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研究生:廖翊淇
研究生(外文):LIAO, YI-CHI
論文名稱:探討運動結合益生菌補充策略對巴金森氏症運動功能障礙的改善效果與可能機轉
論文名稱(外文):Study the effect of Exercise and Probiotic intervention on Motor function with 6-OHDA induced Parkinson's Disease Rat
指導教授:黃惠宇黃惠宇引用關係
指導教授(外文):HUANG, HUI-YU
口試委員:黃惠宇葉篤學黃文經
口試委員(外文):HUANG, HUI-YUYEH, TU-HSUEHHUANG, WEN-CHING
口試日期:2022-07-05
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:代謝與肥胖科學研究所碩士班
學門:醫藥衛生學門
學類:其他醫藥衛生學類
論文種類:學術論文
論文出版年:2022
畢業學年度:110
語文別:中文
論文頁數:90
中文關鍵詞:巴金森氏症運動益生菌運動功能腸道菌叢6-OHDA
外文關鍵詞:Parkinson's diseaseexerciseprobioticsmotor functiongut microbiota6-OHDA
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中文摘要 I
英文摘要 II
目錄 III
表目錄 VII
圖目錄 VIII
第一章 緒論 1
第一節 研究動機 1
第二節 研究目的 2
第二章 文獻回顧 4
第一節 巴金森氏症(Parkinson’s disease) 4
1.1巴金森氏症的盛行率 4
1.2巴金森氏症的臨床症狀與病因 5
1.2.1臨床症狀 5
1.2.2病因 6
1.3巴金森氏症之臨床治療 10
1.4巴金森氏症與腸道菌叢失調 11
第二節 運動與疾病 14
2.1運動的定義與分類 14
2.2運動與行動能力 15
2.2.1運動與大腦神經系統 15
2.2.2運動與肌肉神經傳導 16
2.2.3運動與平衡 16
2.3運動與抗氧化 18
第三節 運動與巴金森氏症 19
第四節 乳酸菌、神經保護作用與腸道菌叢生態 21
第五節 6-OHDA誘導仿巴金森氏症大鼠 24
第三章 實驗設計與方法 25
第一節 實驗設計 25
第二節 不同運動種類及強度模式 28
第三節 益生菌製備 30
第四節 巴金森氏症動物模式 31
第五節 體重、飲食、飲水及組織重量 32
第六節 運動功能障礙評估 33
6.1 Rotarod協調性、平衡感與耐力測試 33
6.2 Catwalk Gait步態分析系統 33
6.3 Beam walking test 獨木橋行走測試 34
6.4 Grip strength握力測試 34
第七節 腦組織取樣 34
第八節 腦與肌肉之粒線體活性分析 35
第九節 腦部病理切片 36
第十節 血清中抗氧化酵素分析 37
第十一節 血液生化分析 37
第十二節 即時定量聚合酶鏈鎖反應(Quantitative real time polymerase chain reaction, qPCR)檢測 38
第十三節 腸道菌群分析 (Gut microbiota analysis) 39
第十四節 統計分析 39
第四章 結果 40
第一節 實驗一結果 40
1.1基本生化數值 40
1.2模型建立 42
1.3抗氧化酵素 43
1.4運動功能評估 44
第二節 實驗二結果 47
2.1仿巴金森氏症大鼠模型確立 47
2.2基本生化數值 48
2.3運動功能評估 50
2.4抗氧化酵素分析 55
2.5神經保護效果 57
2.6腸道菌叢組成 66
第五章 討論 69
第一節 最適合巴金森氏症改善運動障礙的運動模式 69
第二節 運動及益生菌補充延緩巴金森氏症疾病進程與其可能作用機制 72
第六章 結論 78
參考文獻 79
表目錄
表一、The comparison of body weight, food intake and water intake in different type exercise 6-OHDA-induced PD rats groups after 6 weeks intervention. 40
表二、The body weight, food intake and water intake of different groups at different time period in 6-OHDA induced PD rats. 48
表三、The serum biochemical profiles of different groups after 4 weeks intervention in 6-OHDA induced PD rats. 49
表四、實驗一結果整理 69
表五、實驗二結果整理 72
圖目錄
圖一、巴金森氏症的主要特徵。 7
圖二、粒腺體功能障礙與多巴胺神經元死亡。 8
圖三、發炎是巴金森氏症中的惡性循環。 10
圖四、巴金森氏症的發炎包括中樞和周邊發炎。 13
圖五、益生菌在排除病原菌中扮演的角色。 22
圖六、實驗一之實驗流程 26
圖七、實驗二之實驗流程 28
圖八、The effect of the ratio of left hindlimb soleus muscle weight to whole body weight with different type exercise 6 weeks intervention 6-OHDA-induced PD rats. 41
圖九、The result of apomorphine test after 3 weeks or 9 weeks 6-OHDA induced surgery. 42
圖十、The effect of 6 weeks different types of exercise on the catalase activity in 6-OHDA-induced PD. 43
圖十一、The effect of motor function evaluation in different types of exercise 6-OHDA-induced PD rats groups with rotarod test. 44
圖十二、The effect of motor function evaluation in different types of exercise 6-OHDA-induced PD rats groups with catwalk analysis. 45
圖十三、The Apomorphine test in 6-OHDA-induced PD rats after 6-OHDA surgery. 47
圖十四、The effect of grip strength with different groups after 4 weeks intervention in 6-OHDA-induced PD rats. 50
圖十五、The effect of rotarod test with different groups after 4 weeks intervention in 6-OHDA-induced PD rats. 51
圖十六、The effect of beam walking test with different groups after 4 weeks intervention in 6-OHDA-induced PD rats. 52
圖十七、The effect of catwalk gait analysis with different groups after 4 weeks intervention in 6-OHDA-induced PD rats.. 54
圖十八、The effect of antioxidative enzyme with different groups after 4 weeks intervention in 6-OHDA-induced PD rats. 55
圖十九、The effect of dopaminergic neurons with different groups after 4 weeks intervention in 6-OHDA-induced PD rats. 57
圖二十、The effect of mitochondria related gene expression between 4 weeks of different intervention groups in brain tissue. 58
圖二十一、The effect of antioxidative enzyme related gene expression between 4 weeks of different intervention groups in brain tissue. 60
圖二十二、The effect of neurotrophic factor related gene expression between 4 weeks of different intervention groups in brain tissue. 61
圖二十三、The effect of mitochondria related gene expression between 4 weeks of different intervention groups in muscle tissue. 62
圖二十四、The effect of antioxidative enzyme related gene expression between 4 weeks of different intervention groups in muscle tissue. 64
圖二十五、The effect of neurotrophic factor related gene expression between 4 weeks of different intervention groups in muscle tissue. 65
圖二十六、Comparison of alpha-diversity in the gut microbiota composition between 4 weeks different intervention groups. 66
圖二十七、Comparison of beta-diversity in the gut microbiota composition between 4 weeks different intervention groups based on Jensen-Shannon divergence visualized in a PCoA plot. 67
圖二十八、Linear discriminant analysis Effect Size (LEfSe) showed different taxonomies in gut microbiota composition with NC and PD groups. 68
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