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研究生:林育芳
研究生(外文):Yu-Fang Lin
論文名稱:椴木牛樟芝子實體對小鼠發炎性腸病之減緩作用
論文名稱(外文):Ameliorating effects of wood cultivated Antrodia cinnamomea fruiting body on inflammatory bowel disease in mice
指導教授:龔瑞林龔瑞林引用關係
指導教授(外文):Richard Zwe-Ling Kong
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:食品科學系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:101
中文關鍵詞:椴木牛樟芝子實體發炎性腸病小鼠
外文關鍵詞:wood cultivated Antrodia cinnamomea fruiting bodyinflammatory bowel disease in mice
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發炎性腸病是一種好發於20~40歲且有腹痛、腹瀉、體重減輕等症狀的腸道慢性發炎疾病,為造成結腸直腸癌的危險因子之一。牛樟芝在許多研究中已被證實具有抗氧化及抗發炎作用,但於發炎性腸病目前尚無相關研究,故本研究期待以牛樟芝之抗氧化及抗發炎生理作用可緩解發炎性腸病。本研究利用葡萄聚糖硫酸鈉餵食BALB/c小鼠以誘發產生發炎性腸病後,再分別使用1倍 (0.36mg/Kg)、2倍 (0.72mg/Kg) 及5倍 (1.8mg/Kg) 椴木牛樟芝子實體進行管餵,22天後檢測小鼠腸道萎縮情形、體重增減、抗氧化能力 (丙二醛)、發炎介質 (一氧化氮、腫瘤壞死因子-α、介白素-6) 的濃度。實驗結果顯示:經連續餵食椴木牛樟芝子實體於發炎性腸病小鼠22天後,能減緩小鼠腸道萎縮及體重減輕;腸道組織及血清的丙二醛濃度皆有顯著降低:同食,腸道組織及血清的一氧化氮、腫瘤壞死因子-α、介白素-6之濃度,皆有降低效果。由結果可知,椴木牛樟芝子實體對於發炎性腸病的小鼠其臨床症狀、抗氧化能力、抗發炎作用皆有正面影響。因此椴木牛樟芝子實體是一種可緩解發炎性腸病的潛在益處食品。
關鍵詞:發炎性腸病、椴木牛樟芝子實體、發炎反應介質

Inflammatory bowel disease is a important factor that causes colorectal cancer happened. Meanwhile, it is a kind of inflammatory bowel disease, easily relapsing and often occurs on 20 to 40 years-old-generation-disease. Diarrhea, Abdominal pain and Body weight loss usually come with it. Antrodia cinnamomea has been proved that it has anti-inflammatory effects in many researches. In this study, BALB/c strain of mice were feeded with 3% Dextran sulfate sodium (DSS) to induce inflammatory bowel disease. Then feeding the mice with 0.36mg/kg, 0.72mg/kg and 1.8mg/kg of wood cultivated antrodia cinnamomea fruiting body and try to find and discuss the effect of easing intestinal atrophy, stopping body weight loss and reducing the concentration inflammatory substances.This research found, by feeding wood cultivated antrodia cinnamomea for 2 weeks, Intestinal atrophy and weight loss can be eased or decelerated. It also helps to reduce the NO ,TNF-alpha and IL-6 concentration in the blood and intestinal tissue. However, the effect strength is not positively related to the dosage of wood cultivated antrodia cinnamomea. Thus, wood cultivated antrodia cinnamomea is supposed to be a potential health food for easing inflammatory bowel disease.

Keywords: inflammatory bowel disease, Wood Cultivated Antrodia Camphorata Fruiting Body, inflammation, cytokine

致謝……………………………………………………………………........I
名詞縮寫………………………………………………………………..…IV
摘要………………………………………………………………………...V
Abstract…………………………………………………………………. VI
目錄……………………………………………………………………....VII
附錄………………………………………………………………….........V
壹、緒論………………………………………………………………. ..1
貳、文獻回顧……………………………………………………………..3
一、發炎性大腸疾病簡介…………………………………………3
二、發炎反應的簡介………………………………………………5
三、發炎性腸病與發炎反應的關係………………………………7
四、牛樟芝的簡介………………………………………………..11
五、樟芝與發炎反應的關係………………………………………16
六、樟芝對於發炎反應的影響……………………………………18
參、實驗流程……………………………………………………………20
肆、實驗材料與方法 ………………………………………………….22
一、實驗材料 …………………………………………………..22
(一) 樣品來源 ……………………………………………22
(二) 藥品…………………………………………………..22
(三) 儀器設備 ……………………………………………23
二、實驗方法 …………………………………………………..25
(一) 樣品製備 ……………………………………………25
(二) 動物實驗 ………………………………………….. 25
1.動物實驗之飼養 ………………………………. 25
2.動物實驗流程與組別設定 ………………….… 26
3.動物餵食 ………………………………………..26
4.疾病指數評分 …………………………………..27
5.取得老鼠下腔主大動脈血及其他臟器 ……… 27
6.小鼠脾臟細胞之取得 ………………………… 27
7.小鼠腸組織處理 ……………………………… 28
8.血清脂質過氧化影響 ………………………… 28
9.血漿中細胞激素含量測定 …………………… 29
10.急性蛋白含量 ………………………………… 30
11.腎臟及肝臟組織冷凍切片 …………………… 31
三、統計方法 …………………………………………………31
伍、結果 …………………………………………………………… 32
陸、討論……………………………………………………………….41
柒、結論 ………………………………………………………………46
捌、參考文獻………………………………………………………… 47
玖、圖和表 …………………………………………………………...58
拾、附錄……………………………………………………………….77
圖目錄
圖一、餵食不同劑量椴木牛樟芝子實體對發炎性腸病之BALB/c 小鼠
體重的影響……………………………………...………………58
圖二、餵食不同劑量椴木牛樟芝子實體對 BALB/c 小鼠之平均攝食
量……………………………………………………….………59
圖三、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠腸道組織
MDA 的影響。………………………………………………..60
圖四、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠血清MDA
的影響。…………………….…………………………………61
圖五、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠腸道組織
IL-6 影響。……………………………………………….……62
圖六、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠血清IL-6 影
響。 ………………………………………..…………………. 63
圖七、椴木牛樟芝子實體對發炎性腸病之 BALB/c 腸道組織TNF-α
的影響。 …….……………………………………..…. ………64
圖八、椴木牛樟芝子實體對發炎性腸病之 BALB/c 血清TNF-α 的影
響。……….…………………………………………….………65
圖九、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠腸道組織
Nitric oxide 的影響。………………………………….………66
圖十、椴木牛樟芝子實體對發炎性腸病之 BALB/c 小鼠血清
Nitric oxide 的影響。………………………………….………67
圖十一、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成的疾病
指數影響。 …………………………………………………68
圖十二、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成腸道萎
縮之影響。 …………………………………………………69
圖十三、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成的脾臟
腫大之影響。……………………………………………….70
圖十四、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成的脾臟
與體重比值之影響。……………………………………… 71
圖十五、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成的肝臟
腫大之影響。…………………………………………….... 72
圖十六、椴木牛樟芝子實體對 3%DSS 誘導發炎性腸病造成的肝臟
與體重比值之影響。……………………………………….73
表目錄
表一、餵食不同劑量椴木牛樟芝子實體對以 3%DSS 造成發炎性腸
病小鼠,犧牲時其體內器官相對重量之影響。………………74
表二、椴木牛樟芝子實體對發炎性腸炎小鼠腸道組織NO 釋放、脂
質過氧化氫與促細胞激素之影。………………………….… 75
表三、椴木牛樟芝子實體對發炎性腸炎小鼠血清中 NO 釋放、脂質
過氧化氫與促細胞激素之影響。…………………………… 76
附錄目錄
附錄一、台灣地區死因結果…………………………………………77
附錄二、台灣地區十大死亡時鐘……………………………………78
附錄三、發炎性腸道疾病……………………………………………79
附錄四、NF-κB Family 的蛋白質組成及反應路徑 ………………80
附錄五、樟芝子實體………………………………………………….81
附錄六、樟芝的菌絲型態…………………………………………….82
附錄七、牛樟芝的酯類化合物結構 …………………………………83
附錄八、牛樟芝萜類化合物結構 (一) ………………………………84
附錄九、牛樟芝萜類化合物結構 (二) ………………………………85
附錄十、牛樟芝酚類化合物結構 (一) ………………………………86
附錄十一、牛樟芝酚類化合物結構 (二) ……………………………87
附錄十二、牛樟芝固醇類化合物結構……………………………….88
附錄十三、牛樟芝三種栽培法介紹………………………………….89
附錄十四、樟芝子實體化合物……………………………………… 90
附錄十五、疾病指數的評分表……………………………………… 91
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