跳到主要內容

臺灣博碩士論文加值系統

(44.200.194.255) 您好!臺灣時間:2024/07/24 06:28
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:李奕彣
研究生(外文):Yi-Wen Lee
論文名稱:代謝症候群病人之肌少風險因子與營養相關性之探討
論文名稱(外文):Relationship between risk factors of sarcopenia and nutritional status in patients with metabolic syndrome
指導教授:林娉婷
指導教授(外文):Ping-Ting Lin
口試委員:顏啟華陳淑茹
口試日期:2023-07-03
學位類別:碩士
校院名稱:中山醫學大學
系所名稱:營養學系
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2023
畢業學年度:111
語文別:中文
論文頁數:67
中文關鍵詞:代謝症候群肌少症肌肉功能營養狀態
外文關鍵詞:metabolic syndromesarcopeniamuscle functionnutritional status
DOI:10.6834/csmu202300066
相關次數:
  • 被引用被引用:0
  • 點閱點閱:30
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
臺灣代謝症候群盛行率逐年增加,肌少症之盛行率亦隨著臺灣高齡化社會的發展有增加之趨勢。本研究目的為探討代謝症候群之肌少風險因子與營養狀態之相關性。本橫斷面研究招募20歲以上之代謝症候群病人,並收集基本資料;透過雙能量X光吸收儀測量體組成;以握力、背筋力計、啞鈴彎舉次數、坐姿起立、步行速率以及簡易身體功能量表評估肌肉功能;營養狀態以迷你營養評估量表(mini nutritional assessment, MNA)評估,以24小時飲食回憶法瞭解其飲食營養素攝取情形。本研究共招募90名代謝症候群之研究對象,其中50名有肌少症風險。結果發現有肌少症風險者之熱量及維生素B1攝取顯著低於無肌少症風險組(p < 0.05),七成以上有肌少症風險之研究對象鉀、鈣、鎂、鋅、菸鹼酸、維生素B6及葉酸之攝取未達國人膳食營養素參考攝取量,且其MNA總分顯著低於無肌少症風險者(p < 0.05)。進一步以MNA總分(小於26.5分為營養不良風險)進行次分組分析,發現於MNA量表與飲食攝取相關題目,有肌少症風險且有營養不良風險者在蛋白質攝取不足(p = 0.07)、每天攝取不足兩份蔬果(p < 0.01)、每天飲用少於5杯流質(p = 0.03)及自覺營養不良(p < 0.01)之比例有顯著較高於無營養不良者。相關性結果顯示,MNA量表總分與5次坐姿起立秒數、6公尺步行速率、6分鐘步行速率及簡易身體功能量表呈顯著之相關性(p ≤ 0.01)。以邏輯式迴歸分析發現,營養不良風險與低四肢肌肉質量、5次坐姿起立秒數、6分鐘步行速率及肌少症風險呈顯著之正相關,且經調整干擾因子後此顯著性依然存在(p < 0.05)。由前述結果得知,代謝症候群者之飲食營養素攝取有未達建議攝取量之情形,且營養不良與肌肉功能表現不佳有關,故我們建議代謝症候群應監測其營養狀態,以避免暴露於肌少症風險。
The prevalence of metabolic syndrome (MS) in Taiwan is increasing annually. Due to the aging society, the prevalence of sarcopenia also tends to increase in Taiwan. The purpose of the present study was to investigate the relationship between risk factors of sarcopenia and nutritional status in subjects with MS. This cross-sectional study recruited people aged over 20 with MS and collected the characteristics data. The body composition was measured by dual-energy X-ray absorptiometry, and the muscle function was assessed by grip strength, back-leg strength dynamometer, dumbbell curl, chair stand test, gait speed test, and short physical performance battery (SPPB). The nutritional status was assessed by Mini Nutritional Assessment (MNA) questionnaire. The 24-hour diet recall was used to investigate the dietary food and nutrients intake of the subjects. A total number of 90 subjects with MS were included, and 50 subjects were at risk of sarcopenia. The results showed that subjects at risk of sarcopenia had significantly lower calories and vitamin B1 intake (p < 0.01), and over 70% of the subjects at risk of sarcopenia had a lower intake of potassium, calcium, magnesium, zinc, niacin, vitamin B6 and folate, which did not reach the dietary reference intakes. Furthermore, we used the MNA score (< 26.5 points as at risk of malnutrition) for subgroup analysis. We found that subjects at risk of sarcopenia and malnutrition had a higher proportion for consumed less than two servings of protein food daily or weekly (p = 0.07), consumed less than two servings of fruits and vegetables per day (p < 0.01), consumed less than 5 cups of fluid per day (p = 0.03), and self-views as being malnourished (p < 0.01) than those without malnutrition subjects. In addition, the MNA score was significantly correlated with the chair stand test, 6-meter or 6-mins gait speed, and SPPB (p ≤ 0.01). Subjects at risk of malnutrition may have an increased risk of low appendicular skeletal muscle mass index, lower muscle function (chair stand test, 6-meter or 6-mins gait speed), and the risk of sarcopenia (p < 0.05); the statistical significance still existed after adjusting for confounding factors. Subjects with MS may suffer from malnutrition, which is related to poor muscle performance. Thus, we suggest that subjects with MS should monitor their nutritional status to prevent the risk of developing sarcopenia.
壹、摘要 I
一、中文摘要 I
二、英文摘要 II
中英文縮寫對照表 III
貳、文獻探討 1
一、代謝症候群簡介 1
二、肌少症簡介 3
三、代謝與肌肉功能 5
四、營養狀態與肌肉功能 7
參、研究動機與目的 9
肆、材料與方法 10
一、研究設計 10
二、研究對象 10
三、研究方法 12
(一)研究對象之基本資料 12
(二)體位測量 12
(三)身體組成測量 12
(四)肌力適能測量 13
(五)營養狀態評估 15
(六)飲食紀錄 15
(七)肌少症風險及肌少症評估 16
(八)血液生化檢測 16
四、統計分析 17
伍、結果 18
一、代謝症候群研究對象之基本資料 18
二、代謝症候群研究對象之每日營養素攝取情形 19
三、代謝症候群研究對象之迷你營養評估(MNA) 20
四、代謝症候群研究對象有營養不良風險者之基本資料 21
五、代謝症候群有營養不良風險者之迷你營養評估 22
六、代謝症候群研究對象有營養不良風險營養素攝取量 23
七、代謝症候群研究對象MNA總分與肌少症因子之相關性 24
陸、討論 25
一、代謝症候群之肌少症風險探討 25
二、代謝症候群之肌少症風險與營養狀態之探討 28
三、代謝症候群之肌少症風險與飲食營養素攝取量之探討 31
(一)巨量營養素 31
(二)微量營養素 35
四、本研究優勢及限制 37
柒、結論 38
捌、表格 39
表一、代謝症候群研究對象之基本資料、體位測量及肌力適能 40
表二、代謝症候群研究對象之血液生化數值 42
表三、代謝症候群研究對象之每日飲食營養素攝取量 43
表四、代謝症候群研究對象每日飲食營養素攝取量未達DRIs建議攝取量之人數比例 45
表五、代謝症候群研究對象之迷你營養評估 46
表六、代謝症候群有無肌少風險與營養不良風險之基本資料、體位測量及肌力適能 47
表七、代謝症候群有無肌少風險與營養不良風險之血液生化數值 49
表八、代謝症候群有無肌少風險與營養不良風險之迷你營養評估 50
表九、代謝症候群有無肌少風險與營養不良風險之每日飲食營養素攝取量 51
表十、代謝症候群研究對象迷你營養評估量表總分與肌少症組成因子之相關性 53
表十一、利用邏輯式迴歸分析代謝症候群研究對象迷你營養評估總分與肌少症及其組成因子之相關性 54
玖、參考文獻 55
圖目錄
圖一、不健康生活型態之惡性循環…………………………...….5
圖二、研究架構…………………………………………...……….9
圖三、研究流程…………………………………………...……...11
一、中文
衛生福利部國民健康署(2007)。代謝症候群診斷標準。2023年5月30日,取自https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=639&pid=1219
衛生福利部國民健康署(2018)。每日飲食指南手冊。2023年4月12日,取自https://www.hpa.gov.tw/File/Attach/6712/File_6253.pdf
衛生福利部國民健康署(2022a)。2017-2020國民營養健康狀況變遷調查結果。2023年5月24日,取自https://www.hpa.gov.tw/File/Attach/15562/File_18775.pdf
衛生福利部國民健康署(2022b)。國人膳食營養素參考攝取量第八版。2023年5月25日,取自https://www.hpa.gov.tw/Pages/ashx/File.ashx?FilePath=~/File/Attach/12285/File_19961.pdf

二、英文
Al Saedi A, Debruin DA, Hayes A, Hamrick M. Lipid metabolism in sarcopenia. Bone. 2022;164:116539.
Amasene M, Besga A, Medrano M, Urquiza M, Rodriguez-Larrad A, Tobalina I, Barroso J, Irazusta J, Labayen I. Nutritional status and physical performance using handgrip and SPPB tests in hospitalized older adults. Clin Nutr. 2021;40:5547-5555.
Angulo J, El Assar M, Álvarez-Bustos A, Rodríguez-Mañas L. Physical activity and exercise: Strategies to manage frailty. Redox Biol. 2020;35:101513.
Anker SD, Morley JE, von Haehling S. Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle. 2016;7:512-514.
Ansarimoghaddam A, Adineh HA, Zareban I, Iranpour S, HosseinZadeh A, Kh F. Prevalence of metabolic syndrome in Middle-East countries: Meta-analysis of cross-sectional studies. Diabetes Metab Syndr. 2018;12:195-201.
Arjuna T, Soenen S, Hasnawati RA, Lange K, Chapman I, Luscombe-Marsh ND. A Cross-Sectional Study of Nutrient Intake and Health Status among Older Adults in Yogyakarta Indonesia. Nutrients. 2017;9:1240.
Bae EJ, Kim YH. Factors Affecting Sarcopenia in Korean Adults by Age Groups. Osong Public Health Res Perspect. 2017;8:169-178. 
Batsis JA, Mackenzie TA, Emeny RT, Lopez-Jimenez F, Bartels SJ. Low Lean Mass With and Without Obesity, and Mortality: Results From the 1999-2004 National Health and Nutrition Examination Survey. J Gerontol A Biol Sci Med Sci. 2017;72:1445-1451.
Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018;14:513-537.
Baumgartner RN. Body composition in healthy aging. Ann N Y Acad Sci. 2000;904:437-448.
Beaudart C, Locquet M, Touvier M, Reginster JY, Bruyère O. Association between dietary nutrient intake and sarcopenia in the SarcoPhAge study. Aging Clin Exp Res. 2019;31:815-824.
Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ; Health ABC Study. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68:617-23.
Bijlsma AY, Meskers CG, van Heemst D, Westendorp RG, de Craen AJ, Maier AB. Diagnostic criteria for sarcopenia relate differently to insulin resistance. Age (Dordr). 2013;35:2367-75.
Bird JK, Troesch B, Warnke I, Calder PC. The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping systematic review and meta-analysis. Clin Nutr ESPEN. 2021;46:73-86.
Brey CW, Akbari-Alavijeh S, Ling J, Sheagley J, Shaikh B, Al-Mohanna F, Wang Y, Gaugler R, Hashmi S. Salts and energy balance: A special role for dietary salts in metabolic syndrome. Clin Nutr. 2019;38:1971-1985.
Carvalho LP, Basso-Vanelli RP, Di Thommazo-Luporini L, Mendes RG, Oliveira-Junior MC, Vieira RP, Bonjorno-Junior JC, Oliveira CR, Luporini R, Borghi-Silva A. Myostatin and adipokines: The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults. Cytokine. 2018;107:118-124.
Castro-Barquero S, Ruiz-León AM, Sierra-Pérez M, Estruch R, Casas R. Dietary Strategies for Metabolic Syndrome: A Comprehensive Review. Nutrients. 2020;12:2983. 
Celis-Morales CA, Petermann F, Steell L, Anderson J, Welsh P, Mackay DF, Iliodromiti S, Lyall DM, Lean ME, Pell JP, Sattar N, Gill JMR, Gray SR. Associations of Dietary Protein Intake With Fat-Free Mass and Grip Strength: A Cross-Sectional Study in 146,816 UK Biobank Participants. Am J Epidemiol. 2018 1;187:2405-2414.
Chang CF, Yeh YL, Chang HY, Tsai SH, Wang JY. Prevalence and Risk Factors of Sarcopenia among Older Adults Aged ≥65 Years Admitted to Daycare Centers of Taiwan: Using AWGS 2019 Guidelines. Int J Environ Res Public Health. 2021;18:8299.
Chen LK, Arai H, Assantachai P, Akishita M, Chew STH, Dumlao LC, Duque G, Woo J. Roles of nutrition in muscle health of community-dwelling older adults: evidence-based expert consensus from Asian Working Group for Sarcopenia. J Cachexia Sarcopenia Muscle. 2022;13:1653-1672.
Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, Chou MY, Chen LY, Hsu PS, Krairit O, Lee JS, Lee WJ, Lee Y, Liang CK, Limpawattana P, Lin CS, Peng LN, Satake S, Suzuki T, Won CW, Wu CH, Wu SN, Zhang T, Zeng P, Akishita M, Arai H. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014;15:95-101.
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020;21:300-307.
Cho YJ, Lim YH, Yun JM, Yoon HJ, Park M. Sex- and age-specific effects of energy intake and physical activity on sarcopenia. Sci Rep. 2020;10:9822.
Choi KM. Sarcopenia and sarcopenic obesity. Korean J Intern Med. 2016;31:1054-1060.
Chumlea WC. Is the MNA valid in different populations and across practice settings?. J Nutr Health Aging. 2006;10:524-533.
Churilla JR, Summerlin M, Richardson MR, Boltz AJ. Mean Combined Relative Grip Strength and Metabolic Syndrome: 2011-2014 National Health and Nutrition Examination Survey. J Strength Cond Res. 2020;34:995-1000.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412-23.
Cruz-Jentoft AJ, Kiesswetter E, Drey M, Sieber CC. Nutrition, frailty, and sarcopenia. Aging Clin Exp Res. 2017;29:43-48.
Dargelos E, Poussard S, Brulé C, Daury L, Cottin P. Calcium-dependent proteolytic system and muscle dysfunctions: a possible role of calpains in sarcopenia. Biochimie. 2008;90:359-368.
De Lorenzo A, Pellegrini M, Gualtieri P, Itani L, El Ghoch M, Di Renzo L. The Risk of Sarcopenia among Adults with Normal-Weight Obesity in a Nutritional Management Setting. Nutrients. 2022;14:5295.
Dhillon RJ, Hasni S. Pathogenesis and Management of Sarcopenia. Clin Geriatr Med. 2017;33:17-26.
Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, Bauer JM, Boirie Y, Cruz-Jentoft AJ, Dicker D, Frara S, Frühbeck G, Genton L, Gepner Y, Giustina A, Gonzalez MC, Han HS, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Sieber CC, Siervo M, Vettor R, Villareal DT, Volkert D, Yu J, Zamboni M, Barazzoni R. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obes Facts. 2022;15:321-335.
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35:2402-2411.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI. Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int J Mol Sci. 2022;23:786.
Fanelli Kuczmarski M, Pohlig RT, Stave Shupe E, Zonderman AB, Evans MK. Dietary Protein Intake and Overall Diet Quality Are Associated with Handgrip Strength in African American and White Adults. J Nutr Health Aging. 2018;22:700-709. 
Feng L, Gao Q, Hu K, Wu M, Wang Z, Chen F, Mei F, Zhao L, Ma B. Prevalence and Risk Factors of Sarcopenia in Patients With Diabetes: A Meta-analysis. J Clin Endocrinol Metab. 2022;107:1470-1483.
Frampton J, Murphy KG, Frost G, Chambers ES. Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function. Nat Metab. 2020;2:840-848.
Frampton J, Murphy KG, Frost G, Chambers ES. Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older. J Cachexia Sarcopenia Muscle. 2021;12:2134-2144.
Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-S9.
Fukuda T, Bouchi R, Takeuchi T, Tsujimoto K, Minami I, Yoshimoto T, Ogawa Y. Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes: a retrospective observational study. Cardiovasc Diabetol. 2018;17:55.
Gallagher EJ, Leroith D, Karnieli E. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med. 2010;77:511-523.
Ganapathy A, Nieves JW. Nutrition and Sarcopenia-What Do We Know?. Nutrients. 2020;12:1755.
Gao Q, Mei F, Shang Y, Hu K, Chen F, Zhao L, Ma B. Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis. Clin Nutr. 2021;40:4633-4641.
Giezenaar C, Chapman I, Luscombe-Marsh N, Feinle-Bisset C, Horowitz M, Soenen S. Ageing Is Associated with Decreases in Appetite and Energy Intake--A Meta-Analysis in Healthy Adults. Nutrients. 2016;8:28.
Granic A, Mendonça N, Sayer AA, Hill TR, Davies K, Adamson A, Siervo M, Mathers JC, Jagger C. Low protein intake, muscle strength and physical performance in the very old: The Newcastle 85+ Study. Clin Nutr. 2018;37(6 Pt A):2260-2270.

Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-94.
Han E, Kim MK, Im SS, Kim HS, Kwon TK, Jang BK. High Sodium Intake, as Assessed by Urinary Sodium Excretion, Is Associated with Nonalcoholic Fatty Liver Disease or Sarcopenia. Gut Liver. 2023;17:456-465.
Harada H, Kai H, Niiyama H, Nishiyama Y, Katoh A, Yoshida N, Fukumoto Y, Ikeda H. Effectiveness of Cardiac Rehabilitation for Prevention and Treatment of Sarcopenia in Patients with Cardiovascular Disease - A Retrospective Cross-Sectional Analysis. J Nutr Health Aging. 2017;21:449-456.
Heo M, Faith MS, Pietrobelli A, Heymsfield SB. Percentage of body fat cutoffs by sex, age, and race-ethnicity in the US adult population from NHANES 1999-2004. Am J Clin Nutr. 2012;95:594-602.
Hyeon Cho H, Woong Lee D, Hahm MI. Association between nutrition labelling awareness and the metabolic syndrome: results from the Korean National Health and Nutrition Examination Survey (KNHANES) 2016-2018. Br J Nutr. 2021;126:685-694..
Ishii S, Tanaka T, Akishita M, Ouchi Y, Tuji T, Iijima K; Kashiwa study investigators. Metabolic syndrome, sarcopenia and role of sex and age: cross-sectional analysis of Kashiwa cohort study. PLoS One. 2014;9:e112718.
Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017;35:200-221.
Kim BM, Yi YH, Kim YJ, Lee SY, Lee JG, Cho YH, Tak YJ, Hwang HR, Lee SH, Park EJ, Lee Y. Association between Relative Handgrip Strength and Dyslipidemia in Korean Adults: Findings of the 2014-2015 Korea National Health and Nutrition Examination Survey. Korean J Fam Med. 2020;41:404-411.

Kim JH, Cho JJ, Park YS. Relationship between sarcopenic obesity and cardiovascular disease risk as estimated by the Framingham risk score. J Korean Med Sci. 2015;30:264-271.
Kim TN, Park MS, Yang SJ, Yoo HJ, Kang HJ, Song W, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM. Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care. 2010;33:1497-9.
Ko CH, Wu SJ, Wang ST, Chang YF, Chang CS, Kuan TS, Chuang HY, Chang CM, Chou W, Wu CH. Effects of enriched branched-chain amino acid supplementation on sarcopenia. Aging (Albany NY). 2020;12:15091-15103.
Kotsani M, Chatziadamidou T, Economides D, Benetos A. Higher prevalence and earlier appearance of geriatric phenotypes in old adults with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2018;135:206-217.
Kramer CS, Groenendijk I, Beers S, Wijnen HH, van de Rest O, de Groot LCPGM. The Association between Malnutrition and Physical Performance in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies. Curr Dev Nutr. 2022;6:nzac007.
Le Couteur DG, Solon-Biet SM, Cogger VC, Ribeiro R, de Cabo R, Raubenheimer D, Cooney GJ, Simpson SJ. Branched chain amino acids, aging and age-related health. Ageing Res Rev. 2020;64:101198.
Lee J, Hong YP, Shin HJ, Lee W. Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength. J Prev Med Public Health. 2016;49:35-44.
Lee LC, Tsai AC. Mini-Nutritional-Assessment (MNA) without body mass index (BMI) predicts functional disability in elderly Taiwanese. Arch Gerontol Geriatr. 2012;54:e405-e410.
Lengelé L, Bruyère O, Beaudart C, Reginster JY, Locquet M. Malnutrition, assessed by the Global Leadership Initiative on Malnutrition (GLIM) criteria but not by the mini nutritional assessment (MNA), predicts the incidence of sarcopenia over a 5-year in the SarcoPhAge cohort. Aging Clin Exp Res. 2021;33:1507-1517.

Liguori I, Curcio F, Russo G, Cellurale M, Aran L, Bulli G, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Risk of Malnutrition Evaluated by Mini Nutritional Assessment and Sarcopenia in Noninstitutionalized Elderly People. Nutr Clin Pract. 2018;33:879-886.
Li R, Li W, Lun Z, Zhang H, Sun Z, Kanu JS, Qiu S, Cheng Y, Liu Y. Prevalence of metabolic syndrome in Mainland China: a meta-analysis of published studies. BMC Public Health. 2016;16:296.
Lim KH, Riddell LJ, Nowson CA, Booth AO, Szymlek-Gay EA. Iron and zinc nutrition in the economically-developed world: a review. Nutrients. 2013;5:3184-211.
Liu C, Cheung WH, Li J, Chow SK, Yu J, Wong SH, Ip M, Sung JJY, Wong RMY. Understanding the gut microbiota and sarcopenia: a systematic review. J Cachexia Sarcopenia Muscle. 2021;12:1393-1407.
Liu ZJ, Zhu CF. Causal relationship between insulin resistance and sarcopenia. Diabetol Metab Syndr. 2023;15:46.
Mendes J, Afonso C, Moreira P, Padrão P, Santos A, Borges N, Negrão R, Amaral TF. Association of Anthropometric and Nutrition Status Indicators with Hand Grip Strength and Gait Speed in Older Adults. JPEN J Parenter Enteral Nutr. 2019;43:347-356.
Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, Rinfret S, Schiffrin EL, Eisenberg MJ. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56:1113-32.
Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T. Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study. J Epidemiol. 2021;31:320-327.
Napoleone JM, Boudreau RM, Lange-Maia BS, et al. Metabolic Syndrome Trajectories and Objective Physical Performance in Mid-to-Early Late Life: The Study of Women's Health Across the Nation (SWAN). J Gerontol A Biol Sci Med Sci. 2022;77:e39-e47.
Neinast M, Murashige D, Arany Z. Branched Chain Amino Acids. Annu Rev Physiol. 2019;81:139-164.

Nilsson PM, Tuomilehto J, Rydén L. The metabolic syndrome - What is it and how should it be managed?. Eur J Prev Cardiol. 2019;26:33-46.
Nishikawa H, Asai A, Fukunishi S, Nishiguchi S, Higuchi K. Metabolic Syndrome and Sarcopenia. Nutrients. 2021;13:3519.
Norazman CW, Adznam SN, Jamaluddin R. Malnutrition as Key Predictor of Physical Frailty among Malaysian Older Adults. Nutrients. 2020;12:1713.
Norman K, Haß U, Pirlich M. Malnutrition in Older Adults-Recent Advances and Remaining Challenges. Nutrients. 2021;13:2764.
Okamura T, Miki A, Hashimoto Y, Kaji A, Sakai R, Osaka T, Hamaguchi M, Yamazaki M, Fukui M. Shortage of energy intake rather than protein intake is associated with sarcopenia in elderly patients with type 2 diabetes: A cross-sectional study of the KAMOGAWA-DM cohort. J Diabetes. 2019;11:477-483.
Otsuka R, Kato Y, Nishita Y, Tange C, Tomida M, Nakamoto M, Imai T, Ando F, Shimokata H. Age-related Changes in Energy Intake and Weight in Community-dwelling Middle-aged and Elderly Japanese. J Nutr Health Aging. 2016;20:383-90.
Pan L, Xie W, Fu X, Lu W, Jin H, Lai J, Zhang A, Yu Y, Li Y, Xiao W. Inflammation and sarcopenia: A focus on circulating inflammatory cytokines. Exp Gerontol. 2021;154:111544.
Papadopoulou SK. Sarcopenia: A Contemporary Health Problem among Older Adult Populations. Nutrients. 2020;12:1293.
Papadopoulou SK, Voulgaridou G, Kondyli FS, Drakaki M, Sianidou K, Andrianopoulou R, Rodopaios N, Pritsa A. Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression. Diseases. 2022;10:42.
Park SJ, Ryu SY, Park J, Choi SW. Association of Sarcopenia with Metabolic Syndrome in Korean Population Using 2009-2010 Korea National Health and Nutrition Examination Survey. Metab Syndr Relat Disord. 2019;17:494-499.
Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, Celis-Morales C. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2022;13:86-99.
Prasad AS. Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Front Nutr. 2014;1:14.

Prokopidis K, Cervo MM, Gandham A, Scott D. Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective. Nutrients. 2020;12:2285.
Ranallo RF, Rhodes EC. Lipid metabolism during exercise. Sports Med. 1998;26:29-42.
Ravaut G, Légiot A, Bergeron KF, Mounier C. Monounsaturated Fatty Acids in Obesity-Related Inflammation. Int J Mol Sci. 2020;22:330.
Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607.
Richardson CJ, Schalm SS, Blenis J. PI3-kinase and TOR: PIKTORing cell growth. Semin Cell Dev Biol. 2004;15:147-159.
Robinson S, Granic A, Sayer AA. Nutrition and Muscle Strength, As the Key Component of Sarcopenia: An Overview of Current Evidence. Nutrients. 2019;11:2942.
Robinson S, Granic A, Sayer AA. Micronutrients and sarcopenia: current perspectives. Proc Nutr Soc. 2021;80:311-318.
Rondanelli M, Rigon C, Perna S, Gasparri C, Iannello G, Akber R, Alalwan TA, Freije AM. Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption. Nutrients. 2020;12:307.
Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018;20:12.
Sasaki KI, Fukumoto Y. Sarcopenia as a comorbidity of cardiovascular disease. J Cardiol. 2022;79:596-604.
Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022;51:afac220.
Scuteri A, Laurent S, Cucca F, Cockcroft J, Cunha PG, Mañas LR, Mattace Raso FU, Muiesan ML, Ryliškytė L, Rietzschel E, Strait J, Vlachopoulos C, Völzke H, Lakatta EG, Nilsson PM; Metabolic Syndrome and Arteries Research (MARE) Consortium. Metabolic syndrome across Europe: different clusters of risk factors. Eur J Prev Cardiol. 2015;22:486-91.
Seo MH, Kim MK, Park SE, Rhee EJ, Park CY, Lee WY, Baek KH, Song KH, Kang MI, Oh KW. The association between daily calcium intake and sarcopenia in older, non-obese Korean adults: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) 2009. Endocr J. 2013;60:679-86.

Shin JA, Lee JH, Lim SY, Ha HS, Kwon HS, Park YM, Lee WC, Kang MI, Yim HW, Yoon KH, Son HY. Metabolic syndrome as a predictor of type 2 diabetes, and its clinical interpretations and usefulness. J Diabetes Investig. 2013;4:334-43.
Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res. 2019;31:793-798.
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr. 2011;93:402-12.
Tak YJ, Lee JG, Yi YH, Kim YJ, Lee S, Cho BM, Cho YH. Association of Handgrip Strength with Dietary Intake in the Korean Population: Findings Based on the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-1), 2016. Nutrients. 2018;10:1180.
Tamura Y, Omura T, Toyoshima K, Araki A. Nutrition Management in Older Adults with Diabetes: A Review on the Importance of Shifting Prevention Strategies from Metabolic Syndrome to Frailty. Nutrients. 2020;12:3367.
Tan VMH, Pang BWJ, Lau LK, Jabbar KA, Seah WT, Chen KK, Ng TP, Wee SL. Malnutrition and Sarcopenia in Community-Dwelling Adults in Singapore: Yishun Health Study. J Nutr Health Aging. 2021;25:374-381.
Taylor GO, Agbedana EO, Johnson AO. High-density-lipoprotein-cholesterol in protein-energy malnutrition. Br J Nutr. 1982;47:489-494.
Therakomen V, Petchlorlian A, Lakananurak N. Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study. Sci Rep. 2020;10:19551.
Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6:772-783.
Tsai AC, Chang TL, Yang TW, Chang-Lee SN, Tsay SF. A modified mini nutritional assessment without BMI predicts nutritional status of community-living elderly in Taiwan. J Nutr Health Aging. 2010;14:183-189.
Tsai AC, Ho CS, Chang MC. Population-specific anthropometric cut-points improve the functionality of the Mini Nutritional Assessment (MNA) in elderly Taiwanese. Asia Pac J Clin Nutr. 2007;16:656-662.

van Dronkelaar C, van Velzen A, Abdelrazek M, van der Steen A, Weijs PJM, Tieland M. Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review. J Am Med Dir Assoc. 2018;19:6-11.
van Schoor NM, Swart KM, Pluijm SM, Visser M, Simsek S, Smulders Y, Lips P. Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons. Eur J Clin Nutr. 2012;66:174-81.
Vellas B, Villars H, Abellan G, Soto ME, Rolland Y, Guigoz Y, Morley JE, Chumlea W, Salva A, Rubenstein LZ, Garry P. Overview of the MNA--Its history and challenges. J Nutr Health Aging. 2006;10:456-63; discussion 463-5.
Vidoni ML, Pettee Gabriel K, Luo ST, Simonsick EM, Day RS. Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci. 2018;73:546-551.
Wang M, Tan Y, Shi Y, Wang X, Liao Z, Wei P. Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments. Front Endocrinol (Lausanne). 2020;11:568.
Wannamethee SG, Atkins JL. Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. Proc Nutr Soc. 2015;74:405-412.
Waters DL, Wayne SJ, Andrieu S, Cesari M, Villareal DT, Garry P, Vellas B. Sexually dimorphic patterns of nutritional intake and eating behaviors in community-dwelling older adults with normal and slow gait speed. J Nutr Health Aging. 2014;18:228-33.
Wapnir RA. Zinc deficiency, malnutrition and the gastrointestinal tract. J Nutr. 2000 May;130(5S Suppl):1388S-92S.
Wei B, Liu Y, Lin X, Fang Y, Cui J, Wan J. Dietary fiber intake and risk of metabolic syndrome: A meta-analysis of observational studies. Clin Nutr. 2018;37:1935-1942.
Wu CH, Chen KT, Hou MT, Chang YF, Chang CS, Liu PY, Wu SJ, Chiu CJ, Jou IM, Chen CY. Prevalence and associated factors of sarcopenia and severe sarcopenia in older Taiwanese living in rural community: the Tianliao Old People study 04. Geriatr Gerontol Int. 2014;14 Suppl 1:69-75.

Wu X, Li X, Xu M, Zhang Z, He L, Li Y. Sarcopenia prevalence and associated factors among older Chinese population: Findings from the China Health and Retirement Longitudinal Study. PLoS One. 2021;16:e0247617.
Xie WQ, Xiao GL, Fan YB, He M, Lv S, Li YS. Sarcopenic obesity: research advances in pathogenesis and diagnostic criteria. Aging Clin Exp Res. 2021;33:247-252.
Xu W, Perera S, Medich D, Fiorito G, Wagner J, Berger LK, Greenspan SL. Height loss, vertebral fractures, and the misclassification of osteoporosis. Bone. 2011;48:307-11.
Yang C, Jia X, Wang Y, Fan J, Zhao C, Yang Y, Shi X. Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999-2018. BMC Geriatr. 2022;22:979.
Yang SW, Chen YY, Chen WL. Association between oral intake magnesium and sarcopenia: a cross-sectional study.BMC Geriatr. 2022;22:816.
Zhang H, Lin S, Gao T, Zhong F, Cai J, Sun Y, Ma A. Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis. Nutrients. 2018;10:364.
Zujko ME, Rożniata M, Zujko K. Individual Diet Modification Reduces the Metabolic Syndrome in Patients Before Pharmacological Treatment. Nutrients. 2021;13:2102.
電子全文 電子全文(網際網路公開日期:20280706)
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊