跳到主要內容

臺灣博碩士論文加值系統

(44.201.97.138) 您好!臺灣時間:2024/09/09 10:12
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:鍾國廷
研究生(外文):ZHONG, GUO-TING
論文名稱:有氧運動訓練合併植物性高蛋白補充對肥胖老化小鼠之影響
論文名稱(外文):The Effects of Aerobic Exercise Training Combined with Plant-Based High-Protein Supplementation on Obese Aging Mice
指導教授:徐藝洳
指導教授(外文):HSU, YI-JU
口試委員:蕭千祐黃啟彰
口試委員(外文):HSIAO, CHIEN-YUHUANG, CHI-CHANG
口試日期:2024-06-24
學位類別:碩士
校院名稱:國立體育大學
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2024
畢業學年度:112
語文別:中文
論文頁數:55
中文關鍵詞:大豆分離蛋白(ISP)有氧運動高脂飲食老化小鼠
外文關鍵詞:isolated soy proteinaerobic exercisehigh fat dietaging mice
IG URL:bbbbb.yolei
Facebook:鍾國廷
相關次數:
  • 被引用被引用:0
  • 點閱點閱:5
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
目 錄
第壹章 緒論 1
第一節 研究背景 1
第二節 研究目的 3
第貳章 文獻探討 4
第一節 肥胖與老化之研究探討 4
第二節 大豆分離蛋白介紹與研究探討 8
第三節 運動訓練對於生理之影響 13
第四節 文獻結語 15
第參章 材料與方法 16
第一節 實驗測試樣品 16
第二節 實驗動物之飼養與分組 19
第三節 實驗方法與內容 21
第四節 血液與組織樣本之收集及前處理 27
第五節 統計分析 28
第肆章 結果 29
第一節 體重、飲食與組織器官之變化情形 29
第二節 跑步機力竭能力測試 34
第三節 旋轉滾輪跑步平衡能力測試 35
第四節 重量測試 36
第五節 倒掛抓力能力測試 37
第六節 有氧運動合併ISP補充對於臨床血液生化指標之影響 38
第七節 組織病理切片觀察結果 42
第伍章 討論 44
第一節 有氧運動合併ISP補充對肥胖老化小鼠生理狀態之影響 44
第二節 有氧運動合併ISP補充對肥胖小鼠體能表現之影響 46
第三節 有氧運動合併ISP補充對肥胖小鼠臨床血液生化之影響 47
第四節 有氧運動合併ISP補充對肥胖小鼠組織病理切片之影響 49
第陸章 結論 50
參考文獻 51





表 目 錄
表1、大豆分離蛋白營養組成表 16
表2、有氧介入性運動訓練表 22
表3、各組動物體重、飲食量與組織器官重量紀錄 32
表4、各組臨床血液生化指標 38



圖 目 錄
圖1、老化與肥胖相關機轉 7
圖2、肝臟脂肪酸合成代謝機轉 10
圖3、實驗流程圖 21
圖4、跑步機力竭測試 23
圖5、滾輪測試 24
圖6、重量試驗 25
圖7、倒掛抓力測試 26
圖8、實驗期間各組體重變化。 29
圖9、各組犧牲體態照 30
圖10、有氧運動合併ISP補充對跑步力竭運動能力之影響 34
圖11、有氧運動合併ISP補充對滾輪跑步平衡能力之影響 35
圖12、有氧運動合併ISP補充對重量測試之影響 36
圖13、有氧運動合併ISP補充對倒掛抓力能力之影響 37
圖14、有氧運動合併ISP補充對血液生化(A)血糖(GLUCOSE)、(B)高密度脂蛋白-膽固醇(HDL-C)、(C)天門冬胺酸轉胺酶(AST)、(D)血液總蛋白(TP)之影響 41
圖15、有氧運動合併ISP補充對 (A)肝臟、(B)肌肉、(C)附睪脂肪(EFP)病理切片之影響 42
圖16、有氧運動合併ISP補充對 (A)肌肉橫截面積(CSA)與 (B)附睪脂肪平均空泡大小之影響 43


Anthony, T. G., McDaniel, B. J., Knoll, P., Bunpo, P., Paul, G. L., & McNurlan, M. A. (2007). Feeding Meals Containing Soy or Whey Protein after Exercise Stimulates Protein Synthesis and Translation Initiation in the Skeletal Muscle of Male Rats13. J Nutr, 137(2), 357-362.

Ascencio, C., Torres, N., Isoard-Acosta, F., Tovar, A. R., Gómez-Pérez, F. J., & Hernández-Pando, R. (2004). Soy Protein Affects Serum Insulin and Hepatic SREBP-1 mRNA and Reduces Fatty Liver in Rats. J Nutr, 134(3), 522-529.

Batsis, J. A., & Villareal, D. T. (2018). Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol, 14(9), 513-537.

Bosello, O., Cominacini, L., Zocca, I., Garbin, U., Compri, R., Davoli, A., & Brunetti, L. (1988). Short- and long-term effects of hypocaloric diets containing proteins of different sources on plasma lipids and apoproteins of obese subjects. Ann Nutr Metab, 32(4), 206-214.

Brennan, A. M., Standley, R. A., Anthony, S. J., Grench, K. E., Helbling, N. L., DeLany, J. P., Cornnell, H. H., Yi, F., Stefanovic-Racic, M., Toledo, F. G. S., Coen, P. M., Carnero, E. A., & Goodpaster, B. H. (2022). Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(5), 1088–1097.

Bunout, D., de la Maza, M. P., Barrera, G., Leiva, L., & Hirsch, S. (2011). Association between sarcopenia and mortality in healthy older people. Australas J Ageing, 30(2), 89-92.

Butteiger, D. N., Hibberd, A. A., McGraw, N. J., Napawan, N., Hall-Porter, J. M., & Krul, E. S. (2016). Soy Protein Compared with Milk Protein in a Western Diet Increases Gut Microbial Diversity and Reduces Serum Lipids in Golden Syrian Hamsters123. J Nutr, 146(4), 697-705.

Chiang, F. Y., Chen, J. R., Lee, W. J., & Yang, S. C. (2021). Effects of Milk or Soy Milk Combined with Mild Resistance Exercise on the Muscle Mass and Muscle Strength in Very Old Nursing Home Residents with Sarcopenia. Foods, 10(11).

Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009). American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc, 41(7), 1510-1530.

Conover, C. A., Bale, L. K., & Nair, K. S. (2016). Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice. Exp Gerontol, 80, 36-42.

Deacon, R. M. (2013). Measuring the strength of mice. J Vis Exp(76).

Dimina, L., Landais, J., Mathe, V., Jarzaguet, M., Bourgot, C. L., Hermier, D., Mariotti, F., Rémond, D., & Mosoni, L. (2023). Plant protein can be as efficient as milk protein to maintain fat free mass in old rats, even when fat and sugar intakes are high. The Journal of Nutrition, 153(9), 2631–2641.

Dodig, S., Čepelak, I., & Pavić, I. (2019). Hallmarks of senescence and aging. Biochem Med (Zagreb), 29(3), 030501.

Dutta, S., & Sengupta, P. (2016). Men and mice: Relating their ages. Life sciences, 152, 244–248.

Eberlé, D., Hegarty, B., Bossard, P., Ferré, P., & Foufelle, F. (2004). SREBP transcription factors: master regulators of lipid homeostasis. Biochimie, 86(11), 839-848.

Erdman, J. W. (2000). Soy protein and cardiovascular disease. Circulation, 102(20), 2555–2559.

Flegal, K. M., Shepherd, J. A., Looker, A. C., Graubard, B. I., Borrud, L. G., Ogden, C. L., Harris, T. B., Everhart, J. E., & Schenker, N. (2009). Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr, 89(2), 500-508.

Franczyk, B., Gluba-Brzózka, A., Ciałkowska-Rysz, A., Ławiński, J., & Rysz, J. (2023). The Impact of Aerobic exercise on HDL Quantity and Quality: A Narrative review. International Journal of Molecular Sciences, 24(5), 4653.

Fu, P., Zhu, R., Jia, J., Hu, Y., Wu, C., Cieszczyk, P., Holmberg, H., & Gong, L. (2021). Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway. Nutrition & Metabolism, 18(1).

Graber, T. G., Ferguson-Stegall, L., Liu, H., & Thompson, L. V. (2015). Voluntary Aerobic Exercise Reverses Frailty in Old Mice. J Gerontol A Biol Sci Med Sci, 70(9), 1045-1058.

Graber, T. G., Kim, J. H., Grange, R. W., McLoon, L. K., & Thompson, L. V. (2015). C57BL/6 life span study: age-related declines in muscle power production and contractile velocity. Age (Dordr), 37(3), 9773.

Hakkak, R., Gauss, C., Bell, A., & Korourian, S. (2018). Short-Term soy protein isolate feeding prevents liver steatosis and reduces serum ALT and AST levels in obese female zucker rats. Biomedicines, 6(2), 55.

Han, T. S., Tajar, A., & Lean, M. E. (2011). Obesity and weight management in the elderly. Br Med Bull, 97, 169-196.

Herreman, L., Nommensen, P., Pennings, B., & Laus, M. C. (2020). Comprehensive overview of the quality of plant- And animal-sourced proteins based on the digestible indispensable amino acid score. Food Science & Nutrition, 8(10), 5379-5391.

Hsu, Y. J., Huang, W. C., Chiu, C. C., Liu, Y. L., Chiu, W. C., Chiu, C. H., Chiu, Y. S., & Huang, C. C. (2016). Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice. Nutrients, 8(10), 648.

Huang, K. C., Lee, M. S., Lee, S. D., Chang, Y. H., Lin, Y. C., Tu, S. H., & Pan, W. H. (2005). Obesity in the elderly and its relationship with cardiovascular risk factors in Taiwan. Obes Res, 13(1), 170-178.

Iritani, N., Hosomi, H., Fukuda, H., Tada, K., & Ikeda, H. (1996). Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats. J Nutr, 126(2), 380-388.

Jakicic, J. M., Clark, K., Coleman, E., Donnelly, J. E., Foreyt, J., Melanson, E., . . . Volpe, S. L. (2001). American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc, 33(12), 2145-2156.
Laurin, J. L., Reid, J. J., Lawrence, M. M., & Miller, B. F. (2019). Long-term aerobic exercise preserves muscle mass and function with age. Current Opinion in Physiology, 10, 70–74.

Lee, M., Hsu, Y., Wu, F., Huang, C., Li, H., & Chen, W. (2022). Isolated soy protein supplementation combined with resistance training improves muscle strength, mass, and physical performance of aging female mice. Frontiers in Physiology, 13.

Li, D., Ikaga, R., & Yamazaki, T. (2018). Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ. Br J Nutr, 119(11), 1220-1232.

Marandi, S. M., Abadi, N. G., Esfarjani, F., Mojtahedi, H., & Ghasemi, G. (2013). Effects of intensity of aerobics on body composition and blood lipid profile in obese/overweight females. Int J Prev Med, 4, S118-125.

Martínez-Gayo, A., Félix-Soriano, E., Sáinz, N., González-Muniesa, P., & Moreno-Aliaga, M. J. (2022). Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice. Nutrients, 14(20), 4240.

Messina, M. (2016). Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients, 8(12).

Mitchell, R. J., Lord, S. R., Harvey, L. A., & Close, J. C. T. (2014). Associations between obesity and overweight and fall risk, health status and quality of life in older people. Australian and New Zealand Journal of Public Health, 38(1), 13-18.

Moon, Y. A., Hammer, R. E., & Horton, J. D. (2009). Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res, 50(3), 412-423.

Nunes-Souza, V., César-Gomes, C. J., Da Fonseca, L. J. S., Guedes, G. D. S., Smaniotto, S., & Rabelo, L. A. (2016). Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative Medicine and Cellular Longevity, 1987960.

Paddon-Jones, D., Westman, E., Mattes, R. D., Wolfe, R. R., Astrup, A., & Westerterp-Plantenga, M. (2008). Protein, weight management, and satiety. The American Journal of Clinical Nutrition, 87(5), 1558S-1561S.

Pan, W. H., Yeh, W. T., Chen, H. J., Chuang, S. Y., Chang, H. Y., Chen, L., & Wahlqvist, M. L. (2012). The U-shaped relationship between BMI and all-cause mortality contrasts with a progressive increase in medical expenditure: a prospective cohort study. Asia Pac J Clin Nutr, 21(4), 577-587.

Ramírez-Alvarado, C. (2023). Aerobic exercise as a protective factor in older adults with type 2 diabetes mellitus. Mexican journal of medical research ICSA, 11(22), 54-60.

Rizzo, G., & Baroni, L. (2018). Soy, Soy Foods and Their Role in Vegetarian Diets. 10(1), 43.

Ronis, M. J., Chen, Y., Badeaux, J., & Badger, T. M. (2009). Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling. J Nutr, 139(8), 1431-1438.

Samper-Ternent, R., & Al Snih, S. (2012). Obesity in Older Adults: Epidemiology and Implications for Disability and Disease. Rev Clin Gerontol, 22(1), 10-34.

Santos, A. L., & Sinha, S. (2021). Obesity and aging: Molecular mechanisms and therapeutic approaches. Ageing Research Reviews, 67, 101268.

Sayer, A. A., Syddall, H., Martin, H., Patel, H., Baylis, D., & Cooper, C. (2008). The developmental origins of sarcopenia. J Nutr Health Aging, 12(7), 427-432.

Schefer, V., & Talan, M. I. (1996). Oxygen consumption in adult and aged C57BL/6J mice during acute treadmill exercise of different intensity. Experimental Gerontology, 31(3), 387–392.

Schmitt, A., Herzog, P., Röchner, F., Brändle, A. L., Fragasso, A., & Munz, B. (2020). Skeletal muscle effects of two different 10-week exercise regimens, voluntary wheel running, and forced treadmill running, in mice: A pilot study. Physiol Rep, 8(20), e14609.

Seals, D. R., Nagy, E. E., & Moreau, K. L. (2019). Aerobic exercise training and vascular function with ageing in healthy men and women. J Physiol, 597(19), 4901-4914.

Tamura, K., Sasaki, H., Shiga, K., Miyakawa, H., & Shibata, S. (2019). The timing effects of soy protein intake on mice gut microbiota. Nutrients, 12(1), 87.

Tehrani, A. N., Hatami, B., Helli, B., Yari, Z., Daftari, G., Salehpour, A., Hedayati, M., Khalili, E., Hosseini, S. A., & Hekmatdoost, A. (2024). The effect of soy isoflavones on non-alcoholic fatty liver disease and the level of fibroblast growth factor-21 and fetuin A. Scientific Reports, 14(1).

Traylor, D. A., Gorissen, S. H. M., & Phillips, S. M. (2018). Perspective: Protein Requirements and Optimal Intakes in Aging: Are We Ready to Recommend More Than the Recommended Daily Allowance?. Advances in nutrition (Bethesda, Md.), 9(3), 171–182.

Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., Weijs, P., & Tieland, M. (2018). Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity. Nutrients, 10(5).

Velasquez, M. T., & Bhathena, S. J. (2007). Role of dietary soy protein in obesity. Int J Med Sci, 4(2), 72-82.

Waters, D. L., Aguirre, L., Gurney, B., Sinacore, D. R., Fowler, K., Gregori, G., Armamento-Villareal, R., Qualls, C., & Villareal, D. T. (2022). Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(1), 131–139.

Wei, L., Wen, Y.-T., Lee, M.-C., Ho, H.-M., Huang, C.-C., & Hsu, Y.-J. (2019). Effects of isolated soy protein and strength exercise training on exercise performance and biochemical profile in postpartum mice. Metabolism, 94, 18-27.

Westmark, P. R., Lyon, G., Gutierrez, A., Boeck, B., Van Hammond, O., Ripp, N., Pagan-Torres, N. A., Brower, J., Held, P. K., Scarlett, C., & Westmark, C. J. (2024). Effects of soy protein isolate on fragile X phenotypes in mice. Nutrients, 16(2), 284.

電子全文 電子全文(網際網路公開日期:20251031)
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊