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研究生:趙文嘉
研究生(外文):Chao, Wen-Chia
論文名稱:長期運動訓練對於停經合併高血壓大鼠 心血管功能之影響
論文名稱(外文):Effects of Long-term Exercise Training on Cardiovascular Function in Ovariectomized Hypertensive Rats
指導教授:楊艾倫楊艾倫引用關係
指導教授(外文):Yang, Ai-Lun
口試委員:王儷穎簡位先
口試日期:2013-07-11
學位類別:碩士
校院名稱:臺北巿立體育學院
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:89
中文關鍵詞:運動停經高血壓心血管功能
外文關鍵詞:Exercisepostmenopausehypertensioncardiovascular function
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背景和目的:停經後婦女因卵巢功能逐漸衰退,造成雌激素分泌不足,進而影響高血壓、腦中風、和心肌梗塞等心血管疾病之發病率,但至今關於停經合併心血管疾病之研究仍顯不足。許多研究發現高血壓患者會出現心肌肥大和血管功能異常的情形,可能與氧化壓力的上升有關。目前已知停經後婦女除了補充雌激素之外,運動訓練也能有效改善其心血管功能,但關於運動訓練是否有效改善停經合併高血壓婦女之心血管功能仍是未知的。因此本研究目的主要是以停經合併高血壓之動物模式,探討長期運動訓練對於停經合併高血壓之心血管功能的影響,進一步研究其生理機制。方法:本研究使用自發性高血壓大鼠,於十五週大時進行卵巢切除手術,實驗組別分為卵巢切除合併運動訓練組、卵巢切除組和假手術組,並以周齡相符之正常血壓組作為對照組。運動訓練計畫是以跑步機進行運動六十分鐘,每週五天,為期八週。於運動介入前後,分別測量四組血壓、心跳、血管功能和血液抗氧化酵素等參數,最後進行四組分析比較。結果:本研究發現於八週運動訓練後,與卵巢切除組和假手術組相較下,顯示:一、顯著降低收縮壓 (p<0.05);二、顯著增加由乙醯膽鹼、胰島素和類胰島素生長因子-1所調節之血管舒張功能 (p<0.05);三、降低胰島素阻抗 (p<0.05);四、增加一氧化氮生成量 (p<0.05);五、增加血管中一氧化氮合成酶、胰島素受器和類胰島素生長因子-1受器蛋白表現量 (p<0.05);六、增加抗氧化酵素活性 (p<0.05),但不改變脂質過氧化程度。結論:本篇研究發現長期運動介入能有效改善停經合併高血壓之心血管功能。

Background and purpose: Postmenopause is recognized as one of the risk factors for cardiovascular disease due to estrogen deficiency which could induce detrimental effects on cardiovascular function. However, few researches existed regarding the postmenopause with cardiovascular disease. Regular exercise has been reported to improve cardiovascular function and antioxidant activity. However, whether exercise training positively influences cardiovascular function in postmenopause with hypertension remained unclear. Therefore, the purpose of this study was to investigate the effects of long-term exercise training on cardiovascular function in postmenopause with hypertension, and further explore the physiological mechanisms. Methods: Fifteen-week-old female spontaneously hypertension rats (SHR) and Wistar-Kyoto (WKY) rats were used in this study. The SHR were randomly divided into three groups: (1) SHR with sham operation (SHR-sham), (2) SHR with ovariectomy (SHR-O), (3) SHR with ovariectomy and exercise training (SHR-OT). The WKY was used as the normotensive control group. The SHR-OT group was trained by the treadmill at moderate intensity for 5 days/week, 8 weeks. At the end of experiments, the cardiovascular responses and the related vascular protein expression were measured and compared among four groups. The serum levels of antioxidants and oxidants were also examined. Results: In comparison with the SHR-sham and SHR-O groups, the effects of exercise on the SHR-OT group significantly: (1) lowered systolic blood pressure (p<0.05); (2) increased acetylcholine-, insulin-, and IGF-1-induced vasorelaxant responses (p<0.05); (3) reduced insulin resistance (p<0.05); (4) increased nitric oxide production (p<0.05); (5) increased the protein expression of NOS, IR, and IGF-1R (p<0.05); (6) increased the antioxidant activity (p<0.05), but the level of lipid peroxidation remained unchanged. Conclusion: This study suggested that the long-term exercise intervention significantly improved cardiovascular function in postmenopause with hypertension.
原創聲明書
學位考試審定書
摘要
Abstract
謝誌
目錄
表目錄
圖目錄
第壹章 緒論
第一節 研究背景
第二節 研究目的
第三節 研究問題
第四節 研究假設
第貳章 文獻探討
第一節 停經之定義
第二節 停經與心血管疾病
第三節 氧化壓力與心血管疾病
第四節 心血管疾病與胰島素和類胰島素生長因子-1之關係
第五節 運動與心血管疾病
第參章 材料與方法
第一節 實驗動物
第二節 卵巢切除手術
第三節 長期運動訓練計畫
第四節 休息時心搏率與血壓之測量
第五節 胰島素阻抗分析
第六節 血管舒張反應之測量
第七節 一氧化氮含量分析
第八節 脂質過氧化物與抗氧化酵素的活性分析
第九節 檸檬酸合成酶之酵素活性分析
第十節 西方墨點法
第十一節 統計分析
第肆章 結果
第一節 基本生理參數
第二節 胰島素阻抗指標
第三節 檸檬酸合成酶活性分析
第四節 血管之舒張反應
第五節 一氧化氮含量分析
第六節 血管功能之相關蛋白質表現量
第七節 脂質過氧化物含量分析
第八節 抗氧化酵素活性分析
第伍章 討論與結論
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