(34.231.21.123) 您好!臺灣時間:2019/11/15 20:12
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
本論文永久網址: 
line
研究生:郭婕
研究生(外文):Margaret Jip KUO
論文名稱:補充刺五加對運動表現及健康指標的影響
論文名稱(外文):Effects of Eleutherococcus senticosus Extract onExercise Performance and Health Index
指導教授:李寧遠李寧遠引用關係
指導教授(外文):Ning-yuean Lee
學位類別:博士
校院名稱:輔仁大學
系所名稱:食品營養學研究所博士班
學門:醫藥衛生學門
學類:營養學類
論文出版年:2010
畢業學年度:98
語文別:中文
論文頁數:160
中文關鍵詞:刺五加苷耐力運動血乳酸自由基睡眠品質
外文關鍵詞:eleutherosideendurance exerciselactic acidfree radicalsleep quality
相關次數:
  • 被引用被引用:0
  • 點閱點閱:2853
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:379
  • 收藏至我的研究室書目清單書目收藏:2
現今台灣面臨高齡化社會問題,國人需要更多有效保健食品以維護並增進健康。刺五加具‘適應原’(adaptogens) 作用。為探討刺五加對運動表現及健康指標之成效,分別進行四項研究實驗。研究目的:(1) 確定刺五加 (Eleutherococcus senticosus ) 經萃取後其有效成分及各項維生素、礦物質;(2) 補充刺五加對人體有氧能力及抗疲勞功能之效應;(3) 刺五加對第二型糖尿病人慢性病危險因子之影響;(4) 補充刺五加對失眠患者睡眠品質之影響等四項研究實驗。研究一利用HPLC分析大陸產刺五加膠囊及本地花蓮產三葉五加茶包,結果顯示本研究所採用的刺五加膠囊功能性成分主要以刺五加苷B (Eleutheroside B) 及E (Eleutheroside E) 為主,亦含維生素E、咖啡酸及總酚類 (Total phenols)。研究二篩選18名健康男女大學生運動員為受試者,每天補充刺五加600毫克,結果顯示補充刺五加八週後,耐力運動持續時間延長30%,高強度負荷運動中最大心跳率增加4%,運動後游離脂肪酸增加20%,血乳酸下降18%,且均達顯著差異(p<0.05)。研究三,每天補充刺五加1200毫克,十二週後,16名第二型糖尿病人顯著降低空腹血糖及總膽固醇(p<0.05)和減少脂質過氧化物MDA生成,並有提升抗氧化酵素SOD和CAT等活性的趨勢。研究四每天補充刺五加1200毫克八週後,對10名失眠患者可顯著縮短入眠時間,提高非快速動眼期第四期佔總睡眠之比例,並有降低CPSQI總分之趨勢(p<0.05),提昇睡眠品質。綜合以上四項研究之結果,顯示每日補充1200毫克刺五加不會傷肝腎,刺五加能增強人體有氧能力,延長耐力運動時間,對人體具抗疲勞功能;對糖尿病患者可改善空腹血糖與血脂,並增強抗氧化能力;對失眠患者具有增加深層睡眠的作用。因此,推薦刺五加可作為耐力型運動員的有效營養性增補劑,對健康人能補充刺五加並配合運動,增加脂肪的燃燒利用; 有益於糖尿病患血糖與血脂之控制,延緩老化,且提高失眠患者之睡眠品質。
Nowadays, Taiwan is facing the situation of being an aged society. People need more effective supplements to maintain and improve health. Eleutherococcus senticosus (ES) has been stated by ancient China that has the adaptogen function. This study explored the effects of ES by four studies. Research purposes: (1) Determination of the functional components of ES. (2) The effects of 600 mg/d ES supplementation on endurance capacity, cardiovascular functions and anti-fatigue function of trained students for 8 weeks. (3) The effects of 1200 mg/d ES supplementation on the risk factors of chronic disease in Type 2 DM Patients for 12 weeks. (4) The effects of 1200 mg/d ES supplementation on sleeping quality in insomnia patients. Results showed that the main functional componentss of ES were eleutheroside B, eleutheroside E, caffic acid and also contained small amount of Vitamin E and total phenols. (2). Eighteen healthy trained students consumed 600 mg ES for 8 weeks, as the subjects’ endurance time improved 30% (p<0.05), the highest heart rate increased 4% (p<0.05) significantly. After the exhaustion exercise, blood lactic acid decreased 18% and 20% increased in blood free fatty acid showed significant differences (p<0.05). (3). Sixteen patients with type 2 diabetes mellitus consumed ES or placebo capsule 1200 mg/d for 8 weeks, results showed that ES could significantly reduced fasting blood glucose (p<0.05), reduced TC, MDA and improved antioxidant capacity (SOD and CAT activity). (4). Ten patients with insomnia consumed 1200mg/d ES for 8 weeks, results showed that ES significantly reduced sleep latency, increased the duration of NREM state 4 deep sleep and decreased the global CPSQI score (p<0.05). Taking all these four research results, we concluded that ES was found to be safe, tolerable and effective. ES contained antioxidative and anti-fatigue components that enhanced endurance capacity, elevated cardiovascular functions and altered the metabolism for sparing glycogen in recreationally trained athletes. Effective for DM patients for controlling blood glucose and cholesterol, patients with insomnia had a better sleep quality. Therefore, we recommended oral Eleutherococcus senticosus supplementation can be used as an effective nutritional ergogenic aids for endurance athletes. To healthy people, ES would be able to burn more fat during exercise. And ES was effective for improving the sleep quality and has antioxidative function on chronic disease control.
頁次
中文摘要 ....................................................... i
英文摘要 ...................................................... iii
誌 謝 ....................................................... v
目 錄 ...................................................... vii
表目錄 ....................................................... ix
圖目錄 ....................................................... x
英文縮寫與全文對照表 .......................................... xi
博士論文四研究 ............................................... xiii

第一章 研究架構及刺五加介紹 ............................ 1
第一節 研究架構 ................................ 3
第二節 簡介刺五加 .............................. 3
第三節 刺五加於傳統醫學中的功效 ................ 4
第四節 刺五加之臨床應用.......................... 6
第五節 刺五加之毒性反應試驗 .................... 8

第二章 研究一 大陸黑龍江產刺五加與臺灣產三葉五加保健成分之研究
壹、緒言 ........................................ 10
貳、文獻回顧 .................................... 11
參、材料與方法 .................................. 13
肆、結果與討論 .................................. 14
伍、結論 ........................................ 14

第三章 研究二 補充刺五加對人體有氧能力及抗疲勞功能之影響
壹、緒言 ........................................ 25
貳、文獻回顧 .................................... 28
參、材料與方法 .................................. 34
肆、結果與討論 .................................. 41
伍、結論 ........................................ 44

第四章 研究三 刺五加對第二型糖尿病人慢性病危險因子之影響
壹、緒言 .......................................... 50
貳、文獻回顧 ...................................... 55
參、材料與方法 .................................... 63
肆、結果與討論 .................................... 72
伍、結論 .......................................... 76

第五章 研究四 補充刺五加對失眠患者睡眠品質之影響
壹、緒言 ........................................... 82
貳、文獻回顧 ....................................... 85
參、材料與方法 ..................................... 95
肆、結果與討論 ..................................... 107
伍、結論 ............................ .............. 110

第六章 總討論 ............................................. 112

第七章 總結論與建議 ...................................... 118

參考文獻 ...................................................... 122

附錄一 受試者同意書 .......................................... 132
附錄二 中文化匹茲堡睡眠品質量表 .............................. 135
附錄三 SCI 接受文章(函) ...................................... 139
附錄四 TSSCI 接受文章 ....................................... 147
附錄五 科普文章 . ............................................ 155
三軍總醫院營養部(1998)台灣常見食品營養圖鑑。臺北市:行政院衛生署。
久保德三(1993)刺五加的效用,台北:青春出版社。
久鄉晴彥、近藤嘉和(2001)刺五加的驚人療效。台北縣: 正義出版社。52-54頁。
中國醫學科學院藥物研究所(1981)中藥志(第一冊)中國。
中國中醫研究院(1992)實用中醫辭典。台北: 知音出版社。
中國醫藥委員會(1991)中國藥典中藥彩色圖集。台北: 旺文社。
中華人民共和國衛生部藥典委員會(1985)中華人民共和國藥典。中國:人民衛生出版社。
中藥大辭典(1980)第一冊,台北:昭人出版社。
史久良、高奎憲(1987)近五年來我國刺五加研究和發展概況。哈爾濱:黑龍江省中醫研究院。51-64頁。
史大卓(1995)中醫內科治療學。北京:科學技術文獻出版社。428頁。
行政院衛生署 (2000) 健康食品之調節血糖功能評估方法。衛署食字第0890003826號公告。
行政院衛生署(2002)中華民國公共衛生概況。行政院衛生署。
行政院衛生署(2008)中華民國公共衛生概況。行政院衛生署。
行政院衛生署(2003)國人膳食營養素參考攝取量及其說明。行政院衛生署。
三葉五加(2003) 行政院衛生署中醫藥委員會臺灣藥用植物資源名錄。344頁。
曲中原、齊典、朱慧瑜、金哲雄(2004)刺五加總苷抗疲勞實驗研究。中國現代實用醫學雜誌 3卷19期:22-25頁。
安藤幸夫(1995)健康檢查指引。桃園縣:鐘郡出版社。
呂仁和(1997) 糖尿病及其病發症中西醫診治學。北京:人民衛生出版社。524頁。
李宇宙(2000a)睡眠醫學。台北市:健康文化事業股份有限公司。21-23頁。
李宇宙(2000b)身心疾病之睡眠障礙。台灣醫學 4:673-679。
李玉如(2001)音樂治療對安養機構老人睡眠品質與情緒狀態成效之探討。國立台北護理學院護理研究所碩士論文。
余謙 (1999)中藥複方補劑和清劑抗體力性疲勞作用的研究。中國運動醫學雜誌 8:300-303。
吳永寧、王緒卿、起雲峰、王京忠、陳惠京、劉宏志、李若薇、李明、Campbell TC 和陳君石(1996)刺五加製劑增強人體運動能力的研究。衛生研究 25:57-61。
吳永寧、王緒卿、趙雲峰、劉宏志、陳惠京、盧承前、于波、李明、Campbell TC和陳君石(1996)刺五加製劑對小鼠的抗疲勞作用。衛生研究25:177-178。
吳永寧、王緒卿、起雲峰、陳惠京、于波、劉宏志、李明、Campbell TC 和陳君石(1997)用藥時間對刺五加製劑增強運動耐力的影響。中國校醫 11:9-12。
吳永寧、王緒卿、李明、Campbell TC 和陳君石(1998)刺五加製劑對老年人恒定負荷下運動耐力的影響。衛生研究 27:421-424。
吳永寧、王緒卿、起雲峰、陳惠京、于波、李明、Campbell TC 和陳君石(1999)刺五加製劑對大學生恒定負荷下運動耐力的影響。中國校醫 13:1-5。
吳秉純(1986)刺五加的現代藥理學研究。中國:黑龍江省中藥研究室。51-52。
吳秉純(1984)刺五加國內外研究概況。中國:黑龍江省祖國醫藥研究所中藥研究室。
吳金珍(2005)刺五加對第2型糖尿病人血脂值、空腹血糖和抗氧化效力之影響,輔仁大學食品營養研究所碩士論文。
孟慶繁、於笑坤、徐睦芸、李明亮、高智慧、範豪、初宇卓、滕利榮 (2005)刺五加多糖的提取及其抗氧化性吉林大學學報(理學版)43:5。
林亞貞(1998)補充刺五加對羽球選手運動時體內能量代謝及運動表現之影響。輔仁大學食品營養系碩士論文。
林正常(1987)運動生理學實驗指引。台北: 師大書苑發行。
林正常,運動生理學 (2002): 台北:藝軒圖書出版社。273-289頁。
林嘉玲(2000)自費安養機構老人睡眠品質及其相關因素之探討。國立臺灣大學護理學研究所碩士論文。
杭群(1998)刺五加的神奇療效。台北:世茂出版社。
苗明三(2001)食療中藥藥物學。北京:科學出版社。330頁。
亞洲睡眠協會(2000)2000年睡眠調查。亞洲睡眠協會。
祖元剛 (2005)刺五加生活史型特徵及其形成機制。北京:科學出版社。12-15頁。
涉井佳代、遠藤拓郎 (2009) 睡眠圖解事典。臺北縣中和市 : 瑞昇文化。
徐台閣(1990)乳酸的產生移除與測量。中華體育 3卷 4期:75-82頁。
徐峰、趙江燕、劉天碩(2005)刺五加提取物抗疲勞作用的研究。食品科學 26:453-456。
陳三榮(2002)神奇的沙棘與刺五加。台北:元氣齋出版社。178-179頁。
陳秋紅、郭鳳鳴(1994)人參多糖,刺五加提高戰士機能狀態的效果觀察。解放軍預防醫學雜誌12:312-313。
陳揚燕(1996)大學新生睡眠品質與飲食因子之關係探討。國防醫學院公共衛生研究所碩士論文。
陳美麗(1997)經穴指壓對增進機構老人睡眠品質之效果。國立陽明大學臨床護理研究所碩士論文。
陳莖斐、李寧遠(1997)血乳酸值在運動訓練上的應用。國立體育學院論叢 8:93-101。
陳惠英、顏國欽 (1998) 自由基、抗氧化防禦與人體健康。中華營誌 23: 105-121。
陳瓊華 (2006) 探討台灣三葉五加抗癌效果及東部地區護理人員與民眾對中草藥的認知與態度。慈濟大學醫學研究所博士論文。
桃園縣政府衛生局 (2005) 三葉五加草本藥用植物區-涼茶飲品類-三葉五加。
許美智(2001)健康食品之抗疲勞功能評估方法。健康食品保健功效評估方法研討會刊物 (50-55頁)。台北:臺灣保健食品學會。
許倍嘉(2007)三葉五加抗氧化功能性評估之探討。亞洲大學生活應用科學學系碩士論文。
郭婕(1996)刺五加對人體心肺功能、肌力與血液生化之影響。國立體育學院運動科學研究所碩士論文。
郭婕(2002)認識刺五加 健康世界 82-85頁。
郭婕、蘇純慧、程一雄、李寧遠 (2007) 補充刺五加對人體運動後抗氧化力之影響。輔仁大學體育學刊6: 253-265。
張永勳 (1990) 臺灣產三葉五加皮與市售五加皮類藥材之鑑別及活性成分之研究。中國醫藥學院中國藥學研究所碩士論文。
張同吳 (2005)台灣保健植物之多樣性與利用研究。國際藥用植物產業發展研討會專刊。157-174頁。
張旭東、馬傑、張淑慧(2008)刺五加製劑的臨床應用進展。中國藥房19: 231-233。
張宏亮(2007) 運動能提升睡眠品質的原因。健康世界234:94-98。
張東傑、馮昆、張愛武、劉研研(2003)刺五加茶飲料抗疲勞作用的實驗研究。營養學報 25:309-311。
張春榮等 (1996) 中醫辨正聯合靜點丹蔘及刺五加治療高脂血症。實用中西醫結合雜誌9:57-60。
張素珠(2002)不同身體活動量與靜坐者睡眠品質之比較研究。國立臺灣師範大學體育學碩士論文。
張愛芳(2005)實用運動生物化學。北京:北京體育出版社。
梁龍鏡(1988)運動與乳酸的相互影響。中華體育 2:51-55。
黃培泉(1998)臺灣市售生藥刺五加、金線連及絞股藍之抗氧化及保肝活性藥效評估。高雄醫學大學天然藥物研究所碩士論文。
黃席珍(2003)。睡眠忠告。香港:天地圖書。50頁。
黑澤義雄(1994)蝦夷五加健康讀本必定會帶來健康。台北:青春出版社。
傅克治(1981)中國刺五加研究。黑龍江:黑龍江科技出版社。10頁。
睢大篔 (1995) 刺五加葉皂對老年大鼠血清LPO含量及SOD活性的影響。中國老年學雜誌 3:179。
雷啟文、林旭龍 (2003)中年婦女身體活動與睡眠品質之相關研究。衛生教育學報20:151-169。
鄧錦榮(2003) 老年人規律運動與睡眠品質之相關探討。師大體育47:185-192。
楊玲玲(1991)中藥食補與體質。中國飲食文化學術研討會刊物。
楊建銘、黃彥霖、林詩維譯 Charles M. Morin, Colin A.Espie著 (2008) 失眠的評估與治療 : 臨床實務手册。臺北市:心理出版社。
楊陸學(1995)前蘇聯太空人的養生密訣,刺五加解勞耐老功效漸受矚目。常春月刊, 第144期。
楊遵聲(1993)談「睡眠障礙」。醫院藥學10:142-146。
鄒綉菊(1994)敬老院老人睡眠品質與健康狀況之探討。國防醫學院護理學研究所碩士論文。
廖海珠(1994)神奇的刺五加。台北:青春出版社。
廖士程、李明濱、李宇宙 (2000) 睡眠的生物學基礎及臨床意義。台灣醫學4:652-664。
趙ㄧ、黃國鈞(1989)實用補養中藥。中國:中國廣西科學技術出版社。
趙克然、楊毅軍、曹道俊 (2003) 氧自由基與臨床。台北:合記圖書出版社。
蔡宇哲(2001)主觀入睡起始的腦波特徵。國立中正大學心理學研究所碩士論文。
蔡孟哲、王文貞(2002)九十年社會發展趨勢調查之規劃設計與統計結果研析。行政院主計處。
劉柯佑 (2004) 刺五加及其有效成分Syringin 對血糖及血壓的影響。高雄醫學大學天然藥物研究所碩士論文。
劉國升(1993)刺五加片的臨床運用。中醫藥學報2:48-49。
劉勝義(2004)臨床睡眠檢查學。台北市:合記圖書出版社。
藺奕譯(1998)樂在好睡眠(Frank J. Bruno原著)台北市:精美出版社。
謝蜀生(1989) 刺五加多糖免疫調節機理初探。中華微生物學和免疫學雜誌9 : 153。
韓明向、田金洲 (2001) 現代中醫臨床辨病治療學。北京:人民衞生出版社。489-506頁。
錢桂玉(1997)二週常壓低氧適應以及刺五加液對大白鼠生理、血液生化值、運動表現之影響。國立體育學院運動科學研究所碩士論文。
歐明(1999) 常用中藥手冊。台北:旺文社。290-291頁。
羅滋生(1991)關於中藥劑量大小之淺析。中醫藥學報 3:13-14。
24drs.com (2010) 睡眠窒息可能使糖尿病惡化。更新日期: 2010/01/25。


Abascal K and Yarnel E(2003)Increasing vitality with adaptogens: Multifaceted herbs for treating physical and mental stress. Altern Complement Therapies 9:54-60.
American Psychiatric Association(2000)The Diagnostic and Statistical Manual of Mental Disorders(DSM)4th ed.
Anetai M, Jamagishi T and Kaneshima H(1987)Quantitative determination of pharmacologically active constituents in the stems of Acanthopanax senticosus collected in Hokkaido. Hokkaidoritsu Eisei Kenkyushoho 37:85-87.
Aseif MA and Youssef AA(2004)Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta 346:161-170.
Apers S, Naessens T, Van Miert S, Pieters L and Vlietinck A(2005)Quality control of roots of Eleutherococcus senticosus by HPLC. Phytochem Anal 16:55-60.
Applegate E(1999)Effective nutritional ergogenic aids. Int J Sports Nutr 9:229-239.
Araujo AB, Yaggi HK and McKinlay JB(2004)Sleep duration and risk of diabetes in middle-aged and older men -prospective results from the Massachusetts male aging study. Annals of Epidemiology 14:598.
Asano K, TakahashiT, Miyashita M, Matsuzaka A, Muramatsu S, Kuboyama M, Kugo H and Imai J(1986)Effect of Eleutherococcus senticosus Extract on Human Physical Working Capacity. Planta Med 3: 175-177.
Atalay M and Laaksonen DE(2002)Diabetes, oxidative stress and physical exercise. J Sports Sci 1:1-14.
Atli T, Keven K, Avci A, Kutlay S, Turkcapar N, Varli M, Aras S, Ertug E and Canbolat O(2004)Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients. Arch Gerontol Geriatr 39:269-275.
Avidan AY, Fries BE, James ML, Szafara KL, Wright GT and Chervin RD(2005) Insomnia and hypnotic use, recorded in the minimum data set, as predictors of falls and hip fractures in Michigan nursing homes. J Amer Geriatrics Soc 53:955-962.
Backhaus J, Junghanns K, Broocks A, Riemann D and Hohagen F(2002)Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosomatic Res 53:737-740.
Bahrke MS and Morgan WP(2000)Evaluation of the ergogenic properties of ginseng. Sports Med 29:113-133.
Balasubramanyam M, Rema M and Premanand C(2002)Biochemical and molecular mechanisms of diabetic retinopathy. Curr Sci 83:1506-1509.
Baranov AI(1982)Medicinal uses of Ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol 6:339-353.
Barnes DL and Khan IA(2001)A New Lignan Glycoside from Eleutherococcus senticosus. Planta Med 67:776-778.
Baynes JW(1991)Role of oxidative stress in the development of complications in diabetes. Diabetes 40: 405-411.
Beaumont, M., Batejat, D., Coste, O., Doireau, P., Chauffard, F., Enslen, M., et al. (2005). Recovery after prolonged sleep deprivation: Residual effects of slow-release caffeine on recovery sleep, sleepiness and cognitive function. Neuropsychobiology, 51(1), 16-27.
Bhatia S, Shukla R, Madhu SV, Gambhir JK and Prabhu KM(2003)Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem 36: 557-562.
Bleakney TL(2008)Deconstructing an adaptogen: Eleutherococcus senticosus. Holist Nurs Pract 22:220-224.
Bocharov EV, Kucherianu VG, Bocharova OA and Karpova RV(2008) Neuroprotective features of phytoadaptogens. Vestn Ross Akad Med Nauk 4:47-50.
Brekhman II(1957)Ginseng. Leningrad: Medicine. P.182.
Brekhman II and Kirillov OI(1969a)Effect of Eleutherococcus on the alarm-phase of stress. Life Sciences. part I: Physio Pharm 8:113-121.
Brekhman II and Dardymov IV(1969b)New substances of plant origin which increase nonspecific resistance. Ann Rev Pharmacol 9: 419-430.
Buysse DJ, Reynolds CF, Monk TH, Berman SR and Kuper DJ(1989)The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193-213.
Buysse DJ, Reynolds CF, Monk TH, Hoch CC, Yeager AL and Kupfer DJ(1991) Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index(PSQI). Sleep 14:331-338.
Cervena K, Dauvilliers Y, Espa F, Touchon J, Matousek M and Billiard M(2004) Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectra in psychophysiological insomnia. J Sleep Res, 13:385-393.
Cheuvront SN, Moffatt RJ, Biggerstaff KD, Bearden S and McDonough P(1999) Effect of ENDUROX on metabolic responses to submaximal exercise. Int J Sport Nutr 9:434-442.
Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S and Gaddi A(2004)Effects of siberian ginseng(eleutherococcus senticosus maxim.)on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr 38:69-73.
Cohen DC, Eisdorfer C, Prize P, Breen A, Davis M and Dadsby A(1993)Sleep disturbances in the institutionalized aged. J Amer Geriatrics Soc 31: 79-82.
Curless R, French JM, James OF and Wynne HA (1993)Is caffeine a factor in subjective insomnia of elderly people. Age Ageing 22: 41-45.
Dardymov IV(1976)Ginseng, Eleutherococcus(To mechanism of biological
influence). Moskow:Nauka P.189.
Dardymov IV, Khasina EI and Bezdetko GN(1978)Insulin-Like Effect of Eleutherosides from Roots of Eleutherococcus-Senticosus. Rastitel'nye Resursy 14:86-89.
Davydov M and Krikorian AD(2000)Eleutherococcus senticosus(Rupr. & Maxim.) Maxim.(Araliaceae)as an adaptogen: a closer look. J Ethno Pharmacol 72: 345-393.
Deyama T, Nishibe S and Nakazawa Y(2001)Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 22:1057-1070.
DowIing EA, Redondo DR, Branch JD, Jones S, McNabb G and Williams MH(1996) Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. Med Sci Sports Exerc 28: 482-489.
Driver HS, Meintjes AF, Rogers GG and Shapiro CM(1988)Submaximal exercise on sleep patterns in young women before an aerobic programme. Acta Physiologica Scandinavica 133: 8-13.
Edinger JD, Morey MC, Sullivan RJ and Higginbotham MB(1993)Aerobic fitness acute exercise and sleep in older man. Sleep 16: 351-359.
Eschbach LF, Webster MJ, Boyd JC, McArthur PD and Evetovich TK(2000)The effect of siberian ginseng(Eleutherococcus senticosus)on substrate utilization and performance. Int J Sport Nutr Exerc Metab 10: 444-451.
Espie CA(2006)Overcoming Insomnia and Sleep Problems. Robinson Publishing.
Facchinetti F, Neri I and Tarabusi M(2002)Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: A randomized, placebo-controlled trial. Stress and Health 18:11-17.
Farnsworth NR, Kinghorn AD, Soejarto DD and Waller D(1985)Siberian Ginseng (Eleutherococcus senticosus):Current Status as an Adaptogen. Economic and Medicinal Plant Research, Volume 1. London. 155-215.
Feng S, Hu F, Zhao JX, Liu X and Li Y(2006)Determination of eleutheroside E and eleutheroside B in rat plasma and tissue by high-performance liquid chromatography using solid-phase extraction and photodiode array detection. Eur J Pharm Biopharm 62:315-320.
Frolova GM, Ovodov YS and Soprunov NI(1971)Triterpene glycodsides from the leaves of Eleutherococcus senticosus. Isolation and general characteristics. Khimia prirodnyph soedinenii 5:618-622.
Fruentov NK, Seregin Yu M, Kazakevich VM, Mel'Nikov SA and Vyborov SG(1987)The Effect of Extract of the Species of the Family Araliaceae on the Duration of Drug-Induced Sleep. Rastitel'nye Resursy 23:103-109.
Fulder S(1980)The drug that builds Russian. New Scientist 87:576-579.
Geoffrey P. Webb(2006)Dietary supplements & Functional foods. Blackwell Publishing.
George K and Alberti M(1998)Impaired glucose tolerance: what are the clinical implication? Diabetes Res Clin Pract 40: s3-s8.
Gladden LB(2001)Lactic acid: New roles in a new millennium. Proc Natl Acad Sci 98: 395-397.
Glatthaar-Saalmuller B, Sacher F and Esperester A(2001)Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res 50: 223-228.
Golotkin GF and Bojko SN(1966)On the treatment of atherosclerosis with Eleutherococcus. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern Plants. Vladivostok, Far Eastern Publishing House: 213-220.
Goulet ED and Dionne IJ(2005)Assessment of the Effects of Eleutherococcus Senticosus on Endurance Performance. Int J Sport Nutr Exerc Metab 15:75-83.
Halliwell B(1996)Antioxidants in human health and disease. Ann Rev Nutr 1:33-50.
Harinan D(1992)Role of free radicals in aging and disease. Ann N Y Acad Sci 673: 126-141.
Hikino H, Takahashi M, Otake K and Konno C(1986)Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 49: 293-297.
Hiramatsu K and Arimori S(1988)Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes. Diabetes 37:832-837.
Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T and Nakamura H(1996) Hypocholesterolemic effect of sesamin lignin in humans. Atherosclerosis 122: 135-136.
Hirosue T, Matsuzawa M and Kawai H(1986)Mutagenicity and subacute toxicity of Acanthopanax senticosus extracts in rats. J Food Hyg Soc Jpn 27:380-386.
Hong JH, Cha YS and Rhee SJ(2009)Effects of the cellcultured Acanthopanax senticosus Extract on antioxidative defense system and membrane fluidity in the liver of Type 2 Diabetes mouse. J Clin Biochem Nutr 45:101–109.
Hurley BF, Nemeth PM, Martin WH, Hagberg JM, Dalsky GP and Holloszy JO(1986) Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60: 562-567.
Ide T, Kushiro M, Takahashi Y, Shinohara K, Fukuda N and Sirato-yasumoto S(2003) Sesamin, a sesame lignan, as a potent serum lipid-lowering food component. JARQ 37:151–158.
Jakus V(2000)The role of free radicals, oxidative stress and antioxidant systems in diabetic vascular disease. Bratisl Lek Listy 101:541-551.
Jasper H H(1958)“The Ten-twenty Electrode Systems of the International Federation,” Electroencephalography and Clinical Neurophysiology 10: 371-375.
Kawamura M, Heinecke JW and Chait A(1994)Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. J Clin Invest 94:771-778.
Kiens B, Essen-Gustavsson B, Christensen NJ and Saltin B(1993)Skeletal muscle substrate utilization during sub-maximal exercise in man: effect of endurance training. J Physiol (London) 469: 459-478.
Kim HY and Kim K(2003)Protein glycation inhibitory and antioxidative activities of some plant extracts in vitro. J Agric Food Chem 51:1586-1591.
Laughton MJ, Evans PJ, Moroney MA, Hoult JR and Halliwell B(1991)Inhibition of
mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochemical Pharmacology 42:1673-1681.
Lawrence ME and Kirby DF(2002)Nutrition and sports supplements: fact or fiction. J Clin Gastroenterol 35: 299-306.
Lerner R(1982)Sleep loss in the aged: implications for nursing practice. J Gerontological Nursing 8:323-328.
Lee S, Son D, Ryu J, Lee YS, Jung SH, Kang J, Lee SY, Kim HS and Shin KH(2004) Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components. Arch Pharm Res 27:106-110.
Lee-Chiolng Teofile Jr.(2008)Sleep medicine: essentials and review. Oxford, New York. Oxford University Press
Li C, Wang XY, Hu XW, Fang HT and Qiao SY(2008)Determination of eleutheroside B in antifatigue fraction of Acanthopanax senticosus by HPLC. Zhongguo Zhong Yao Za Zhi 33:2800-2802.
Li XC, Barnes DL and Khan IA(2001)A New Lignan Glycoside from Eleutherococcus senticosus. Planta Med 67: 776-778.
Lipinski B(2001)Pathophysiology of oxidative stress in diabetes mellitus. J Diabetes Complications 15: 203-210.
Liu K Y, Wu YC, Liu IM, Yu WC and Cheng JT(2008)Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats. Neurosci Lett 28: 195-199.
Mahon NF(1995)The contributions of sleep to perceived health status during adolescence. Public Health Nurs 12:127-133.
Marx JL(1987)Oxygen free radicals linked to many disease. Science 235: 529-531.

Maslov LN and Guzarova NV(2007)Cardioprotective and antiarrhythmic properties of preparations from Leuzea carthamoides, Aralia mandshurica, and Eleutherococcus senticosus. Eksp Klin Farmakol 70:48-54.
Maughan RJ, King DS and Lea T(2004)Dietary supplements. J Sports Sci 22: 95-113.
McGuffin M, Hobbs C, Upton R and Goldberg A(1997)Botanical safety handbook. Boca Raton, FL: CRC Press.
Mclaveu DS(1996)Dietary antioxidants and disease. Med Digest 14: 5-10.
McNaughton L, Egan G and Caelli G(1989)A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int Clin Nutr Rev 9: 32-35.
Medon PJ, Ferguson PW and Watson CF(1984)Effect of Eleutherococcus senticosus Extracts on Hexobarbital metabolism in vivo and in vitro. J Ethnopharmacol 10: 235-241.
Medon PJ, Thompson EB and Farnsworth NR(1981)Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and chronic administration in mice. Acta Pharmacol Sin 2:281-285.
Mertig RG(2007)The nurse’s guide to teaching diabetes self-management. Springer publishing company, New York.
Morgan K, Dallosso H and Ebrahim S(1988)Characteristics of subjective insomnia in the elderly living at home. Age and Ageing, 17:1-7.
Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G and Wagner H(2005)Randomized trial of a fixed combination(KanJang)of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections.: Phytomed 12:539-547.
National Institute of Health(1995)Insomnia. Retrieved May 28, 2007, from http://www.nhlbi.nih.gov/health/public/sleep/insomnia.pdf.
National Institutes of Health(2005)State-of-the-Science conference statement on manifestations and management of chronic insomnia in adults. Retrieved May 20, 2007, from http://consensus.nih.gov/2005/2005InsomniaSOS026PDF.pdf.
Ni HX and Luo SS(2001)Effect of Acanthopanax senticosus injection on plasma and urinary endothelin in early stage of diabetic nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi 21:105-107.
Nishibe S, Kinoshita H and Takeda H(1990)Phenolic compounds from stem bark of
Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem Pharm Bull(Tokyo)38:1763-1765.
Niu HS, Hsu FL, Liu IM and Cheng JT(2007)Increase of beta-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats. Horm Metab Res 39:894-898.
Niu HS, Liu IM, Cheng JT, Lin CL and Hsu FL(2008)Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats. Planta Med 74:109-113.
Ohashi H(1989)Eleutherococcus Araliae of Japan. J Japanese Botany 64: 216-218.
Opara EC, Abdel-Rahman E, Soliman S, Kamel WA, Souka S, Lowe JE and Abdel-Aleem S(1999)Depletion of total antioxidant capacity in type 2 Diabetes. Metab 48:1414-1417.
Panossian A and Wagner H(2005)Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res 19: 819-838.
Panossian A and Wikman G(2009)Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 4:198-219.
Park HR, Park E, Rim AR, Jeon KI, Hwang JH and Lee SC(2006)Antioxidant activity of extracts from Acanthopanax senticosus. African J Biotechnology 5: 2388-2396.
Park SH, Lee SG, Kang SK and Chung SH(2006)Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice. Arch Pharm Res 29:768-776.
Parmeggiani PL and Velluti RA(2005)The Physiologic nature of sleep. Imperial college press. London.
Plowman SA, Dustman, K, Walicek H, Corless C and Ehlers G(1999)The effects of ENDUROX on the physiological responses to stair-stepping exercise. Res Q Exerc Sport 70: 385-388.
Provalova NV, Skurikhin EG, Pershina OV, Suslov NI, Minakova MY and Dygai AM (2002)Mechanisms underlink the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation. Bull Exp Biol Med 133:428-432.
Rechtschaffen A and Kales A(1968)A manual of standardized terminology, technique and scoring system for sleep stages of human sleep. Brain Research Institute Los Angeles, Cal: UCLA USA.
Reed S(2009)Essential physiology biochemistry. Wiley-blackwell.
Rogala E, Skopinska-Rozewska E, Sawicka T, Sommer E, Prosinska J and Drozd J (2003)The influence of Eleuterococcus senticosus on cellular and humoral immunological response of mice. Pol J Vet Sci 6:37-39.
Roxas M and Jurenka J(2007)Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev 12:25-48.
Ryu J, Son D, Kang J, Kim HS, Kim BK and Lee S(2004)A benzenoid from the stem of Acanthopanax senticosus. Arch Pharm Res 27:912-914.
Sakurai T and Tsuchiya S(1988)Superoxide production from non-enzymatically glycated protein. FEBS Lett 236:406-410.
Sateia MJ, Doghramji K, Hauri PJ and Morin CM(2000)Evaluation of chronic insomnia: an American academy of sleep medicine review. Sleep 23:243-308.
Savard MH, Savard J, Simard S and Ivers H (2005)Empirical validation of the insomnia severity index in cancer patients. Psycho-Oncology 14:429-441.
Schmolz MW, Sacher F and Aicher B (2001)The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother Res 15:268-270.
Seghrouchni I, Drai J, Bannier E, Riviere J, Calmard P, Garcia I, Orgiazzi J and Revol A (2002)Oxidative stress parameters in type 1, type 2 and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency. Clin Chim Acta 321:89-96.
Segiet-Kujawa E and Kaloga M(1991)Triterpenoid Saponins of Eleutherococcus-Senticosus Roots. J Natural Products(Lloydia)54:1044-1048.
Shi J, Ho CT and Shahidi F(2005)Asian Functional Foods. CRC Press. Taylor & Francis P.32-24.
Singh NA, Clements KM and Fiatarone MA(1997)A randomized controlled trial of the effect of exercise on sleep. Sleep 20:95-101.
Slacanin I, Marston A, Hostettmann K, Guédon D and Abbe P(1991)The isolation of Eleutherococcus senticosus constituents by centrifugal partition chromatography and their quantitative determination by highperformance liquid chromatography. Phytochemical Analysis 2:137-142.
Sugiura H, Nishida H and Iwata H(1992)Effects of Eleutherococcus extracts on oxidative enzyme activity in skeletal muscle, superoxide dismutase activity and lipid peroxidation in mice. Japanese J Fit Sports Med 41:304-312.
Stahelin HB(1999)The impact of antioxidants on chronic disease in ageing and in old age. Intermal J Vitam Nutr Res 69:146-149.
Steinmann GG, Esperester A and Joller P(2001)Immunopharmacological in vitro effects of Eleutherococcus senticosus extracts. Arzneimittelforschung 51:76-83.
Soares CN(2005)Insomnia in women: An overlooked epidemic? Arch Women’s Mental Health 8:205-213.
Szolomicki J, Samochowiec L, Wojcicki J, Drozdzik M and Szolomicki S(2000)The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother Res 14:30-35.
Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW and Bush AJ(2007) Comorbidity of chronic insomnia with medical problems. Sleep 30: 213-218.
Thacher PV, Pigeon WR and Perlis ML (2006) Do patients with sleep maintenance insomnia have a problem with sleep maintenance? Behavioral Sleep Med, 4: 203-218.
Tsai PS, Wang SY, Wang MY, Su CT, Yang TT, Huang CJ and Fang SC(2005) Psychometric evaluation of the Chinese version of the Pittsburgh Sleep Quality Index(CPSQI)in primary insomnia and control subjects. Qual Life Res 14: 1943-1952.
Turkoski BB(2006)Managing insomnia. Orthopaedic Nursing 25:339-347.
Vitiello MV, Prinz PN and Schwartz RS(1994)Slow wave sleep but not overall sleep quality of healthy older man and women is improved by increased aerobic fitness. Sleep Res 23:149.
Wagner H, Heidrun N, Munchen H and Winterhoff M(1992)Drugs with Adaptogenic Effects for Strengthening the powers of resistance. Phytotherapie 13:42-54.
Wang Z, Lin J and Zhang Z(2003)Advances in the study on chemical constituents and pharmacology of Acanthopanax senticosus(Rupr. et Maxim.)Zhong Yao Cai 26:603-606.
Wang ZC, Qiao SY, Ma AD and Bao YY(2003)High-performance liquid chromatography combined with mass spectrum analysis for identifying the antifatigue components in Acanthopanax senticosus Harms. Di Yi Jun Yi Da Xue Xue Bao 23:355-357.
Watts GF and Playford DA(1998)Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis. Atherosclerosis 141:17-30.
WHO Monographs on Selected Medicinal Plants(2004)Volume 2:358.
Wilson JF(2005)Is sleep the new vital sign? Annals of Internal Med 142:877-880.
Winterhoff H, Nörr H and Wagner H(1993)Effects of Eleutherococcus senticosus on the pituitary adrenal system of rats. Pharmaceutical and Pharmacological Letters 3:95-98.
Wolfe RR, Klein S, Carraro F and Weber JM(1990)Role of triglyceride fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol 258: 382-389.
Wu YN, Wang XQ, Zhao YF, Wang JZ, Chen HJ and Liu HZ(1996)Effect of Ciwujia (Radix acanthopanacis senticosus) preparation on human stamina. J Hyg Res 25: 57-61.
Yang JY, Lee KS and Kim MK(2004)Effect of Acanthopanax senticosus on lipoprotein lipase in 3T3-L1 adipocytes. Phytother Res 18:160-163.
Yat PN, Arnason JT and Awang DVC(1998)An improved extraction procedure for the rapid, quantitative high-performance liquid chromatographic estimation of the main eleutherosides(B and E)in Eleutherococcus senticosus(Eleuthero). Phytochemical Analysis 9:291-295.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔