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研究生:涂庭瑞
研究生(外文):Tu, Ting-Jui
論文名稱:金奈米結構多重感測頭在自動化高通量生物親和力測量之開發與應用
論文名稱(外文):The development and applications of gold nanostructure-based multiple sensing heads for automatic and high throughput bioaffinity measurement
指導教授:魏培坤
指導教授(外文):Wei, Pei-Kuen
口試委員:魏培坤鄭郅言陳奕帆
口試委員(外文):Wei, Pei-KuenCheng, Ji-YenChen, Yih-Fan
口試日期:2023-07-12
學位類別:碩士
校院名稱:國立陽明交通大學
系所名稱:生醫光電研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2023
畢業學年度:111
語文別:中文
論文頁數:57
中文關鍵詞:表面電漿子共振射出成型晶片即時性檢測非標定性檢測高通量檢測生物檢測光學生物感測器
外文關鍵詞:Surface Plasmon Resonance(SPR)Injection Molding MicrochipReal-timeLabel-freeHigh-throughputBiosensingOptical Biosensor
相關次數:
  • 被引用被引用:0
  • 點閱點閱:33
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  • 下載下載:0
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目次
摘要 i
Abstract ii
目次 iii
圖目次 v
表目次 viii
第一章 緒論 1
1.1前言 1
1.2研究背景與動機 3
第二章 實驗原理與分析方法 7
2.1表面電漿共振理論 7
2.1.1 表面電漿共振簡介 7
2.1.2 表面電漿共振原理 7
2.1.3 表面電漿共振激發方法 12
2.1.4 週期性金屬奈米狹縫表面電漿共振激發 13
2.2實驗結果分析方式 15
2.2.1 AB分析法簡介 15
2.2.2 彩色AB分析法 16
第三章 實驗設備與多重感測頭製作 18
3.1奈米週期性結構射出成型晶片 18
3.2鍍膜設備 19
3.2.1電子束真空蒸鍍系統 19
3.2.2 原子層沉積系統 20
3.3掃描式電子顯微鏡 21
3.4多重感測頭製作與設備 22
3.4.1氣壓式熱壓機 22
第四章 自動化光學量測系統 24
4.1自動化光學量測系統架構 24
4.1.1 穿透式強度光譜系統 24
4.1.2 穿透式影像檢測系統 28
4.1.3 反射式影像檢測系統 33
4.2 LabView量測系統整合 36
第五章 實驗方法與結果分析 38
5.1影像系統校正 38
5.2光學感測陣列之感測能力 40
5.2.1葡萄糖水溶液折射率應用 40
5.3抗原抗體結合實驗 44
5.3.1實驗流程 44
5.3.2實驗數據與結果 46
第六章 SPR感測頭與BLI技術比較 51
6.1生物膜干涉技術介紹 51
6.2本實驗與BLI技術比較 52
第七章 結論與未來發展 54
參考資料 55
[1] Gauglitz, G. (1996). Opto‐chemical and opto‐immuno sensors. Sensors update, 1(1), 1-48.
[2] Homola, J., S.S. Yee, and G. Gauglitz, Surface plasmon resonance sensors. Sensors and actuators B: Chemical, 1999. 54(1-2): p. 3-15.
[3] Ritchie, R.H., et al., Surface-plasmon resonance effect in grating diffraction. Physical review letters, 1968. 21(22): p. 1530.
[4] Raether, H., Surface Plasmons on Smooth and Rough Surfaces and on Gratings. Vol. 111. 1988.
[5] 蔡柏政, 鋁與氧化鋁覆蓋奈米狹縫中菲諾共振應用於高靈敏度生物晶片, 國立臺灣海洋大學光電科學研究所碩士論文,2017.
[6] Nylander, C., B. Liedberg, and T. Lind, Gas detection by means of surface plasmon resonance. Sensors and Actuators, 1982. 3: p. 79-88.
[7] Liedberg, B., C. Nylander, and I. Lunström, Surface plasmon resonance for gas detection and biosensing. Sensors and actuators, 1983. 4: p. 299-304.
[8] Homola, J., Present and future of surface plasmon resonance biosensors. Analytical and bioanalytical chemistry, 2003. 377: p. 528-539.
[9] MacBeath, G. and S.L. Schreiber, Printing proteins as microarrays for high-throughput function determination. Science, 2000. 289(5485): p. 1760-1763.
[10] Ebbesen, T.W., et al., Extraordinary optical transmission through sub-wavelength hole arrays. nature, 1998. 391(6668): p. 667-669.
[11] Lezec, H.J., et al., Beaming Light from a Subwavelength Aperture. Science, 2002. 297(5582): p. 820-822.
[12] Raether, H., Surface plasmons on smooth surfaces. Surface plasmons on smooth and rough surfaces and on gratings, 2006: p. 4-39.
[13] Barnes, W.L., A. Dereux, and T.W. Ebbesen, Surface plasmon subwavelength optics. nature, 2003. 424(6950): p. 824-830.
[14] Chou, S.Y., P.R. Krauss, and P.J. Renstrom, Imprint of sub‐25 nm vias and trenches in polymers. Applied physics letters, 1995. 67(21): p. 3114-3116.
[15] Brolo, A.G., et al., Surface plasmon sensor based on the enhanced light transmission through arrays of nanoholes in gold films. Langmuir, 2004. 20(12): p. 4813-4815.
[16] Lee, K.-L., et al., Enhancing surface plasmon detection using template-stripped gold nanoslit arrays on plastic films. ACS nano, 2012. 6(4): p. 2931-2939.
[17] 何一德, 自動化機械手臂在表面電漿檢測器的發展與應用,國立臺灣海洋大學光電科學研究所碩士論文, 2018.
[18] Wood, R.W., XLII. On a remarkable case of uneven distribution of light in a diffraction grating spectrum. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science, 1902. 4(21): p. 396-402.
[19] Fano, U., The theory of anomalous diffraction gratings and of quasi-stationary waves on metallic surfaces (Sommerfeld’s waves). JOSA, 1941. 31(3): p. 213-222.
[20] 邱國斌,蔡定平,金屬表面電漿簡介,物理雙月刊, vol. 28, pp.472-485, 2006.
[21] Lee, K.-L., et al., Enhancing surface sensitivity of nanostructure-based aluminum sensors using capped dielectric layers. ACS omega, 2017. 2(10): p. 7461-7470.
[22] Lee, K.-L., et al., Highly sensitive aluminum-based biosensors using tailorable Fano resonances in capped nanostructures. Scientific reports, 2017. 7(1): p. 1-14.
[23] 駱書成, 曲率光柵開發應用於影像式光譜儀和高通量感測, 國立暨南國際大學應用材料及光電工程學系碩士論文, 2016.
[24] Pan, M.-Y., et al., Resonant position tracking method for smartphone-based surface plasmon sensor. Analytica chimica acta, 2018. 1032: p. 99-106.
[25] Chou, S.Y., P.R. Krauss, and P.J. Renstrom, Nanoimprint lithography. Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena, 1996. 14(6): p. 4129-4133.
[26] Hu, W., et al., A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film. Biosensors and Bioelectronics, 2004. 19(11): p. 1465-1471.
[27] Hua, F., et al., Polymer imprint lithography with molecular-scale resolution. Nano letters, 2004. 4(12): p. 2467-2471.
[28] Zayats, A.V., I.I. Smolyaninov, and A.A. Maradudin, Nano-optics of surface plasmon polaritons. Physics reports, 2005. 408(3-4): p. 131-314.
[29] Homola, J., Electromagnetic theory of surface plasmons. Surface plasmon resonance based sensors, 2006: p. 3-44.
[30] Hoa, X.D., A. Kirk, and M. Tabrizian, Towards integrated and sensitive surface plasmon resonance biosensors: A review of recent progress. Biosensors and bioelectronics, 2007. 23(2): p. 151-160.
[31] Guillaumée, M., et al., Polarization sensitive silicon photodiodes using nanostructured metallic grids. Applied Physics Letters, 2009. 94(19): p. 193503.
[32] Sundaram, V. and S. Wen, An easy method to perform e-beam negative tone lift-off fabrication on dielectric material with a sandwiched conducting polymer layer. Journal of Micromechanics and Microengineering, 2011. 21(6): p. 065021.
[33] Nazem, S., M. Malekmohammad, and M. Soltanolkotabi, Theoretical and experimental study of a surface plasmon sensor based on Ag-MgF 2 grating coupler. Applied Physics B, 2020. 126: p. 1-11.
[34] Cytiva. (2021). Principles of surface plasmon resonance (SPR). Retrieved June 15 from https://www.facebook.com/cytiva/videos/principles-of-surface-plasmon-resonance-spr/280084517108128/?locale=zh_CN.
[35] Biosensing Instrument (2015). How Does Surface Plasmon Resonance Work? Retrieved June 15 from https://biosensingusa.com/technologies/surface-plasmon-resonance/surface-plasmon-resonance-work/
[36] ZWO ASI (2019). ZWO ASI183MC Pro Spectrum. Retrieved June 15 from https://astronomy-imaging-camera.com/product/asi183mc-pro-color/
[37] Bashir, A., et al., Chapter 3 - Interfaces and surfaces, in Chemistry of Nanomaterials, T.I. Awan, A. Bashir, and A. Tehseen, Editors. 2020, Elsevier. p. 51-87.
[38] 柯忠廷、陳敏璋 (2014) 。原子層沉積技術之發展與應用。科儀新知,頁38-46。
[39] Inc., E. O. (2020). 585nm Fluorescence Bandpass Filter: 36nm FWHM OD >6.0 Coating Performance. Retrieved June 15 from https://www.edmundoptics.com/p/585nm-cwl-25mm-dia-36nm-bandwidth-od-6-fluorescence-filter/3361/
[40] SARTORIUS. (2022). Discover what makes fluidic-free Octet BLI detection special. Retrieved June 15 from https://www.sartorius.com/en/products/protein-analysis/octet-bli-detection
[41] SARTORIUS. (2021). What is Bio-Layer Interferometry (BLI) Label-Free Technology? Retrieved June 15 from https://www.sartorius.com/en/applications/life-science-research/label-free-detection/bli-technology
[42] Shrivastav, A.M., U. Cvelbar, and I. Abdulhalim, A comprehensive review on plasmonic-based biosensors used in viral diagnostics. Communications biology, 2021. 4(1): p. 70.
[43] Neumann, T., et al., SPR-based fragment screening: advantages and applications. Current topics in medicinal chemistry, 2007. 7(16): p. 1630-1642.
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