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研究生:王聖斐
研究生(外文):Wang,Sheng-Fei
論文名稱:八週運動和低蛋胺酸飲食對高血壓血管舒張功能之影響
論文名稱(外文):Effect of 8-week Exercise and Low-methionine Diet on Vasorelaxation in Hypertension
指導教授:楊艾倫楊艾倫引用關係
指導教授(外文):Yang, Ai-Lun
口試日期:2015-07-13
學位類別:碩士
校院名稱:臺北市立大學
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:79
中文關鍵詞:高血壓蛋胺酸運動血管舒張功能
外文關鍵詞:HypertensionMethionineExerciseVasorelaxation
相關次數:
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  • 下載下載:3
  • 收藏至我的研究室書目清單書目收藏:1
背景與目的:許多文獻指出蛋胺酸過量會造成心血管疾病、動脈硬化及膽固醇堆積,而限制蛋胺酸攝取可以防止脂肪堆積與血脂異常。然而關於運動訓練結合低蛋胺酸飲食對於心血管功能之影響目前所知仍然有限。因此,本研究目的以高血壓之動物模型,探討低蛋胺酸飲食與運動訓練介入對高血壓血管舒張功能之影響,並進一步探討其生理機制。方法:本研究使用六週齡自發性高血壓雄性大鼠(SHR),隨機分成3組,分別為: (1) 餵食含0.86%蛋胺酸之高血壓對照組 (SHR)、(2) 餵食含0.172%蛋胺酸之高血壓低蛋胺酸組(SHR-Met)、(3) 餵食含0.172%蛋胺酸合併運動訓練之高血壓低蛋胺酸合併運動組 (SHR-Met-Ex),另以相同週齡的正常血壓雄性大鼠(WKY) 做為對照組。低蛋胺酸餵食與運動訓練皆為期八週,各組於實驗結束時,以組織浴系統評估血管舒張功能,並進行相關蛋白質和血液分析,隨後進行各組之統計和比較。結果:本研究結果指出,經八週低蛋胺酸飲食與運動介入後:一、SHR-Met 及 SHR-Met-Ex 組之血清中胰島素含量與HOMA-IR 數值皆顯著低於SHR 組;二、SHR-Met 組及 SHR-Met-Ex 組乙醯膽鹼、胰島素與類胰島素生長因子-1 調節之血管舒張反應顯著高於 SHR 組;三、SHR-Met 及 SHR-Met-Ex 組之血管組織中胰島素接受器、類胰島素生長因子- 1接受器與內皮細胞一氧化氮合成酶的蛋白質表現量皆顯著高於 SHR 組;四、SHR-Met 及 SHR-Met-Ex 組血清之一氧化氮濃度皆顯著高於 SHR 組。結論:綜合以上結果,本研究證實八週低蛋胺酸飲食和運動介入對高血壓之血管功能有正向的影響。

Purpose: Evidences indicate that excessive methionine causes cardiovascular disease and methionine restriction may prevent dyslipidemia. However, effects of exercise training and methionine restriction on cardiovascular function in hypertension had not been fully explored. Therefore, the aim of our study was to investigate effects of eight-week exercise training and methionine restriction on vasorelaxation in hypertension and their underlying mechanisms. Methods: Six-week-old male spontaneously hypertensive rats (SHR) were randomly divided into three groups: sedentary control diet (SHR), SHR with low-methionine diet (SHR-Met), and SHR with low-methionine diet and exercise training (SHR-Met-Ex) groups. The Wistar-Kyoto (WKY) rats were used as the normotensive control group. The low-methionine diet and exercise training was intervened for 8 weeks. At the end of experiments, the vasorelaxation was evaluated by the organ bath system among four groups. Also, some of related vascular proteins and blood analyses were examined and compared. Results: After the 8-week intervention, we compared the findings with the SHR group: 1) the serum insulin concentration and HOMA-IR was significantly reduced in SHR-Met and SHR-Met-Ex groups; 2) the vasorelaxation mediated by acetylcholine, insulin, and IGF-1 was significantly increased in SHR-Met and SHR-Met-Ex groups; 3) the protein expression of insulin receptor, IGF-1 receptor, and eNOS was significantly increased in SHR-Met and SHR-Met-Ex groups; 4) the serum NO concentration was significantly increased in SHR-Met and SHR-Met-Ex groups. Conclusions: This study indicated that methionine restriction and exercise training had positive influences on vascular function in hypertension.
目錄

原創聲明書………………………………………………………………...ii
學位考試審定書…………………………………………………………..iii
中文摘要…………………………………………………………………..iv
英文摘要…………………………………………………………………..vi
謝誌………………………………………………………………………viii
目錄…………………………………………………………………….....ix
圖目錄…………………………………………………………………….xi

第壹章 緒論 1
第一節 研究背景 1
第二節 研究目的 1
第三節 研究問題 2
第四節 研究假設 2
第貳章 文獻探討 4
第一節 素食與心血管功能 4
第二節 蛋胺酸與心血管疾病 8
第三節 血管內皮功能、高血壓和心血管疾病之關係 11
第四節 體內激素與心血管疾病之關係 13
第五節 運動與心血管疾病 15
第參章 材料與方法 18
第一節 實驗動物的分組 18
第二節 長期低蛋胺酸和耐力運動訓練設計 19
第三節 血清胰島素阻抗分析 20
第四節 血清與胸主動脈的採取與保存 20
第五節 血管段活性試驗與舒張反應之量測 21
第六節 血管舒張反應之訊息傳遞分子作用 22
第七節 西方墨點法 23
第八節 一氧化氮濃度分析 25
第九節 統計分析 26
第肆章 結果 27
第一節 胰島素阻抗指標比較 27
第二節 血管舒張反應之比較 27
第三節 血管功能相關蛋白表現量分析比較 31
第伍章 討論與結論 34
參考文獻 41
圖………………………………………………………………………. 63


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