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研究生:季照芸
研究生(外文):Chao-Yun Chi
論文名稱:使用陽壓呼吸輔助器治療睡眠呼吸中止症可以改善感音性聽力喪失
論文名稱(外文):Continuous Positive Airway Pressure (CPAP) Treatment Improves Pure Tone Audiometry Threshold in Sensorineural Hearing Loss Patients with Sleep-Disordered Breathing
指導教授:丁化丁化引用關係李信達李信達引用關係
指導教授(外文):Hua TingShin-Da Lee
口試委員:杭良文鄧玉貴賴慶祥
口試委員(外文):Liang-Wen HangYu-Kuei TengChing-Hsiang Lai
口試日期:2023-01-31
學位類別:博士
校院名稱:中山醫學大學
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2023
畢業學年度:111
語文別:中文
論文頁數:63
中文關鍵詞:持續性陽壓呼吸輔助器阻塞性睡眠呼吸中止症睡眠呼吸障礙感音神經性聽力損失純音聽力檢查睡眠多項生理檢查
外文關鍵詞:continuous positive airway pressureobstructive sleep apneasleep-disordered breathingneural deafnesspure-tone audiometrypolysomnography
DOI:10.6834/csmu202300034
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本文研究了持續性陽壓呼吸輔助器治療對伴有睡眠呼吸障礙的感音神經性聽力損失患者聽力損傷的影響。這項回顧性和觀察性研究於 2016年9月至 2021年2 月進行,累計77名同時有感音神經性聽力損失和睡眠呼吸障礙受試者(平均年齡60.7±11.1年)。其中28人接受持續性陽壓呼吸輔助器治療(平均年齡63.0±8.5歲)。在我們的方法中,低、中、高和均頻的聽力閾值通過治療前的基準線 (Baseline, BL)、三個月 (3 months, 3m)、六個月 (6 months, 6m) 和 12個月 (12 months, 12m)的純音聽力檢查進行評估。我們的研究結果發現,所有參與者,至少有三種頻率在基準線的值與年長、男性、吸煙、喝酒、冠狀動脈疾病、高血壓和呼吸暫停低通氣指數呈正相關(各個p皆< 0.05)。此外,與治療前BL 相應測量值作對比,使用持續性陽壓呼吸輔助器治療滿6個月(CPAP-6 m),聽力閥值在低、中、高和均頻的改變狀況分別為-5.60±2.33, -5.82±2.56,以及-5.10±2.26 dB (所有p < 0.05)。而使用持續性陽壓呼吸輔助器治療滿12個月(CPAP-12 m),聽力閥值在低、中、高和均頻的改變狀況分別為-7.97±2.74、-8.15±2.35,以及-6.67±2.37 dB (所有p< 0.01)。而且,低、中、和均頻和使用持續性陽壓呼吸輔助器治療呈負相關。此外,亦發現高頻、中頻和均頻與年齡呈正相關(高頻和均頻之於年齡: r=0.50,0.41; p皆 < 0.001,中頻之於年齡: r=0.32; p <0.01)。我們得出結論,在合併有睡眠呼吸障礙的感音神經性聽力損失病患者中,使用持續性陽壓呼吸輔助器六個月後,會明顯改善低頻和中頻的聽力閾值,這種情況至少能持續一年。
This research investigates the effects of continuous positive airway pressure (CPAP) on hearing impairment in sensorineural hearing loss (SNHL) patients with sleep-disordered breathing (SDB). This retrospective and observational study took place from September 2016 to February 2021, accumulating 77 subjects with SNHL and SDB (60.7±11.1 years). Of which, 28 received CPAP treatment (63.0±8.5 years). In our methodology, hearing thresholds at low, medium, high, and average frequencies are assessed by pure-tone audiometry at baseline (BL), three (3 m), six (6 m), and 12 (12 m) months. Our results show that the BL of at least three frequencies in all subjects is positively associated with old age, males, smoking, alcohol, coronary artery disease, hypertension, and apnea-hypopnea index [AHI] (all p < 0.05). Moreover, low, medium, and average frequencies are negatively correlated at CPAP-6 m (-5.60±2.33, -5.82±2.56, and -5.10±2.26 dB; all p < 0.05) and CPAP-12 m (-7.97±2.74, -8.15±2.35, and -6.67±2.37 dB; all p < 0.01) against corresponding measures of CPAP-BL. High, medium, and average frequencies positively correlated with age (p < 0.001 for high and average frequencies and <0.01 for medium frequencies, respectively). We conclude that in SNHL patients with SDB, hearing thresholds at low and medium frequencies improves under CPAP use after six months, which persists at least to the end of one year.
目錄
致謝……………………………………… Ι
中文摘要………………………………… Ⅱ
英文摘要………………………………… Ⅳ

第一章 研究背景 ………………………… 1
第一節 感音性聽力障礙疾病介紹…… 1
1.1 病因 ……………………………… 1
1.2 機轉 ……………………………… 1
1.3 診斷 ……………………………… 2
1.4 治療 ……………………………… 3
1.5 目前醫學相關瓶頸 ……………… 5
第二節 睡眠呼吸障礙 (Sleep-disordered breathing, SDB)疾病介紹…… 6
1.1 病因 ……………………………… 6
1.2 機轉 ……………………………… 7
1.3 診斷 ……………………………… 7
1.4 治療 ………………………………13
1.5目前醫學相關瓶頸以及本研究設計動機………………………………………20
第二章 研究方法 …………………………21
第一節 研究設計 ………………………21
第二節 收案族群分布 …………………21
1.1 收案條件(Inclusion Criteria)…21
1.2 排除條件(Exclusion Criteria)…21
1.3受試者研究分布流程圖……………22
(Flow Chart,圖一;Figure 1)…23
第三節 研究細節原則(Protocol) ……24
1.1 病歷紀錄 …………………………24
1.2睡眠多項生理檢查…………………25
Polysomnography (PSG)
1.3 純音聽力檢查 …………………… 26
Pure-tone Audiometry (PTA)
1.4持續性陽壓呼吸輔助器介紹………27
Continuous Positive Airway Pressure (CPAP)
1.5 相關疾病定義以及介紹……………28
1.6 統計…………………………………28

第三章 研究結果…………………………31
第一節 成功收案參與者分析…………31
第二節 收案者基本資料以及共病分析.31
(表一;Table 1) ……………34
第三節 感音性聽力受損和各種體質、疾病和治療間的關係……………35
1.1 低頻感音性聽力受損 ……………35
1.2 中頻感音性聽力受損 ……………35
1.3 高頻感音性聽力受損 ……………35
1.4 全頻感音性聽力受損 ……………35
(表二;Table 2) ……………37
第四節 使用持續性陽壓呼吸輔助器治療後,於不同時間段對於感音性聽力受損的變化 …………………38
1.1 低頻感音性聽力受損變化…………38
1.2 中頻感音性聽力受損變化…………38
1.3 高頻感音性聽力受損變化…………38
1.4全頻感音性聽力受損變化…………38
(表三;Table 3) …………………40
(圖二;Figure 2)…………………41
第五節 結果總結 ………………………42
第四章 討論 ………………………………43
第一節 本研究結果討論 ………………43
第二節 本研究結果和國際已發表相關論文交叉討論 ……………………43
第三節 本研究限制因素 ………………47
第四節 本研究現有貢獻和未來展望 …47
第五章 結論 ………………………………49
第六章 參考書籍以及論文 (References)…50
第七章 作者其他論文發表列表 …………57
第八章 作者學術、臨床經歷、以及研究領域………………………………………………59
第九章 作者得獎紀錄/特殊事蹟 ………61
第十章 博士班期間SCI論文發表………63
1. Peter, C.; Weber, S.K. Anatomy and Physiology of Hearing. In Byron J. Bailey’s Head and Neck Surgery. Otolaryngology, 4th ed; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2007.
2. Lin, F.R. Hearing Loss and Cognition Among Older Adults in the United States. J. Gerontol. Ser. A Boil. Sci. Med. Sci. 2011, 66, 1131–1136. [CrossRef]
3. Cacioppo, J.T.; Hawkley, L.C.; Norman, G.J.; Berntson, G.G. Social isolation. Ann. N. Y. Acad. Sci. 2011, 1231, 17–22. [CrossRef]
4. Yang, Z.; Cosetti, M. Safety and outcomes of cochlear implantation in the elderly: A review of recent literature. J. Otol. 2016, 11,1–6. [CrossRef]
5. Lin, Y.-H.; Wu, C.-C.; Hsu, C.-J.; Hwang, J.-H.; Liu, T.-C. The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese. Laryngoscope 2011, 121, 1303–1307. [CrossRef] [PubMed]
6. Arts, H.A. Sensorineural Hearing Loss in Adults. In Cummings Otolaryngology Head and Neck Surgery, 4th ed.; Mosby: St. Louis, MO, USA, 2004.
7. Guimaraes, P.; Frisina, S.T.; Mapes, F.; Tadros, S.F.; Frisina, D.R.; Frisina, R.D. Progestin negatively affects hearing in aged women. Proc. Natl. Acad. Sci. USA 2006, 103, 14246–14249. [CrossRef] [PubMed]
8. Van Eyken, E.; Van Camp, G.; Van Laer, L. The complexity of age-related hearing impairment: Contributing environmental and genetic factors. Audiol. Neurotol. 2007, 12, 345–358. [CrossRef] [PubMed]
9. Snell, K.B.; Frisina, D.R. Relationships among age-related differences in gap detection and word recognition. J. Acoust. Soc. Am. 2000, 107, 1615–1626. [CrossRef] [PubMed]
10. Hwang, J.-H.; Li, C.-W.; Wu, C.W.; Chen, J.-H.; Liu, T.-C. Aging Effects on the Activation of the Auditory Cortex during Binaural Speech Listening in White Noise: An fMRI Study. Audiol. Neurotol. 2007, 12, 285–294. [CrossRef] [PubMed]
11. Wade Chien and Daniel J Lee. Cummings Otolaryngology Head and Neck Surgery Chapter 129 – Physiology of the Auditory System.
12. Yamahara, K.; Yamamoto, N.; Nakagawa, T.; Ito, J. Insulin-like growth factor 1: A novel treatment for the protection or regeneration of cochlear hair cells. Hear. Res. 2015, 330, 2–9. [CrossRef]
13. Dorota Olex-Zarychta. Successful treatment of sudden sensorineural hearing loss by means of pharmacotherapy combined with early hyperbaric oxygen therapy. Medicine (Baltimore). 2017 Dec; 96(51): e9397. doi: 10.1097/MD.0000000000009397
14. Eric R. Oliver and George T. Hashisaki. Chapter 160- Sudden Sensory Hearing Loss. In Byron J. Bailey’s Head and Neck Surgery. Otolaryngology, 4th ed; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2007.
15. Anne Elizabeth Conlin. Treatment of Sudden Sensorineural Hearing Loss. A Systematic Review. Arch Otolaryngol Head Neck Surg. 2007;133:573-581.
16.Luigi Capuano, Matteo Cavaliere, Giuseppe Parente, Alberto, Damiano, Gabriella Pezzuti, Dante Lopardo, Maurizio Iemma. Hyperbaric oxygen for idiopathic sudden hearing loss: is the routine application helpful? Acta Otolaryngol. 2015 Jul;135(7):692-7. doi: 10.3109/00016489.2015.1023355. Epub 2015 Mar 26.
17.Xin-chang Zhang, Xiu-ping Xu, Wen-tao Xu, Wen-zhen Hou, Ying-ying Cheng, Chang-xi Li, Guang-xia Ni. Acupuncture Therapy for Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLOS ONE | DOI:10.1371/journal.pone.0125240 April 28, 2015
18. Catherine V. Palmer and Barry E. Hirsch. Chapter 164- Hearing Aids and Assistive Listening Devices. In Byron J. Bailey’s Head and Neck Surgery. Otolaryngology, 4th ed; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2007.
19. Oliver F. Adunka and Craig A. Buchman. Chapter 163- Cochlear Implants and Other Implantable Auditory Prostheses. In Byron J. Bailey’s Head and Neck Surgery. Otolaryngology, 4th ed; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2007.
20. A.Abdellaoui , P. Tran Ba Huy. Success and failure factors for hearing-aid prescription: Results of a French national survey. European Annals of Otorhinolaryngology, Head and Neck diseases (2013) 130, 313—319.
http://dx.doi.org/10.1016/j.anorl.2012.09.01
21.Hoyos, C.M.; Killick, R.; Keenan, D.M.; Baxter, R.; Veldhuis, J.D.; Liu, P.Y. Continuous Positive Airway Pressure Increases Pulsatile Growth Hormone Secretion and Circulating Insulin-like Growth Factor-1 in a Time-Dependent Manner in Men with Obstructive Sleep Apnea: A Randomized Sham-Controlled Study. Sleep 2014, 37, 733–741. [CrossRef]
22. Flemons,W.; Tsai,W. Quality of life consequences of sleep-disordered breathing. J. Allergy Clin. Immunol. 1997, 99, S750–S756. [CrossRef]
23. Young, T.; Palta, M.; Dempsey, J.; Skatrud, J.;Weber, S.; Badr, S. The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults. N. Engl. J. Med. 1993, 328, 1230–1235. [CrossRef]
24. Lee Shangold. Sleep Apnea and Snoring 2nd ed. Chapter 4 - Clinical Polysomnography
25. Gu, X.; Luo, X.; Wang, X.; Tang, J.; Yang, W.; Cai, Z. The correlation between obstructive sleep apnea and diabetic neuropathy: A meta-analysis. Prim. Care Diabetes 2018, 12, 460–466. [CrossRef] [PubMed]
26. Mentek, M.; Aptel, F.; Godin-Ribuot, D.; Tamisier, R.; Pepin, J.-L.; Chiquet, C. Diseases of the retina and the optic nerve associated with obstructive sleep apnea. Sleep Med. Rev. 2018, 38, 113–130. [CrossRef]
27. Martines, F.; Ballacchino, A.; Sireci, F.; Mucia, M.; La Mattina, E.; Rizzo, S.; Salvago, P. Audiologic profile of OSAS and simple snoring patients: The effect of chronic nocturnal intermittent hypoxia on auditory function. Eur. Arch. Oto-Rhino-Laryngol. 2015, 273, 1419–1424. [CrossRef]
28. Seo, Y.J.; Park, S.Y.; Chung, H.J.; Kim, C.-H.; Lee, J.-G.; Kim, S.H.; Cho, H.-J. Lowest Oxyhemoglobin Saturation May Be an Independent Factor Influencing Auditory Function in Severe Obstructive Sleep Apnea. J. Clin. Sleep Med. 2016, 12, 653–658. [CrossRef] [PubMed]
29. Chopra, A.; Jung, M.; Kaplan, R.C.; Appel, D.W.; Dinces, E.A.; Dhar, S.; Zee, P.C.; Gonzalez, F.; Lee, D.J.; Ramos, A.R.; et al. Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos. J. Clin. Sleep Med. 2016, 12, 719–726. [CrossRef]
30. Kayabasi, S.; Hizli, O.; Yildirim, G. The association between obstructive sleep apnea and hearing loss: A cross-sectional analysis. Eur. Arch. Oto-Rhino-Laryngol. 2019, 276, 2215–2221. [CrossRef]
31. Spinosi, M.C.; D’Amico, F.; Passàli, G.; Cingi, C.; Rodriguez, H.; Passàli, D. Hearing loss in mild OSAS and simple snoring patients. Otolaryngol. Polska 2017, 71, 11–15. [CrossRef]
32. Hoffstein, V.; Haight, J.; Cole, P.; Zamel, N. Does Snoring Contribute to Presbycusis? Am. J. Respir. Crit. Care Med. 1999, 159, 1351–1354. [CrossRef]
33. Sheu, J.-J.; Wu, C.-S.; Lin, H.-C. Association between Obstructive Sleep Apnea and Sudden Sensorineural Hearing Loss: A Population-Based Case-Control Study. Arch. Otolaryngol. Head Neck Surg. 2012, 138, 55–59. [CrossRef]
34. Hwang, J.-H.; Chen, J.-C.; Hsu, C.-J.; Liu, T.-C. Association of Obstructive Sleep Apnea and Auditory Dysfunctions in Older Subjects. Otolaryngol. Neck Surg. 2010, 144, 114–119. [CrossRef]
35. David Kent, Jeffrey Stanley, R. Nisha Aurora, Corinna Levine, Daniel J. Gottlieb, Matthew D. Spann, Carlos A. Torre, Katherine Green, Christopher G. Harrod. Referral of adults with obstructive sleep apnea for surgical consultation: an American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine, 2021 Dec 1;17(12):2499-2505. doi: 10.5664/jcsm.9592
36. Lee Shangold and Ofer Jacobowitz. Sleep Apnea and Snoring 2nd ed. Chapter 8 - CPAP, APAP, and BiPAP
37. Mohamed El Shayeb, Leigh-Ann Topfer, Tania Stafinski, Lawrence Pawluk, and Devidas Menon. Diagnostic accuracy of level 3 portable sleep tests versus level 1 polysomnography for sleep-disordered breathing: a systematic review and meta-analysis. doi: 10.1503/cmaj.130952
38. Stanley Yung-Chuan Liu, Leh-Kiong Huon, Soroush Zaghi, Robert Riley, and Carlos Torre. An Accurate Method of Designing and Performing Individual-Specific Genioglossus Advancement. American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016. doi: 10.1177/0194599816670366.
39. Madeline J.L. Ravesloot, Linda Benoist, Nico de Vries. Sleep Apnea and Snoring 2nd ed. Chapter 6 - Drug-Induced Sleep Endoscopy (DISE).
40. G A Stephen, P S Eichling, S F Quan. Treatment of sleep disordered breathing and obstructive sleep apnea. Minerva Med. 2004 Aug;95(4):323-36.
41. Venkata Koka, Andrea De Vito , Gabriel Roisman , Michel Petitjean , Giulio Romano Filograna Pignatelli, Davide Padovani, Winfried Randerath. Orofacial Myofunctional Therapy in Obstructive Sleep Apnea Syndrome: A Pathophysiological Perspective. Medicina (Kaunas). 2021 Apr 1;57(4):323. doi: 10.3390/medicina57040323
42. Ofer Jacobowitz. Sleep Apnea and Snoring 2nd ed. Chapter 10 - Oral Appliances for OSA
43. Stanley Yung-Chuan Liu, Nelson B. Powell and Robert W. Riley. Sleep Apnea and Snoring 2nd ed. Chapter 17 - Algorithm for Multilevel Treatment: The Riley, Powell, and Liu Stanford Experience.
44. Stanley Yung-Chuan Liu, Nelson B. Powell and Robert W. Riley. Sleep Apnea and Snoring 2nd ed. Chapter 57 - Maxillofacial Surgical Techniques for Hypopharyngeal Obstruction in Obstructive Sleep Apnea.
45. Stanley Yung-Chuan Liu, Christian Guilleminault and Audrey Jung-Sun Yoon. Sleep Apnea and Snoring 2nd ed. Chapter 59 - Distraction Osteogenesis Maxillary Expansion (DOME) for Adult Obstructive Sleep Apnea Patients.
46. Jessie Chao-Yun Chi, Shin-Da Lee , Chia-Yi Lee, Stanley Yung Liu, Hua Ting, and Yih-Jeng Tsai. Endonasal Septoplasty Using a Septal Cartilaginous Batten Graft for Managing Caudal Septal Deviation. Healthcare 2022, 10, 1739. https://doi.org/10.3390/healthcare10091739.
47. She, W.D.; Zhang, Q.; Chen, F.; Jiang, P.; Wang, J. Peri-uvulopalatopharyngoplasty otoacoustic emissions in patients with obstructive sleep apnea-hypopnea syndrome. Zhonghua Er Bi Yan Hou Ke Za Zhi 2004, 39, 48–51.
48. Jessie Chao-Yun Chi, Rayleigh Ping-Ying Chiang, Tse-Yu Chou, Chih-Hung Shu, An-Suey Shiao, Chia-Mo Lin. The role of lateral pharyngoplasty in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2015 Feb; 272(2):489-96. Epub 2014 Sep 12. DOI: 10.1007/s00405-014-3253-6.
49. Liu SY, Hutz MJ, Poomkonsarn S, Chang CP, Awad M, Capasso R. Palatopharyngoplasty Resolves Concentric Collapse in Patients Ineligible for Upper Airway Stimulation. Laryngoscope. 2020 Dec;130(12):E958-E962. doi: 10.1002/lary.28595
50. Patrick J. Strollo, Jr.,Ryan J. Soose, Joachim T. Maurer, Nico de Vries, Jason Cornelius, Oleg Froymovich, Ronald D. Hanson, Tapan A. Padhya, David L. Steward, M. Boyd Gillespie, B. Tucker Woodson, Paul H. Van de Heyning. Upper-Airway Stimulation for Obstructive Sleep Apnea. N Engl J Med 2014; 370:139-149. DOI: 10.1056/NEJMoa1308659
51. Zhao, Y.Y.;Wang, R.; Gleason, K.J.; Lewis, E.F.; Quan, S.F.; Toth, C.M.; Morrical, M.; Rueschman, M.;Weng, J.;Ware, J.H.; et al. Effect of Continuous Positive Airway Pressure Treatment on Health-Related Quality of Life and Sleepiness in High Cardiovascular Risk Individuals with Sleep Apnea: Best Apnea Interventions for Research (BestAIR) Trial. Sleep 2017, 40. [CrossRef]
52. Nakayama, M.; Masuda, A.; Ando, K.B.; Arima, S.; Kabaya, K.; Inagaki, A.; Nakamura, Y.; Suzuki, M.; Brodie, H.; Diaz, R.C.; et al. A Pilot Study on the Efficacy of Continuous Positive Airway Pressure on the Manifestations of Meniere’s Disease in Patients with Concomitant Obstructive Sleep Apnea Syndrome. J. Clin. Sleep Med. 2015, 11, 1101–1107. [CrossRef]
53. Kauta, S.R.; Keenan, B.T.; Goldberg, L.; Schwab, R.J. Diagnosis and Treatment of Sleep Disordered Breathing in Hospitalized Cardiac Patients: A Reduction in 30-Day Hospital Readmission Rates. J. Clin. Sleep Med. 2014, 10, 1051–1059. [CrossRef]
54. Zahnert, T. The Differential Diagnosis of Hearing Loss. Dtsch. Aerzteblatt Online 2011, 108, 433–444. [CrossRef]
55. Leung, M.A.; Flaherty, A.; Zhang, J.A.; Hara, J.; Barber, W.; Burgess, L. Sudden Sensorineural Hearing Loss: Primary Care Update. Hawaii J. Med. Public Health 2016, 75, 172–174.
56. Punjabi, N.M.; Caffo, B.S.; Goodwin, J.L.; Gottlieb, D.J.; Newman, A.B.; O’Connor, G.T.; Rapoport, D.M.; Redline, S.; Resnick, H.E.; Robbins, J.A.; et al. Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study. PLoS Med. 2009, 6, e1000132. [CrossRef]
57. Irish, L.A.; Kline, C.; Gunn, H.E.; Buysse, D.J.; Hall, M.H. The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep Med. Rev. 2015, 22, 23–36. [CrossRef]
58. Ting, H.; Lo, H.-S.; Chang, S.-Y.; Chung, A.-H.; Kuan, P.-C.; Yuan, S.-C.; Huang, C.-N.; Lee, S.-D. Post- to pre-overnight sleep systolic blood pressures are associated with sleep respiratory disturbance, pro-inflammatory state and metabolic situation in patients with sleep-disordered breathing. Sleep Med. 2009, 10, 720–725. [CrossRef]
59. Hertenstein, E.; Gabryelska, A.; Spiegelhalder, K.; Nissen, C.; Johann, A.F.; Umarova, R.; Riemann, D.; Baglioni, C.; Feige, B. Reference Data for Polysomnography-Measured and Subjective Sleep in Healthy Adults. J. Clin. Sleep Med. 2018, 14, 523–532. [CrossRef]
60. Unger, T.; Borghi, C.; Charchar, F.; Khan, N.A.; Poulter, N.R.; Prabhakaran, D.; Ramirez, A.; Schlaich, M.; Stergiou, G.S.; Tomaszewski, M.; et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension 2020, 75, 1334–1357. [CrossRef] [PubMed]
61. World Health Organization. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation;World Health Organization: Geneva, Switzerland, 2006; p. 21, ISBN 978-92-4-159493-6.
62. Vijan, S. Type 2 Diabetes. Ann. Intern. Med. 2010, 152, ITC3-1. [CrossRef] [PubMed]
63. National Cholesterol Education Program. ATP III Guidelines At.-A-Glance Quick Desk Reference; National Cholesterol Education Program: Bethesda, MD, USA, 2013.
64. Montgomery, D.C. Design and Analysis of Experiments, 5th ed.;Wiley: New York, NY, USA, 2001; ISBN 9780471316497.
65. Liang, K.-Y.; Zeger, S.L. Longitudinal data analysis using generalized linear models. Biometrika 1986, 73, 13–22. [CrossRef]
66. Hardin, J.; Hilbe, J. Generalized Estimating Equations; Chapman and Hall/CRC: London, UK, 2003; ISBN 978-1-58488-307-4.
67. Johnsson, L.-G.; Hawkins, J.E. Sensory and Neural Degeneration with Aging, as Seen in Microdissections of the Human Inner Ear. Ann. Otol. Rhinol. Laryngol. 1972, 81, 179–193. [CrossRef]
68. Fischer, Y.; Yakinthou, A.; Mann,W.J. Prevalence of obstructive sleep apnea syndrome (OSA) in patients with sudden hearing loss. A pilot study. HNO 2003, 51, 462–466. [CrossRef]
69. Li, X.; Chen, W.-J.; Zhang, X.-Y.; Liang, S.-C.; Guo, Z.-P.; Lu, M.-L.; Ye, J.-Y. Inner ear function in patients with obstructive sleep apnea. Sleep Breath. 2019, 24, 65–69. [CrossRef]
70. Lisan, Q.; Van Sloten, T.; Climie, R.E.; Boutouyrie, P.; Guibout, C.; Thomas, F.; Danchin, N.; Jouven, X.; Empana, J. Sleep apnoea is associated with hearing impairment: The Paris prospective study 3. Clin. Otolaryngol. 2020, 45, 681–686. [CrossRef]
71. Gozeler, M.S.; Sengoz, F.; Kilic, K.; Sakat, M.S. Auditory Function of Patients with Obstructive Sleep Apnea Syndrome: A Study.Eurasian J. Med. 2020, 52, 176–179. [CrossRef] [PubMed]
72. Deniz, M.; Ersözlü, T. Evaluation of the changes in the hearing system over the years among patients with OSAS using a CPAP device. CRANIO®® 2020, 1–4. [CrossRef]
73. Seo, Y.J.; Ju, H.M.; Lee, S.H.; Kwak, S.H.; Kang, M.J.; Yoon, J.-H.; Kim, C.-H.; Cho, H.-J. Damage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea with Chronic Intermittent Hypoxia. Sleep 2017, 40. [CrossRef]
74. Matsumura, E.; Matas, C.G.; Sanches, S.G.G.; Magliaro, F.C.L.; Pedreño, R.M.; Genta, P.R.; Lorenzi-Filho, G.; Carvallo, R.M.M. Severe obstructive sleep apnea is associated with cochlear function impairment. Sleep Breath. 2017, 22, 71–77. [CrossRef]
75. Seidman, M.D.; Ahmad, N.; Joshi, D.; Seidman, J.; Thawani, S.; Quirk, W.S. Age-related hearing loss and its association with reactive oxygen species and mitochondrial DNA damage. Acta Oto-Laryngol. 2004, 124, 16–24. [CrossRef] [PubMed]
76. Sha, S.-H.; Taylor, R.; Forge, A.; Schacht, J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear. Res. 2001, 155, 1–8. [CrossRef]
77. Matsuura, S.; Kuno, M.; Nakamura, T. Intracranial Pressure and Auditory Evoked Responses of the Cat. Acta Oto-Laryngol. 1986, 102, 12–19. [CrossRef]
78. Beebe, D.W.; Gozal, D. Obstructive sleep apnea and the prefrontal cortex: Towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J. Sleep Res. 2002, 11, 1–16. [CrossRef]
79. Kotterba, S.; Rasche, K. Acoustic evoked potentials (AEP) in obstructive sleep apnea syndrome. Pneumologie 1996, 50, 924–926.
80. Duzlu, M.; Köktürk, O.; Kemaloglu, Y.K.; Eravcı, F.C.; Küçükünal, I.S.; Karamert, R.; ˙Iriz, A. The effect of obstructive sleep apnea syndrome on the central auditory system. Turk. J. Med. Sci. 2018, 48, 5–9. [CrossRef]
81. Laratta, C.R.; Ayas, N.T.; Povitz, M.; Pendharkar, S.R. Diagnosis and treatment of obstructive sleep apnea in adults. Can. Med. Assoc. J. 2017, 189, E1481–E1488. [CrossRef]
82. Tucci, D.L.; Merson, M.H.; Wilson, B.S. A Summary of the Literature on Global Hearing Impairment. Otol. Neurotol. 2010, 31, 31–41. [CrossRef]
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