跳到主要內容

臺灣博碩士論文加值系統

(44.192.94.177) 您好!臺灣時間:2024/07/25 10:42
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:康雅慧
研究生(外文):Ya-Huei Kang
論文名稱:含鐵四物飲對鐵缺乏未停經婦女鐵質狀態改善之效果
論文名稱(外文):Effects of iron-containing Si-Wu drink on improvement of iron status in iron-deficient pre-menopausal women
指導教授:趙振瑞趙振瑞引用關係
指導教授(外文):Jane C-J Chao
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:95
中文關鍵詞:鐵質缺乏四物血清鐵儲鐵蛋白鐵調節素細胞激素IL-6未停經婦女
外文關鍵詞:iron deficiencySi-Wuferritinserum ironhepcidinIL-6pre-menopausal women
相關次數:
  • 被引用被引用:1
  • 點閱點閱:1670
  • 評分評分:
  • 下載下載:17
  • 收藏至我的研究室書目清單書目收藏:0
根據世界衛生組織之報告,目前全世界罹患缺鐵性貧血推估有2.1億。四物主要由當歸、川芎、熟地及白芍四種藥材所組成之中國傳統藥方,具有調節經期、補血及活血的功效。女性每個月經週期中血液流失鐵質,且飲食中鐵質攝取不足,使得身體中鐵質容易缺乏。本研究針對鐵質缺乏之未停經婦女於連續三次月經週期結束後,探討補充6天含鐵四物飲是否能改善月經週期鐵質流失之情形。篩選60位20-50歲未停經婦女受試者,依其血中儲鐵蛋白(ferritin)之生化值分為兩組,儲鐵蛋白小於20 ng/mL為L組,大於等於20 ng/mL為N組。實驗開始時受試者當月月經來潮(第一個月)之第16天與下次月經(第二個月)結束後隔天進行抽血作為基準值。並於第二個月抽血結束後給予連續6天含鐵四物飲(一天一瓶,含5 mg 亞鐵/每瓶120 mL),第三與四個月月經結束後給予連續6天含鐵四物飲,於第二、三及四個月月經來潮之第16天抽血,此三次抽血作為飲用含鐵四物飲實驗值。結果顯示未給予含鐵四物飲L組之血清鐵、儲鐵蛋白及鐵調節素(hepcidin)濃度相較於N組濃度稍低,給予含鐵四物飲後,L組顯著增加血液中儲鐵蛋白、血清鐵與鐵調節素之濃度。L組給予含鐵四物飲顯著降低於未給予含鐵四物飲血液中interleukin-6(IL-6)之濃度。給予含鐵四物飲對於鐵質缺乏之未停經婦女可改善鐵質狀態,並降低發炎指標。

Iron deficiency anemia is the most common type of anemia, affecting approximately 2.1 billion people around the world. Si-Wu is a traditional Chinese herbal medicine that has been widely used for regulating menstruation by promoting blood circulation and supplying iron. Si-Wu is comprised of four herbs, Angelica sinensis, Chuanxiong, Rehmannia glutinosa ,and Paeonia lactiflora. Pre-menopausal women are particularly susceptible to iron deficiency anemia due to blood loss during menstruation, especially when the diet is low in iron intake. This study investigated the effectiveness of iron-containing Si Wu drink in alleviating iron deficiency in pre-menopausal women. Sixty pre-menopausal women (20-50 years of age) were divided into two groups based on their blood ferritin levels; those with blood ferritin less than 20 ng/mL were designated as L (iron-deficient) group, and those with blood ferritin greater than 20ng/mL were designated as N (normal iron) group. The blood was drawn on the sixteenth day of their first menstruation (first month) and on the day after their next menstruation cycle (second month) to serve as the basal level of blood iron level. After the second blood collection and after each subsequent menstruation (second-fourth months), subjects were given one bottle of iron-containing (5 mg ferrous/bottle) Si-Wu drink a day for six days. Blood was drawn on the sixteenth day of the second, third, and fourth menstruations to serve as the experimental level of blood iron with iron-containing Si-Wu drink supplement. Prior to administration of Si Wu drinks, the L group showed lower blood ferritin, serum iron, and hepcidin than the N group. After consumption of iron-containing Si-Wu drinks, subjects in the L group had significantly increased blood ferritin, serum iron, and hepcidin, and significantly reduced pro-inflammatory factor interleukin-6 (IL-6). However, the N group showed no significant changes. Therefore, supplementation with iron-containing Si-Wu drink alleviates iron deficiency and suppresses inflammation in iron-deficient pre-menopausal women.

中文摘要…………………………………………………………………I
Abstract………………………………………………………………….II
致謝…………………………………………………………………….IV
目錄 ……………………………………………………………………VI
表目錄…………………………………………………………………..X
圖目錄 …………………………………………………………………XI
第一章 緒論……………………………………………….…………..1
第二章 文獻回顧…………………………………………………...…4
第一節 鐵之相關介紹…………………………………………….4
一、 鐵的生化與生理功能 4
二、 體內鐵質代謝與生物利用率 6
三、 鐵質建議量 10
四、 鐵質攝取過量 10
五、 鐵質補充劑與造成危害 10
第二節 缺鐵性貧血之簡介……………………………………...12
一、 缺鐵性貧血之流行病學數據 12
二、 鐵質缺乏之因素 12
三、 缺鐵性貧血之診斷標準 22
四、 缺鐵性貧血之進程 26
五、 缺鐵性貧血之族群與症狀 28
六、 缺鐵性貧血之受試者給予鐵劑 29
第三節 四物之成分……………………………………………...31
一、 當歸 (Angelica sinensis) 31
二、 川芎 (Chuanxiong) 32
三、 熟地 (Rehmannia glutinosa) 32
四、 白芍 (Paeonia lactiflora) 33
五、 四物對於貧血之影響 33
第三章 研究目的…………………………………………………….35
第四章 實驗材料與方法…………………………….………………36
第一節 受試者招募……………………………………………..36
第二節 實驗設計………………………………………………..38
第三節 分析方法及項目………………………………………..39
一、 飲食管理與基本紀錄 39
二、 含鐵四物飲之產品組成 39
三、 血液樣本 40
四、 血液分析 41
五、 統計分析 49
第五章 結果………………………………………………………….50
一、 受試者之基本資料 50
二、 飲食攝取量 52
三、 運動時間 54
四、 血液分析生化值 56
第六章 討論………………………………………………………….72
第一節 鐵質缺乏之診斷………………………………………...72
一、 血液生化指標 72
第二節 易造成鐵質缺乏之原因………………………………...74
一、 飲食 74
二、 運動 77
第三節 含鐵四物飲改善鐵質缺乏……………………………...78
一、 鐵質狀態 78
二、 紅血球狀態 79
三、 鐵質吸收相關因子 80
第四節 研究限制………………………………………………...82
第七章 結論………………………………………………………….83
第八章 參考文獻…………………………………………………….84
第九章 附件………………………………………………………….93


Ahmad J, Rafat D (2013) HbA1c and iron deficiency: a review. Diabetes Metab Syndr 7:118-122.
Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341:1986-1995.
Annibale B, Capurso G, Delle Fave G (2003) The stomach and iron deficiency anaemia: a forgotten link. Dig Liver Dis 35:288-295.
Auersperger I, Skof B, Leskosek B, Knap B, Jerin A, Lainscak M (2013) Exercise-induced changes in iron status and hepcidin response in female runners. PLoS One 8:e58090.
Beard J, Tobin B (2000) Iron status and exercise. Am J Clin Nutr 72:594s-597s.
Beard JL, Connor JR (2003) Iron status and neural functioning. Annu Rev Nutr 23:41-58.
Beghe C, Wilson A, Ershler WB (2004) Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am J Med 116 Suppl 7A:3s-10s.
Beyan C, Beyan E, Kaptan K, Ifran A, Uzar AI (2007) Post-gastrectomy anemia: evaluation of 72 cases with post-gastrectomy anemia. Hematology 12:81-84.
Bolan CD, Kurlander RJ, Schechter GP (2013) Interpretation of Standard Hematologic Tests. The Bethesda Handbook of Clinical Hematology 405-426.
Carmel R (2008) Nutritional anemias and the elderly. Semin Hematol 45:225-234.
Cartwright GE, Lauritsen MA, Humphreys S, Jones PJ, Merrill IM, Wintrobe MM (1946) The Anemia Associated With Chronic Infection. Science 103:72-73.
Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP (2008) An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS One 3:e4030.
Chien LW, Chang HC, Liu CF (2013) Effect of yoga on serum homocysteine and nitric oxide levels in adolescent women with and without dysmenorrhea. J Altern Complement Med 19:20-23.
Clark SF (2008) Iron deficiency anemia. Nutr Clin Pract 23:128-141.
Coad J, Conlon C (2011) Iron deficiency in women: assessment, causes and consequences. Curr Opin Clin Nutr Metab Care 14:625-634.
Cook JD, Monsen ER (1977) Vitamin C, the common cold, and iron absorption. Am J Clin Nutr 30:235-241.
Cook JD, Reddy MB (2001) Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 73:93-98.
Crichton RR, Charloteaux-Wauters M (1987) Iron transport and storage. Eur J Biochem 164:485-506.
Crichton RR, Wilmet S, Legssyer R, Ward RJ (2002) Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem 91:9-18.
Dawson-Hughes B, Seligson FH, Hughes VA (1986) Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal women. Am J Clin Nutr 44:83-88.
Di Santolo M, Stel G, Banfi G, Gonano F, Cauci S (2008) Anemia and iron status in young fertile non-professional female athletes. Eur J Appl Physiol 102:703-709.
Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL (2010) Proinflammatory state, hepcidin, and anemia in older persons. Blood 115:3810-3816.
Fisher K (1985) Summary of a report on assessment of the iron nutritional status of the United States population. Expert Scientific Working Group. Am J Clin Nutr 42:1318-1330.
Ganz T, Nemeth E (2011) Hepcidin and disorders of iron metabolism. Annu Rev Med 62:347-360.
Ganz T, Nemeth E (2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823:1434-1443.
Giamberardino MA, Berkley KJ, Iezzi S, de Bigontina P, Vecchiet L (1997) Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men. Pain 71:187-197.
Gleerup A, Rossander-Hulthen L, Gramatkovski E, Hallberg L (1995) Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. Am J Clin Nutr 61:97-104.
Goodhand JR, Kamperidis N, Rao A, Laskaratos F, McDermott A, Wahed M, Naik S, Croft NM, Lindsay JO, Sanderson IR, Rampton DS (2012) Prevalence and management of anemia in children, adolescents, and adults with inflammatory bowel disease. Inflamm Bowel Dis 18:513-519.
Haas JD, Brownlie Tt (2001) Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 131:676S-688S; discussion 688S-690S.
Hallberg L (2001) Perspectives on nutritional iron deficiency. Annu Rev Nutr 21:1-21.
Hallberg L, Bengtsson C, Garby L, Lennartsson J, Rossander L, Tibblin E (1979) An analysis of factors leading to a reduction in iron deficiency in Swedish women. Bull World Health Organ 57:947-954.
Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hulten L (1991) Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 53:112-119.
Hershko C, Camaschella C (2014) How I treat unexplained refractory iron deficiency anemia. Blood 123:326-333.
Hershko C, Patz J, Ronson A (2007) The anemia of achylia gastrica revisited. Blood Cells Mol Dis 39:178-183.
Hou YZ, Zhao GR, Yuan YJ, Zhu GG, Hiltunen R (2005) Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis. J Ethnopharmacol 100:140-144.
Joosten E, Hiele M, Pelemans W, Haesen E (1992) Blood loss from diagnostic laboratory tests in elderly patients. J Am Geriatr Soc 40:298.
Kiho T, Watanabe T, Nagai K, Ukai S (1992) Hypoglycemic activity of polysaccharide fraction from rhizome of Rehmannia glutinosa Libosch. f. hueichingensis Hsiao and the effect on carbohydrate metabolism in normal mouse liver. Yakugaku Zasshi 112:393-400.
Killip S, Bennett JM, Chambers MD (2007) Iron deficiency anemia. Am Fam Physician 75:671-678.
Kobune M, Miyanishi K, Takada K, Kawano Y, Nagashima H, Kikuchi S, Murase K, Iyama S, Sato T, Sato Y, Takimoto R, Kato J (2011) Establishment of a simple test for iron absorption from the gastrointestinal tract. Int J Hematol 93:715-719.
Kojima S, Inaba K, Kobayashi S, Kimura M (1996) Inhibitory effects of traditional Chinese medicine Shimotsu-to and its included crude fractions on adjuvant-induced chronic inflammation of mice. Biol Pharm Bull 19:47-52.
Li W, Guo J, Tang Y, Wang H, Huang M, Qian D, Duan JA (2012) Pharmacokinetic comparison of ferulic acid in normal and blood deficiency rats after oral administration of Angelica sinensis, ligusticum chuanxiong and their combination. Int J Mol Sci 13:3583-3597.
Liang QD, Lu XQ, Ma ZC, Tan HL, Ma BP, Gao Y, Wang SQ (2004) Preliminary study on hematopoietic constituents of si-wu-tang. Zhongguo Zhong Yao Za Zhi 29:546-549.
Liu C, Li J, Meng FY, Liang SX, Deng R, Li CK, Pong NH, Lau CP, Cheng SW, Ye JY, Chen JL, Yang ST, Yan H, Chen S, Chong BH, Yang M (2010) Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC Complement Altern Med 10:1-12.
Liu TC, Lin SF, Chang CS, Yang WC, Chen TP (2004) Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia: a Taiwanese study. Int J Hematol 80:416-420.
Lozoff B, Corapci F, Burden MJ, Kaciroti N, Angulo-Barroso R, Sazawal S, Black M (2007) Preschool-aged children with iron deficiency anemia show altered affect and behavior. J Nutr 137:683-689.
Lozoff B, Kaciroti N, Walter T (2006) Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr 84:1412-1421.
Ma ZC, Gao Y, Tang HL, Wang SQ (2003) The effects of si-wu-tang on serum protein of blood deficient mice induced by radiation. Zhongguo Zhong Yao Za Zhi 28:1050-1053.
MacKenzie EL, Iwasaki K, Tsuji Y (2008) Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal 10:997-1030.
Mitamura T, Kitazono M, Yoshimura O, Yakushiji M (1989) The influence of green tea upon the improvement of iron deficiency anemia with pregnancy treated by sodium ferrous citrate. Nihon Sanka Fujinka Gakkai Zasshi 41:688-694.
Morck T, Cook J (1981) Factors affecting the bioavailability of dietary iron. Cereal Foods World 12:667-672.
Motoya T, Miyashita M, Kawachi A, Yamada K (2000) Effects of ascorbic acid on interactions between ciprofloxacin and ferrous sulphate, sodium ferrous citrate or ferric pyrophosphate, in mice. J Pharm Pharmacol 52:397-401.
Munoz M, Garcia-Erce JA, Remacha AF (2011) Disorders of iron metabolism. Part II: iron deficiency and iron overload. J Clin Pathol 64:287-296.
Murray-Kolb LE, Beard JL (2009) Iron deficiency and child and maternal health. Am J Clin Nutr 89:946s-950s.
Nappi C, Tommaselli GA, Morra I, Massaro M, Formisano C, Di Carlo C (2009) Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. Acta Obstet Gynecol Scand 88:1031-1035.
Nielsen P, Gabbe EE, Fischer R, Heinrich HC (1994) Bioavailability of iron from oral ferric polymaltose in humans. Arzneimittelforschung 44:743-748.
Pan WH, Wu HJ, Yeh CJ, Chuang SY, Chang HY, Yeh NH, Hsieh YT (2011) Diet and health trends in Taiwan: comparison of two nutrition and health surveys from 1993-1996 and 2005-2008. Asia Pac J Clin Nutr 20:238-250.
Papanikolaou G, Pantopoulos K (2005) Iron metabolism and toxicity. Toxicol Appl Pharmacol 202:199-211.
Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810.
Polin V, Coriat R, Perkins G, Dhooge M, Abitbol V, Leblanc S, Prat F, Chaussade S (2013) Iron deficiency: from diagnosis to treatment. Dig Liver Dis 45:803-809.
Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89:1052-1057.
Ramakrishnan U, Yip R (2002) Experiences and challenges in industrialized countries: control of iron deficiency in industrialized countries. J Nutr 132:820s-824s.
Rasmussen K (2001) Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal mortality? J Nutr 131:590S-601S; discussion 601S-603S.
Rizvi S, Schoen RE (2011) Supplementation with oral vs. intravenous iron for anemia with IBD or gastrointestinal bleeding: is oral iron getting a bad rap? Am J Gastroenterol 106:1872-1879.
Rockey DC, Cello JP (1993) Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med 329:1691-1695.
Sakuma K, Ogawa M, Kimura M, Yamamoto K, Ogihara M (1998) Inhibitory effects of shimotsu-to, a traditional Chinese herbal prescription, on ultraviolet radiation-induced cell damage and prostaglandin E2 release in cultured Swiss 3T3 cells. Yakugaku Zasshi 118:241-247.
Sarker SD, Nahar L (2004) Natural medicine: the genus Angelica. Curr Med Chem 11:1479-1500.
Schumann K, Ettle T, Szegner B, Elsenhans B, Solomons NW (2007) On risks and benefits of iron supplementation recommendations for iron intake revisited. J Trace Elem Med Biol 21:147-168.
Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT (2005) Identification of an intestinal heme transporter. Cell 122:789-801.
Shils ME, Shike M (2006) Modern nutrition in health and disease. pp. 176-188.Lippincott Williams & Wilkins.
Skikne BS, Flowers CH, Cook JD (1990) Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 75:1870-1876.
Stein J, Dignass AU (2013) Management of iron deficiency anemia in inflammatory bowel disease - a practical approach. Ann Gastroenterol 26:104-113.
Stein J, Hartmann F, Dignass AU (2010) Diagnosis and management of iron deficiency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol 7:599-610.
Theil EC (2004) Iron, ferritin, and nutrition. Annu Rev Nutr 24:327-343.
Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, Sonnweber T, Eberwein L, Witcher DR, Murphy AT, Wroblewski VJ, Wurz E, Datz C, Weiss G (2009) Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood 113:5277-5286.
Ulvik RJ, Moller R, Hervig T (2013) Dietary supplement of iron for iron deficiency. Tidsskr Nor Laegeforen 133:845-849.
Van Wyck DB, Martens MG, Seid MH, Baker JB, Mangione A (2007) Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial. Obstet Gynecol 110:267-278.
Wians FH, Jr., Urban JE, Keffer JH, Kroft SH (2001) Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration. Am J Clin Pathol 115:112-118.
Wood RJ, Ronnenberg AG. Iron. In: Shils ME, Shike M, Ross AC,Caballero B, Cousins RJ, eds (2006)Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins 248-270.
Wu SJ, Pan WH, Yeh NH, Chang HY (2011) Trends in nutrient and dietary intake among adults and the elderly: from NAHSIT 1993-1996 to 2005-2008. Asia Pac J Clin Nutr 20:251-265.
Xu FH, Uebaba K (1999) Effect of Kampo formulations (traditional Chinese medicine) on circulatory parameters. Acupunct Electrother Res 24:11-28.
Yeh LL, Liu JY, Lin KS, Liu YS, Chiou JM, Liang KY, Tsai TF, Wang LH, Chen CT, Huang CY (2007) A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea. PLoS One 2:e719.
Yeh LL, Liu JY, Liu YS, Lin KS, Tsai TF, Wang LH (2009) Anemia-related hemogram, uterine artery pulsatility index, and blood pressure for the effects of Four-Agents-Decoction (Si Wu Tang) in the treatment of primary dysmenorrhea. J Altern Complement Med 15:531-538.
Yi L, Liang Y, Wu H, Yuan D (2009) The analysis of Radix Angelicae Sinensis (Danggui). J Chromatogr A 1216:1991-2001.
Zarychanski R, Houston DS (2008) Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response? Cmaj 179:333-337.
Zhang L, Jiang YR, Guo CY, Wu CF, Chen KJ, Yin HJ (2009) Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits. Chin J Integr Med 15:359-364.
Zhang RX, Li MX, Jia ZP (2008) Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 117:199-214.
Zhang W, Dai SM (2012) Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol 14:27-31.
Zimmermann MB, Hurrell RF (2007) Nutritional iron deficiency. Lancet 370:511-520. 
王瑞蓮、高美丁、翁瑤棽、詹恭巨、蕭寧馨(2012)國人膳食營養素參考攝取量極其說明第七版修訂版。pp. 518-573,衛生福利部食品藥物管理署,台北市。
陳志偉、祝彼得、許惠玉、劉曾敏、陳杏花、秦建(2007)四物湯配方顆粒與四物湯對骨髓抑制小鼠造血損傷恢復作用的比較研究。現代預防醫學 34:3058-3062。
楊嵐、祝彼得、陳為(2006)四物湯對再生障礙性貧血小鼠骨隨細胞增殖的影響研究。四川動物 4:881-883。
溫武慶、林家義(2005)鐵相關檢驗於診斷缺鐵性貧血的準確性及效益評估。內科學誌16:269-273。
潘文涵、章雅惠、陳正義、吳幸娟、曾明淑、高美丁(1999)國民營養健康狀況變遷調查 1993-1996以二十四小時飲食回顧法評估國人膳食營養狀況。pp.37-52,衛生福利部,台北市。
蕭寧馨、葉文婷、潘文涵(1998)國民營養健康狀況與變遷調查 1993-1996國人鐵營養狀況與缺鐵盛行率1993-1994。pp.197-208,衛生福利部,台北市。


QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top