跳到主要內容

臺灣博碩士論文加值系統

(44.222.64.76) 您好!臺灣時間:2024/06/13 09:07
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:陳文瑩
研究生(外文):Wen-Yin Chen
論文名稱:探討雙極性情感疾患認知功能及其中維生素D的角色
論文名稱(外文):Exploration of cognitive dysfunction and the roles of Vitamin D in Bipolar disorder
指導教授:郭柏秀郭柏秀引用關係
指導教授(外文):Po-Hsiu Kuo
口試委員:陳為堅張慶國盧孟良李朝雄
口試委員(外文):Wei-J ChenChin-Kuo ChangMong-Liang LuChau-Shoun Lee
口試日期:2022-10-28
學位類別:博士
校院名稱:國立臺灣大學
系所名稱:流行病學與預防醫學研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2022
畢業學年度:111
論文頁數:116
中文關鍵詞:雙極性疾患認知功能統合分析網狀脈絡分析維生素D神經絲輕鏈
外文關鍵詞:bipolar disordercognitive functionmeta-analysisnetwork meta-analysisvitamin Dneurofilament light chain
DOI:10.6342/NTU202210040
相關次數:
  • 被引用被引用:0
  • 點閱點閱:146
  • 評分評分:
  • 下載下載:36
  • 收藏至我的研究室書目清單書目收藏:1
背景:
雙極性情感疾患為一慢性精神疾病,病程常反覆發作而導致嚴重的疾病負擔。研究指出部分雙極性疾患患者伴有認知功能缺損,此認知缺損影響生活品質及預後,但縱貫性研究呈現其異質性的文獻仍相對稀少。此外針對雙極性情感疾患的認知缺損,生物治療的選擇仍不清楚。許多退化性神經及精神疾病被指出有高比例的維生素D低下,且維生素D缺乏和認知功能相關,但還未有研究探討在雙極性情感疾患中維生素D和認知表現的關聯以及介入補充的效果。
目的及方法:
招募雙極性情感疾患個案。以病歷回顧建立一回溯性世代,接著進行包含橫斷性研究並由其中部分特性者進入介入性研究。
1. 回溯性世代研究追蹤一年以上之認知功能變化以呈現縱貫性認知的差異。分析比較認知退化相關之危險因子及功能表現。
2. 針對雙極性情感疾患認知功能缺損的不同生物治療介入,進行網狀脈絡分析。
3. 探討雙極性情感疾患病人維生素D缺乏之危險因子,並探究維生素D濃度和整體認知或特定認知面向是否相關,同時探討和神經軸突完整性的交互作用
4. 量化確認維生素D介入對認知功能之實證。提出對雙極性情感疾患認知缺損適合之維生素D介入模式及病人特徵。
依上述研究結果未來可進行隨機雙盲實驗,探討補充維生素D對雙極性情感疾患穩定期之認知功能療效及影響的機轉。
結果:
回溯性世代研究指出部分的雙極性情感疾患其認知功能會逐步退化,且和較多的情緒發作伴隨精神病症狀有關。網狀脈絡分析作生物治療整合比較則呈現出紅血球生成素(erythropoietin)、睡茄(Withania somnifera)及加蘭他敏(galantamine)各別在注意力、工作記憶及語言學習上有顯著益處,但針對雙極性情感疾患認知功能之研究仍有許多異質性,分析結果顯示並無任一藥物或神經生理刺激能改善所有認知面向。在病例對照的相關性研究中發現,約百分之七十二的雙極性情感疾患病人有維生素D缺乏,且在成年晚期組病人中(45至65歲),與較多住院次數及較低身體活動量相關。綜合認知能力及語意流暢呈現和維生素D及神經軸突完整性之交互作用相關;此外年齡亦在此相關中扮演效應修正因子。維生素D對認知功能的統合分析結果顯示在整體認知功能上有顯著益處,特別當研究族群為脆弱族群或伴隨維生素D缺乏時會呈現更大的益處。針對認知功能的效應,維生素D的介入亦建議須補足其維生素D濃度至足夠。因上述累積之研究發現,預期雙極性情感疾患患者伴隨維生素D缺乏者,後續接受維生素D補充對其認知功能應有其療效,值得下一步的臨床試驗。
結論:
本研究指出雙極性情感疾患認知功能退化的異質性,分別此次族群將有利於後續基因型及臨床研究。針對雙極性情感疾患的認知缺損,目前並無實證指出較佳的生物治療。由其他樣本之統合分析結果顯示維生素D對認知功能可為一安全有效的介入,且維生素D確實在雙極性情感疾患之認知功能上扮演部分角色,故值得進行下一步的隨機雙盲試驗。此系列針對雙極性情感疾患的認知研究,可作為未來個別化介入指引的藍圖。
Background:
Bipolar disorder (BD) is a chronic mental disease related to recurrent episodes along with huge disease burden. Part of the BD patients who presented with cognitive deficits implied a poor prognosis and quality of life. The studies of cognitive function on longitudinal trajectory across the bipolar illness are scarce. In addition, comparing efficacy of biological interventions targeting to treat cognitive deficits in BD is unexplored. The majority of the observational studies demonstrate the high prevalence of hypovitamin D in wide ranges of neuropsychiatry diseases, and there was a significant association between compromised cognition and vitamin D deficiency; however, the effect of supplement and association between vitamin D and cognition in BD and the underlying mechanism is unclear.
Aims and Methods:
We enrolled patients with bipolar disorder. First, we established a retrospective cohort from medical chart review. Second, cross-sectional study was used for assessing the association between cognition and vitamin D levels. Third, part of the BD patients will be further enrolled in the randomized controlled trial (RCT).
1. To specify the subgroup of bipolar disorder patients with or without cognitive decline as their heterogeneity and to analysis the clinical risk factors and functional outcomes.
2. To perform network meta-analysis (NMA), to compare the efficacy of different biological interventions for cognition in BD patients.
3. To examine the risk factors of hypovitamin D and the interaction with neuro-axonal integrity in BD patients and the association with their cognitive profiles.
4. To reveal the evidence of vitamin D supplement model for cognitive function among different target populations, through meta-analysis.
We will conduct RCT, to examine the efficacy of vitamin D supplement on cognitive performance and to dissect the related mechanism in euthymic BD.
Results:
The retrospective cohort study characterized the longitudinal cognitive heterogeneity in BD patients. We found that episodes with psychotic features was an independent risk factor for cognitive decline. The results from NMA implied that adjunctive of erythropoietin, Withania somnifera, and galantamine were beneficial for attention, working memory, and verbal learning in euthymic BD patients than treatment as usual, respectively. However, considerable variability in measurements of cognitive domains in BD was observed, and no intervention resulted in superior benefits across all cognitive domains. From cross-sectional study, we noted 72% of the BD patients were with vitamin D deficient. In the older age group (45< age <65), more frequent hospital admissions and lower physical activity levels were identified in the group with vitamin D deficiency than in that without. We identified the interaction effects between vitamin D and neurofilament light chain on composite neurocognitive score and domain of verbal fluency, and the effects were modified by age. The meta-analysis revealed a significant effect of vitamin D on global cognition but not on specific cognitive domains. Subgroup analysis indicated that the effect size of vitamin D increased for vulnerable populations and those with baseline vitamin D deficiency. In addition, we suggested that the intervention model should be applied for correcting the baseline vitamin D deficiency. Based on the aforementioned findings, we anticipated that subgroup of BD patients with cognitive deficits and vitamin D deficiency may benefit from vitamin D supplement for their cognitive deficits.
Conclusion:
Our results can specify and characterize the longitudinal cognitive heterogeneity in bipolar patients. These findings may potentially facilitate further genetic and biological studies to define more valid subtypes of bipolar disorder. Through the NMA, we first clarify the limitation and intervention effect from current available biological interventions. The meta-analysis provided the evidence about vitamin D model focusing on cognitive function. In addition, vitamin D plays a role to cognition in BD and interacts with the status of neuroaxonal integrity. From these results, further randomized trial will reveal the efficacy of vitamin D for cognitive deficits in BD patients. These series of studies can be a blueprint for future personalized intervention for cognitive deficits in BD patients and bring great impact on clinical care.
中文摘要 I
ABSTRACT III
CHAPTER 1. INTRODUCTION 1
1.1 COGNITIVE PERFORMANCE IN BIPOLAR DISORDER 1
1.1.1 Cognitive function in bipolar disorder affects the prognosis 1
1.1.2 Evidence of cognitive change in BD 2
1.2 CURRENT TREATMENT AND ROLE OF VITAMIN D FOR COGNITIVE DEFICITS IN BD 4
1.2.1 Limitation of interventions for cognitive deficits in BD 4
1.2.2 Role of vitamin D as potential treatment for cognitive deficits 5
1.2.3 Association between vitamin D and cognition in BD 7
1.2.4 The mechanism of vitamin D in neuroprotection 8
1.3 HYPOTHESIS 10
CHAPTER 2 SPECIFIC AIMS 11
2.1 STUDY AIMS 11
2.2. RESEARCH BLUEPRINT 12
CHAPTER 3 MATERIAL AND METHODS 13
3.1 RESEARCH METHOD FOR AIM 1 13
3.1.1 Study participants 13
3.1.2 Assessments and measurements 14
3.1.3 Statistical analysis 16
3.2 RESEARCH METHOD FOR AIM 2 19
3.2.1 Systematic literature review 19
3.2.2 Data extraction and assessment risk of bias 20
3.2.3 Outcome selection and network development 20
3.2.4 Statistical analysis 21
3.3 RESEARCH METHOD FOR AIM 3 23
3.3.1 Participants 23
3.3.2 Measurements 23
3.3.3 Statistical analysis 25
3.4 RESEARCH METHOD FOR AIM 4 27
3.4.1 Systematic literature review 27
3.4.2 Data extraction and risk of bias assessment 28
3.4.3 Outcomes selection 29
3.4.4 Statistical analysis 29
CHAPTER 4 RESULTS AND DISCUSSION 31
4.1 THE HETEROGENEITY OF LONGITUDINAL COGNITIVE DECLINE IN BIPOLAR DISORDER WITH CLINICAL CHARACTERISTICS AND FUNCTIONAL OUTCOMES (AIM 1) 31
4.1.1 Patient characteristics 31
4.1.2 Functional outcomes and BAC-A in BD patients with cognitive declines 31
4.1.3 Risk factors for cognitive decline and decline curve in patients with BD 32
4.1.4 Correlation between cognitive and functional domains 33
4.1.5 Discussion 33
4.1.6 Limitations 37
4.1.7 Conclusions 38
4.2 EFFECT OF PHARMACOLOGICAL AND NEUROSTIMULATION INTERVENTIONS FOR COGNITIVE DOMAINS IN BIPOLAR DISORDER: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS (AIM 2) 39
4.2.1 Systematic literature review 39
4.2.2 Cognitive outcomes for network development in euthymic BD 39
4.2.3 Cognitive outcomes for network development in patients with BD experiencing depressive or manic episodes 41
4.2.4 Partially ordered set with Hasse Diagram 41
4.2.5 Risk of bias assessment 42
4.2.6 Discussion 42
4.2.7 Limitation 44
4.2.8 Conclusion 45
4.3 EFFECT OF INTERACTIONS BETWEEN VITAMIN D AND NEUROFILAMENT LIGHT CHAIN LEVELS ON COGNITIVE DOMAINS IN BIPOLAR DISORDER (AIM 3) 46
4.3.1 Patient characteristics and age effect 46
4.3.2 Comparison of vitamin D status 46
4.3.3 Interaction effect of vitamin D and NfL on cognition 47
4.3.4 Discussion 48
4.3.5 Limitations 52
4.3.6 Conclusions 53
4.4 THE EFFECT OF VITAMIN D SUPPLEMENT ON COGNITIVE OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS (AIM 4) 54
4.4.1 Baseline characteristics of included studies 54
4.4.2 Effect of vitamin D supplement on global cognitive function and specific cognitive domains 55
4.4.3 Subgroup analysis and meta-regression 55
4.4.4 Publication bias, risk of bias assessment and sensitivity analysis 57
4.4.5 Discussion 58
4.4.6 Limitations 60
4.4.7 Conclusion 62
CHAPTER 5. OVERALL DISCUSSION AND CONCLUSION 63
REFERENCES 106
APPENDIX 116
Abe, S., O. Ezaki and M. Suzuki. Medium-chain triglycerides (8:0 and 10:0) increase mini-mental state examination (mmse) score in frail elderly adults in a randomized controlled trial. Journal of Nutrition. 2020;150(9): 2383-2390.
Achalia, R., A. Sinha, A. Jacob, G. Achalia, V. Kaginalkar, G. Venkatasubramanian, et al. A proof of concept machine learning analysis using multimodal neuroimaging and neurocognitive measures as predictive biomarker in bipolar disorder. Asian J Psychiatr. 2020;50: 101984.
Aggio, V., L. Fabbella, A. Finardi, E. B. Mazza, C. Colombo, A. Falini, et al. Neurofilaments light: Possible biomarker of brain modifications in bipolar disorder. J Affect Disord. 2021;300: 243-248.
Ahmadi, S., K. Mirzaei, A. Hossein-Nezhad and G. Shariati. Vitamin D receptor FokI genotype may modify the susceptibility to schizophrenia and bipolar mood disorder by regulation of dopamine D1 receptor gene expression. Minerva Med. 2012;103(5): 383-391.
Al-Amin, M., D. Bradford, R. K. P. Sullivan, N. D. Kurniawan, Y. Moon, S. H. Han, et al. Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. Hum Brain Mapp. 2019;40(2): 394-406.
Al Shweiki, M. R., P. Steinacker, P. Oeckl, B. Hengerer, A. Danek, K. Fassbender, et al. Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. J Psychiatr Res. 2019;113: 137-140.
Alirezaei, Z., M. H. Pourhanifeh, S. Borran, M. Nejati, H. Mirzaei and M. R. Hamblin. Neurofilament Light Chain as a Biomarker, and Correlation with Magnetic Resonance Imaging in Diagnosis of CNS-Related Disorders. Mol Neurobiol. 2020;57(1): 469-491.
Allott, K. and T. E. Van Rheenen. The complexities of understanding cognitive trajectory in bipolar disorder. Bipolar Disord. 2020.
Altunsoy, N., R. N. Yuksel, M. Cingi Yirun, A. Kilicarslan and C. Aydemir. Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity. Nord J Psychiatry. 2018;72(3): 221-225.
Andreeva, V. A., S. Whegang-Youdom, M. Touvier, K. E. Assmann, L. Fezeu, S. Hercberg, et al. Midlife dietary vitamin D intake and subsequent performance in different cognitive domains. Ann Nutr Metab. 2014;65(1): 81-89.
Annweiler, C. and O. Beauchet. Vitamin D and cognition: recommendations for future trials. J Am Geriatr Soc. 2013;61(6): 1049-1050.
Annweiler, C., L. Doineau, L. Gerigne, A. Provendier, S. N. Karras, O. Beauchet, et al. Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults. Curr Alzheimer Res. 2018;15(7): 664-670.
Annweiler, C., E. Maby, M. Meyerber and O. Beauchet. Hypovitaminosis D and executive dysfunction in older adults with memory complaint: A memory clinic-based study. Dementia and Geriatric Cognitive Disorders. 2014;37(5-6): 286-293.
Annweiler, C., M. Montero-Odasso, D. J. Llewellyn, S. Richard-Devantoy, G. Duque and O. Beauchet. Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis. 2013;37(1): 147-171.
Arnson, Y., D. Itzhaky, M. Mosseri, V. Barak, B. Tzur, N. Agmon-Levin, et al. Vitamin D inflammatory cytokines and coronary events: a comprehensive review. Clin Rev Allergy Immunol. 2013;45(2): 236-247.
Barro, C., T. Chitnis and H. L. Weiner. Blood neurofilament light: a critical review of its application to neurologic disease. Ann Clin Transl Neurol. 2020;7(12): 2508-2523.
Bauer, I. E., R. S. Keefe, M. Sanches, R. Suchting, C. E. Green and J. C. Soares. Evaluation of cognitive function in bipolar disorder using the Brief Assessment of Cognition in Affective Disorders (BAC-A). J Psychiatr Res. 2015;60: 81-86.
Bauer, I. E., M. C. Pascoe, B. Wollenhaupt-Aguiar, F. Kapczinski and J. C. Soares. Inflammatory mediators of cognitive impairment in bipolar disorder. J Psychiatr Res. 2014;56: 18-27.
Bavato, F., F. Cathomas, F. Klaus, K. Gütter, C. Barro, A. Maceski, et al. Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum. J Psychiatr Res. 2021;140: 141-148.
Beauchet, O., C. P. Launay, K. Galery, C. Vilcocq, F. Dontot-Payen, B. Rousseau, et al. Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial. Nutrients. 2019;11(12).
Bell, K. E., H. Fang, T. Snijders, D. J. Allison, M. A. Zulyniak, A. Chabowski, et al. A multi-ingredient nutritional supplement in combination with resistance exercise and high-intensity interval training improves cognitive function and increases n-3 index in healthy older men: A randomized controlled trial. Frontiers in Aging Neuroscience. 2019;11(MAY).
Belzeaux, R., C. Annweiler, J. A. Bertrand, O. Beauchet, S. Pichet, F. Jollant, et al. Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode. J Affect Disord. 2018;225: 302-305.
Beydoun, M. A., S. Hossain, M. T. Fanelli-Kuczmarski, H. A. Beydoun, J. A. Canas, M. K. Evans, et al. Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults. J Clin Endocrinol Metab. 2018;103(4): 1654-1668.
Boerman, R., D. Cohen, P. F. Schulte and A. Nugter. Prevalence of Vitamin D Deficiency in Adult Outpatients With Bipolar Disorder or Schizophrenia. J Clin Psychopharmacol. 2016;36(6): 588-592.
Bora, E., C. Hidiroglu, A. Ozerdem, O. F. Kacar, G. Sarisoy, F. Civil Arslan, et al. Executive dysfunction and cognitive subgroups in a large sample of euthymic patients with bipolar disorder. Eur Neuropsychopharmacol. 2016;26(8): 1338-1347.
Bora, E. and C. Pantelis. Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls. Schizophr Bull. 2015;41(5): 1095-1104.
Bora, E., S. Vahip, F. Akdeniz, A. S. Gonul, A. Eryavuz, M. Ogut, et al. The effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patients. Bipolar Disord. 2007;9(5): 468-477.
Bora, E., M. Yucel and C. Pantelis. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord. 2009;113(1-2): 1-20.
Bourne, C., O. Aydemir, V. Balanza-Martinez, E. Bora, S. Brissos, J. T. Cavanagh, et al. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand. 2013;128(3): 149-162.
Bright, P., E. Jaldow and M. D. Kopelman. The National Adult Reading Test as a measure of premorbid intelligence: a comparison with estimates derived from demographic variables. J Int Neuropsychol Soc. 2002;8(6): 847-854.
Buchanan, R. W., R. R. Conley, D. Dickinson, M. P. Ball, S. Feldman, J. M. Gold, et al. Galantamine for the treatment of cognitive impairments in people with schizophrenia. Am J Psychiatry. 2008;165(1): 82-89.
Byrn, M. A., W. Adams, S. Penckofer and M. A. Emanuele. Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial. J Diabetes Res. 2019;2019: 5696391.
Byrn, M. A. and P. M. Sheean. Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence. Nutrients. 2019;11(4).
Chei, C. L., P. Raman, Z. X. Yin, X. M. Shi, Y. Zeng and D. B. Matchar. Vitamin D levels and cognition in elderly adults in China. J Am Geriatr Soc. 2014;62(11): 2125-2129.
Chen, H.-Y., M.-S. Hua, J. Zhu and Y.-H. Chen. Selection of factor-based WAIS-III tetrads in the Taiwan standardized sample: A guide to clinical practice. Chinese Journal of Psychology. 2008;50(1): 91-109.
Chen, H. and M. S. Hua. Selecting Tetradic Short Forms of the Taiwan Wechsler Adult Intelligence Scale IV. Assessment. 2020;27(7): 1633-1644.
Chen, M. H., Y. L. Liu, H. W. Kuo and S. J. Tsai. Neurofilament Light Chain Is a Novel Biomarker for Major Depression and Related Executive Dysfunction. Neurol Sci. 2022;25(2): 99-105.
Chen, R. A., C. Y. Lee, Y. Lee, C. F. Hung, Y. C. Huang, P. Y. Lin, et al. Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders. PeerJ. 2019;7: e7432.
Cheng, Y. C., Y. C. Huang and W. L. Huang. The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis. Depress Anxiety. 2020;37(6): 549-564.
Chou, Y. C., C. H. Chu, M. H. Wu, G. C. Hsu, T. Yang, W. Y. Chou, et al. Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. J Epidemiol. 2011;21(5): 329-336.
Cojic, M., R. Kocic, A. Klisic and G. Kocic. The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study. Front Endocrinol (Lausanne). 2021;12: 610893.
Comes, M., A. Rosa, M. Reinares, C. Torrent and E. Vieta. Functional Impairment in Older Adults With Bipolar Disorder. J Nerv Ment Dis. 2017;205(6): 443-447.
Czepielewski, L., L. Daruy Filho, E. Brietzke and R. Grassi-Oliveira. Bipolar disorder and metabolic syndrome: a systematic review. Braz J Psychiatry. 2013;35(1): 88-93.
Daffner, K. R., S. A. Gale, A. M. Barrett, B. F. Boeve, A. Chatterjee, H. B. Coslett, et al. Improving clinical cognitive testing: report of the AAN Behavioral Neurology Section Workgroup. Neurology. 2015;85(10): 910-918.
Darwish, H., R. Haddad, S. Osman, S. Ghassan, B. Yamout, H. Tamim, et al. Effect of Vitamin D Replacement on Cognition in Multiple Sclerosis Patients. Sci Rep. 2017;7: 45926.
De Koning, E. J., P. Lips, B. W. J. H. Penninx, P. J. M. Elders, A. C. Heijboer, M. Den Heijer, et al. Vitamin D supplementation for the prevention of depression and poor physical function in older persons: The D-Vitaal study, a randomized clinical trial. American Journal of Clinical Nutrition. 2019;110(5): 1119-1130.
de la Fuente-Tomas, L., P. Sierra, M. Sanchez-Autet, B. Arranz, A. Garcia-Blanco, G. Safont, et al. A clinical staging model for bipolar disorder: longitudinal approach. Transl Psychiatry. 2020;10(1): 45.
Dean, A. J., M. A. Bellgrove, T. Hall, W. M. J. Phan, D. W. Eyles, D. Kvaskoff, et al. Effects of vitamin D supplementation on cognitive and emotional functioning in young adults—A randomised controlled trial. PLoS ONE. 2011;6(11).
Denniss, R. J., L. A. Barker and C. J. Day. Improvement in cognition following double-blind randomized micronutrient interventions in the general population. Frontiers in Behavioral Neuroscience. 2019;13.
Dewa, L. H., A. Kalniunas, S. Orleans-Foli, S. Pappa and P. Aylin. Detecting signs of deterioration in young patients with serious mental illness: a systematic review. Syst Rev. 2021;10(1): 250.
Dhesi, J. K., S. H. Jackson, L. M. Bearne, C. Moniz, M. V. Hurley, C. G. Swift, et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004;33(6): 589-595.
Dias, V. V., V. Balanzá-Martinez, M. G. Soeiro-de-Souza, R. A. Moreno, M. L. Figueira, R. Machado-Vieira, et al. Pharmacological approaches in bipolar disorders and the impact on cognition: a critical overview. Acta Psychiatr Scand. 2012;126(5): 315-331.
Diniz, B. S., A. L. Teixeira, F. Cao, A. Gildengers, J. C. Soares, M. A. Butters, et al. History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis. Am J Geriatr Psychiatry. 2017;25(4): 357-362.
Duarte, W., R. Becerra and K. Cruise. The Relationship Between Neurocognitive Functioning and Occupational Functioning in Bipolar Disorder: A Literature Review. Eur J Psychol. 2016;12(4): 659-678.
Eghtedarian, R., S. Ghafouri-Fard, H. Bouraghi, B. M. Hussen, S. Arsang-Jang and M. Taheri. Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder. BMC Psychiatry. 2022;22(1): 178.
Ehrenreich, H., B. Fischer, C. Norra, F. Schellenberger, N. Stender, M. Stiefel, et al. Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis. Brain. 2007;130(Pt 10): 2577-2588.
Ehrenreich, H., D. Hinze-Selch, S. Stawicki, C. Aust, S. Knolle-Veentjer, S. Wilms, et al. Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin. Mol Psychiatry. 2007;12(2): 206-220.
Endres, D., R. Dersch, O. Stich, A. Buchwald, E. Perlov, B. Feige, et al. Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes: A One-Year Cohort Study at a German Tertiary Care Hospital. Front Psychiatry. 2016;7: 168.
Eyles, D. W., T. H. Burne and J. J. McGrath. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2013;34(1): 47-64.
Feart, C., C. Helmer, B. Merle, F. R. Herrmann, C. Annweiler, J. F. Dartigues, et al. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimers Dement. 2017;13(11): 1207-1216.
Ferrand, L., V. Hennion, O. Godin, F. Bellivier, J. Scott and B. Etain. Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders? J Clin Med. 2022;11(8).
Ferrari, A. J., E. Stockings, J. P. Khoo, H. E. Erskine, L. Degenhardt, T. Vos, et al. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord. 2016;18(5): 440-450.
Fourrier, C., G. Singhal and B. T. Baune. Neuroinflammation and cognition across psychiatric conditions. CNS Spectr. 2019;24(1): 4-15.
Friedman, J. H. and C. B. Roosen. An introduction to multivariate adaptive regression splines. Stat Methods Med Res. 1995;4(3): 197-217.
Gariballa, S. and S. Forster. Effects of dietary supplements on depressive symptoms in older patients: A randomised double-blind placebo-controlled trial. Clinical Nutrition. 2007;26(5): 545-551.
Gil, Á., J. Plaza-Diaz and M. D. Mesa. Vitamin D: Classic and Novel Actions. Ann Nutr Metab. 2018;72(2): 87-95.
Gildengers, A. G., D. Chisholm, M. A. Butters, S. J. Anderson, A. Begley, M. Holm, et al. Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression? Psychol Med. 2013;43(4): 801-811.
Gildengers, A. G., B. H. Mulsant, A. Begley, S. Mazumdar, A. V. Hyams, C. F. Reynolds Iii, et al. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord. 2009;11(7): 744-752.
Goldberg, J. F., M. Harrow and L. S. Grossman. Course and outcome in bipolar affective disorder: a longitudinal follow-up study. Am J Psychiatry. 1995;152(3): 379-384.
Goodwill, A. M., S. Campbell, S. Simpson, Jr., M. Bisignano, C. Chiang, L. Dennerstein, et al. Vitamin D status is associated with executive function a decade later: Data from the Women's Healthy Ageing Project. Maturitas. 2018;107: 56-62.
Goodwill, A. M. and C. Szoeke. A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition. J Am Geriatr Soc. 2017;65(10): 2161-2168.
Guglielmo, R., K. W. Miskowiak and G. Hasler. Evaluating endophenotypes for bipolar disorder. Int J Bipolar Disord. 2021;9(1): 17.
Gurholt, T. P., K. Osnes, M. Nerhus, K. N. Jorgensen, V. Lonning, A. O. Berg, et al. Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Sci Rep. 2018;8(1): 10817.
Harvey, P. D., H. Hassman, L. Mao, G. M. Gharabawi, R. A. Mahmoud and L. M. Engelhart. Cognitive functioning and acute sedative effects of risperidone and quetiapine in patients with stable bipolar I disorder: a randomized, double-blind, crossover study. J Clin Psychiatry. 2007;68(8): 1186-1194.
Hendricks, R., D. Baker, J. Brumm, T. Davancaze, C. Harp, A. Herman, et al. Establishment of neurofilament light chain Simoa assay in cerebrospinal fluid and blood. Bioanalysis. 2019;11(15): 1405-1418.
Hewison, M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf). 2012;76(3): 315-325.
Higgins JPT, T. J., Chandler J, Cumpston M, Li T, Page MJ, Welch VA . . (2019). " Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019)." 2019 Available from www.training.cochrane.org/handbook.
Hiller, A. L., C. F. Murchison, B. M. Lobb, S. O'Connor, M. O'Connor and J. F. Quinn. A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson's disease: Does age matter? PLoS One. 2018;13(9): e0203637.
Hoffecker, B. M., L. M. Raffield, D. L. Kamen and T. K. Nowling. Systemic lupus erythematosus and vitamin D deficiency are associated with shorter telomere length among African Americans: a case-control study. PLoS One. 2013;8(5): e63725.
Holmøy, T., E. Røsjø, H. Zetterberg, K. Blennow, J. C. Lindstrøm, L. H. Steffensen, et al. Vitamin D supplementation and neurofilament light chain in multiple sclerosis. Acta Neurol Scand. 2019;139(2): 172-176.
Hänninen, K., O. Jääskeläinen, S. K. Herukka and M. Soilu-Hänninen. Vitamin D supplementation and serum neurofilament light chain in interferon-beta-1b-treated MS patients. Brain Behav. 2020;10(9): e01772.
Hu, J., J. Jia, Y. Zhang, R. Miao, X. Huo and F. Ma. Effects of vitamin D3 supplementation on cognition and blood lipids: a 12-month randomised, double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2018;89(12): 1341-1347.
Hu, J., J. Jia, Y. Zhang, R. Miao, X. Huo and F. Ma. Effects of vitamin D(3) supplementation on cognition and blood lipids: a 12-month randomised, double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2018;89(12): 1341-1347.
Hu, S. H., J. B. Lai, D. R. Xu, H. L. Qi, B. S. Peterson, A. M. Bao, et al. Efficacy of repetitive transcranial magnetic stimulation with quetiapine in treating bipolar II depression: a randomized, double-blinded, control study. Scientific reports. 2016;6: 30537.
Huang, S. Y., W. W. Lin, H. C. Ko, J. F. Lee, T. J. Wang, Y. H. Chou, et al. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. Alcohol Clin Exp Res. 2004;28(3): 374-384.
Humble, M. B. Vitamin D, light and mental health. J Photochem Photobiol B. 2010;101(2): 142-149.
Jain, S., S. D. Shukla, K. Sharma and M. Bhatnagar. Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat. Phytother Res. 2001;15(6): 544-548.
Jakobsson, J., M. Bjerke, C. J. Ekman, C. Sellgren, A. G. Johansson, H. Zetterberg, et al. Elevated concentrations of neurofilament light chain in the cerebrospinal fluid of bipolar disorder patients. Neuropsychopharmacology. 2014;39(10): 2349-2356.
Jakobsson, J., E. Pålsson, C. Sellgren, F. Rydberg, A. Ekman, H. Zetterberg, et al. CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder. Br J Psychiatry. 2016;208(2): 195-196.
Jia, J., J. Hu, X. Huo, R. Miao, Y. Zhang and F. Ma. Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2019;90(12): 1347-1352.
Jorde, R., J. Kubiak, J. Svartberg, O. M. Fuskevag, Y. Figenschau, I. Martinaityte, et al. Vitamin D supplementation has no effect on cognitive performance after four months in mid-aged and older subjects. J Neurol Sci. 2019;396: 165-171.
Jorde, R., J. Kubiak, J. Svartberg, O. M. Fuskevåg, Y. Figenschau, I. Martinaityte, et al. Vitamin D supplementation has no effect on cognitive performance after four months in mid-aged and older subjects. Journal of the Neurological Sciences. 2019;396: 165-171.
Katisko, K., A. Cajanus, O. Jääskeläinen, A. Kontkanen, P. Hartikainen, V. E. Korhonen, et al. Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. J Neurol. 2020;267(1): 162-167.
Kennel, K. A., M. T. Drake and D. L. Hurley. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8): 752-757; quiz 757-758.
Kesby, J. P., D. W. Eyles, T. H. Burne and J. J. McGrath. The effects of vitamin D on brain development and adult brain function. Mol Cell Endocrinol. 2011;347(1-2): 121-127.
Kim, H. K., H. J. Chung, H. G. Lê, B. K. Na and M. C. Cho. Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers. PLoS One. 2021;16(2): e0246541.
Kim, T. D., G. Hong, J. Kim and S. Yoon. Cognitive Enhancement in Neurological and Psychiatric Disorders Using Transcranial Magnetic Stimulation (TMS): A Review of Modalities, Potential Mechanisms and Future Implications. Exp Neurobiol. 2019;28(1): 1-16.
Kohler, S. and E. Marlinge. Cognitive aging of bipolar patients. Geriatr Psychol Neuropsychiatr Vieil. 2019;17(2): 179-188.
Krivoy, A., R. Onn, Y. Vilner, E. Hochman, S. Weizman, A. Paz, et al. Vitamin D Supplementation in Chronic Schizophrenia Patients Treated with Clozapine: A Randomized, Double-Blind, Placebo-controlled Clinical Trial. EBioMedicine. 2017;26: 138-145.
Kuboyama, T., C. Tohda and K. Komatsu. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005;144(7): 961-971.
Kueider, A. M., T. Tanaka, Y. An, M. H. Kitner-Triolo, E. Palchamy, L. Ferrucci, et al. State- and trait-dependent associations of vitamin-D with brain function during aging. Neurobiol Aging. 2016;39: 38-45.
Kuhle, J., C. Barro, U. Andreasson, T. Derfuss, R. Lindberg, Å. Sandelius, et al. Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa. Clin Chem Lab Med. 2016;54(10): 1655-1661.
Kulkarni, S. K. and A. Dhir. Withania somnifera: an Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5): 1093-1105.
Landel, V., C. Annweiler, P. Millet, M. Morello and F. Feron. Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails. J Alzheimers Dis. 2016;53(2): 419-444.
Lapid, M. I., M. T. Drake, J. R. Geske, C. B. Mundis, T. L. Hegard, S. Kung, et al. Hypovitaminosis D in psychogeriatric inpatients. J Nutr Health Aging. 2013;17(3): 231-234.
Lee, C. Y., S. Y. Lee, Y. C. Huang, C. F. Hung, Y. Lee, M. I. Lee, et al. The Chinese version of the Brief Assessment of Cognition in Affective Disorders: normative data of a Mandarin-speaking population. Clin Neuropsychol. 2018;32(sup1): 1-14.
Lee, C. Y., L. J. Wang, Y. Lee, C. F. Hung, Y. C. Huang, M. I. Lee, et al. Differentiating bipolar disorders from unipolar depression by applying the Brief Assessment of Cognition in Affective Disorders. Psychol Med. 2018;48(6): 929-938.
Lee, M. S., W. H. Pan, K. L. Liu and M. S. Yu. Reproducibility and validity of a Chinese food frequency questionnaire used in Taiwan. Asia Pac J Clin Nutr. 2006;15(2): 161-169.
Lewandowski, K. E., J. M. McCarthy, D. Öngür, L. A. Norris, G. Z. Liu, R. J. Juelich, et al. Functional connectivity in distinct cognitive subtypes in psychosis. Schizophr Res. 2019;204: 120-126.
Lin, L. and H. Chu. Quantifying publication bias in meta-analysis. Biometrics. 2018;74(3): 785-794.
Liu, N., T. Zhang, L. Ma, W. Wei, Z. Li, X. Jiang, et al. Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. Adv Nutr. 2021;12(6): 2255-2264.
Liu, Y. L., F. Bavato, A. N. Chung, T. H. Liu, Y. L. Chen, M. C. Huang, et al. Neurofilament light chain as novel blood biomarker of disturbed neuroaxonal integrity in patients with ketamine dependence. World J Biol Psychiatry. 2021;22(9): 713-721.
LoPinto-Khoury, C., L. Brennan and S. Mintzer. Impact of carbamazepine on vitamin D levels: A meta-analysis. Epilepsy Res. 2021;178: 106829.
Macfarlane, D. J., C. C. Lee, E. Y. Ho, K. L. Chan and D. T. Chan. Reliability and validity of the Chinese version of IPAQ (short, last 7 days). J Sci Med Sport. 2007;10(1): 45-51.
Macqueen, G. and T. Young. Cognitive effects of atypical antipsychotics: focus on bipolar spectrum disorders. Bipolar Disord. 2003;5 Suppl 2: 53-61.
Magioncalda, P., M. Martino, B. Conio, N. Piaggio, R. Teodorescu, A. Escelsior, et al. Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder. J Affect Disord. 2016;193: 39-50.
Magioncalda, P., M. Martino, S. Tardito, B. Sterlini, B. Conio, V. Marozzi, et al. White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: Combined DTI and immunological investigation in the different phases of bipolar disorder. Brain Behav Immun. 2018;73: 192-204.
Manders, M., L. C. P. G. M. De Groot, W. H. L. Hoefnagels, R. A. M. Dhonukshe-Rutten, W. Wouters-Wesseling, A. J. M. J. Mulders, et al. The effect of a nutrient dense drink on mental and physical function in institutionalized elderly people. Journal of Nutrition, Health and Aging. 2009;13(9): 760-767.
Manel, N., M. B. Manel, G. Wassim, E. A. Slim, J. Khalil, S. Omri, et al. [Bipolar disorder vulnerability: The vitamin D path]. Can J Psychiatry. 2019: 706743719870513.
Marsh, W. K., J. L. Penny and A. J. Rothschild. Vitamin D supplementation in bipolar depression: A double blind placebo controlled trial. J Psychiatr Res. 2017;95: 48-53.
Martino, D. J., S. A. Strejilevich, M. Scapola, A. Igoa, E. Marengo, E. D. Ais, et al. Heterogeneity in cognitive functioning among patients with bipolar disorder. J Affect Disord. 2008;109(1-2): 149-156.
Mayne, P. E. and T. H. J. Burne. Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness. Trends Neurosci. 2019;42(4): 293-306.
McNeill, G., A. Avenell, M. K. Campbell, J. A. Cook, P. C. Hannaford, M. M. Kilonzo, et al. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: A randomised controlled trial. Nutrition Journal. 2007;6.
Meeker, K. L., O. H. Butt, B. A. Gordon, A. M. Fagan, S. E. Schindler, J. C. Morris, et al. Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage. Neurobiol Dis. 2022;166: 105662.
Milborrow, S. (2011). Earth Package in R.
Miller, J. W., D. J. Harvey, L. A. Beckett, R. Green, S. T. Farias, B. R. Reed, et al. Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults. JAMA Neurol. 2015;72(11): 1295-1303.
Mirhosseini, N., H. Vatanparast, M. Mazidi and S. M. Kimball. The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis. J Clin Endocrinol Metab. 2017;102(9): 3097-3110.
Miskowiak, K. W., A. F. Carvalho, E. Vieta and L. V. Kessing. Cognitive enhancement treatments for bipolar disorder: A systematic review and methodological recommendations. Eur Neuropsychopharmacol. 2016;26(10): 1541-1561.
Miskowiak, K. W., H. Ehrenreich, E. M. Christensen, L. V. Kessing and M. Vinberg. Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: a double-blind, randomized, placebo-controlled phase 2 trial. J Clin Psychiatry. 2014;75(12): 1347-1355.
Moher, D., A. Liberati, J. Tetzlaff and D. G. Altman. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339.
Moore, R. C., A. L. Harmell, P. D. Harvey, C. R. Bowie, C. A. Depp, A. E. Pulver, et al. Improving the understanding of the link between cognition and functional capacity in schizophrenia and bipolar disorder. Schizophr Res. 2015;169(1-3): 121-127.
Moorhead, T. W., J. McKirdy, J. E. Sussmann, J. Hall, S. M. Lawrie, E. C. Johnstone, et al. Progressive gray matter loss in patients with bipolar disorder. Biol Psychiatry. 2007;62(8): 894-900.
Moran, C., A. Scotto di Palumbo, J. Bramham, A. Moran, B. Rooney, G. De Vito, et al. Effects of a Six-Month Multi-Ingredient Nutrition Supplement Intervention of Omega-3 Polyunsaturated Fatty Acids, vitamin D, Resveratrol, and Whey Protein on Cognitive Function in Older Adults: A Randomised, Double-Blind, Controlled Trial. J Prev Alzheimers Dis. 2018;5(3): 175-183.
Mur, M., M. J. Portella, A. Martinez-Aran, J. Pifarre and E. Vieta. Long-term stability of cognitive impairment in bipolar disorder: a 2-year follow-up study of lithium-treated euthymic bipolar patients. J Clin Psychiatry. 2008;69(5): 712-719.
Nerhus, M., A. O. Berg, C. Simonsen, M. Haram, B. Haatveit, S. R. Dahl, et al. Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders. J Clin Psychiatry. 2017;78(7): e750-e757.
Nwosu, B. U., B. Meltzer, L. Maranda, C. Ciccarelli, D. Reynolds, L. Curtis, et al. A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics. J Pediatr Endocrinol Metab. 2011;24(9-10): 619-626.
Nystad, A. E., Ø. Torkildsen and S. Wergeland. Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model. J Neuroimmunol. 2018;321: 61-65.
Ohi, K., C. Sumiyoshi, H. Fujino, Y. Yasuda, H. Yamamori, M. Fujimoto, et al. A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient. Front Psychiatry. 2017;8: 293.
Oliveira, A. C. R., C. A. Magalhaes, C. M. G. Loures, V. G. Fraga, L. C. de Souza, H. C. Guimaraes, et al. BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline. Arq Neuropsiquiatr. 2018;76(11): 760-766.
Oliveira, A. C. R., C. A. Magalhães, C. M. G. Loures, V. G. Fraga, L. C. de Souza, H. C. Guimarães, et al. BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline. Arq Neuropsiquiatr. 2018;76(11): 760-766.
Ortelbach, N., J. Rote, A. M. L. Dingelstadt, A. Stolzenburg, C. Koenig, G. O'Malley, et al. The big five model in bipolar disorder: a latent profile analysis and its impact on longterm illness severity. Int J Bipolar Disord. 2022;10(1): 1.
Owusu, J. E., S. Islam, S. S. Katumuluwa, A. R. Stolberg, G. L. Usera, A. A. Anwarullah, et al. Cognition and Vitamin D in Older African-American Women– Physical performance and Osteoporosis prevention with vitamin D in older African Americans Trial and Dementia. Journal of the American Geriatrics Society. 2019;67(1): 81-86.
Paterson, A. and G. Parker. Lithium and cognition in those with bipolar disorder. Int Clin Psychopharmacol. 2017;32(2): 57-62.
Păunescu, R. and I. Micluţia. Outcome of cognitive performances in bipolar euthymic patients after a depressive episode: a longitudinal naturalistic study. Ann Gen Psychiatry. 2015;14: 32.
Pavlovic, A., K. Abel, C. E. Barlow, S. W. Farrell, M. Weiner and L. F. DeFina. The association between serum vitamin d level and cognitive function in older adults: Cooper Center Longitudinal Study. Prev Med. 2018;113: 57-61.
Perlis, R. H., R. W. Baker, C. A. Zarate, E. B. Brown, L. M. Schuh, H. H. Jamal, et al. Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial. Journal of clinical psychiatry. 2006;67(11): 1747‐1753.
Pettersen, J. A. Does high dose vitamin D supplementation enhance cognition?: A randomized trial in healthy adults. Exp Gerontol. 2017;90: 90-97.
Pettersen, J. A., S. Fontes and C. L. Duke. The effects of vitamin D insufficiency and seasonal decrease on cognition. The Canadian Journal of Neurological Sciences / Le Journal Canadien Des Sciences Neurologiques. 2014;41(4): 459-465.
Pettersen, J. A., S. Fontes and C. L. Duke. The effects of Vitamin D Insufficiency and Seasonal Decrease on cognition. Can J Neurol Sci. 2014;41(4): 459-465.
Pezzoli, S., L. Emsell, S. W. Yip, D. Dima, P. Giannakopoulos, M. Zarei, et al. Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data. Neurosci Biobehav Rev. 2018;84: 162-170.
Pusceddu, I., C. J. Farrell, A. M. Di Pierro, E. Jani, W. Herrmann and M. Herrmann. The role of telomeres and vitamin D in cellular aging and age-related diseases. Clin Chem Lab Med. 2015;53(11): 1661-1678.
Røsjø, E., J. C. Lindstrøm, T. Holmøy, K. M. Myhr, K. N. Varhaug and Ø. Torkildsen. Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis. Front Neurol. 2020;11: 329.
Rakofsky, J. J., B. W. Dunlop, J. L. Beyer, A. M. Oliver, E. E. Mansson, M. T. Sancheti, et al. Cognitive effects of quetiapine XR in patients with euthymic bipolar disorder. J Clin Psychopharmacol. 2014;34(3): 383-385.
Robinson, L. J., J. M. Thompson, P. Gallagher, U. Goswami, A. H. Young, I. N. Ferrier, et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1-3): 105-115.
Rodriguez, A. J., A. Mousa, P. R. Ebeling, D. Scott and B. de Courten. Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2018;8(1): 1169.
Rosa, A. R., M. Reinares, C. Franco, M. Comes, C. Torrent, J. Sanchez-Moreno, et al. Clinical predictors of functional outcome of bipolar patients in remission. Bipolar Disord. 2009;11(4): 401-409.
Rossom, R. C., M. A. Espeland, J. E. Manson, M. W. Dysken, K. C. Johnson, D. S. Lane, et al. Calcium and vitamin D supplementation and cognitive impairment in the women's health initiative. J Am Geriatr Soc. 2012;60(12): 2197-2205.
Rucker, G. and G. Schwarzer. Resolve conflicting rankings of outcomes in network meta-analysis: Partial ordering of treatments. Res Synth Methods. 2017;8(4): 526-536.
Ryan, K. A., S. Assari, B. D. Pester, K. Hinrichs, K. Angers, A. Baker, et al. Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling. J Affect Disord. 2016;199: 87-94.
Samalin, L., I. de Chazeron, E. Vieta, F. Bellivier and P. M. Llorca. Residual symptoms and specific functional impairments in euthymic patients with bipolar disorder. Bipolar Disord. 2016;18(2): 164-173.
Samamé, C., B. L. Cattaneo, M. C. Richaud, S. Strejilevich and I. Aprahamian. The long-term course of cognition in bipolar disorder: a systematic review and meta-analysis of patient-control differences in test-score changes. Psychol Med. 2022;52(2): 217-228.
Samame, C., D. J. Martino and S. A. Strejilevich. Longitudinal course of cognitive deficits in bipolar disorder: a meta-analytic study. J Affect Disord. 2014;164: 130-138.
Sanchez-Morla, E. M., A. Lopez-Villarreal, E. Jimenez-Lopez, A. I. Aparicio, V. Martinez-Vizcaino, R. J. Roberto, et al. Impact of number of episodes on neurocognitive trajectory in bipolar disorder patients: a 5-year follow-up study. Psychol Med. 2019;49(8): 1299-1307.
Sandberg, L., M. Biström, J. Salzer, M. Vågberg, A. Svenningsson and P. Sundström. Vitamin D and axonal injury in multiple sclerosis. Mult Scler. 2016;22(8): 1027-1031.
Santos, J. L., A. Aparicio, A. Bagney, E. M. Sanchez-Morla, R. Rodriguez-Jimenez, J. Mateo, et al. A five-year follow-up study of neurocognitive functioning in bipolar disorder. Bipolar Disord. 2014;16(7): 722-731.
Sargin, D., H. Friedrichs, A. El-Kordi and H. Ehrenreich. Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research. Best Pract Res Clin Anaesthesiol. 2010;24(4): 573-594.
Schietzel, S., K. Fischer, P. Brugger, E. J. Orav, K. Renerts, M. Gagesch, et al. Effect of 2000 IU compared with 800 IU vitamin D on cognitive performance among adults age 60 years and older: a randomized controlled trial. Am J Clin Nutr. 2019;110(1): 246-253.
Schneider, A. L. C., D. Zhao, P. L. Lutsey, R. F. Gottesman, A. R. Sharrett, A. M. Rawlings, et al. Serum Vitamin D Concentrations and Cognitive Change Over 20 Years: The Atherosclerosis Risk in Communities Neurocognitive Study. Neuroepidemiology. 2018;51(3-4): 131-137.
Schouws, S. N., H. C. Comijs, A. Dols, A. T. Beekman and M. L. Stek. Five-year follow-up of cognitive impairment in older adults with bipolar disorder. Bipolar Disord. 2016;18(2): 148-154.
Schrauwen, E. and S. N. Ghaemi. Galantamine treatment of cognitive impairment in bipolar disorder: four cases. Bipolar Disord. 2006;8(2): 196-199.
Scott, J. F., L. M. Das, S. Ahsanuddin, Y. Qiu, A. M. Binko, Z. P. Traylor, et al. Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study. J Invest Dermatol. 2017;137(10): 2078-2086.
Seelye, A., P. Thuras, B. Doane, C. Clason, W. VanVoorst and S. Urosevic. Steeper aging-related declines in cognitive control processes among adults with bipolar disorders. J Affect Disord. 2019;246: 595-602.
Shi, L., L. M. Schuh, P. T. Trzepacz, L. X. Huang, M. A. Namjoshi and M. Tohen. Improvement of positive and negative syndrome scale cognitive score associated with olanzapine treatment of acute mania. Current Medical Research and Opinion. 2004;20(9): 1371-1376.
Siebert, C., P. Pierozan, J. Kolling, T. M. Dos Santos, M. C. Sebotaio, E. P. Marques, et al. Vitamin D(3) Reverses the Hippocampal Cytoskeleton Imbalance But Not Memory Deficits Caused by Ovariectomy in Adult Wistar Rats. Neuromolecular Med. 2017;19(2-3): 345-356.
Sikoglu, E. M., A. A. Navarro, D. Starr, Y. Dvir, B. U. Nwosu, S. M. Czerniak, et al. Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders. J Child Adolesc Psychopharmacol. 2015;25(5): 415-424.
Small, B. J., K. S. Rawson, C. Martin, S. L. Eisel, C. D. Sanberg, C. L. McEvoy, et al. Nutraceutical intervention improves older adults' cognitive functioning. Rejuvenation Research. 2014;17(1): 27-32.
Solé, B., E. Jiménez, C. Torrent, M. Reinares, C. D. M. Bonnin, I. Torres, et al. Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies. Int J Neuropsychopharmacol. 2017;20(8): 670-680.
Sole, B., C. M. Bonnin, E. Jimenez, C. Torrent, I. Torres, C. Varo, et al. Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach. Acta Psychiatr Scand. 2018;137(6): 516-527.
Sonkurt, H. O., A. E. Altınöz, E. Çimen, F. Köşger and G. Öztürk. The role of cognitive functions in the diagnosis of bipolar disorder: A machine learning model. Int J Med Inform. 2021;145: 104311.
Spedding, S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014;6(4): 1501-1518.
Speeckaert, M. M. and J. R. Delanghe. 25-hydroxyvitamin D in patients with cognitive decline. JAMA Neurology. 2016;73(3): 356-357.
Sussman, N., J. Mullen, B. Paulsson and M. Vågerö. Rates of remission/euthymia with quetiapine in combination with lithium/divalproex for the treatment of acute mania. J Affect Disord. 2007;100 Suppl 1: S55-63.
Suwalska, A., A. Borkowska and J. Rybakowski. [Cognitive deficits in the bipolar affective disorder]. Psychiatr Pol. 2001;35(4): 657-668.
Terachi, S., T. Yamada, S. Pu, K. Yokoyama, H. Matsumura and K. Kaneko. Comparison of neurocognitive function in major depressive disorder, bipolar disorder, and schizophrenia in later life: A cross-sectional study of euthymic or remitted, non-demented patients using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J). Psychiatry Res. 2017;254: 205-210.
Torrent, C., A. Martinez-Aran, C. del Mar Bonnin, M. Reinares, C. Daban, B. Sole, et al. Long-term outcome of cognitive impairment in bipolar disorder. J Clin Psychiatry. 2012;73(7): e899-905.
Travica, N., M. Berk and W. Marx. Neurofilament light protein as a biomarker in depression and cognitive function. Curr Opin Psychiatry. 2022;35(1): 30-37.
Treuer, T. and M. Tohen. Predicting the course and outcome of bipolar disorder: a review. Eur Psychiatry. 2010;25(6): 328-333.
Tsai, S. Y., H. C. Lee, C. C. Chen and Y. L. Huang. Cognitive impairment in later life in patients with early-onset bipolar disorder. Bipolar Disord. 2007;9(8): 868-875.
Uitterlinden, A. G., Y. Fang, J. B. Van Meurs, H. A. Pols and J. P. Van Leeuwen. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338(2): 143-156.
Ustun, T. B., N. Kostanjesek, S. Chatterji, J. Rehm and O. World Health (2010). Measuring health and disability : manual for WHO Disability Assessment Schedule (WHODAS 2.0) / edited by T.B. Üstün, N. Kostanjsek, S. Chatterji, J.Rehm. Geneva, World Health Organization.
Van Rheenen, T. E., K. E. Lewandowski, I. E. Bauer, F. Kapczinski, K. Miskowiak, K. E. Burdick, et al. Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence. Bipolar Disord. 2020;22(1): 13-27.
Vanegas, J. and F. Vásquez. [Multivariate Adaptive Regression Splines (MARS), an alternative for the analysis of time series]. Gac Sanit. 2017;31(3): 235-237.
Velosa, J., A. Delgado, E. Finger, M. Berk, F. Kapczinski and T. de Azevedo Cardoso. Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses. Acta Psychiatr Scand. 2020;141(6): 510-521.
Vijayakumar, M., A. Bk, B. George and V. Bhatia. Vitamin D Status in Children on Anticonvulsant Therapy. Indian J Pediatr. 2021.
Volkert, J., J. Kopf, J. Kazmaier, F. Glaser, K. C. Zierhut, M. A. Schiele, et al. Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances. Eur Neuropsychopharmacol. 2015;25(2): 192-202.
Volkert, J., M. A. Schiele, J. Kazmaier, F. Glaser, K. C. Zierhut, J. Kopf, et al. Cognitive deficits in bipolar disorder: from acute episode to remission. Eur Arch Psychiatry Clin Neurosci. 2016;266(3): 225-237.
Vrabie, M., V. Marinescu, A. Talaşman, O. Tăutu, E. Drima and I. Micluţia. Cognitive impairment in manic bipolar patients: important, understated, significant aspects. Ann Gen Psychiatry. 2015;14: 41.
Wang, L. J., Y. C. Huang, C. F. Hung, C. K. Chen, Y. C. Chen, P. Y. Lee, et al. The Chinese Version of the Brief Assessment of Cognition in Schizophrenia: Data of a Large-Scale Mandarin-Speaking Population. Arch Clin Neuropsychol. 2017;32(3): 289-296.
Wenclewska, S., I. Szymczak-Pajor, J. Drzewoski, M. Bunk and A. Śliwińska. Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders. Int J Mol Sci. 2019;20(12).
White, I. R. Network Meta-analysis. The Stata Journal. 2015;15(4): 951-985.
WHO Collaborating Centre for Drug Statistics Methodology, W. ( 2018-02-07). "DDD Definition and general considerations." 2020, from https://www.whocc.no/atc_ddd_index/.
Wimalawansa, S. J. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology (Basel). 2019;8(2).
Wise, T., J. Radua, G. Nortje, A. J. Cleare, A. H. Young and D. Arnone. Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder. Biol Psychiatry. 2016;79(4): 293-302.
Woodward, N. D. and S. Heckers. Brain Structure in Neuropsychologically Defined Subgroups of Schizophrenia and Psychotic Bipolar Disorder. Schizophr Bull. 2015;41(6): 1349-1359.
Wouters-Wesseling, W., L. W. Wagenaar, M. Rozendaal, J. B. Deijen, L. C. De Groot, J. G. Bindels, et al. Effect of an enriched drink on cognitive function in frail elderly persons. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2005;60(2): 265-270.
Xu, N., B. Huggon and K. E. A. Saunders. Cognitive Impairment in Patients with Bipolar Disorder: Impact of Pharmacological Treatment. CNS Drugs. 2020;34(1): 29-46.
Yan, J., J. Feng, N. Craddock, I. R. Jones, E. H. Cook, Jr., D. Goldman, et al. Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Neurosci Lett. 2005;380(1-2): 37-41.
Yang, L. L., D. Zhao, L. L. Kong, Y. Q. Sun, Z. Y. Wang, Y. Y. Gao, et al. High-frequency repetitive transcranial magnetic stimulation (rTMS) improves neurocognitive function in bipolar disorder. J Affect Disord. 2019;246: 851-856.
Yang, T., H. Wang, Y. Xiong, C. Chen, K. Duan, J. Jia, et al. Vitamin D Supplementation Improves Cognitive Function through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial. Journal of Alzheimer's Disease. 2020;78(4): 1509-1518.
Yatham, L. N., I. J. Torres, G. S. Malhi, S. Frangou, D. C. Glahn, C. E. Bearden, et al. The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord. 2010;12(4): 351-363.
Yoo, T., W. Choi, J. H. Hong, J. Y. Lee, J. M. Kim, I. S. Shin, et al. Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders. Psychiatry Investig. 2018;15(4): 396-401.
Young, A. H., P. Gallagher, S. Watson, D. Del-Estal, B. M. Owen and I. N. Ferrier. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology. 2004;29(8): 1538-1545.
Young, R. C., J. T. Biggs, V. E. Ziegler and D. A. Meyer. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133: 429-435.
Yuan, A. and R. A. Nixon. Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies. Front Neurosci. 2021;15: 689938.
Zimmerman, M., J. H. Martinez, D. Young, I. Chelminski and K. Dalrymple. Severity classification on the Hamilton Depression Rating Scale. J Affect Disord. 2013;150(2): 384-388.
Zou, Y., B. Guo, S. Yu, D. Wang, L. Qiu and Y. Jiang. Effect of vitamin D supplementation on glycose homeostasis and islet function in vitamin D deficient or insufficient diabetes and prediabetes: a systematic review and meta-analysis. J Clin Biochem Nutr. 2021;69(3): 229-237.
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊