|
Department of Health, Executive Yuan, Taiwan, R.O.C. http://www.doh.gov.tw/cht/ index.aspx
Avizienyte, E., Loukola, A., Roth, S., Hemminki, A., Tarkkanen, M., Salovaara, R., Arola, J., Butzow, R., Husgafvel-Pursiainen, K., Kokkola, A., et al. (1999). LKB1 somatic mutations in sporadic tumors. Am J Pathol 154, 677-681.
Avizienyte, E., Roth, S., Loukola, A., Hemminki, A., Lothe, R. A., Stenwig, A. E., Fossa, S. D., Salovaara, R., and Aaltonen, L. A. (1998). Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res 58, 2087-2090.
Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R., and Clevers, H. C. (2003). Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. Embo J 22, 3062-3072.
Bardeesy, N., Sinha, M., Hezel, A. F., Signoretti, S., Hathaway, N. A., Sharpless, N. E., Loda, M., Carrasco, D. R., and DePinho, R. A. (2002). Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419, 162-167.
Bignell, G. R., Barfoot, R., Seal, S., Collins, N., Warren, W., and Stratton, M. R. (1998). Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 58, 1384-1386.
Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, H. C., and Alessi, D. R. (2003). MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. Embo J 22, 5102-5114.
Carretero, J., Medina, P. P., Pio, R., Montuenga, L. M., and Sanchez-Cespedes, M. (2004). Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 23, 4037-4040.
Chu, Y. W., Yang, P. C., Yang, S. C., Shyu, Y. C., Hendrix, M. J., Wu, R., and Wu, C. W. (1997). Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 17, 353-360. Connolly, D. C., Katabuchi, H., Cliby, W. A., and Cho, K. R. (2000). Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher''s syndrome. Am J Pathol 156, 339-345.
Dong, S. M., Kim, K. M., Kim, S. Y., Shin, M. S., Na, E. Y., Lee, S. H., Park, W. S., Yoo, N. J., Jang, J. J., Yoon, C. Y., et al. (1998). Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. Cancer Res 58, 3787-3790.
Dunaief, J. L., Strober, B. E., Guha, S., Khavari, P. A., Alin, K., Luban, J., Begemann, M., Crabtree, G. R., and Goff, S. P. (1994). The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79, 119-130.
Elias, A. D. (1997). Small cell lung cancer: state-of-the-art therapy in 1996. Chest 112, 251S-258S.
Esteller, M., Avizienyte, E., Corn, P. G., Lothe, R. A., Baylin, S. B., Aaltonen, L. A., and Herman, J. G. (2000). Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 19, 164-168.
Fernandez, P., Carretero, J., Medina, P. P., Jimenez, A. I., Rodriguez-Perales, S., Paz, M. F., Cigudosa, J. C., Esteller, M., Lombardia, L., Morente, M., et al. (2004). Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. Oncogene 23, 5084-5091.
Finan, M. C., and Ray, M. K. (1989). Gastrointestinal polyposis syndromes. Dermatol Clin 7, 419-434.
Forcet, C., Etienne-Manneville, S., Gaude, H., Fournier, L., Debilly, S., Salmi, M., Baas, A., Olschwang, S., Clevers, H., and Billaud, M. (2005). Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum Mol Genet 14, 1283-1292.
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., and Paul, C. L. (1992). A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 89, 1827-1831. Ghaffar, H., Sahin, F., Sanchez-Cepedes, M., Su, G. H., Zahurak, M., Sidransky, D., and Westra, W. H. (2003). LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res 9, 2998-3003.
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz-Correa, M., and Offerhaus, J. A. (2000). Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119, 1447-1453.
Guldberg, P., thor Straten, P., Ahrenkiel, V., Seremet, T., Kirkin, A. F., and Zeuthen, J. (1999). Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene 18, 1777-1780.
Hardie, D. G. (2005). New roles for the LKB1-->AMPK pathway. Curr Opin Cell Biol 17, 167-173.
Hardie, D. G., Scott, J. W., Pan, D. A., and Hudson, E. R. (2003). Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546, 113-120.
Harris, T. E., and Lawrence, J. C., Jr. (2003). TOR signaling. Sci STKE 2003, re15.
Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R., and Hardie, D. G. (2003). Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2, 28.
Heighway, J., Knapp, T., Boyce, L., Brennand, S., Field, J. K., Betticher, D. C., Ratschiller, D., Gugger, M., Donovan, M., Lasek, A., and Rickert, P. (2002). Expression profiling of primary non-small cell lung cancer for target identification. Oncogene 21, 7749-7763.
Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Hoglund, P., et al. (1998). A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391, 184-187.
Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A. M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., et al. (1997). Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 15, 87-90. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. (1996). Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93, 9821-9826.
Huang, S., Shu, L., Dilling, M. B., Easton, J., Harwood, F. C., Ichijo, H., and Houghton, P. J. (2003). Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 11, 1491-1501.
Jenne, D. E., Reimann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Muller, O., Back, W., and Zimmer, M. (1998). Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 18, 38-43.
Jimenez, A. I., Fernandez, P., Dominguez, O., Dopazo, A., and Sanchez-Cespedes, M. (2003). Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3''-phosphate kinase/PTEN pathway. Cancer Res 63, 1382-1388.
Karuman, P., Gozani, O., Odze, R. D., Zhou, X. C., Zhu, H., Shaw, R., Brien, T. P., Bozzuto, C. D., Ooi, D., Cantley, L. C., and Yuan, J. (2001). The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7, 1307-1319.
Kato, N., Romero, M., Catasus, L., and Prat, J. (2004). The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors. Hum Pathol 35, 1101-1104.
Kelley, M. J., Nakagawa, K., Steinberg, S. M., Mulshine, J. L., Kamb, A., and Johnson, B. E. (1995). Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. J Natl Cancer Inst 87, 756-761.
Kemp, B. E., Mitchelhill, K. I., Stapleton, D., Michell, B. J., Chen, Z. P., and Witters, L. A. (1999). Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci 24, 22-25.
Kemp, B. E., Stapleton, D., Campbell, D. J., Chen, Z. P., Murthy, S., Walter, M., Gupta, A., Adams, J. J., Katsis, F., van Denderen, B., et al. (2003). AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans 31, 162-168. Kok, K., Osinga, J., Carritt, B., Davis, M. B., van der Hout, A. H., van der Veen, A. Y., Landsvater, R. M., de Leij, L. F., Berendsen, H. H., Postmus, P. E., and et al. (1987). Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 330, 578-581.
Marignani, P. A. (2005). LKB1, the multitasking tumour suppressor kinase. J Clin Pathol 58, 15-19.
Marignani, P. A., Kanai, F., and Carpenter, C. L. (2001). LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem 276, 32415-32418.
Martin, S. G., and St Johnston, D. (2003). A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421, 379-384.
McWilliams, A., MacAulay, C., Gazdar, A. F., and Lam, S. (2002). Innovative molecular and imaging approaches for the detection of lung cancer and its precursor lesions. Oncogene 21, 6949-6959.
Mehenni, H., Gehrig, C., Nezu, J., Oku, A., Shimane, M., Rossier, C., Guex, N., Blouin, J. L., Scott, H. S., and Antonarakis, S. E. (1998). Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am J Hum Genet 63, 1641-1650.
Miyoshi, H., Nakau, M., Ishikawa, T. O., Seldin, M. F., Oshima, M., and Taketo, M. M. (2002). Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 62, 2261-2266.
Nezu, J., Oku, A., and Shimane, M. (1999). Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. Biochem Biophys Res Commun 261, 750-755.
Osada, H., and Takahashi, T. (2002). Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene 21, 7421-7434.
Ossipova, O., Bardeesy, N., DePinho, R. A., and Green, J. B. (2003). LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol 5, 889-894.
Park, W. S., Moon, Y. W., Yang, Y. M., Kim, Y. S., Kim, Y. D., Fuller, B. G., Vortmeyer, A. O., Fogt, F., Lubensky, I. A., and Zhuang, Z. (1998). Mutations of the STK11 gene in sporadic gastric carcinoma. Int J Oncol 13, 601-604.
Resta, N., Simone, C., Mareni, C., Montera, M., Gentile, M., Susca, F., Gristina, R., Pozzi, S., Bertario, L., Bufo, P., et al. (1998). STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer. Cancer Res 58, 4799-4801.
Resta, N., Stella, A., Susca, F. C., Di Giacomo, M., Forleo, G., Miccolis, I., Rossini, F. P., Genuardi, M., Piepoli, A., Grammatico, P., and Guanti, G. (2002). Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients. Hum Mutat 20, 78-79.
Rosell, R., Felip, E., Garcia-Campelo, R., and Balana, C. (2004). The biology of non-small-cell lung cancer: identifying new targets for rational therapy. Lung Cancer 46, 135-148.
Rowan, A., Bataille, V., MacKie, R., Healy, E., Bicknell, D., Bodmer, W., and Tomlinson, I. (1999). Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. J Invest Dermatol 112, 509-511.
Sanchez-Cespedes, M., Ahrendt, S. A., Piantadosi, S., Rosell, R., Monzo, M., Wu, L., Westra, W. H., Yang, S. C., Jen, J., and Sidransky, D. (2001). Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 61, 1309-1313.
Sanchez-Cespedes, M., Parrella, P., Esteller, M., Nomoto, S., Trink, B., Engles, J. M., Westra, W. H., Herman, J. G., and Sidransky, D. (2002). Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 62, 3659-3662.
Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. S., Williams, M. R., Morrice, N., Deak, M., and Alessi, D. R. (2001). Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem 276, 19469-19482.
Sato, N., Rosty, C., Jansen, M., Fukushima, N., Ueki, T., Yeo, C. J., Cameron, J. L., Iacobuzio-Donahue, C. A., Hruban, R. H., and Goggins, M. (2001). STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 159, 2017-2022.
Sato, S., Nakamura, Y., and Tsuchiya, E. (1994). Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res 54, 5652-5655.
Scoot, W.J. (2000). Lung Cancer: a guide to diagnosis and treatment. Addicus Books, Inc., Omaha, Nebraska.
Sekido, Y., Fong, K. M., and Minna, J. D. (1998). Progress in understanding the molecular pathogenesis of human lung cancer. Biochim Biophys Acta 1378, F21-59.
Shamji, A. F., Nghiem, P., and Schreiber, S. L. (2003). Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 12, 271-280.
Shaw, R. J., Bardeesy, N., Manning, B. D., Lopez, L., Kosmatka, M., DePinho, R. A., and Cantley, L. C. (2004a). The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6, 91-99.
Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., and Cantley, L. C. (2004b). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 101, 3329-3335.
Smith, D. P., Rayter, S. I., Niederlander, C., Spicer, J., Jones, C. M., and Ashworth, A. (2001). LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Hum Mol Genet 10, 2869-2877.
Smith, D. P., Spicer, J., Smith, A., Swift, S., and Ashworth, A. (1999). The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 8, 1479-1485.
Soria, J. C., Johnson, B. E., and Chevalier, T. L. (2003). Imatinib in small cell lung cancer. Lung Cancer 41 Suppl 1, S49-53.
Spicer, J., and Ashworth, A. (2004). LKB1 kinase: master and commander of metabolism and polarity. Curr Biol 14, R383-385.
Spicer, J., Rayter, S., Young, N., Elliott, R., Ashworth, A., and Smith, D. (2003). Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22, 4752-4756.
Stein, S. C., Woods, A., Jones, N. A., Davison, M. D., and Carling, D. (2000). The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 345 Pt 3, 437-443.
Su, G. H., Hruban, R. H., Bansal, R. K., Bova, G. S., Tang, D. J., Shekher, M. C., Westerman, A. M., Entius, M. M., Goggins, M., Yeo, C. J., and Kern, S. E. (1999). Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154, 1835-1840.
Su, J. Y., Erikson, E., and Maller, J. L. (1996). Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. J Biol Chem 271, 14430-14437.
Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A. F., and Minna, J. D. (1989). p53: a frequent target for genetic abnormalities in lung cancer. Science 246, 491-494.
Tiainen, M., Vaahtomeri, K., Ylikorkala, A., and Makela, T. P. (2002). Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 11, 1497-1504.
Tiainen, M., Ylikorkala, A., and Makela, T. P. (1999). Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A 96, 9248-9251.
Virmani, A. K., Fong, K. M., Kodagoda, D., McIntire, D., Hung, J., Tonk, V., Minna, J. D., and Gazdar, A. F. (1998). Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chromosomes Cancer 21, 308-319.
Wang, W., Yang, X., Lopez de Silanes, I., Carling, D., and Gorospe, M. (2003). Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 278, 27016-27023.
Wang, Z. J., Churchman, M., Campbell, I. G., Xu, W. H., Yan, Z. Y., McCluggage, W. G., Foulkes, W. D., and Tomlinson, I. P. (1999). Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours. Br J Cancer 80, 70-72.
Wang, Z. J., Taylor, F., Churchman, M., Norbury, G., and Tomlinson, I. (1998). Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am J Pathol 153, 363-366.
Watts, J. L., Morton, D. G., Bestman, J., and Kemphues, K. J. (2000). The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127, 1467-1475.
Wistuba, II, Mao, L., and Gazdar, A. F. (2002). Smoking molecular damage in bronchial epithelium. Oncogene 21, 7298-7306.
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., and Carling, D. (2003). LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13, 2004-2008.
Ylikorkala, A., Avizienyte, E., Tomlinson, I. P., Tiainen, M., Roth, S., Loukola, A., Hemminki, A., Johansson, M., Sistonen, P., Markie, D., et al. (1999). Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet 8, 45-51.
Ylikorkala, A., Rossi, D. J., Korsisaari, N., Luukko, K., Alitalo, K., Henkemeyer, M., and Makela, T. P. (2001). Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293, 1323-1326.
Yoo, L. I., Chung, D. C., and Yuan, J. (2002). LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer 2, 529-535.
Yu, C. J., Yang, P. C., Shew, J. Y., Hong, T. M., Yang, S. C., Lee, Y. C., Lee, L. N., Luh, K. T., and Wu, C. W. (1996). Mucin mRNA expression in lung adenocarcinoma cell lines and tissues. Oncology 53, 118-126.
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