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研究生:Sajid Ali
論文名稱(外文):Patient-Specific Computational Fluid Dynamics Analysis of Blood Flow in Coronary Arteries Using OpenFOAM: Based on Validation of the Food and Drug Administration Nozzle Benchmark
指導教授:SHIH, TZU-CHINGSHIH, TZU-CHING引用關係
口試委員:施子卿洪子倫陳柏源
口試委員(外文):SHIH, TZU-CHINGHORNG, TZYY-LENGCHEN, PO-YUAN
口試日期:2022-05-25
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:生物醫學影像暨放射科學學系碩士班
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2022
畢業學年度:110
語文別:英文
論文頁數:90
外文關鍵詞:OpenFOAMCoronary artery DiseaseFDA nozzle benchmark
IG URL:naqvi1599
相關次數:
  • 被引用被引用:0
  • 點閱點閱:60
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  • 下載下載:2
  • 收藏至我的研究室書目清單書目收藏:0
Cardiovascular diseases (CVDs) include stroke, heart failure, ischemic heart disease, and other cardiac and vascular conditions. It is an account of the vital cause of mortality and morbidity and is a subsidizer of reduced quality of life all over the world-wide. According to the ranking among all cardiac diseases, coronary artery disease (CAD) is second place. The most common diagnostic methods for CAD are invasive and non-invasive coronary angiography. Recently, computational fluid dynamics (CFD) method was rapidly growing in the prognosis of coronary artery disease. This study aims to simulate the coronary blood using computed tomography coronary angiography (CTCA) images with different theoretical flow models using open-source CFD OpenFOAM, allowing freedom of meshing, manipulation, simulation, and post-processing of any difficulty involving fluid mechanics. The study examined the ideal the Food and Drug Administration (FDA) nozzle benchmark for the validation and seventeen coronary arteries of nine patients (n=17). Three-dimensional (3D) reconstructions of coronary artery images of nine patients were achieved by CTCA 64-detector scanners. The inlet velocity of the coronary artery in the simulation was applied to 0.00223 m/s. The density and dynamic viscosity of the blood used in this study were 1,060 kg/m3 and 3.5 cP, respectively. The boundary condition of the artery wall was no-slip. In this study, the value of fractional flow reserve from computed tomography coronary angiography (FFRCTCA) in five cases (n = 5) was larger or equal to 0.8, in eleven cases, the FFRCTCA value was smaller or equal to 0.8 (n = 11) and in one case, the FFRCTCA value was equal to 0.8 (n=1). In Case 5, the FFRCTCA (0.0136) value is lower than the cutoff ≤ 0.8, which shows the severity of the stenosis. The velocity of blood flow observed in the center of the stenosis region was 0.0168 m/s, which was 7.5 times faster than the inlet velocity of 0.00223 m/s. CFD was used to calculate the FFRCTCA and center velocity for nine patient-specific models of the coronary artery to present a non-invasive and highly precise method for the estimated physiological significance of stenosed coronary arteries. The present study shows an admirable correlation between FFRCTCA and velocity to stenosis, when clinical testing is difficult or impossible, which may provide information to bridge knowledge gaps. Further research is needed to determine the diagnostic efficiency and clinical implications of our findings.
Abstract i
List of Abbreviations iv
List of Figures v
List of Tables ix
Chapter 1 1
Introduction 1
1.1 Anatomy of a coronary artery: 3
1.2 The circulation system: 5
1.3 Fluid mechanics: 6
1.4 Computational fluid dynamics (CFD): 7
1.5 OpenFOAM description: 8
1.6 Condition used for coronary artery simulation: 9
Chapter 2 10
Materials and Methods 10
2.1 Experimental process was divided into two parts 10
2.2 The FDA nozzle benchmark: 12
2.3 Metric comparison: 13
2.4 Grid independence test: 14
2.5 Cross-sectional velocity of different Reynolds numbers 16
2.6 Reynolds numbers at throat and sudden expansion: 18
2.7 Centerline pressure: 20
2.8 Transient flow 22
2.9 The FDA nozzle benchmark geometry simulation 24
2.10 Computational tomography coronary angiography 25
2.11 Mimics (Materialise Mimics Research 20.2) 27
2.12 ANSYS SpaceClaim (ANSYS CFD 2020 R) 29
2.13 ANSYS ICEM : (ANSYS CFD 2020 R) 32
2.14 Patches and meshing: 34
2.15 OpenFOAM 35
2.16 Courant number 36
2.17 ParaView (ParaView 5.9.0) 38
2.18 MATLAB (MATLAB R2021b) 39
Chapter 3 40
3.1 The coronary artery geometry simulation 42
3.2 Fractional flow reserve computed tomography coronary angiography (FFRCTCA) in coronary artery stenosis: 48
3.3 Blood flow velocity in coronary arteries: 51
Chapter 4 53
Discussion 53
Chapter 5 63
Conclusions 63
Appendix 64
A.1 SurfaceFeatureExtractedDict 64
A.2 CheckMesh 66
A.3 Boundary 70
A.4 transportPropertise 72
A.5 P 73
A.6 U 75
A.7 controlDict 77
A.8 foamDataToFluentDict 80
A.9 fvSchemes 81
A.10 fvSolution 83
A.10 Clinical diagnostic report 87
References 88


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