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研究生:陳宏斌
研究生(外文):CHEN,HUNG-BIN
論文名稱:男性氯乙烯聚合工人下一代出生異常之研究
論文名稱(外文):Adverse Birth Outcomes among the Offspring of Male Polyvinyl Chloride Workers
指導教授:陳保中陳保中引用關係
指導教授(外文):Chen,Pau-Chung
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:職業醫學與工業衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文出版年:2002
畢業學年度:88
語文別:中文
中文關鍵詞:氯乙烯聚氯乙烯性別比低出生體重兒早產兒新生兒死亡嬰兒死亡先天缺陷
外文關鍵詞:VCMPVCsex ratiolow birth weightpremature deliveriesperinatal deathsinfant deathsbirth defects
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目的﹕
氯乙烯製造的塑膠被廣泛用來製做眾多的日常用品。IARC將氯乙烯定為第一類致癌物,它會導致肝血管肉瘤,其他還有人報導會產生肝細胞癌、腦瘤及肺癌等。動物模式顯示,氯乙烯代謝過程中產生的中間產物CEO (chloroethylene oxide)及CAA (chloroacetaldehyde),會與DNA、RNA形成鍵結物,造成染色體或基因改變。我們想對氯乙烯的致突變性在流行病學上有所驗證,及對相關的人體健康有進一步的了解,除了在癌症方面的研究之外,似乎可以選擇在發病潛伏期較短及個案較容易收集的生殖流行病學上進行研究。氯乙烯的致突變性如果表現在生殖細胞上,理論上將可能引起遺傳物質的改變,而產生諸如:生育降低、流產、死產、早產、低出生體重、週產期死亡、先天缺陷等危險性增高的結果。過去國內並無關於這方面的研究,故從事此研究。
方法:
以回溯性世代研究的方式進行。以來自台灣地區12家氯乙烯相關工廠之暴露男性所建立職業世代之後代為暴露組,對照族群將使用氯乙烯工廠當地鄉鎮,扣除工業區所在村里的所有非氯乙烯工人世代出生嬰兒。探討氯乙烯單體暴露對男性工人下一代出生異常的情形;包括性別比、低出生體重兒、早產兒、新生兒死亡、嬰兒死亡、及先天缺陷疾病等。出生資料檔來自內政部戶政司。研究族群和生殖結果間資料的聯結以男性工人的身份證字號、姓名進行。對於潛在的干擾因子盡量以適當的統計方法加以控制,我們並未計劃使用問卷以獲得更詳細的資料。
結果﹕
暴露氯乙烯男性工人職業世代經整理後共3925人。使用身份証字號聯結此職業世代和出生資料檔後,共得到5252個出生人數。(資料進一步分析中)
結論:

Aim.
Plastics, composed of PVC, was widely used to manufacture variety of daily ware. IARC regarded VCM as a group one carcinogen. Many studies had demonstrated the causal association between VCM and angiosarcoma of liver. Additionally, hepatocellular carcinoma, brain tumor, lung cancer were also reported. According to animal model, intermediates of VCM; CEO(chloroethylene oxide) and CAA(chloroacetaldehyde), can form adducts with DNA or RNA macromolecule. These adducts cause changes of chromosome or gene. We want to conduct epidemiological studies to illuminate mutagenicity of VCM and further understand related issues of human health, in addition to field of cancer researches, it seems practicable to select reproductive epidemiological researches that having the advantages of shorter induction time and easier cases collection. If mutagenicity of VCM appeared on germ cells, theoretically , it would cause some abnormal reproductive outcomes via genetic substance change, such as fertility decrease, miscarriages, stillbirths, premature deliveries, low birth weight, perinatal deaths, birth defects. So far, there are only few studies on these related field , so we conduct this study .
Method.
This is a retrospective cohort study design. Exposure group is the occupational cohort who are male workers from 12 VCM related factories in Taiwan. Reference group is a properly selected population without possible VCM exposure. Neonatal birth files are from Population Affairs Administration of Ministry of Interior. We link the occupational populations and the reproductive outcomes by means of individual worker’s identification number, name, address. Potential confounding factors are controlled by statistical methods possibly. We don’t apply questionnaires for advanced information in our current study.
Result.
There are 3925 useable subjects in the VCM occupational cohort after processing. 5252 neonates was captured totally after linking these cohort subjects and neonatal birth files.
Conclusion.

XX

1. IARC. Monographs on the evaluation of carcinogenic risks to humen. 1987; suppl 7: 373-376.
2. Giri AK. Genetic toxicology of vinyl chloride —A review. Mutat Res 1995; 339: 1-14.
3. Infante PF, …et al. Genetic risks of vinyl chloride. Lancet 1976; 1: 734-735.
4. Clemmesen J. Mutagenicity and teratogenicity of vinyl chloride monomer (VCM) — epidemiological evidence. Mutat Res 1982; 98: 97-100.
5. Infante P. Oncogenic and mutagenic risks in communities with polyvinyl chloride production facilities. Ann NY Acad Sci 1976; 271: 49-57.
6. Lindbohm ML,... et al. Spontaneous abortions among women employed in the plastic industry. Am J Ind Med 1985; 8: 579-86.
7. Edmonds LD,... et al. Congenital central nervous system malformations and vinyl chloride monomer exposure: a community study. Teratology 1978; 17: 137-142
8. Theriault G,… et al. Evaluation of the association between birth defects and exposure to ambient vinyl chloride. Teratology 1983; 27: 359-370.
9. Hemminki K & Vineis P: Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals: Chemicals other than drugs. Teratogen Carcinogen Mutagen 1985; 5:251-318
10. Mur JM, Mandereau L, Deplan F et al: Spontaneous abortion and exposure to vinyl chloride. Lancet 1992; 339:127-128.
11. Edmonds LD et al: Congenital malformations and vinyl chloride. Lancet 1975; 2:1098.
12. Paddle GM: Genetic risks of vinyl chloride. Lancet 1976; 1:1079.
13. Uzych L: Human male exposure to vinyl chloride and possible teratogenic and mutagenic risks: a review. Human Toxicol 1988; 7:517-527.
14. Mirkova E, Mihaylova A, Nosko M. 1978.﹝Embryotoxic and teratogenic effects in vinyl chloride .Higiena i zdraveopazane 21:440-443. (Bulgarian)
15. John JA, Smith FA Leong BKJ et al: The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats and rabbits. Toxicol Appl Pharmacol 1977; 39:497-513.
16. John JA, Smith FA, Schwetz BA. 1981. Vinyl chloride: Inhalation teratology study in mice, rats, and rabbits. Environ Health Perspect 41:171-177.
17. Hatch M, Kline J, Stein Z. 1981. Power considerations in studies of reproductive effects of vinyl chloride and some structural analogs. Environ Health Perspect 41: 195-201.
18. Stallones RA.1987. The use and abuse of subgroup analysis in epidemiological research. Prev Med 16:183-194.
19. Infante PF, Wagoner JK, Waxweiler RJ. 1976b. Carcinogenic, mutagenic, and teratogenic risks associated with vinyl chloride. Mutat Res 41:131-142.
20. Rosenman KD, Rizzo JE, Conomos MG, et al. 1989. Central nervous system malformations in relation to polyvinyl chloride production facilities. Arch Environ Health 44:279-282.
21. Bi W, Wang Y, Huang M, et al. 1985. Effects of vinyl chloride on testis in rats. Ecotoxicology and Environmental Safety 10:281-289.
22. Torkelson TR, Oyen F, Rowe VK. 1961. The toxicity of vinyl chloride as determined by repeated exposure of laboratory animals. Am Ind Hyg Assoc J 22:354-361.
23. Sokal JA, Baranski B, Majka J, et al. 1980. Experimental studies on the chronic toxic effects of vinyl chloride in rats. J Hyg Epidemiol Microbiol Immunol 24:285-294.
24. Anderson D, Hodge MCE, Purchase IFH. 1976. Vinyl chloride: Dominant lethal studies in male CD-1 mice. Mutat Res 40:359-370.
25. Short RD, Minor JL, Winston JM, et al. 1977. A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride. J Toxicol Environ Health 3:965-968.
26. RTECS: Registry of Toxic Effects of Chemical Substances. National Institute for Occupational Safety and Health, Cincinnati, Ohio (CD-ROM version), Micromedex, Inc, Englewood, CO, edition expires 7/31/96.
27.Himeno S. Okuda H. Suzuki T. Lack of dominant lethal effects in male CD-1 mice after short-term and long-term exposures to vinyl chloride monomer. Toxicology Letters. 16(1-2):47-53, 1983 Apr.

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1. 林素貞,張翊峰,李正豐(1999),「水泥業二氧化碳減量模式預測與衝擊評估」,能源季刊,第二十九卷第四期,pp.2~16。
2. 林素貞,楊維修(1997),「溫室氣體減量之課稅機制探討」,能源季刊,第二十七卷第四期,pp.19~31。
3. 林素貞,張翊峰(1995),「以投入產出分析產業能源耗用與污染排放量之關鍵性~以1991年臺灣地區為例」,能源季刊,第二十五卷第四期,pp.52~74。
4. 林素貞,李正豐(1999),「石化工業產業關聯對能源及二氧化碳之乘數效應」,能源季刊,第二十九卷第三期,pp.26~42。
5. 林素貞,張子見,張翊峰,李正豐(1996),「以因素分析探討臺灣地區產業二氧化碳排放量之變動趨勢與關鍵因素」,能源季刊,第二十六卷第一期,pp.123~144。
6. 何介人(1998),「我國體系最完整,歷久不衰的產業-紡織工業」,技術尖兵,第46期,pp.4~6。
7. 王塗發(1986),「投入產出分析及其應用─臺灣地區實證研究」,臺灣銀行季刊,第三十七卷,第一期,pp.186~218。
8. 陳雄文,賴麗瑩(1997),「氣候變化綱要公約發展趨勢及我國因應方向」,能源季刊,第二十七卷第四期,pp.32~45。
9. 張耀仁(1994),「歐體提議的能源/碳稅動向」,臺灣經濟研究月刊,第17卷,第8期,pp.115~118。
10. 張耀仁,吳美玲(1994),「瑞典實施碳稅的經驗和利弊」,臺灣經濟研究月刊,第17卷,第4期,pp.59~64。
11. 許志義,劉彩雲(1989),「臺灣地區能源消費與經濟成長之投入產出分析」,能源季刊,pp.1~20。
12. 黃肇英,方良吉(1993),「氣候變化綱要公約、各國的立場、與台灣地區因應策略的考慮」,能源季刊,,第二十三卷,第三期,pp.130~154。
13. 楊秀玲(1997),「傳統紡織業之蛻變」,臺灣經濟研究月刊,第二十卷,第十一期,pp.55~59。
14. 楊任徵(1999),「造成我CO2上升關鍵因素之尺度分析」,能源季刊,第二十九卷,第二期,pp.62~77。
15. 賴麗瑩(1998),「京都議定書之分析及未來發展趨勢」,能源季刊,第二十八卷第三期,pp.2~16。
 
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