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研究生:陳彥樺
研究生(外文):CHEN, YEN-HUA
論文名稱:臺灣杭菊和油菊萃取物抗氧化能力與抑制酪胺酸酶活性分析
論文名稱(外文):Analyses of Antioxidant Abilities and Anti-tyrosinase Activities of Taiwan Chrysanthemum morifolium Ramat and Chrysanthemum indicum L. Extracts.
指導教授:蔡明勳蔡明勳引用關係
指導教授(外文):TSAI, MIMG-SHIUN
口試委員:王淑紅、李世傑、吳建一、謝昌衛
口試委員(外文):WANG, SUE-HONG、LEE, SHIH-CHIEH、WU, JANE‑YII、HSIEH, CHANG‑WEI
口試日期:2021-07-20
學位類別:博士
校院名稱:大葉大學
系所名稱:生物科技與產業博士學位學程
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2021
畢業學年度:109
語文別:中文
論文頁數:76
中文關鍵詞:臺灣杭菊臺灣油菊不同溶劑萃取物成分分析抗氧化能力體外抑制酪胺酸酶活性
外文關鍵詞:Chrysanthemum morifolium Ramat var. Taiwan Hang JuChrysanthemum indicum L.Different solventsComponent analysesAntioxidant activityin vitro tyrosinase-inhibition activity
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菊花在亞洲的傳統用法是藥物也是食物。本研究比較臺灣苗栗縣銅鑼鎮所栽種的臺灣杭菊-白雪(1號)與臺灣杭菊-黃金菊(2號)、原生小油菊(3號)以及花蓮縣栽種的小油菊(4號)等四種材料,使用四種不同的溶劑分別進行萃取,分別為乙醇、乙酸乙酯、正己烷及蒸餾水,測定萃取物的總類黃酮、總酚、總醣、還原醣、總綠原酸及四種不同綠原酸之含量,再分析其抗氧化能力與體外抑制酪胺酸酶活性,比較不同品種和產地的菊花以不同溶劑萃取,主要成分含量以及抗氧化能力和體外抑制酪胺酸酶活性之間的相關性。在抗氧化能力方面,萃取物當中DPPH自由基清除能力、亞鐵離子螯合能力及還原力為臺灣杭菊1號的乙醇萃取物最優異,其次為原生小油菊、臺灣杭菊2號與花蓮小油菊的乙醇萃取物;體外抑制酪胺酸酶活性也以臺灣杭菊1號乙醇萃取物最高,其次為原生小油菊、臺灣杭菊2號與花蓮小油菊乙醇萃取物。分析不同萃取物的成分發現臺灣杭菊1號乙醇萃取物的總類黃酮(每克含16.71 毫克蘆丁當量)、總酚(每克含7.01毫克沒食子酸當量)及總綠原酸(每克含6595.46微克)含量最高,其次為臺灣杭菊2號蒸餾水萃取物,含量第三高為原生小油菊蒸餾水萃取物;臺灣杭菊1號蒸餾水萃取物的總醣(每克含9.24毫克)及還原糖(每克含23.32微克)含量較高。由這些結果推測臺灣杭菊1號乙醇萃取物因總類黃酮含量及總酚含量最高,可能是最有價值的天然抗氧化劑來源,並且因總綠原酸含量最高而可能有最佳的抑制酪胺酸酶活性。因此,臺灣杭菊1號乙醇萃取物建議可以應用在日常保健飲料或食品中做為抗氧化力的來源,以及化妝品中的美白功效成分。
The traditional usage of chrysanthemum in Asia is medicine as well as food. This study compares two varieties of Chrysanthemum morifolium Ramat and two C. indicum L. cultured in two different places. C. morifolium Ramat var. Taiwan Hang Ju No. 1 (No. 1) and No. 2 (No. 2) were purchased from Tongluo Town, Miaoli County, Taiwan, and C. indicum L. from Tongluo Town (named as No. 3) and C. indicum L. from Hualien County (named as No. 4). These four materials were used four different solvents, including ethanol, ethyl acetate, n-hexane and distilled water, to extract their components, respectively. Contents of total flavonoids, total phenols, total sugars, reducing sugars, total chlorogenic acid and four different kinds of chlorogenic acids were determined in these 16 extracts. Their antioxidant capacities and in vitro tyrosinase-inhibition activities were analyzed. The correlations between contents of total flavonoids, phenols, and chlorogenic acids, antioxidant capacities, and in vitro tyrosinase-inhibition activities were determined. In terms of antioxidant capacity, among these 16 extracts, the DPPH free radical scavenging ability, ferrous ion chelating ability and reducing power are all the best in the No. 1 ethanol extract, followed by the No. 3, the No. 2 and No. 4 ethanol extracts. The activities of in vitro tyrosinase-inhibition are the highest in the distilled water extract of No. 1, followed by No. 3, No. 2, and No. 4 distilled water extracts. Analyzing the components of different extracts, the ethanol extract of No. 1 showed the highest content of total flavonoids (16.71 mg rutin equivalent/g dry weight), total phenols (7.01 mg gallic acid equivalent/g dry weight) and total chlorogenic acid (6595.46 μg/g dry weight), followed by the distilled water extract of No. 2, then the distilled water extract of No. 3. The content of total sugar (9.24 mg/g) and reducing sugar (23.32 μg/g) of the distilled water extract of No. 1 are both the highest among all distilled water extracts. From these results, it is speculated that the ethanol extract of No. 1 may be the most valuable source of natural antioxidants because of the highest contents of total flavonoids and total phenols. The highest total chlorogenic acid content may result in the highest inhibitory activity of in vitro tyrosinase. Therefore, the ethanol extract of No. 1 is suggested to have potential uses in daily healthy drinks or foods and whitening components for cosmetic products.
封面內頁
簽名頁
中文摘要 iii
ABSTRACT v
誌謝 vii
目錄 viii
圖目錄 x
表目錄 xi
1. 緒論 1
1.1 研究背景 1
1.2 研究目的 2
2. 文獻回顧 3
2.1氧化反應 3
2.2美白 5
2.3綠原酸 6
2.4杭菊花及其功能 7
2.5小油菊花及其功能 9
3. 材料與方法 11
3.1 實驗材料與試劑 11
3.2 實驗步驟 14
3.3 實驗方法 16
4. 結果 37
4.1 四種植物使用四種溶劑萃取結果 37
4.2 抗氧化能力 45
4.3 美白能力 54
5. 討論 61
6. 結論 65
7. 參考文獻 66
8. 附錄-學術論文發表 76

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