 ..........................................................26
2.7.5 Caffeine的使用劑量規範 ..........................................................27
第三章 研究目的與架構 ..........................................................28
第一節 研究目的 ..........................................................28
第二節 研究架構 ..........................................................29
第四章 材料與方法 ..........................................................30
第一節 研究材料 ..........................................................30
4.1.1 實驗藥品與耗材 ..........................................................30
4.1.2 儀器與設備 ..........................................................30
4.1.3 受試皮膚 ..........................................................31
第二節 實驗室咖啡因、水楊酸及沉香醇之檢測方法 ..........................................................33
4.2.1 樣本備製 ..........................................................33
4.2.2 液相層析儀分析條件 ..........................................................34
第三節 實驗方法與流程 ..........................................................37
4.3.1 實驗流程 ..........................................................37
第四節 數據統計及分析 ..........................................................40
第五章 研究結果 ..........................................................41
第一節 皮膚基本資料 ..........................................................41
第二節 咖啡因及水楊酸於單一暴露狀態下皮膚吸收動力學參數之比較
..........................................................43
第三節 咖啡因及水楊酸於混合暴露狀態下皮膚吸收動力學參數之比較
..........................................................45
第四節 單一與混合暴露下之皮膚吸收動力學參數比較 ..........................................................48
第五節 單一及混合暴露下與咖啡因及水楊酸膠帶撕貼之回收率比較
..........................................................49
第六節 混合暴露下沉香醇之皮膚吸收及回收率 ..........................................................52
第六章 討論 ..........................................................55
第一節 混合暴露模式之重要性 ..........................................................55
第二節 皮膚完整度測試之探討 ..........................................................55
第三節 動力學參數之探討 ..........................................................56
6.3.1 通量 (Jss) ..........................................................56
6.3.2滲透係數 (Permeability coefficient) ..........................................................58
6.3.3延遲時間 (Lag time) ..........................................................59
第四節 咖啡因與水楊酸之皮膚吸收與其他文獻比較 ..........................................................60
6.4.1 單一暴露 ..........................................................60
6.4.2 混合暴露 ..........................................................62
第五節 回收率 ..........................................................64
第七章 結論與建議 ..........................................................67
第一節 結論 ..........................................................67
第二節 研究限制 ..........................................................67
第三節 應用與建議 ..........................................................69
第八章 參考文獻 ..........................................................70

圖目錄
圖 1 皮膚構造圖 ..........................................................6
圖 2 皮膚吸收途徑 ..........................................................7
圖 3 流動式經皮擴散槽 ( Flow- through diffusion cell) ..........................................................10
圖 4 靜態式經皮擴散槽 (Static diffusion cell) ..........................................................11
圖 5 研究架構圖 ..........................................................29
圖 6 實驗流程圖 ..........................................................37
圖 7 單一暴露狀態下咖啡因之濃度-時間 ..........................................................43
圖 8 單一暴露狀態下水楊酸之濃度-時間 ..........................................................43
圖 9 單一暴露狀態下咖啡因及水楊酸之累積皮膚吸收量 ..........................................................44
圖 10 混合暴露狀態下咖啡因之濃度-時間 ..........................................................45
圖 11 混合暴露狀態下水楊之濃度-時間 ..........................................................46
圖 12 混合暴露狀態下咖啡因及水楊酸之累積皮膚吸收量 ..........................................................47
圖 13 不同模式下咖啡因與水楊酸在皮膚的分布狀況 ..........................................................49
圖 14 與咖啡因混合暴露下沉香醇之時間濃度圖 ..........................................................52
圖 15 與水楊酸混合暴露下沉香醇之時間濃度圖 ..........................................................52
圖 16 混合暴露下沉香醇在皮膚的分布狀況 ..........................................................53

表目錄
表 1 沉香醇 (Linalool) 之基本資料 ..........................................................16
表 2 水楊酸 (Salicylic acid) 之基本資料 ..........................................................20
表 3 咖啡因 (Caffeine) 之基本資料 ..........................................................24
表 4 高效能液相層析儀與偵測器之分析條件 ..........................................................34
表 5 皮膚基本資料與 TEWL及電阻之前後測 ..........................................................42
表 6 單一暴露模式下咖啡因及水楊酸之經皮吸收參數比較 ..........................................................44
表 7 混合暴露模式下咖啡因及水楊酸之經皮吸收參數比較 ..........................................................47
表 8 咖啡因在單一及混合暴露模式之經皮吸收參數比較
..........................................................48
表 9 水楊酸在單一及混合暴露模式之經皮吸收參數比較
........................................................48
表 10 不同模式下咖啡因及水楊酸在皮膚上分布之質量 ..........................................................49
表 11 不同模式下咖啡因及水楊酸之回收率 ..........................................................50
表 12 分別與咖啡因及水楊酸混合之沉香醇回收率
..........................................................53

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