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研究生:王鈺雯
研究生(外文):Yu-Wen Wang
論文名稱:使用行動電話與腦腫瘤相關性之文獻回顧
論文名稱(外文):Association for Mobile Phones Use and Brain Neoplasms:A Literature review
指導教授:陳保中陳保中引用關係
指導教授(外文):Pau-Chung Chen
口試委員:謝武勳林靜君
口試委員(外文):Wu-Shiun HsiehChing-Chun Lin
口試日期:2013-05-29
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:公共衛生碩士學位學程
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:55
中文關鍵詞:行動電話電磁波腦腫瘤輻射線神經膠質瘤腦膜瘤聽神經瘤
外文關鍵詞:Mobile phoneelectromagnetic wavesbrain neoplasmradiationgliomameningiomaacoustic neuroma
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自1980年代行動電話的發明後,行動電話通訊的普遍與發展為人們帶來了生活上與商業上的種種便利。但因使用行動電話而造成暴露在電磁波的危害健康議題,愈來愈引起民眾的關注。
本研究的目的是用文獻蒐集並加以統合分析的研究方法,來探究使用行動電話與罹患腦腫癌之風險的醫學文獻證據。文獻研究方式,以文獻搜尋是使用電腦查尋資料庫包含有MEDLINE(Pub Med database醫學資料庫www.ncbi.nlm.nih.gov)、EMBASE、Cochrane Library、思博網(CEPS)和台灣碩博士論文知識加值系統等醫學資料庫之相關文獻,搜尋關於使用行動電話影響罹患腦腫瘤危險性的研究報告,以用使用行動電話和罹患腦腫瘤的相關病例對照研究,以目前的醫學研究尚無一致的定論使用行動電話會增加罹患腦腫瘤的危險性。關於這些使用行動電話的研究,在研究方法上仍有一些限制,造成在推論上的困難。本研究將相關病例對照研究整合分析,增加研究個案數來探討行動電話使用與增加罹患腦瘤風險。
而在經過統合發現,腦膠質瘤的發生與長時間使用動電話(超過四百小時及十年以上者)其勝算比分別為1.09(1.00,1.19)及1.24(1.09,1.40),而使用超過十年的類比及數位行動電話,其好發率的勝算比分為1.28(1.14,1.44)及1.14(1.05,1.23)而行動電話慣用手與好發位置同側勝算比為1.24(1.14,1.34)。
經由整合統計而經然對於電磁波暴露造成腦膠質瘤風險的生物機制,未來仍需要更多的相關研究,來釐清使用行動電話是否會對人體的健康造成傷害。


After the invention of mobile phones in 1980s, the communication have become more convenient and more often than ever. However, the health-related issues in the exposure of electromagnetic waves along with the use of mobile phones attract more and more attention from the public.
The aim of the study was to explore the association between the use of mobile phones and the incidence risk of brain tumors by reviewing related literature and meta-analysis. The related literature were search through database systems include MEDLINE, EMBASE, Cochrane Library, CEPS and National Digital Library of Theses and Dissertations in Taiwan (NDLTD in Taiwan). Those articles were included only for case-control studies. According to the articles reviewed, the consistent relationship between the mobile phones use and increased risk of brain tumors (glioma, meningioma, acoustic neuroma) was still unavailable. According to the limited cases and methods, we use the meta-analysis to explore the association of the mobile phone use and the increase risk of the brain tumor.
After the meta-analysis had been carried out, for people who have used mobile phones more than 400 hours and those who have used mobile phones more than 10years, the odds ratios for the risk of suffering from glioma are 1.09 (95% confidence interval: 1.00-1.19) and 1.24(95% confidence interval: 1.09-1.40). For people who have used analogous mobile phones and those who have used digital mobile phones more than 10 years, the odds ratios for the risk of suffering from glioma are 1.28 (95% confidence interval: 1.14-1.44) and 1.14(95% confidence interval: 1.05-1.23). For people with ipsilateral mobile phones, the odds ratio for the risk of suffering from glioma is 1.24 (95% confidence interval: 1.14-1.34).

Further researches are needed to clarify the biological mechnism lying between the risk of suffering form glioma and exposure of electromagnetic waves and to elucidate the health impact of mobile phones.
Key word: Mobile phone, electromagnetic waves, brain neoplasm, radiation, glioma, meningioma, acoustic neuroma


致謝.............................................................................................................I
中文摘要....................................................................................................II
英文摘要..................................................................................................III
圖目錄......................................................................................................VI
表目錄……………………………………………………………….…VII
第一章 緒論............................................................................................1
第一節 研究背景............................................................................................1
第二節 實習單位簡介....................................................................................3
第三節 專有名詞解釋....................................................................................5
第二章 材料與方法................................................................................7
第一節 文獻搜尋過程......................................................................................7
第二節 文獻甄選準則......................................................................................8
第三節 整合分析粗勝算比及其信賴區間之計算方式..................................9
第三章 結果..........................................................................................10
第一節 使用行動電話/腦膠質瘤................................................................17
第二節 使用行動電話/腦膜瘤....................................................................24
第三節 使用行動電話/聽神經瘤................................................................31
第四章 討論..........................................................................................39
第五章 結論與建議..............................................................................48
第六章 參考文獻..................................................................................49


1.Diem E., Schwarz C., Adlkofer F., Jahn O. & Rudiger H. (2005).
Non-thermal DNA breakage by mobile-phone radiation (1800MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 583(2): p. 178-183.
2.Nylund R. & Leszczynski D. (2006). Mobile phone radiation causes
changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent. Proteomics, 6(17): p. 4769-4780.
3.Panagopoulos D.J., Chavdoula E.D., Nezis I.P. & Margaritis L.H. (2007).
Cell death induced by GSM 900-MHz and DCS 1800-MHz mobile telephony radiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 626(1-2): p. 69-78.
4.Remondini D., Nylund R., Reivinen J., Poulletier de Gannes F., Veyret B.,
Lagroye I., Haro E., Angeles Trillo M., Capri M., Franceschi C. Schlatterer K., Gminski R., Fitzner R., Tauber R., Schuderer J., Kuster N., Leszczynski D., Bersani F. & Maercker C. (2006). Gene expression changes in human cells after exposure to mobile phone microwaves. Proteomics, 6(17): p. 4745-4754.
5.Thorlin T., Rouquette JM., Hamnerius Y., Hansson E., Persson M., Bjorklund
U., Rosengren L. Ronnback L. & Persson M. (2006). Exposure of cultured astroglial and microglial brain cells to 900 MHz microwave radiation. Radiat Res, 166(2): p. 409-21.
6.Valberg, P.A. (1997). Radio frequency radiation (RFR): the nature of exposure
and carcinogenic potential. Cancer Causes Control, 8(3): p. 323-32.
7.Goldsmith, J.R. (1997). Epidemiologic evidence relevant to radar (microwave)
effects. Environ Health Perspect, 105 Suppl 6: p. 1579-87.
8.Hyland, G.J. (2000). Physics and biology of mobile telephony. Lancet,
356(9244): p. 1833-6.
9.McKinlay, A.F. (1997). Possible health effects related to the use of
radiotelephones. Radiol Prot Bull, 187: p. 9-16.
10.Repacholi, M.H. (1998). Low-level exposure to radiofrequency
electromagnetic fields: health effects and research needs. Bioelectromagnetics, 19(1): p. 1-19.
11.Baan R., Grosse Y., Lauby-Secretan B., El Ghissassi F., Bouvard V.,
Benbrahim-Tallaa L., Guha N., Islami F, Galichet L. & Straif K.
(2011). Carcinogenicity of radiofrequency electromagnetic fields.
Lancet Oncology, 12(7): p. 624-626.
12.Ahlbom A., Green A., Kheifets L., Savits D. & Swerdlow A. (2004).
Epidemiology of health effects of radiofrequency exposure. Environ Health Perspect, 112(17): p. 1741-54.
13.Moulder J.E., Foster K.R., Erdreich L.S. & McNamee J.P. (2005). Mobile
phones, mobile phone base stations and cancer: a review. Int J Radiat Biol, 81(3): p. 189-203.
14.National Radiological Protection Board(NRPB). (2004). Mobile phones and
health 2004: report by the board of NRPB. Doc NRPB, 15: 1-114.
15.Markova, E., O.G. Malmgren L., & Belyaev I.Y. (2010). Microwaves from
Mobile Phones Inhibit 53BP1 Focus Formation in Human Stem Cells More Strongly Than in Differentiated Cells: Possible Mechanistic Link to Cancer Risk. Environmental Health Perspectives, 118(3): p. 394-399.
16.Gladson C.L., Prayson R.A. & Liu W. (2010). The pathobiology of glioma
tumors. Annu Rev Pathol, 5: p. 33-50.
17.Muscat J.E., Malkin M.G., Thompson S., Shore R.E., Stellman S.D., McRee
D., Neugut A.I. & Wynder E.L. (2000). Handheld cellular telephone use and risk of brain cancer. Journal of the American Medical Association, 284(23): p. 3001-3007.
18.Inskip P.D., Tarone R.E., Hatch E.E., Wilcosky T.C., Shapiro W.R., Selker
R.G., Fine H.A., Black P.M., Loeffler J.S. & Linet M.S. (2001). Cellular-telephone use and brain tumors. New England Journal of Medicine, 344(2): p. 79-86.
19.Auvinen A., Hietanen M., Luukkonen R. & Koskela RS. (2002). Brain tumors
and salivary gland cancers among cellular telephone users. Epidemiology, 13(3): p. 356-9.
20.Muscat J.E., Malkin M.G., Shore R.E., Thompson S., Neugut A.I., Stellman
S.D. & Bruce J. (2002). Handheld cellular telephones and risk of acoustic neuroma. Neurology, 58(8): p. 1304-6.
21.Christensen H.C., Schuz J., Kosteljanetz M., Skovgaard Poulsen H., Thomsen
J. & Johansen C. (2004). Cellular telephone use and risk of acoustic neuroma. American Journal of Epidemiology, 159(3): p. 277-283.
22.Lonn S., Ahlbom A., Hall P. & Feychting M. (2004). Mobile phone use and
the risk of acoustic neuroma. Epidemiology, 15(6): p. 653-659.
23.Christensen H.C., Schuz J., Kosteljanetz M., Skovgaard Poulsen H., Boice
J.D., McLaughlin J.K. & Johansen C. (2005). Cellular telephones and risk for brain tumors - A population-based, incident case-control study. Neurology, 64(7): p. 1189-1195.
24.Hardell L., Carlberg M. & Hansson Mild K. (2005). Case-control study on
cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003. Neuroepidemiology, 25(3): p. 120-8.
25.Lonn S., Ahlbom A., Hall P. & Feychting M. (2005). Long-Term Mobile
Phone Use and Brain Tumor Risk. American Journal of Epidemiology, 161(6): p. 526-535.
26.Schoemaker M.J., Swerdlow A.J., Ahlbom A., Auvinen A., Blaasaas K.G.,
Cardis E., Christensen H. C., Feychting M., Hepworth S.J., Johansen C., Klaeboe L., Lonn S., McKinney P.A., Muir K., Raitanen J., Salminen T., Thomsen J. & Tynes T. (2005). Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries. Br J Cancer, 93(7): p. 842-8.
27.Hardell L., Carlberg M. & Hansson Mild K. (2006). Pooled analysis of two
case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997-2003. Int Arch Occup Environ Health, 79(8): p. 630-9.
28.Hardell L., Carlberg M. & Hansson Mild K. (2006). Pooled analysis of two
case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997-2003. International Journal of Oncology, 28(2): p. 509-18.
29.Hepworth S.J., Schoemaker M.J., Muir K.R., Swerdlow A.J., A van Ton geren
M.J. & McKinney P.A. (2006). Mobile phone use and risk of glioma in adults: case-control study. BMJ, 332(7546): p. 883-7.
30.Schuz J., Bohler E., Berg G., Schlehofer B., Hettinger I., Schlaefer K.,
Wahrendorf J., Kunna-Grass K. & Blettner M. (2006). Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol, 163(6): p. 512-20.
31.Takebayashi T., Akiba S., Kikuchi Y., Taki M., Wake K., Watanabe S. &
Yamaguchi N. (2006). Mobile phone use and acoustic neuroma risk in Japan. Occupational and Environmental Medicine, 63(12): p. 802-807.
32.Klaeboe L., Blaasaas K.G. & Tynes T. (2007). Use of mobile phones in
Norway and risk of intracranial tumours. Eur J Cancer Prev, 16(2): p. 158-64.
33.Lahkola A., Auvinen A., Raitenen J., Schoemaker M.J., Christensen H.C.,
Feychting M., Johansen C., Klaeboe L., Lonn S., Swerdlow A.J., Tynes T. & Salminen T. (2007). Mobile phone use and risk of glioma in 5 North European countries. Int J Cancer, 120(8): p. 1769-75.
34.Lahkola A., Salminen T., Raitenen J., Heinavaara S., Schoemaker M.J.,
Christensen H.C., Johansen C., Klaeboe L., Lonn S., Swerdlow A.J., Tynes T. & Auvinen A. (2008). Meningioma and mobile phone use--a collaborative case-control study in five North European countries. International Journal of Epidemiology, 37(6): p. 1304-1313.
35.Sadetzki S., Chetrit A., Jarsu-Hakak A., Cardis E., Deutch Y., Duvdevani S.,
Zultan A., Novikov I., Freedman L. & Wolf M. (2008). Cellular Phone Use and Risk of Benign and Malignant Parotid Gland Tumors--A Nationwide Case-Control Study. American Journal of Epidemiology, 167(4): p. 457-467.
36.Takebayashi T., Varsier N., Kikuchi Y., Wake K., Taki M., Watanabe S., Akiba
S. & Yamaguchi N. (2008). Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case-control study. Br J Cancer, 98(3): p. 652-9.
37.The INTERPHONE Study Group. (2010). Brain tumour risk in relation to
mobile telephone use: results of the INTERPHONE international case-control study. International Journal of Epidemiology, 39(3): p. 675-694.
38.Aydin D., Feychting M., Schuz J., Tynes T., Veje Andersen T., Samso Schmidt
L., Harbo Poulsen A., Johansen C., Prochazka M., Lannering B., Klaeboe L., Eggen T., Jenni D., Grotzer M., Von der Weid N., Kuehni C.E. & Roosli M. (2011). Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study. Journal of the National Cancer Institute, 103(16): p. 1264-1276.
39.Cardis E., Armstrong B.K., Bowman J.D., Giles G.G., Hours M., Krewski D.,
McBride M., Parent M.E., Sadetzki S., Woodward A. Brown J., Chetrit A., Figuerola J., Hoffmann C., Jarus-Hakak A., Montestruq L., Nadon L., Richardson L., Villegas R. & Vrijheid M. (2011). Risk of brain tumours in relation to estimated RF dose from mobile phones: results from five Interphone countries. Occupational and Environmental Medicine, 68(9): p. 631-640.
40.Sato Y., Akiba S., Kubo O. & Yamaguchi N. (2011). A case-case study of
mobile phone use and acoustic neuroma risk in Japan. Bioelectromagnetics, 32(2): p. 85-93.
41.Carlberg M. & Hardell L. On the association between glioma, wireless
phones, heredity and ionising radiation. Pathophysiology, 19(4), p.243-252.
42.Johansen C, Boice Jr. JD., McLaughlin JK & Olsen JH. (2001). Cellular
telephones and cancer-a nationwide cohort study in Denmark. Journal of the National Cancer Institute, 93(3): p.203-207.
43.Schuz J, Jacobsen R, Olsen JH., Boice Jr. JD., McLaughlin JK & Johansen C.
(2006). Cellular phone use and cancer risk: Update of a nationwide Danish cohort, Journal of the National Cancer Institute, 98(23): p.203-207.
44.Frei P, Poulsen AH, Johasen C, Olsen JH., Steding-Jessen M. & Schuz J
(2011). Use of mobile phones and risk of brain tumours: update of Danish cohort study. BMJ.
45. Ardoino L., Barbieri E. & Vecchia P. (2004). Determinantsof exposure to
electromagnetic fields from mobile phones. Radiat Prot Dosimetry, 111(4): p.403–406.
46.Vrijheid M., Cardis E., Armstrong B.K., Auvinen A., Berg G. & Blaasaas
K.G. (2006). Validation of short term recall of mobile phone use for the Interphone study. Occup Environ Med, 63(4): p.237–243.
47.Inyang I., Benke G.P., McKenzie R.J., Anderson V. and Abramson M.J.
(2007). Comparison of measuring instruments for radiofrequency radiation from mobile telephones in epidemiological studies: Implications for exposure assessment. J Expos Sci Environ Epidemiol, 18(2): p.134–141.
48.Florian I.S., Ungureanu G. & Berce C. (2013). Risk factors for gliomas. An
extensive review. Romanian Neurosurgery, XXI: p.5-21.
49.Behin A., Khe H.X., Carpenter A.F. & Delattre J.Y. (2003). Primary brain
tumours in adults. The Lancet 361, p.323-331.
50. Camp-Sorrell D. (2006). Brain tumors: Facing trouble head-on. Nursing made
Incredibly Easy!, 4(3), p.20-28.
51. Navas-Acien A, Pollan M., Gustavsson P. & Plato N. (2002). Occupation,
exposure to chemical and risk of gliomas and meningiomas in Sweden. J. Ind. Med. 42, p.214-227.
52. Cocco P., Dosemeci M., & Heineman E.F. (1998). Brain tumor and
occupational exposure to lead. J. Occup. Environ. Med. 40, p.937-942.
53.Siemiatycki J., Richardson L., Straif K., Latreille B., Lakhani R., Campbell S.,
Rousseau M.C. & Boffetta P. (2004). Listing occupational carcinogens. Environ Health Perspect. 112, p.1447-1459.
54.Hardell L., Mild K.H. & Calberg M. (2002). Case-control study on the use of
cellular and cordless phones and the risk for malignant brain tumours. Int. J. Radiat. Biol. 78, p.931-936.
55.Schlehofer B., Blettner M., Preston-Martin S., Niehoff D., Wahrendorf J.,
Arslan A., Ahlbom A., Choi W. N., Giles G. G.,Howe G. R., Little J., Menegoz F. & Ryan, P. (1999). Role of medical history in brain tumour development. Results from the international adult brain tumour study. Int. J. Cancer. 82, p.155 – 160.
56.Elexpuru-Camiruaga J., Buxton N., Kandula V., Dias P. S., Campbell D.,
McIntosh J., Broome J., Jones P., Inskip A. & Alldersea J. (1995). Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res. 55, p.4237 – 4239.
57.Kelsey K. T., Wrensch M., Zuo Z. F., Miike R. & Wiencke J. K. (1997). A
population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors. Pharmacogenetics, 7, p.463 – 468.
58.Ezer R., Alonso M., Pereira E., Kim M., Allen J. C., Miller D. C., &
Newcomb E. W. (2002). Identification of glutathione S-transferase (GST) polymorphisms in brain tumors and association with susceptibility to pediatric astrocytomas. J. Neurooncol. 59, p.123 – 134.
59.De Roos A. J., Rothman N., Inskip P. D., Linet M. S., Shapiro W. R., Selker
R. G., Fine H. A., Black P. M., Pittman G. S. & Bell, D. A. (2003). Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 12, p.14 – 22.
60.Department of Health(United Kindom), Scottish Executive, The Northern
Ireland Executive and The National Assembly for Wales. (2000). Mobile Phones and Health.
61. Interdisziplina re Gesellschaft fur Umweltmedizin e. V. (2002). FREIBURGER APPEAL. Retrieved from http://www.powerwatch.org.uk/pdfs/20021019_englisch.pdf
62. Azoulay Y. & Rinat Z. (2008, July 28). Health Ministry calls for parents to
limit kids'' use of cell phones. Haaretz News. Retrieved from http://www.haaretz.com/print-edition/news/health-ministry-calls-for-parents-to-limit-kids-use-of-cell-phones-1.250559
63. Robinson S. (2009, August 15). Japan: Law Banning Cell Phones for Kids Passed in Ishikawa. Global Voices. Retrieved from http://globalvoicesonline.org/2009/08/15/japan-law-banning-cell-phones-for-kids-passed-in-ishikawa/
64. Minister of Transport of New Zealand (2009). Land Transport (Road User) Amendment Rule 2009.
65. Environmental Health Trust (2013). Worldwide Cell Phone Safety
Recommendations and Policies-Finland, retrieved from
http://ehtrust.org/finland/
66. Kapdi M., Hoskote S.S. & Joshi S.R. (2008). Health hazards of mobile
phones: An India perspective. Journal of The Association of Physicians of India, 56, p.893-897.
67. Environmental Health Trust (2013). Worldwide Cell Phone Safety
Recommendations and Policies-USA-California, retrieved from http://ehtrust.org/california/
68. Environmental Health Trust (2013). Worldwide Cell Phone Safety
Recommendations and Policies-USA-Maine, retrieved from
http://ehtrust.org/maine/
69. Environmental Health Trust (2013). Worldwide Cell Phone Safety
Recommendations and Policies-Belgium, retrieved from http://ehtrust.org/belgium/
70. Environmental Health Trust (2013). Worldwide Cell Phone Safety
Recommendations and Policies-France, retrieved from
http://ehtrust.org/france/
71. Australian Radiation Protection and Nuclear Safty Agency (2013). Mobile
phones and children. Fact Sheet in electromagnetic energy(EME) Series No.11.
72. 國民健康局(2011)。兒童與青少年使用行動電話之建議事項,取自
http://bhp.doh.gov.tw/download/RecentConcern/兒童與青少年使用行動電話之建議事項.pdf
73. 教育部(2011)。校園攜帶行動電話使用規範原則,教育部臺環字第
1000153196B號函。
74. Ferlay J., Steliarova-Foucher E., Lortet-Tieulent J., Rosso S., Coeburgh
J.W.W., Comber H., Forman D. & Bray F. (2013). Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer, 49, p.1374-1403.


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