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研究生:陳彥妤
研究生(外文):Yen-Yu Chen
論文名稱:利用靜電紡絲製備用於運輸載體的pH敏感型聚縮酮/聚乳酸微米串珠纖維
論文名稱(外文):Preparation of polyketal/Poly(Lactic Acid) bead-on-string microfibers for delivery vehicle by electrospinning
指導教授:何明樺何明樺引用關係
指導教授(外文):Ming-Hua Ho
口試委員:謝學真高震宇
口試委員(外文):Hsyue-Jen HsiehChen-Yu Kao
口試日期:2021-08-19
學位類別:碩士
校院名稱:國立臺灣科技大學
系所名稱:化學工程系
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2021
畢業學年度:109
語文別:中文
論文頁數:146
中文關鍵詞:靜電紡絲運輸載體微米串珠纖維
外文關鍵詞:electrospinningdelivery vehiclebead-on-string microfibers
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摘要
Abstract
誌謝
目錄
表目錄
圖目錄
專有名詞及縮寫
第一章 緒論
第二章 文獻回顧
2.1 急性炎症疾病
2.2 藥物釋放系統
2.3 生物可降解性之高分子藥物載體
2.4 生物可降解性之智慧型高分子
2.5 以乳化溶劑蒸發技術製備PK產物
2.6 靜電紡絲原理
第三章 實驗材料與方法
3.1實驗藥品
3.2實驗儀器
3.3實驗步驟
3.3.1 PK共聚物合成
3.3.2製備PK/PDLLA微米串珠纖維
3.3.3製備PK/PLLA微米串珠纖維
3.4 材料鑑定與性質鑑定
3.4.1 PK共聚物分子量(GPC)分析
3.4.2 PK共聚物衰減全反射-傅立葉轉換紅外線光譜(ATR-FTIR)分析
3.4.4掃描式電子顯微鏡(SEM)分析
3.4.5衰減全反射-傅立葉轉換紅外線光譜(ATR-FTIR)分析
3.4.6 接觸角(Contact Angle)量測分析
3.4.7 膨潤性(Swelling)測試
3.4.8 重量損失(Weight Loss)測試
3.5 體外釋放
3.6 體外細胞實驗
3.6.1 PK/PDLLA與PK/PLLA微米串珠纖維製作
3.6.2實驗操作
3.6.3 細胞來源
3.6.4 培養基配製
3.6.5 細胞培養
3.6.6 細胞冷凍保存
3.6.7 細胞解凍及培養
3.6.8 細胞計數
3.6.9 粒線體活性測試
第四章 實驗結果與討論
4.1 PK共聚物合成與物性評估
4.1.1 PK共聚物分子量分析
4.1.2 PK共聚物官能基分析
4.1.3 PK共聚物產率評估
4.2 PK/PDLLA微米串珠纖維製程討
4.2.1 電壓影響
4.2.2 流速的影響
4.2.3 工作距離的影響
4.2.4 PK/PDLLA共混物濃度的影響
4.2.5 比例的影響
4.3 PK/PLLA微米串珠纖維製程探討
4.3.1 電壓的影響
4.3.2 工作距離的影響
4.3.3 比例的影響
4.4 官能基分析
4.5 親疏水性分析
4.6 膨潤性檢測
4.6.1 PK/PDLLA微米串珠纖維的膨潤性檢測
4.6.2 PK/PLLA微米串珠纖維的膨潤性檢測
4.7 重量損失測試
4.7.1 PK/PDLLA微米串珠纖維的重量損失測試
4.7.2 PK/PLLA微米串珠纖維的重量損失測試
4.8 體外控制釋放
4.8.1 PK/PDLLA微米串珠纖維的釋放
4.8.2 PK/PLLA微米串珠纖維的釋放
4.9 生物相容性
第五章 結論
參考文獻
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