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研究生:陳乙菘
研究生(外文):Yi-Song Chen
論文名稱:深層培養生產具有維護肝臟功能之樟芝發酵產物
論文名稱(外文):Submerged cultivation of Antrodia cinnamomea for manufacturing the fermentation products possessing liver protective function
指導教授:沈立言沈立言引用關係
指導教授(外文):Lee-Yan Sheen
學位類別:博士
校院名稱:國立臺灣大學
系所名稱:食品科技研究所
學門:農業科學學門
學類:食品科學類
論文出版年:2008
畢業學年度:96
語文別:中文
論文頁數:117
中文關鍵詞:樟芝菌絲體人類肝癌細胞初代肝細胞四氯化碳活性成分
外文關鍵詞:A. cinnamomeamyceliahepatoma cell lineprimary rat hepatocytesCCl4activity compounds
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本研究評估並建立可生產具有抑制人類肝癌細胞活性與護肝功能特性的樟芝(Antrodia cinnamomea, AC)深層發酵條件,結果發現搖瓶發酵8週的樟芝菌絲體乙醇萃取物具有較佳抑制Hep3B生長的活性,其中以glucose為碳源發酵8週的樟芝菌絲體乙醇萃取物(AC8-Em-glu)對Hep3B生長抑制的IC50最低,為76.2
The objective of this research was to establish proper fermentation conditions for submerged cultivation of Antrodia cinnamomea (AC) to produce a fermentation product with antihepatoma activity. AC was fermented for 1, 2, 4, 6 and 8 weeks with galactose, lactose and glucose as carbon sources of the submerged cultivation medium in 250 ml flask. The cell viability of Hep3B was more inhibited with the treatment of ethanolic extract of AC mycelia fermented for 8 weeks than those fermented for 1, 2, 4 and 6 weeks. The IC50 of ethanolic extract of AC mycelia fermented for 8 weeks with glucose as a carbon source (AC8-Em-glu) was 76.2
中文摘要 1
英文摘要 3
前言 5
研究架構 7
文獻整理 8
一、樟芝相關之研究 8
(一)化學成分鑑定方面 8
(二)生理活性方面 18
第一章 不同發酵樟芝菌絲體乙醇萃取物對人類肝癌細胞之抑制活性 26
一、摘要 26
二、研究背景及緣由 27
三、材料與方法 28
(一)樟芝深層發酵 28
(二)樟芝樣品之前處理 29
(三)樟芝發酵產物相關性質之分析 30
(四)不同發酵條件發酵樟芝乙醇萃取物抑制肝癌活性之分析 31
(五)探討樟芝菌絲體乙醇萃取物對Hep3B及HepG2 細胞週期之影響 34
(六)探討樟芝菌絲體乙醇萃取物對Hep3B及HepG2細胞內caspase-3活性之影響 35
四、結果與討論 36
(一)不同250 mL搖瓶發酵條件的樟芝菌絲體 36
(二)不同250 mL搖瓶發酵條件的樟芝菌絲體乙醇萃取物對人類肝癌細胞之影響 36
(三)5 L發酵槽深層發酵之樟芝菌絲體 37
(四)不同發酵時間5 L發酵槽深層發酵之樟芝菌絲體對人類肝癌細胞之影響 38
(五)500 L發酵槽深層發酵 39
(六)不同發酵時間500 L發酵槽深層發酵樟芝菌絲體乙醇萃取物對人類肝癌細胞之影響 39
(七)可能有效成分之分析 39
(八)樟芝菌絲體乙醇萃取物對HepG2及Hep3B cell-cycle之影響 40
(九)探討樟芝菌絲體乙醇萃取物對Hep3B及HepG2細胞內caspase-3活性之影響 41
五、結論 42
第二章 樟芝菌絲體乙醇萃取物對大白鼠初代肝細胞之影響 64
一、摘要 64
二、研究背景及緣由 65
三、材料與方法 66
(一)探討樟芝發酵菌絲體乙醇萃取物對大白鼠正常初代肝細胞之影響 66
(二)樟芝發酵菌絲體乙醇萃取物對四氯化碳誘導大白鼠初代肝細胞損傷之影響 71
四、結果與討論 72
(一)樟芝發酵菌絲體乙醇萃取物對正常大白鼠初代肝細胞之影響 72
(二)樟芝發酵菌絲體乙醇萃取物對四氯化碳大白鼠誘導初代肝細胞損傷之影響 74
五、 結論 76
第三章 樟芝發酵菌絲體乙醇萃取物對四氯化碳誘導大白鼠肝損傷之影響 90
一、摘要 90
二、研究背景及目的 91
三、材料與方法 92
四、結果與討論 94
五、結論 96
第四章 樟芝發酵菌絲體乙醇萃取物之化學成分分析 99
一、摘要 99
二、研究背景及目的 100
三、材料與方法 101
四、結果與討論 102
五、結論 103
參考文獻 114
附錄 122
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