臺灣博碩士論文加值系統

磁共振造影（MRI）是目前熱門且能力強大的分子影像儀器，其中顯影劑是很重要且關鍵的角色，顯影劑可以提供更優良的組織影像對比度和影像解析度，但顯影劑發展受到元素選擇限制（T1顯影劑）和可選擇的超順磁性材料（T2顯影劑）在臨床醫學需求的限制，目前顯影劑的研發或改良都面臨到了瓶頸，無法有突破性的進展。因此本研究研發一種富含穩定同位素17O的四氧化三鐵磁性奈米粒子（Fe317O4 NPs），相較於Fe3O4 NPs，具有更低的T2值和更高的r2值，因此Fe317O4 NPs具有更高的組織對比度和偵測靈敏度。Fe317O4 NPs對 MRI顯影劑的發展瓶頸可說是一個突破性的進展，也是創新及有潛力的奈米材料。最重要的是Fe317O4 NPs沒有輻射傷害問題，在一般環境下就可以使用，Fe3O4 NPs是目前被允許可使用在人體的奈米材料，故Fe317O4 NPs成為新一代的兼具T1和T2型顯影劑是非常具有機會和潛力。

Magnetic resonance imaging（MRI）is currently a popular and powerful molecular imaging technology, in which contrast agents play a very important and critical role. Contrast agents can provide better tissue image contrast and resolution, but the development of contrast agents is limited in current situation. The main problem of T1 contrast agent is elemental selectivity is limited. The main limitation of T2 contrast agent is that only iron oxide nanoparticles can be used clinically. Current development or improvement of contrast agents is facing a bottleneck and cannot make breakthrough progress. Therefore, this study developed the 17O-rich iron oxide nanoparticles（Fe317O4 NPs）. Compared with Fe3O4 NPs, Fe317O4 NPs have a lower T2 value and a higher r2 value. Thus, Fe317O4 NPs are expected to have higher tissue contrast and detection sensitivity. Fe317O4 NPs is an innovative and promising nanomaterial and a breakthrough development for MRI contrast agents. The most important point is that Fe317O4 NPs do not have radiation damage and can be used in normal environment. Fe3O4 NPs are nanomaterials that are currently allowed to be used in the human body. Therefore, Fe317O4 NPs have great opportunities and potential to become a new generation of T1 and T2 contrast agents.

總目錄
謝誌 I
摘要 III
Abstract IV
總目錄 V
圖目錄 VII
表目錄 VIII
第一章 序論 1
1-1前言 1
1-2研究動機 3
第二章 理論基礎與材料介紹 5
2-1 MRI之基本介紹 5
2-3奈米材料的介紹與應用 8
2-6順磁性 12
第三章 實驗設計與分析 15
3-1實驗藥品 15
3-2實驗器材與儀器設備 16
3-2-1實驗器材 16
3-2-2儀器設備 17
3-3實驗流程與步驟 18
3-3-1一般四氧化三鐵奈米粒子NH2-Fe3O4 NPs的製備 18
3-3-2 NH2-Fe317O4 NPs實驗組組1與實驗組2的製備 19
3-4數據量測 22
第四章 結果與討論 23
4-1四氧化三鐵奈米粒子的合成和其材料表面特徵之探討 23
4-1-1紅外線光譜儀（FTIR）數據分析 23
4-1-3粒徑及表面電位（DLS）數據分析 27
4-2 NH2-Fe3O4 NPs及NH2-Fe317O4 NPs的材料結構特徵探討 28
4-2-1 X光繞射分析儀（XRD）數據分析 28
第五章 結論 37
參考文獻 38

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