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研究生(外文):Lin, Yu-Mei
論文名稱(外文):Effects of Protocatechuic Acid Supplementation on Cardiovascular Function in Ovariectomized Hypertensive Rats
指導教授(外文):Yang, Ai-Lun
外文關鍵詞:postmenopausehypertensionprotocatechuic acidcardiovascular functionantioxidant capacity
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背景與目的:根據美國心臟協會指出,停經後的女性因卵巢功能衰退,雌激素分泌減少,導致高血壓的罹病率較同年齡之男性高。造成女性停經後高血壓的原因可能與血管內皮功能異常、氧化壓力增加及動脈硬化等因素相關。有研究發現體內氧化壓力的改變會促使高血壓的發生,此外,經研究證實多酚類可藉由降低氧化壓力,改善心血管功能和預防心血管疾病的發生。原兒茶酸 (protocatechuic acid, PCA) 為一結構簡單的多酚類化合物,且為天然抗氧化劑,能夠清除自由基,但尚無研究探討原兒茶酸的補充對於停經合併高血壓之心血管功能的影響,因此本研究之目的主要探討原兒茶酸的補充對於停經合併高血壓之心血管功能的影響和其生理機制。方法:本研究之動物模式為自發性高血壓大鼠 (spontaneously hypertensive rat, SHR),於十五週大時進行卵巢切除,並於十七週大時介入,分成卵巢切除組 (SHR-O)、卵巢切除合併原兒茶酸補充組 (SHR-OP) 及假手術組 (SHR-sham),且以週齡相符之正常血壓鼠 (Wistar-Kyoto rat, WKY) 作為對照組。原兒茶酸補充組是給予每天每公斤體重200毫克之原兒茶酸添加至飲用水中,餵食八週。於原兒茶酸介入前後分別測量四組血壓、心跳、血管功能和血清抗氧化酵素等參數,最後進行四組分析比較。結果:本研究發現於八週原兒茶酸介入後,與假手術及卵巢切除組相比之結果顯示:一、收縮壓顯著下降;二、由乙醯膽鹼、胰島素及類胰島素生長因子-1所調節之血管舒張功能增加;三、胰島素阻抗下降;四、一氧化氮生成量增加;五、抗氧化能力增加;六、血管一氧化氮合成酶、胰島素受器及類胰島素生長因子 -1受器蛋白質表現量增加。結論:本研究發現經長期原兒茶酸補充能顯著改善停經合併高血壓族群之心血管功能和抗氧化能力。
Background and purpose: The American Heart Association has reported that the prevalence of hypertension-related cardiovascular complications is higher in postmenopausal women than in age-matched men. The possible causes of hypertension in postmenopausal women could be due to endothelial dysfunction, and increased oxidative stress, and arterial stiffness. There is growing evidence that polyphenols exert antioxidant effects to ameliorate the cardiovascular function. A simple phenolic acid, protocatechuic acid (PCA; 3,4-dihydroxybenzoic acid), shows a potent antioxidant capacity. However, whether PCA has positive effects on cardiovascular function in postmenopausal hypertension remains unknown. In this study, we explored the effects of PCA supplementation on cardiovascular function in postmenopausal hypertension. Methods: Female spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were used in this study. At fifteen weeks old, the SHR were sham-operated or bilaterally ovariectomized. After one week, these rats were divided into SHR with sham-operation (SHR-sham), SHR with ovariectomy (SHR-O) and SHR with ovariectomy and PCA supplementation (SHR-OP) groups. The SHR-OP group was supplemented with PCA solution (200 mg/kg/day) in their daily water consumption for 8 weeks. After the PCA supplementation, we measured and compared the blood pressure, vasorelaxant responses, and antioxidant capacity among four groups. Results: After 8-week PCA supplementation, we found that compared with the SHR-sham and SHR-O groups, (1) systolic blood pressure was significantly decreased (p<0.05); (2) acetylcholine-, insulin-, and IGF-1-induced vasorelaxant responses were significantly improved (p<0.05); (3) insulin resistance was significantly reduced (p<0.05); (4) nitric oxide production was significantly increased (p<0.05); (5) antioxidant capacity was enhanced (p<0.05); (6) the protein expression of NOS, IR, and IGF-1R was improved (p<0.05). Conclusion: Long-term PCA supplementation can significantly improve cardiovascular function and antioxidant capacity in the population of postmenopausal hypertension.
第壹章 緒論
第一節 研究背景
第二節 研究目的
第三節 研究問題
第四節 研究假設
第貳章 文獻探討
第一節 停經與高血壓
第二節 氧化壓力與心血管疾病
第三節 多酚與抗氧化之關係
第四節 原兒茶酸與心血管疾病
第五節 胰島素、類胰島素生長因子-1與心血管疾病
第參章 材料與方法
第一節 實驗動物
第二節 卵巢切除手術
第三節 休息時心搏率與血壓之測量
第四節 胰島素阻抗試驗
第五節 血管舒張反應之測量
第六節 一氧化氮之含量分析
第七節 脂質過氧化物及抗氧化酵素之活性分析
第八節 西方墨點法
第九節 統計分析
第肆章 結果
第一節 基本生理參數
第二節 胰島素阻抗試驗
第三節 血管舒張反應之測量
第四節 一氧化氮之含量分析
第五節 脂質過氧化物及抗氧化酵素之活性分析
第六節 血管功能相關蛋白質表現量
第伍章 討論

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