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研究生:梁俊偉
研究生(外文):Jun-WeilLiang
論文名稱:牛樟芝子實體之成分研究
論文名稱(外文):The constituents of the fruit body of Taiwanofungus camphoratus
指導教授:吳天賞吳天賞引用關係
指導教授(外文):Tian-Shung Wu
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學系碩博士班
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:197
中文關鍵詞:台芝屬牛樟芝
外文關鍵詞:AntrodiaTaiwanofungus camphoratus
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由牛樟芝(Taiwanofungus camphoratus)之子實體共分離得到45個化合物。2個化合物coenzyme Q3 (20)及benzocamphorin F (29)為首次從天然界分離。8個為新化合物經由分析光譜確定出結構式,分別為camphoratin K (12)、camphoratin L (13)、camphoratin M (14)、camphoratin N (15)、
camphoratin O (17)、benzocamphorin G (30)、benzocamphorin H (31)、benzocamphorin I (44)。其中Camphoratin L (13)及camphoratin O (17)為天然界之新骨架化合物。另外35個化合物經由光譜分析確認其化學結構式,分別為methyl antcinate A (1)、antcin A (2)、zhankuic acid A methyl ester (3)、
zhankuic acid A (antcin B) (4)、zhankuic acid C (5)、zhankuic acid D (6)、
zhankuic acid B (7)、antcin C (8)、camphoratin E (9)、camphoratin F (10)、
methyl antcinate H (11)、1-hydroxy-p-menth-3-en-2-one (18)、nerolidol (19)、
4-acetylantroquinonol B (21)、ergosterol (22)、ergosterol peroxide (23)、
camphoratin I (24)、sesamin (25)、4-hydroxysesamin (26)、antrocamphin B (27)、
antrocamphin A (28)、methyl 3,4,5-trimethoxybenzoate (32)、
methyl 2,3,4,5-tetramethoxybenzoate (33)、
1-methyl-2,3,4,5-trimethoxybenzene (34)、
2,3,6-trimethoxy-5-methylphenol (35)、benzocamphorin C (36)、
methyl 2,5-dimethoxy-3,4-methylenedioxybenzoate (37)、
4,7-dimethoxyl-5-methyl-1,3-benzodioxole (38)、
4,5-dimethoxyl-6-methyl-1,3-benzodioxole (39)、
2,3-(methlenedioxy)-4-methyl-5-methylphenol (40)、
2,2’,5,5’-tetramethoxyl-3,4,3’,4’-bi-methylenedioxyl-6,6’-dimethylbiphenyl (41)、benzocamphorin E (42)、benzocamphorin D (43)、alkyl ferulate (45)。
上述化合物的結構乃是利用1維和2維核磁共振光譜、質譜、紫外光譜以及紅外線光譜決定,而已知化合物則與文獻所報導的物理性質和光譜數據進行比對後得到確認;另外所分離之化合物的生物活性則正測試中。

Forty five compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Two compounds were Coenzyme Q3 (20) and benzocamphorin F (29) which were reported for the first time from natural sources. Eight new compounds were characterized as camphoratin K (12), camphoratin L (13), camphoratin M (14), camphoratin N (15), camphoratin O (17), benzocamphorin G (30), benzocamphorin H (31), benzocamphorin I (44) by spectroscopic analyses. Among them, (13) and (17) were characterized as novel carbon skeleton. On the other hand, thirty five known compounds were identified as methyl antcinate A (1), antcin A (2), zhankuic acid A methyl ester (3), zhankuic acid A (antcin B) (4), zhankuic acid C (5), zhankuic acid D (6), zhankuic acid B (7), antcin C (8), camphoratin E (9), camphoratin F (10), methyl antcinate H (11), antcin K (16), 1-hydroxy-p-menth-3-en-2-one (18), nerolidol (19), 4-acetylantroquinonol B (21), ergosterol (22),
ergosterol peroxide (23), camphoratin I (24), sesamin (25),
4-hydroxysesamin (26), antrocamphin B (27), antrocamphin A (28),
methyl 3,4,5-trimethoxybenzoate (32),
methyl 2,3,4,5-tetramethoxybenzoate (33),
1-methyl-2,3,4,5-trimethoxybenzene (34),
2,3,6-trimethoxy-5-methylphenol (35), benzocamphorin C (36),
methyl 2,5-dimethoxy-3,4- methylenedioxybenzoate (37),
4,7-dimethoxyl-5-methyl-1,3-benzodioxole (38),
4,5-dimethoxyl-6-methyl-1,3-benzodioxole (39),
2,3-(methlenedioxy)-4-methyl-5-methylphenol (40),
2,2’,5,5’-tetramethoxyl-3,4,3’,4’-bi-methylenedioxyl-6,6’-dimethylbiphenyl (41), benzocamphorin E (42), benzocamphorin D (43), and alkyl ferulate (45).
The structures of the isolated compounds were elucidated by 1H-, 13C-, 2D-NMR, MS, UV and IR spectral analyses and the comparison of spectroscopic data with those reported in the literatures. The bioactive assay of the isolated compounds are in progress.

目錄
Abstract I
中文摘要 III
謝誌 V
第一章 緒論 1
第一節:前言 1
第二節:牛樟芝之形態介紹 2
第二章 台芝屬真菌之藥理研究回顧 3
第三章 台芝屬真菌之成分研究回顧 23
第四章 牛樟芝成分之萃取與分離 41
第五章 化學構造解析 51
第一節 Antcin A (2)之構造解析 51
第二節 Camphoratin K (12)之構造解析 54
第三節 Camphoratin L (13)之構造解析 62
第四節 Camphoratin M (14)之構造解析 70
第五節 Camphoratin N (15)之構造解析 80
第六節 Camphoratin O (17)之構造解析 88
第七節 Coenzyme Q3 (20)之構造解析 97
第八節 4-Acetylantroquinonol (21)之構造解析 107
第九節 Antrocamphin A (28)之構造解析 115
第十節 Benzocamphorin F (29)之構造解析 117
第十一節 Benzocamphorin G (30)之構造解析 123
第十二節 Benzocamphorin H (31)之構造解析 129
第十三節 Benzocamphorin D (43)之構造解析 135
第十四節 Benzocamphorin I (44)之構造解析 138
第十五節 其他化合物構造解析 144
第十六節 樟芝酸及相關類固醇之光譜特徵 145
第六章 Camphortin L (13)和O (17)生合成之路徑推演 157
第七章 結論 158
第八章 實驗部分 160
第一節 本實驗所使用之儀器 160
第二節 牛樟芝子實體成分分離 162
第三節 光譜數據 167
參考文獻 185
1. 邱年永; 張光雄, 原色台灣藥用圖鑑. 南天書局: 台北, 1998; Vol. 6, p 5.
2. Wu, S. H.; Yu, Z. H.; Dai, Y. C.; Chen, C. T.; Su, C. H., Taiwanofungus, a polypore new genus. Fung. Sci., 2004, 19, 109-116.
3. Yu, Z. H.; Wu, S. H.; Wang, D. M.; Chen, C. T., Phylogenetic relationships of Antrodia species and related taxa based on analyses of nuclear large subunit ribosomal DNA sequences. Botanical Studies, 2010, 51, 53-60.
4. Wen, C. L.; Teng, C. L.; Chiang, C. H.; Chang, C. C.; Hwang, W. L.; Kuo, C. L.; Hsu, S. L., Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-beta signaling pathway. Phytomedicine, 2012, 19, 424-435.
5. Du, Y. C.; Wu, T. Y.; Chang, F. R.; Lin, W. Y.; Hsu, Y. M.; Cheng, F. T.; Lu, C. Y.; Yen, M. H.; Tsui, Y. T.; Chen, H. L.; Hou, M. F.; Lu, M. C.; Wu, Y. C., Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata. J. Pharm. Biomed. Anal., 2012, 58, 182-192.
6. Lin, S. Y.; Sheen, L. Y.; Chiang, B. H.; Yang, J. S.; Pan, J. H.; Chang, Y. H.; Hsu, Y. M.; Chiang, J. H.; Lu, C. C.; Wu, C. L.; Chung, J. G., Dietary effect of Antrodia camphorata extracts on immune responses in WEHI-3 leukemia BALB/c mice. Nutr. Cancer, 2010, 62, 593-600.
7. Chen, Y. J.; Chou, C. J.; Chang, T. T., Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. Toxicol In Vitro, 2009, 23, 418-424.
8. Rao Yerra, K.; Fang, S. H.; Tzeng, Y. M., Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J. Ethnopharmacol., 2007, 114, 78-85.
9. Hseu, Y. C.; Yang, H. L.; Lai, Y. C.; Lin, J. G.; Chen, G. W.; Chang, Y. H., Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutr. Cancer, 2004, 48, 189-197.
10. Hseu, Y. C.; Chang, W. C.; Hseu, Y. T.; Lee, C. Y.; Yech, Y. J.; Chen, P. C.; Chen, J. Y.; Yang, H. L., Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life Sci., 2002, 71, 469-482.
11. Chen, C. H.; Yang, S. W.; Shen, Y. C., New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum. J. Nat. Prod., 1995, 58, 1655-1661.
12. Wang, L. C.; Wang, S. E.; Wang, J. J.; Tsai, T. Y.; Lin, C. H.; Pan, T. M.; Lee, C. L., In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid beta-protein-induced neurotoxicity and memory impairment. Appl. Microbiol. Biotechnol., 2012, 94, 1505-1509.
13. Cheng, J. J.; Huang, N. K.; Lur, H. S.; Kuo, C. I.; Lu, M. K., Characterization and biological functions of sulfated polysaccharides from sulfated-salt treatment of Antrodia cinnamomea. Process Biochem. (Amsterdam, Neth.), 2009, 44, 453-459.
14. Lu, M. K.; Cheng, J. J.; Lai, W. L.; Lin, Y. R.; Huang, N. K., Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors. Life Sci., 2006, 79, 252-258.
15. Chen, C. C.; Shiao, Y. J.; Lin, R. D.; Shao, Y. Y.; Lai, M. N.; Lin, C. C.; Ng, L. T.; Kuo, Y. H., Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. J. Nat. Prod., 2006, 69, 689-691.
16. Huang, N. K.; Cheng, J. J.; Lai, W. L.; Lu, M. K., Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol. Lett., 2005, 244, 213-219.
17. Tsai, P. Y.; Ka, S. M.; Chang, J. M.; Lai, J. H.; Dai, M. S.; Jheng, H. L.; Kuo, M. T.; Chen, P.; Chen, A., Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. Arthritis Rheum., 2012, 64, 232-242.
18. Tsai, P. Y.; Ka, S. M.; Chao, T. K.; Chang, J. M.; Lin, S. H.; Li, C. Y.; Kuo, M. T.; Chen, P.; Chen, A., Antroquinonol reduces oxidative stress through enhancing Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic. Biol. Med., 2011, 50, 1503-1516.
19. Chang, J. M.; Lee, Y. R.; Hung, L. M.; Liu, S. Y.; Kuo, M. T.; Wen, W. C.; Chen, P., An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice. Evid Based Complement Alternat Med, 2008, doi:10.1093/ecam/nen1057.
20. Lin, W. L.; Lee, Y. J.; Wang, S. M.; Huang, P. Y.; Tseng, T. H., Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B. Eur. J. Pharmacol., 2012, 680, 8-15.
21. Yu, C. C.; Chiang, P. C.; Lu, P. H.; Kuo, M. T.; Wen, W. C.; Chen, P.; Guh, J. H., Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem, 2011, DOI:10.1016/j.jnutbio.2011.1004.1015.
22. Yeh, C. T.; Yao, C. J.; Yan, J. L.; Chuang, S. E.; Lee, L. M.; Chen, C. M.; Yeh, C. F.; Li, C. H.; Lai, G. M., Apoptotic Cell Death and Inhibition of Wnt/beta-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus. Evid Based Complement Alternat Med, 2011, DOI:10.1155/2011/750230.
23. Yang, H. L.; Kuo, Y. H.; Tsai, C. T.; Huang, Y. T.; Chen, S. C.; Chang, H. W.; Lin, E.; Lin, W. H.; Hseu, Y. C., Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem. Toxicol., 2011, 49, 290-298.
24. Shi, L. S.; Chao, C. H.; Shen, D. Y.; Chan, H. H.; Chen, C. H.; Liao, Y. R.; Wu, S. J.; Leu, Y. L.; Shen, Y. C.; Kuo, Y. H.; Lee, E. J.; Qian, K.; Wu, T. S.; Lee, K. H., Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Bioorg. Med. Chem., 2011, 19, 677-683.
25. Rao, Y. K.; Wu, A. T.; Geethangili, M.; Huang, M. T.; Chao, W. J.; Wu, C. H.; Deng, W. P.; Yeh, C. T.; Tzeng, Y. M., Identification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells. Chem. Res. Toxicol., 2011, 24, 238-245.
26. Lu, Z. M.; Xu, Z. H., Antcin A contributs to anti-inflammatory effect of Niuchangchih (Antrodia camphorata). Acta Pharmacol. Sin., 2011, 32, 981-982.
27. Liu, F. S.; Yang, P. Y.; Hu, D. N.; Huang, Y. W.; Chen, M. J., Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells. Int J Gynecol Cancer, 2011, 21, 1172-1179.
28. Lin, Y. W.; Chiang, B. H., 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J. Agric. Food Chem., 2011, 59, 8625-8631.
29. Lien, H. M.; Kuo, P. T.; Huang, C. L.; Kao, J. Y.; Lin, H.; Yang, D. Y.; Lai, Y. Y., Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. Evid Based Complement Alternat Med, 2011, 2011, DOI:10.1093/ecam/nep1230.
30. Kumar, V. B.; Yuan, T. C.; Liou, J. W.; Yang, C. J.; Sung, P. J.; Weng, C. F., Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. Mutat. Res., 2011, 707, 42-52.
31. Hsieh, Y. C.; Rao, Y. K.; Whang-Peng, J.; Huang, C. Y.; Shyue, S. K.; Hsu, S. L.; Tzeng, Y. M., Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J. Agric. Food Chem., 2011, 59, 10943-10954.
32. Chiou, J. F.; Wu, A. T.; Wang, W. T.; Kuo, T. H.; Gelovani, J. G.; Lin, I. H.; Wu, C. H.; Chiu, W. T.; Deng, W. P., A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. Evid Based Complement Alternat Med, 2011, 2011, doi:10.1093/ecam/nep1228.
33. Chen, L. Y.; Sheu, M. T.; Liu, D. Z.; Liao, C. K.; Ho, H. O.; Kao, W. Y.; Ho, Y. S.; Lee, W. S.; Su, C. H., Pretreatment with an ethanolic extract of Taiwanofungus camphoratus (Antrodia camphorata) enhances the cytotoxic effects of amphotericin B. J. Agric. Food Chem., 2011, 59, 11255-11263.
34. Chang, C. Y.; Cheng, T. J.; Chang, F. R.; Wang, H. Y.; Kan, W. C.; Li, S. L.; Huang, L. H.; Chen, Y. C.; Tsai, W. C.; Huang, C. H.; Cheng, C. H.; Lee, G. Y.; Shyue, S. W.; Chen, Y. P.; Lin, K. C.; Chuu, J. J., Macrophage mediated anti-proliferation effects of Antrodia camphorata non-polysaccharide based extracts on human hepatoma cells. Biosci., Biotechnol., Biochem., 2011, 75, 624-632.
35. Yang, H. L.; Kuo, Y. H.; Tsai, C. T.; Huang, Y. T.; Chen, S. C.; Chang, H. W.; Lin, E.; Lin, W. H.; Hseu, Y. C., Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem. Toxicol., 2010, 49, 290-298.
36. Wu, S. J.; Leu, Y. L.; Chen, C. H.; Chao, C. H.; Shen, D. Y.; Chan, H. H.; Lee, E. J.; Wu, T. S.; Wang, Y. H.; Shen, Y. C.; Qian, K.; Bastow, K. F.; Lee, K. H., Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. J. Nat. Prod., 2010, 73, 1756-1762.
37. Wang, L.; Zhao, C.; Tian, X.; Song, A., Acute toxicity and in vivo inhibiting effects upon hepatoma H22 of ethanol precipitate of Antrodia camphorata culture filtrate. Mycosystema, 2010, 29, 612-615.
38. Tsai, W. C.; Rao, Y. K.; Lin, S. S.; Chou, M. Y.; Shen, Y. T.; Wu, C. H.; Geethangili, M.; Yang, C. C.; Tzeng, Y. M., Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. Bioorg. Med. Chem. Lett., 2010, 20, 6145-6148.
39. Lin, Y. W.; Pan, J. H.; Liu, R. H.; Kuo, Y. H.; Sheen, L. Y.; Chiang, B. H., The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. J. Sci. Food Agric., 2010, 90, 1739-1744.
40. Huang, G. J.; Huang, S. S.; Lin, S. S.; Shao, Y. Y.; Chen, C. C.; Hou, W. C.; Kuo, Y. H., Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice. J. Agric. Food Chem., 2010, 58, 7445-7452.
41. Huang, C. H.; Chang, C. C.; Lin, C. M.; Wang, S. T.; Wu, M. T.; Li, E. I.; Chang, H. C.; Lin, C. C., Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunol. Immunother., 2010, 59, 1259-1272.
42. Hsieh, Y. C.; Rao, Y. K.; Wu, C. C.; Huang, C. Y. F.; Geethangili, M.; Hsu, S. L.; Tzeng, Y. M., Methyl Antcinate A from Antrodia camphorata Induces Apoptosis in Human Liver Cancer Cells through Oxidant-Mediated Cofilin- and Bax-Triggered Mitochondrial Pathway. Chem. Res. Toxicol., 2010, 23, 1256-1267.
43. Hseu, Y. C.; Huang, H. C.; Hsiang, C. Y., Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging. Food Chem. Toxicol., 2010, 48, 2319-2325.
44. Chiang, P. C.; Lin, S. C.; Pan, S. L.; Kuo, C. H.; Tsai, I. L.; Kuo, M. T.; Wen, W. C.; Chen, P.; Guh, J. H., Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways. Biochem. Pharmacol., 2010, 79, 162-171.
45. Chan, Y. Y.; Chang, C. S.; Chien, L. H.; Wu, T. F., Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. J. Ethnopharmacol., 2010, 127, 652-661.
46. Yu, Y. L.; Chen, I. H.; Shen, K. Y.; Huang, R. Y.; Wang, W. R.; Chou, C. J.; Chang, T. T.; Chu, C. L., A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation. Eur. J. Immunol., 2009, 39, 2482-2491.
47. Yeh, C. T.; Rao, Y. K.; Yao, C. J.; Yeh, C. F.; Li, C. H.; Chuang, S. E.; Luong, J. H. T.; Lai, G. M.; Tzeng, Y. M., Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett. (Shannon, Irel.), 2009, 285, 73-79.
48. Lu, M. C.; Hwang, S. L.; Chang, F. R.; Chen, Y. H.; Chang, T. T.; Hung, C. S.; Wang, C. L.; Chu, Y. H.; Pan, S. H.; Wu, Y. C., Immunostimulatory effect of Antrodia camphorata extract on functional maturation of dendritic cells. Food Chem., 2009, 113, 1049-1057.
49. Lu, M. C.; Du, Y. C.; Chuu, J. J.; Hwang, S. L.; Hsieh, P. C.; Hung, C. S.; Chang, F. R.; Wu, Y. C., Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch. Toxicol., 2009, 83, 121-129.
50. Deng, J. Y.; Chen, S. J.; Jow, G. M.; Hsueh, C. W.; Jeng, C. J., Dehydroeburicoic Acid Induces Calcium- and Calpain-Dependent Necrosis in Human U87MG Glioblastomas. Chem. Res. Toxicol., 2009, 22, 1817-1826.
51. Cha, W. S.; Ding, J. L.; Choi, D., Comparative evaluation of antioxidant, nitrite scavenging, and antitumor effects of Antrodia camphorata extract. Biotechnol. Bioprocess Eng., 2009, 14, 232-237.
52. Shen, C. C.; Lin, C. F.; Huang, Y. L.; Wan, S. T.; Chen, C. C.; Sheu, S. J.; Lin, Y. C.; Chen, C. C., Bioactive components from the mycelium of Antrodia salmonea. J. Chin. Chem. Soc. (Taipei, Taiwan), 2008, 55, 854-857.
53. Lu, M. K.; Cheng, J. J.; Lai, W. L.; Lin, Y. J.; Huang, N. K., Fermented Antrodia cinnamomea Extract Protects Rat PC12 Cells from Serum Deprivation-Induced Apoptosis: The Role of the MAPK Family. J. Agric. Food Chem., 2008, 56, 865-874.
54. Kuo, M. C.; Chang, C. Y.; Cheng, T. L.; Wu, M. J., Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate. J. Ethnopharmacol., 2008, 120, 196-203.
55. Hseu, Y. C.; Chen, S. C.; Chen, H. C.; Liao, J. W.; Yang, H. L., Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food Chem. Toxicol., 2008, 46, 2680-2688.
56. Ho, C. M.; Huang, C. C.; Huang, C. J.; Cheng, J. S.; Chen, I. S.; Tsai, J. Y.; Jiann, B. P.; Tseng, P. L.; Kuo, S. J.; Jan, C. R., Effects of Antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells. Chin. J. Physiol., 2008, 51, 78-84.
57. Chen, Y. Y.; Chang, H. H.; Lee, H. Y.; Sheu, F., Immunomodulatory and anti-tumor effects of oral administration with Antrodia cinnamomea fruiting bodies in BALB/c mice. Taiwan Nongye Huaxue Yu Shipin Kexue, 2008, 46, 87-95.
58. Chang, C. Y.; Huang, Z. N.; Yu, H. H.; Chang, L. H.; Li, S. L.; Chen, Y. P.; Lee, K. Y.; Chuu, J. J., The adjuvant effects of Antrodia camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. J. Ethnopharmacol., 2008, 118, 387-395.
59. Wang, G. J.; Lin, S. Y.; Wu, W. C.; Hou, W. C., DPPH radical scavenging and semicarbazide-sensitive amine oxidase inhibitory and cytotoxic activities of Taiwanofungus camphoratus (Chang-chih). Biosci., Biotechnol., Biochem., 2007, 71, 1873-1878.
60. Peng, C. C.; Chen, K. C.; Y, P. R.; Chyau, C. C.; Su, C. H.; Mei, H. L. H., Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. J. Ethnopharmacol., 2007, 109, 93-103.
61. Lu, Y. C.; Huang, C. C.; Huang, C. J.; Chu, S. T.; Chi, C. C.; Su, H. H.; Hsu, S. S.; Wang, J. L.; Chen, I. S.; Liu, S. I.; Kuang, J. K.; Ho, C. M.; Kuo, S. J.; Jan, C. R., Effects of Antrodia camphorata on viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation in MG63 human osteosarcoma cells. Drug Dev. Res., 2007, 68, 71-78.
62. Lee, T. H.; Lee, C. K.; Tsou, W. L.; Liu, S. Y.; Kuo, M. T.; Wen, W. C., A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. Planta Med., 2007, 73, 1412-1415.
63. Hsu, Y. L.; Kuo, P. L.; Cho, C. Y.; Ni, W. C.; Tzeng, T. F.; Ng, L. T.; Kuo, Y. H.; Lin, C. C., Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway. Food Chem. Toxicol., 2007, 45, 1249-1257.
64. Hseu, Y. C.; Chen, S. C.; Tsai, P. C.; Chen, C. S.; Lu, F. J.; Chang, N. W.; Yang, H. L., Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata. Food Chem. Toxicol., 2007, 45, 1107-1115.
65. Chen, K. C.; Peng, C. C.; Peng, R. Y.; Su, C. H.; Chiang, H. S.; Yan, J. H.; H. M., H. L., Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells. Nutr. Cancer, 2007, 57, 111-121.
66. Yang, H. L.; Chen, C. S.; Chang, W. H.; Lu, F. J.; Lai, Y. C.; Chen, C. C.; Hseu, T. H.; Kuo, C. T.; Hseu, Y. C., Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett., 2006, 231, 215-227.
67. Wu, H.; Pan, C. L.; Yao, Y. C.; Chang, S. S.; Li, S. L.; Wu, T. F., Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell. Proteomics, 2006, 6, 826-835.
68. Peng, C. C.; Chen, K. C.; Peng, R. Y.; Su, C. H.; Hsieh Li, H. M., Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts. Cancer Lett., 2006, 243, 109-119.
69. Kuo, P. L.; Hsu, Y. L.; Cho, C. Y.; Ng, L. T.; Kuo, Y. H.; Lin, C. C., Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food Chem. Toxicol., 2006, 44, 1316-1326.
70. Song, T. Y.; Hsu, S. L.; Yeh, C. T.; Yen, G. C., Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway. J. Agric. Food Chem., 2005, 53, 5559-5564.
71. Hsu, Y. L.; Kuo, Y. C.; Kuo, P. L.; Ng, L. T.; Kuo, Y. H.; Lin, C. C., Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer Lett., 2005, 221, 77-89.
72. Nakamura, N.; Hirakawa, A.; Gao, J. J.; Kakuda, H.; Shiro, M.; Komatsu, Y.; Sheu, C. C.; Hattori, M., Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line. J. Nat. Prod., 2004, 67, 46-48.
73. Liu, J. J.; Huang, T. S.; Hsu, M. L.; Chen, C. C.; Lin, W. S.; Lu, F. J.; Chang, W. H., Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicol. Appl. Pharmacol., 2004, 201, 186-193.
74. Song, T. Y.; Yen, G. C., Protective Effects of Fermented Filtrate from Antrodia camphorata in Submerged Culture against CCl4-Induced Hepatic Toxicity in Rats. J. Agric. Food Chem., 2003, 51, 1571-1577.
75. Huang, G. J.; Deng, J. S.; Huang, S. S.; Shao, Y. Y.; Chen, C. C.; Kuo, Y. H., Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice. Food Chem., 2012, 132, 709-716.
76. Wu, M. T.; Tzang, B. S.; Chang, Y. Y.; Chiu, C. H.; Kang, W. Y.; Huang, C. H.; Chen, Y. C., Effects of Antrodia camphorata on Alcohol Clearance and Antifibrosis in Livers of Rats Continuously Fed Alcohol. J. Agric. Food Chem., 2011, 59, 4248-4254.
77. Lu, Z. M.; Tao, W. Y.; Xu, H. Y.; Ao, Z. H.; Zhang, X. M.; Xu, Z. H., Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats. Nat Prod Res, 2011, 25, 684-695.
78. Kumar, K. J.; Chu, F. H.; Hsieh, H. W.; Liao, J. W.; Li, W. H.; Lin, J. C.; Shaw, J. F.; Wang, S. Y., Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. J. Ethnopharmacol., 2011, 136, 168-177.
79. Lu, Z. M.; Tao, W. Y.; Xu, H. Y.; Ao, Z. H.; Zhang, X. M.; Xu, Z. H., Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats. Nat Prod Res, 2010, 25, 684-695.
80. Huang, C. H.; Chang, Y. Y.; Liu, C. W.; Kang, W. Y.; Lin, Y. L.; Chang, H. C.; Chen, Y. C., Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. J. Agric. Food Chem., 2010, 58, 3859-3866.
81. Phuong do, T.; Ma, C. M.; Hattori, M.; Jin, J. S., Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother. Res., 2009, 23, 582-584.
82. Suk, F. M.; Lin, S. Y.; Chen, C. H.; Yen, S. J.; Su, C. H.; Liu, D. Z.; Hou, W. C.; Hung, L. F.; Lin, P. J.; Liang, Y. C., Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats. Biosci., Biotechnol., Biochem., 2008, 72, 1704-1713.
83. Ho, Y. C.; Lin, M. T.; Duan, K. J.; Chen, Y. S., The hepatoprotective activity against ethanol-induced cytotoxicity by aqueous extract of Antrodia cinnamomea. J. Chin. Inst. Chem. Eng., 2008, 39, 441-447.
84. Lu, Z.; Ao, Z.; Tao, W.; Zou, X.; Fu, H., Protection of ethanol-induced acute liver injury by Antrodia camphorata powder. Zhongcaoyao, 2007, 38, 420-422.
85. Lin, W. C.; Kuo, S. C.; Lin, W. L.; Fang, H. L.; Wang, B. C., Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol, 2006, 12, 2369-2374.
86. Han, H. F.; Nakamura, N.; Zuo, F.; Hirakawa, A.; Yokozawa, T.; Hattori, M., Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice. Chem. Pharm. Bull., 2006, 54, 496-500.
87. Huang, R. L.; Huang, Q.; Chen, C. F.; Chang, T. T.; Chou, C. J., Anti-viral effects of active compounds from Antrodia camphorata on wild-type and lamivudine-resistant mutant HBV. Chin. Pharm. J. (Taipei, Taiwan), 2003, 55, 371-379.
88. Hsiao, G.; Shen, M. Y.; Lin, K. H.; Lan, M. H.; Wu, L. Y.; Chou, D. S.; Lin, C. H.; Su, C. H.; Sheu, J. R., Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J. Agric. Food Chem., 2003, 51, 3302-3308.
89. Lee, I. H.; Huang, R. L.; Chen, C. T.; Chen, H. C.; Hsu, W. C.; Lu, M. K., Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiol. Lett., 2002, 209, 63-67.
90. Huang, G. J.; Pan, C. H.; Liu, F. C.; Wu, T. S.; Wu, C. H., Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the lambda-carrageenan-induced paw edema model. Food Chem. Toxicol., 2012, DOI:10.1016/j.fct.2012.1001.1041.
91. Wu, M. D.; Cheng, M. J.; Wang, W. Y.; Huang, H. C.; Yuan, G. F.; Chen, J. J.; Chen, I. S.; Wang, B. C., Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea. Nat Prod Res, 2011, 25, 1488-1496.
92. Wen, C. L.; Chang, C. C.; Huang, S. S.; Kuo, C. L.; Hsu, S. L.; Deng, J. S.; Huang, G. J., Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo. J. Ethnopharmacol., 2011, 137, 575-584.
93. Lee, C. L.; Huang, C. H.; Wang, H. C.; Chuang, D. W.; Wu, M. J.; Wang, S. Y.; Hwang, T. L.; Wu, C. C.; Chen, Y. L.; Chang, F. R.; Wu, Y. C., First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents. Org. Biomol. Chem., 2011, 9, 70-73.
94. Lin, E. S.; Yang, C. T.; Chou, H. J.; Chang, T. T., Screening of antioxidant activities by the edible basidiomycete Antrodia cinnamomea strains in submerged culture. J. Food Biochem., 2010, 34, 1141-1156.
95. Yang, S. S.; Wang, G. J.; Wang, S. Y.; Lin, Y. Y.; Kuo, Y. H.; Lee, T. H., New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata. Planta Med., 2009, 75, 512-516.
96. Wu, M. D.; Cheng, M. J.; Wang, B. C.; Yech, Y. J.; Lai, J. T.; Kuo, Y. H.; Yuan, G. F.; Chen, I. S., Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages. J. Nat. Prod., 2008, 71, 1258-1261.
97. Hseu, Y. C.; Chen, S. C.; Yech, Y. J.; Wang, L.; Yang, H. L., Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. J. Ethnopharmacol., 2008, 118, 237-245.
98. Wu, Y. Y.; Chen, C. C.; Chyau, C. C.; Chung, S. Y.; Liu, Y. W., Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata. Acta Pharmacol Sin, 2007, 28, 258-267.
99. Wu, M. D.; Cheng, M. J.; Wang, B. C.; Wang, W. Y.; Lai, J. T.; Yuan, G. F., Chemical constituents from the mycelia of Antrodia cinnamomea. J. Chil. Chem. Soc., 2007, 52, 1338-1340.
100. Tsai, M. C.; Song, T. Y.; Shih, P. H.; Yen, G. C., Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomea in submerged culture. Food Chem., 2007, 104, 1115-1122.
101. Shen, C. C.; Wang, Y. H.; Chang, T. T.; Lin, L. C.; Don, M. J.; Hou, Y. C.; Liou, K. T.; Chang, S.; Wang, W. Y.; Ko, H. C.; Shen, Y. C., Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea. Planta Med., 2007, 73, 1208-1213.
102. Liu, D. Z.; Liang, H. J.; Chen, C. H.; Su, C. H.; Lee, T. H.; Huang, C. T.; Hou, W. C.; Lin, S. Y.; Zhong, W. B.; Lin, P. J.; Hung, L. F.; Liang, Y. C., Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. J. Ethnopharmacol., 2007, 113, 45-53.
103. Huang, S. J.; Mau, J. L., Antioxidant properties of methanolic extracts from Antrodia camphorata with various doses of γ-irradiation. Food Chem., 2007, 105, 1702-1710.
104. Chen, J. J.; Lin, W. J.; Liao, C. H.; Shieh, P. C., Anti-inflammatory Benzenoids from Antrodia camphorata. J. Nat. Prod., 2007, 70, 989-992.
105. Chen, C. C.; Liu, Y. W.; Ker, Y. B.; Wu, Y. Y.; Lai, E. Y.; Chyau, C. C.; Hseu, T. H.; Peng, R. Y., Chemical Characterization and Anti-inflammatory Effect of Polysaccharides Fractionated from Submerge-Cultured Antrodia camphorata Mycelia. J. Agric. Food Chem., 2007, 55, 5007-5012.
106. Shen, C. C.; Shen, Y. C.; Wang, Y. H.; Lin, L. C.; Don, M. J.; Liou, K. T.; Wang, W. Y.; Hou, Y. C.; Chang, T. T., New lanostanes and naphthoquinones isolated from Antrodia salmonea and their antioxidative burst activity in human leukocytes. Planta Med., 2006, 72, 199-203.
107. Mau, J. L.; Huang, P. N.; Huang, S. J.; Chen, C. C., Antioxidant properties of methanolic extracts from two kinds of Antrodia camphorata mycelia. Food Chem., 2004, 86, 25-31.
108. Song, T. Y.; Yen, G. C., Antioxidant Properties of Antrodia camphorata in Submerged Culture. J. Agric. Food Chem., 2002, 50, 3322-3327.
109. Chen, Y. C.; Liu, Y. L.; Li, F. Y.; Chang, C. I.; Wang, S. Y.; Lee, K. Y.; Li, S. L.; Chen, Y. P.; Jinn, T. R.; Tzen, J. T., Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids. Acta Pharmacol Sin, 2011, 32, 904-911.
110. Hsieh, Y. H.; Chu, F. H.; Wang, Y. S.; Chien, S. C.; Chang, S. T.; Shaw, J. F.; Chen, C. Y.; Hsiao, W. W.; Kuo, Y. H.; Wang, S. Y., Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms. J. Agric. Food Chem., 2010, 58, 3153-3158.
111. Chien, S. C.; Chen, M. L.; Kuo, H. T.; Tsai, Y. C.; Lin, B. F.; Kuo, Y. H., Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata. J. Agric. Food Chem., 2008, 56, 7017-7022.
112. Cheng, J. J.; Yang, C. J.; Cheng, C. H.; Wang, Y. T.; Huang, N. K.; Lu, M. K., Characterization and functional study of Antrodia camphorata lipopolysaccharide. J. Agric. Food Chem., 2005, 53, 469-474.
113. Shen, Y. C.; Wang, Y. H.; Chou, Y. C.; Chen, C. F.; Lin, L. C.; Chang, T. T.; Tien, J. H.; Chou, C. J., Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata. Planta Med., 2004, 70, 310-314.
114. Shen, Y. C.; Chou, C. J.; Wang, Y. H.; Chen, C. F.; Chou, Y. C.; Lu, M. K., Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiol. Lett., 2004, 231, 137-143.
115. Zhang, X. J.; Chen, S. J.; Chen, G. M., Study of Antrodia camphorata polysaccharide (ACP) on immunoregulation function in mice. Fujian Shifan Daxue Xuebao, Ziran Kexueban, 2011, 27, 79-84.
116. Liu, K. J.; Leu, S. J.; Su, C. H.; Chiang, B. L.; Chen, Y. L.; Lee, Y. L., Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. Immunology, 2010, 129, 351-362.
117. Juan, Y. S.; Mannikarottu, A.; Mien, C. S.; Li, S.; Lin Alpha, D.; Lan, C. C.; Schuler, C.; Leggett Robert, E.; Levin Robert, M., Protective effect of Antrodia camphorata on bladder ischemia/reperfusion injury. Int. Urol. Nephrol., 2010, 42, 637-645.
118. Chen, C. J.; Vijaya Krishna, R.; Tsai, C. C.; Wu, W. H.; Chao, L. K.; Hwang, K. H.; Chien, C. M.; Chang, H. Y.; Chen, S. T., Structure and functions of γ-dodecalactone isolated from Antrodia camphorata for NK cell activation. Bioorg. Med. Chem., 2010, 18, 6896-6904.
119. Cheng, P. C.; Hsu, C. Y.; Chen, C. C.; Lee, K. M., In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicol. Appl. Pharmacol., 2008, 227, 291-298.
120. Chen, Y. J.; Cheng, P. C.; Lin, C. N.; Liao, H. F.; Chen, Y. Y.; Chen, C. C.; Lee, K. M., Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. Int Immunopharmacol, 2008, 8, 458-467.
121. Chen, M. L.; Lin, B. F., Evaluation of the regulatory effects of dietary materials on allergic immune responses by in vitro and in vivo assay. Taiwan Nongye Huaxue Yu Shipin Kexue, 2007, 45, 316-326.
122. Cheng, J. J.; Lu, M. K.; Lin, C. Y.; Chang, C. C., Characterization and functional elucidation of a fucosylated 1,6-α-D-mannogalactan polysaccharide from Antrodia cinnamomea. Carbohydr. Polym., 2011, 83, 545-553.
123. Li, Y. H.; Chung, H. C.; Liu, S. L.; Chao, T. H.; Chen, J. C., A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice. Int Heart J, 2009, 50, 207-220.
124. Liu, D. Z.; Liang, Y. C.; Lin, S. Y.; Lin, Y. S.; Wu, W. C.; Hou, W. C.; Su, C. H., Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem., 2007, 71, 23-30.
125. Yang, H. L.; Hseu, Y. C.; Chen, J. Y.; Yech, Y. J.; Lu, F. J.; Wang, H. H.; Lin, P. S.; Wang, B. C., Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification. Am. J. Chin. Med., 2006, 34, 217-231.
126. Cheng, J. J.; Huang, N. K.; Chang, T. T.; Ling, W. D.; Lu, M. K., Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Life Sci., 2005, 76, 3029-3042.
127. Chen, S. C.; Lu, M. K.; Cheng, J. J.; Wang, D. L., Antiangiogenic activities of polysaccharides isolated from medicinal fungi. FEMS Microbiol. Lett., 2005, 249, 247-254.
128. Wang, G. J.; Tseng, H. W.; Chou, C. J.; Tsai, T. H.; Chen, C. T.; Lu, M. K., The vasorelaxation of Antrodia camphorata mycelia: Involvement of endothelial Ca2+-NO-cGMP pathway. Life Sci., 2003, 73, 2769-2783.
129. Chen, T. I.; Chen, C. W.; Lin, T. W.; Wang, D. S.; Chen, C. C., Developmental toxicity assessment of medicinal mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou (higher basidiomycetes) submerged culture mycelium in rats. Int J Med Mushrooms, 2011, 13, 505-511.
130. Chen, T. I.; Chen, C. C.; Lin, T. W.; Tsai, Y. T.; Nam, M. K., A 90-day subchronic toxicological assessment of Antrodia cinnamomea in Sprague-Dawley rats. Food Chem. Toxicol., 2011, 49, 429-433.
131. Male, K. B.; Crowley, S. M.; Collins, S. G.; Tzeng, Y.-M.; Luong, J. H. T., Cell-based impedance spectroscopy for probing inhibitory effects of steroids and ergostane/lanosta-related compounds. Anal. Methods, 2010, 2, 870-877.
132. Geethangili, M.; Fang, S. H.; Lai, C. H.; Rao, Y. K.; Lien, H. M.; Tzeng, Y. M., Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation. Food Chem., 2009, 119, 149-153.
133. Young, D. S.; Chiang, H. C.; Liu, L. K., Identification of bioactive components in Antrodia cinnamomea by MS/MS via EI ionization. J. Chin. Chem. Soc. (Taipei), 1998, 45, 123-129.
134. Shen, Y. C.; Yang, S. W.; Lin, C. S.; Chen, C. H.; Kuo, Y. H.; Chen, C. F., Zhankuic acid F: a new metabolite from a formosan fungus Antrodia cinnamomea. Planta Med., 1997, 63, 86-88.
135. Yang, S. W.; Shen, Y. C.; Chen, C. H., Steroids and triterpenoids of Antrodia cinnamomea,a fungus parasitic on Cinnamomum micranthum. Phytochemistry, 1996, 41, 1389-1392.
136. Cherng, I. H.; Wu, D. P.; Chiang, H. C., Triterpenoids from Antrodia cinnamomea. Phytochemistry, 1996, 41, 263-267.
137. Wu, D. P.; Chiang, H. C., Constituents of Antrodia cinnamomea. J. Chin. Chem. Soc. (Taipei), 1995, 42, 797-800.
138. Chiang, H. C.; Wu, D. P.; Cherng, I. W.; Ueng, C. H., A sesquiterpene lactone, phenyl and biphenyl compounds from Antrodia cinnamomea. Phytochemistry, 1995, 39, 613-616.
139. Cherng, I. H.; Chang, H. C.; Cheng, M. C.; Wang, Y., Three new triterpenoids from Antrodia cinnamomea. J. Nat. Prod., 1995, 58, 365-371.
140. Negishi, E. I.; Liou, S. Y.; Xu, C.; Hou, S., A Novel, Highly Selective, and General Methodology for the Synthesis of 1,5-Diene-Containing Oligoisoprenoids of All Possible Geometrical Combinations Exemplified by an Iterative and Convergent Synthesis of Coenzyme Q10. Org. Lett., 2002, 4, 261-264.
141. Chiang, B. H.; Lin, Y. W. Purification of an anti-cancer agent from Antrodia camphorata. European, Patent number:2010-954112, 2010.

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