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研究生:李冠葦
研究生(外文):Li, Guan-Wei
論文名稱:深層海水對急性腸胃炎的預防及治療功效之探討
論文名稱(外文):Exploration of preventive and therapeutic effects of deep ocean water on acute gastroenteritis
指導教授:鄭劍廷
指導教授(外文):Chien, Chiang-Ting
學位類別:碩士
校院名稱:國立臺灣師範大學
系所名稱:生命科學系
學門:生命科學學門
學類:生物學類
論文出版年:2021
畢業學年度:109
語文別:中文
論文頁數:83
中文關鍵詞:深層海水胃潰瘍潰瘍性結腸炎自由基細胞凋亡
外文關鍵詞:deep ocean watergastric ulcerulcerative colitisfree radicleapoptosis
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腸胃道是人體進行食物消化與養分吸收最主要的位置,在維持身體正常運作中扮演重要角色。除幽門螺旋桿菌感染外,不良生活習慣、不當用藥、壓力累積等導致胃潰瘍產生,反覆患病且未改善,則易導致胃出血、胃穿孔,甚至罹患胃癌。另一方面,潰瘍性結腸炎是一種自發性結腸黏膜慢性炎症,當前療法不易根治且易復發,近年亞洲各國患病率逐年增加,長期患潰瘍性結腸炎容易讓腸黏膜發育不全,也會使罹癌風險增加。對生活步調緊湊的社會而言,如何有效緩解、控制胃潰瘍及潰瘍性結腸炎症狀、降低發病率並有效治療是重要的研究議題。深層海水得自海平面200公尺以下富含各種離子與高生物活性的有機成分之低溫、乾淨穩定的無污染水。先前研究顯示,深層海水中的部分物質具有清除活性氧物質之功效且能抑制十二指腸潰瘍與細胞凋亡,本研究欲探討飲用深層海水的保護特性,降低胃潰瘍與結腸發炎反應,緩和急性胃腸發炎病狀。實驗結果顯示,深層海水能減少因潰瘍產生的自由基、透過抑制p38與NF-κB活化降低發炎反應、調節P2X7相關路徑減緩細胞凋亡,具抗氧化、抗炎、抗凋亡之功效。
Gastrointestinal tract is the main place to digest food and to absorb nutrients in human body. It plays an important role for maintaining health in our body. Helicobacter pylori infection is the most common cause of gastric ulcer, bad eating habitats, and excess mental stress are all causes as well. If people has gotten gastric ulcer repeatedly for a long time, it will turn into gastric hemorrhage, gastric perforation, and gastric cancer. Ulcerative colitis is a spontaneous chronic inflammation of colonic mucosa. It is also easy to make the intestinal mucosa underdeveloped, and even leads to intestinal cancer. The count of patients bothered by ulcerative colitis in Asian countries is getting higher recently. For the fast-moving society, how to effectively alleviate and control gastric ulcer and ulcerative colitis, reduce their incidence, and explore effective treatments are important. The deep ocean water is obtained from low-temperature, clean, non-polluting water rich in various ions and highly biologically active organic components below 200 meters below sea level. Previous study indicated that some substances in deep ocean water have the effect of removing active oxygen substances and can inhibit duodenal ulcers and apoptosis. This research aims to alleviate the inflammation and symptoms of gastric ulcer, ulcerative colitis, and acute gastroenteritis by drinking the deep ocean water. Our data found that deep ocean water confers antioxidant, anti-inflammation and anti-apoptosis activity, or property to protect stomach and colon against oxidative stress.
1. 緒論 1
1-1. 腸胃道疾病 1
1-2. 胃潰瘍 2
1-3. 潰瘍性結腸炎 2
1-4. 深層海水 3
1-5. 研究重要性與目的 4
2. 研究材料與方法 5
2-1. 深層海水 5
2-2. 胃潰瘍 6
2-2.1. 實驗動物 6
2-2.2. 實驗動物分組 6
2-2.3. 胃潰瘍動物模式的誘發 7
2-2.4. 實驗動物處理 7
2-3. 潰瘍性結腸炎 8
2-3.1. 實驗動物 8
2-3.2. 實驗動物分組 8
2-3.3. 潰瘍性結腸炎動物模式的誘發 9
2-3.4. 實驗動物處理 9
2-4. 自由基測定 10
2-4.1. 深層海水清除自由基的效果 10
2-4.2. 胃部組織自由基含量測定 10
2-5. 胃液重量數值檢測 11
2-6. 腸道壓力數值檢測 11
2-6.1. 活體直腸壓力 11
2-6.2 離體結腸肌肉張力測定 12
2-7. 病理組織切片染色分析 12
2-7.1. 蘇木紫-伊紅染色(H&E stain) 13
2-7.2. TUNEL 14
2-7.3. 甲苯胺藍染色 14
2-7.4. 免疫組織化學染色(Immunohistochemistry,IHC) 15
2-8. 西方墨點法(Western Blot, WB) 16
2-9. 組織發炎、細胞凋亡檢測 17
2-10. 統計分析 18
3. 實驗結果 19
3-1. 深層海水中的有效成分分析 19
3-2. 深層海水清除自由基之功效 19
3-3. Shay’s ulcer胃潰瘍模式處理對胃部組織自由基含量變化 19
3-4. H&E stain評估Shay’s ulcer胃潰瘍模式處理對胃部組織之影響 20
3-5. Shay’s ulcer胃潰瘍模式處理配合不同硬度之深層海水其胃液變化量 21
3-6. 西方墨點法評估深層海水處理對胃部組織之MAPK發炎相關蛋白質變化量 21
3-7. 組織免疫染色評估深層海水處理對胃部組織之MAPK發炎相關蛋白質變化量 24
3-8. 西方墨點法評估深層海水處理對胃部組織細胞凋亡程度之影響 27
3-9. TUNEL染色評估深層海水處理對胃部組織細胞凋亡程度之影響 28
3-10. 以組織外觀觀察飲用深層海水對結腸炎之作用 28
3-11. 以腸道功能評估不同時間點給予深層海水對於結腸炎之作用 29
3-12. H&E stain評估不同時間點給予深層海水對結腸組織之影響 30
3-13. 西方墨點法評估不同時間點給予深層海水對結腸組織之自由基傷害影響 31
3-14. 組織免疫染色評估不同時間點給予深層海水對結腸組織之自由基傷害影響 31
3-15. 西方墨點法評估不同時間點給予深層海水對結腸組織細胞凋亡程度之影響 32
3-16. 組織免疫染色評估不同時間點給予深層海水對結腸組織細胞凋亡程度之影響 33
3-17. 甲苯胺藍染色評估不同時間點給予深層海水對結腸組織中肥大細胞數量之變化 34
4. 討論 35
5. 結論 41
參考資料 42
圖與表格 51
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