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研究生:吳欣霈
研究生(外文):Wu, Sin-Pei
論文名稱:正常及蟹足腫纖維母細胞於膠原蛋白凝膠培養下重塑膠原蛋白纖維之研究
論文名稱(外文):How normal and keloid fibroblasts remodel collagen fibers in 3-dimensional collagen gel
指導教授:湯銘哲湯銘哲引用關係
指導教授(外文):Tang, Ming-Jer
口試委員:郭津岑許釗凱王仰高
口試委員(外文):Kuo, Jean-ChengHsu, Chao-KaiWang, Yang-Kao
口試日期:2023-07-19
學位類別:碩士
校院名稱:國立成功大學
系所名稱:生理學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2023
畢業學年度:111
語文別:英文
論文頁數:34
中文關鍵詞:蟹足腫共軸系統皮膚真皮成纖維細胞β1-integrin體外培養膠原蛋白
外文關鍵詞:Keloidco-axial systemskin dermal fibroblastβ1-integrinin vitro collagen cultured
相關次數:
  • 被引用被引用:0
  • 點閱點閱:32
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
中文摘要 I
ABSTRACT II
致謝 IV
CONTENTS V
FIGURE CONTENTS VI
INTRODUCTION 1
MATERIAL AND METHODS 7
RESULTS 11
DISCUSSION 16
REFERENCES 19
FIGURES 21
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2.Eming, S.A., P. Martin, and M. Tomic-Canic, Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med, 2014. 6(265): p. 265sr6.
3.Sun, B.K., Z. Siprashvili, and P.A. Khavari, Advances in skin grafting and treatment of cutaneous wounds. Science, 2014. 346(6212): p. 941-945.
4.Gauglitz, G.G., et al., Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Molecular medicine, 2011. 17(1): p. 113-125.
5.Nangole, F.W. and G.W. Agak, Keloid pathophysiology: fibroblast or inflammatory disorders? JPRAS open, 2019. 22: p. 44-54.
6.Limandjaja, G.C., et al., The keloid disorder: heterogeneity, histopathology, mechanisms and models. Frontiers in cell and developmental biology, 2020. 8: p. 360.
7.Liu, L., et al., Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression. FASEB J, 2021. 35(7): p. e21705.
8.Gumucio, J.P., et al., Scleraxis is required for the growth of adult tendons in response to mechanical loading. Journal of Clinical Investigation, 2020. 5(13): p. e138295.
9.Galloway, M.T., A.L. Lalley, and J.T. Shearn, The Role of Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair. Journal of Bone and Joint Surgery, 2013. 95(17): p. 1620-1628.
10.Deng, C.C., et al., Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun, 2021. 12(1): p. 3709.
11.Nang'ole, W.F., et al., Do Mesenchymal Stem Cells Influence Keloid Recurrence? Stem Cells Cloning, 2022. 15: p. 77-84.
12.Zhang, Q., et al., Collagen gel contraction assays: From modelling wound healing to quantifying cellular interactions with three-dimensional extracellular matrices. Eur J Cell Biol, 2022. 101(3): p. 151253.
13.Hsu, C.-K., et al., Caveolin-1 controls hyperresponsiveness to mechanical stimuli and fibrogenesis-associated RUNX2 activation in keloid fibroblasts. Journal of Investigative Dermatology, 2018. 138(1): p. 208-218.
14.Lu, P., et al., Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol, 2011. 3(12).
15.Brakebusch, C. and R. Fassler, The integrin-actin connection, an eternal love affair. EMBO J, 2003. 22(10): p. 2324-33.
16.Walters, N.J. and E. Gentleman, Evolving insights in cell-matrix interactions: elucidating how non-soluble properties of the extracellular niche direct stem cell fate. Acta Biomater, 2015. 11: p. 3-16.
17.Yu, C.H., et al., Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation. Proc Natl Acad Sci U S A, 2011. 108(51): p. 20585-90.
18.Bainbridge, P., Wound healing and the role of fibroblasts. J Wound Care, 2013. 22(8): p. 407-8, 410-12.
19.Luo, S., Benathan, M., Raffoul, W., Panizzon, R.G. and Egloff, D.V., Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plastic and reconstructive surgery, 2001. 107(1).
20.Ehrlich, H.P. and K.E. Moyer, Cell-populated collagen lattice contraction model for the investigation of fibroblast collagen interactions. Methods Mol Biol, 2013. 1037: p. 45-58.
21.Shakiba, D., et al., The Balance between Actomyosin Contractility and Microtubule Polymerization Regulates Hierarchical Protrusions That Govern Efficient Fibroblast-Collagen Interactions. ACS Nano, 2020. 14(7): p. 7868-7879.
22.Cai, L., et al., The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review. Tissue Eng Regen Med, 2017. 14(1): p. 15-30.
23.Ann Jordan, M., D. Thrower, and L. Wilson, Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : Implications for the role of microtubule dynamics in mitosis. Journal of Cell Science, 1992. 102(3): p. 401-416.
24.Xu, Y., et al., Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1. J Biol Chem, 2000. 275(50): p. 38981-9.
25.Limandjaja, G.C., et al., The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models. Front Cell Dev Biol, 2020. 8: p. 360.
26.Yeh, Y.C., et al., Transforming growth factor-beta1 induces Smad3-dependent beta1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol, 2010. 177(4): p. 1743-54.
27.Batra, N., et al., Mechanical stress-activated integrin alpha5beta1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A, 2012. 109(9): p. 3359-64.
28.Wu, S.Z. and M. Bezanilla, Actin and microtubule cross talk mediates persistent polarized growth. J Cell Biol, 2018. 217(10): p. 3531-3544.
29.Gumucio, J.P., et al., Scleraxis is required for the growth of adult tendons in response to mechanical loading. JCI Insight, 2020. 5(13).
30.Chen, X., et al., Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes. Sci Rep, 2012. 2: p. 977.
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