|
Barrows, D., Feng, L., Carroll, T. S., & Allis, C. D. (2020). Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer. Proc Natl Acad Sci U S A, 117(41), 25732-25741. doi:10.1073/ pnas.2008017117 Benyoucef, A., Palii, C. G., Wang, C., Porter, C. J., Chu, A., Dai, F., . . . Brand, M. (2016). UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes Dev, 30(5), 508-521. doi:10.1101/gad.276790.115 Boyer, A. S., Walter, D., & Sorensen, C. S. (2016). DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities. Semin Cancer Biol, 37-38, 16-25. doi:10.1016/j.semcancer.2016.01.001 Brandsma, I., & Gent, D. C. (2012). Pathway choice in DNA double strand break repair: observations of a balancing act. Genome Integr, 3(1), 9. doi:10.1186/2041-9414-3-9 Bryant, J. A., & Aves, S. J. (2011). Initiation of DNA replication: functional and evolutionary aspects. Ann Bot, 107(7), 1119-1126. doi:10.1093/aob/mcr075 Chatterjee, N., & Walker, G. C. (2017). Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen, 58(5), 235-263. doi:10.1002/em.22087 Chen, R., & Wold, M. S. (2014). Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair. Bioessays, 36(12), 1156-1161. doi:10.1002/bies.201400107 Choi, W., & Lee, E. S. (2022). Therapeutic Targeting of DNA Damage Response in Cancer. International Journal of Molecular Sciences, 23(3). doi:10.3390/ijms23031701 Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., . . . Elledge, S. J. (2010). A chromatin localization screen reveals poly (ADP ribose)- regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A, 107(43), 18475-18480. doi:10.1073/ pnas.1012946107 Cruz-Garcia, A., Lopez-Saavedra, A., & Huertas, P. (2014). BRCA1 accelerates CtIP- mediated DNA-end resection. Cell Rep, 9(2), 451-459. doi:10.1016/ j.celrep.2014.08.076 Das, P., & Taube, J. H. (2020). Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity. Cancers (Basel), 12(10). doi:10.3390/cancers12102792 Devbhandari, S., Jiang, J., Kumar, C., Whitehouse, I., & Remus, D. (2017). Chromatin Constrains the Initiation and Elongation of DNA Replication. Mol Cell, 65(1), 131-141. doi:10.1016/j.molcel.2016.10.035 Dewar, J. M., & Walter, J. C. (2017). Mechanisms of DNA replication termination. Nat Rev Mol Cell Biol, 18(8), 507-516. doi:10.1038/nrm.2017.42 Dobbelstein, M., & Sorensen, C. S. (2015). Exploiting replicative stress to treat cancer. Nat Rev Drug Discov, 14(6), 405-423. doi:10.1038/nrd4553 Du, J., Yin, N., Xie, T., Zheng, Y., Xia, N., Shang, J., . . . Liu, F. (2018). Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair. DNA Repair (Amst), 70, 67-71. doi:10.1016/j.dnarep.2018.09.002 Duan, R., Du, W., & Guo, W. (2020). EZH2: a novel target for cancer treatment. J Hematol Oncol, 13(1), 104. doi:10.1186/s13045-020-00937-8 Ekholm-Reed, S., Mendez, J., Tedesco, D., Zetterberg, A., Stillman, B., & Reed, S. I. (2004). Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol, 165(6), 789-800. doi:10.1083/jcb.200404092 Fallah, M. S., Szarics, D., Robson, C. M., & Eubanks, J. H. (2020). Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders. Front Genet, 11, 613098. doi:10.3389/fgene.2020.613098 Gaillard, H., Garcia-Muse, T., & Aguilera, A. (2015). Replication stress and cancer. Nat Rev Cancer, 15(5), 276-289. doi:10.1038/nrc3916 Gan, L., Yang, Y., Li, Q., Feng, Y., Liu, T., & Guo, W. (2018). Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential. Biomark Res, 6, 10. doi:10.1186/s40364-018-0122-2 Gralewska, P., Gajek, A., Marczak, A., & Rogalska, A. (2020). Participation of the ATR/ CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer. J Hematol Oncol, 13(1), 39. doi:10.1186/s13045-020-00874-6 Greer, E. L., & Shi, Y. (2012). Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet, 13(5), 343-357. doi:10.1038/nrg3173 Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N., & Tarsounas, M. (2023). Targeting DNA damage response pathways in cancer. Nat Rev Cancer, 23(2), 78-94. doi:10.1038/ s41568-022-00535-5 Guertin, A. D., Martin, M. M., Roberts, B., Hurd, M., Qu, X., Miselis, N. R., . . . Shumway, D. S. (2012). Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition. Hakem, R. (2008). DNA-damage repair; the good, the bad, and the ugly. EMBO J, 27(4), 589-605. doi:10.1038/emboj.2008.15 Hong, S., Cho, Y. W., Yu, L. R., Yu, H., Veenstra, T. D., & Ge, K. (2007). Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A, 104(47), 18439-18444. doi:10.1073/pnas.0707292104 Hua, C., Chen, J., Li, S., Zhou, J., Fu, J., Sun, W., & Wang, W. (2021). KDM6 Demethylases and Their Roles in Human Cancers. Front Oncol, 11, 779918. doi:10.3389/ fonc.2021.779918 Hyun, K., Jeon, J., Park, K., & Kim, J. (2017). Writing, erasing and reading histone lysine methylations. Exp Mol Med, 49(4), e324. doi:10.1038/emm.2017.11 Jambhekar, A., Dhall, A., & Shi, Y. (2019). Roles and regulation of histone methylation in animal development. Nat Rev Mol Cell Biol, 20(10), 625-641. doi:10.1038/ s41580-019-0151-1 Kim, J. H., Sharma, A., Dhar, S. S., Lee, S. H., Gu, B., Chan, C. H., . . . Lee, M. G. (2014). UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res, 74(6), 1705-1717. doi:10.1158/0008-5472.CAN-13-1896 Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., . . . Maehara, Y. (2018). DNA replication stress and cancer chemotherapy. Cancer Sci, 109(2), 264-271. doi:10.1111/cas.13455 Krajewska, M., Fehrmann, R. S., de Vries, E. G., & van Vugt, M. A. (2015). Regulators of homologous recombination repair as novel targets for cancer treatment. Front Genet, 6, 96. doi:10.3389/fgene.2015.00096 Labib, K., & Gambus, A. (2007). A key role for the GINS complex at DNA replication forks. Trends Cell Biol, 17(6), 271-278. doi:10.1016/j.tcb.2007.04.002 Laugesen, A., Hojfeldt, J. W., & Helin, K. (2016). Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer. Cold Spring Harb Perspect Med, 6(9). doi:10.1101/cshperspect.a026575 Lee, M. G., Villa, R., Trojer, P., Norman, J., Yan, K. P., Reinberg, D., . . . Shiekhattar, R. (2007). Demethylation of H3K27 RegulatesPolycomb Recruitment andH2A Ubiquitination. Li, H., & Stillman, B. (2012). The origin recognition complex: a biochemical and structural view. Subcell Biochem, 62, 37-58. doi:10.1007/978-94-007-4572-8_3 Li, L. Y., Guan, Y. D., Chen, X. S., Yang, J. M., & Cheng, Y. (2020). DNA Repair Pathways in Cancer Therapy and Resistance. Front Pharmacol, 11, 629266. doi:10.3389/ fphar.2020.629266 Liu, K., Zheng, M., Lu, R., Du, J., Zhao, Q., Li, Z., . . . Zhang, S. (2020). The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review. Cancer Cell Int, 20, 213. doi:10.1186/s12935-020-01304-w Lord, C. J., & Ashworth, A. (2017). PARP inhibitors: Synthetic lethality in the clinic. Mallen-St Clair, J., Soydaner-Azeloglu, R., Lee, K. E., Taylor, L., Livanos, A., Pylayeva- Gupta, Y., . . . Bar-Sagi, D. (2012). EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev, 26(5), 439-444. doi:10.1101/gad.181800.111 Marechal, A., & Zou, L. (2013). DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol, 5(9). doi:10.1101/cshperspect.a012716 Miller, S. A., Mohn, S. E., & Weinmann, A. S. (2010). Jmjd3 and UTX play a demethylase- independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell, 40(4), 594-605. doi:10.1016/j.molcel.2010.10.028 Ngoi, N. Y. L., Pham, M. M., Tan, D. S. P., & Yap, T. A. (2021). Targeting the replication stress response through synthetic lethal strategies in cancer medicine. Trends Cancer, 7(10), 930-957. doi:10.1016/j.trecan.2021.06.002 Petrizzelli, F., Biagini, T., Barbieri, A., Parca, L., Panzironi, N., Castellana, S., . . . Mazza, T. (2020). Mechanisms of pathogenesis of missense mutations on the KDM6A-H3 interaction in type 2 Kabuki Syndrome. Comput Struct Biotechnol J, 18, 2033-2042. doi:10.1016/j.csbj.2020.07.013 Pike, A. M., Friend, C. M., & Bell, S. P. (2023). Distinct RPA functions promote eukaryotic DNA replication initiation and elongation. Nucleic Acids Res, 51(19), 10506-10518. doi:10.1093/nar/gkad765 Renaudin, X. (2021). Reactive oxygen species and DNA damage response in cancer. Int Rev Cell Mol Biol, 364, 139-161. doi:10.1016/bs.ircmb.2021.04.001 Sengoku, T., & Yokoyama, S. (2011). Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev, 25(21), 2266-2277. doi:10.1101/gad.172296.111 Shen, T., & Huang, S. (2012). The role of Cdc25A in the regulation of cell proliferation and a p o p t o s i s . A n t i c a n c e r A g e n t s M e d C h e m , 1 2 ( 6 ) , 6 3 1 - 6 3 9 . doi:10.2174/187152012800617678 Shi, Y., Wang, X. X., Zhuang, Y. W., Jiang, Y., Melcher, K., & Xu, H. E. (2017). Structure of the PRC2 complex and application to drug discovery. Acta Pharmacol Sin, 38(7), 963-976. doi:10.1038/aps.2017.7 Strzalka, W., & Ziemienowicz, A. (2011). Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot, 107(7), 1127-1140. doi:10.1093/aob/mcq243 Suzuki, T., Hirokawa, T., Maeda, A., Harata, S., Watanabe, K., Yanagita, T., . . . Takiguchi, S. (2022). ATR inhibitor AZD6738 increases the sensitivity of colorectal cancer cells to 5‑fluorouracil by inhibiting repair of DNA damage. Oncol Rep, 47(4). doi:10.3892/ or.2022.8289 Tang, X., Cai, W., Cheng, J., Lu, P., Ma, S., Chen, C., . . . Sheng, J. (2019). The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation. Cancer Cell Int, 19, 144. doi:10.1186/s12935-019-0841-y Thanasoula, M., Escandell, J. M., Suwaki, N., & Tarsounas, M. (2012). ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. EMBO J, 31(16), 3398-3410. doi:10.1038/emboj.2012.191 Tran, N., Broun, A., & Ge, K. (2020). Lysine Demethylase KDM6A in Differentiation, Development, and Cancer. doi:10.1128/MCB Tsakraklides, V., & Bell, S. P. (2010). Dynamics of pre-replicative complex assembly. J Biol Chem, 285(13), 9437-9443. doi:10.1074/jbc.M109.072504 Ubhi, T., & Brown, G. W. (2019). Exploiting DNA Replication Stress for Cancer Treatment. Cancer Res, 79(8), 1730-1739. doi:10.1158/0008-5472.CAN-18-3631 Van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., . . . Futreal, P. A. (2009). Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet, 41(5), 521-523. doi:10.1038/ng.349 Walport, L. J., Hopkinson, R. J., Chowdhury, R., Schiller, R., Ge, W., Kawamura, A., & Schofield, C. J. (2016). Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nat Commun, 7, 11974. doi:10.1038/ncomms11974 Wang, L., & Shilatifard, A. (2019). UTX Mutations in Human Cancer. Cancer Cell, 35(2), 168-176. doi:10.1016/j.ccell.2019.01.001 Wang, S. P., Tang, Z., Chen, C. W., Shimada, M., Koche, R. P., Wang, L. H., . . . Roeder, R. G. (2017). A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell, 67(2), 308-321 e306. doi:10.1016/j.molcel.2017.06.028 Wilson, Z., Odedra, R., Wallez, Y., Wijnhoven, P. W. G., Hughes, A. M., Gerrard, J., . . . Lau, A. (2022). ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib. Cancer Res, 82(6), 1140-1152. doi:10.1158/0008-5472.CAN-21-2997 Xie, G., Liu, X., Zhang, Y., Li, W., Liu, S., Chen, Z., . . . Liang, J. (2017). UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor. Oncogene, 36(39), 5497-5511. doi:10.1038/ onc.2017.157 Yamaguchi, H., & Hung, M. C. (2014). Regulation and Role of EZH2 in Cancer. Cancer Res Treat, 46(3), 209-222. doi:10.4143/crt.2014.46.3.209 Yano, K., & Shiotani, B. (2023). Emerging strategies for cancer therapy by ATR inhibitors. Cancer Sci, 114(7), 2709-2721. doi:10.1111/cas.15845 Yao, Y., & Dai, W. (2014). Genomic Instability and Cancer. J Carcinog Mutagen, 5. doi:10.4172/2157-2518.1000165 Zannini, L., Delia, D., & Buscemi, G. (2014). CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol, 6(6), 442-457. doi:10.1093/jmcb/mju045 Zhang, J., Jing, L., Li, M., He, L., & Guo, Z. (2019). Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review). Mol Med Rep, 19(5), 3963-3971. doi:10.3892/mmr.2019.10111
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