|
1.Ministry of Health and Welfare [http://www.mohw.gov.tw/]
2.Lin WJ, Jiang RS, Wu SH, Chen FJ, Liu SA: Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study. J Oncol 2011, 2011:525976-525981.
3.Wu JY, Yi C, Chung HR, Wang DJ, Chang WC, Lee SY, Lin CT, Yang YC, Yang WC: Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol 2010, 46:226-231.
4.Thomas MB, Abbruzzese JL: Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005, 23:8093-8108.
5.Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Chiba K, Hoshino Y, Okumoto T: Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) 1994, 47:208-215.
6.Brinkmann V, Lynch KR: FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol 2002, 14:569-575.
7.Tedesco-Silva H, Mourad G, Kahan BD, Boira JG, Weimar W, Mulgaonkar S, Nashan B, Madsen S, Charpentier B, Pellet P, Vanrenterghem Y: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation 2005, 79:1553-1560.
8.Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 2000, 275:19513-19520.
9.Olivera A, Kohama T, Tu Z, Milstien S, Spiegel S: Purification and characterization of rat kidney sphingosine kinase. J Biol Chem 1998, 273:12576-12583.
10.Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S: Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999, 147:545-558.
11.Xia P, Gamble JR, Wang L, Pitson SM, Moretti PA, Wattenberg BW, D''Andrea RJ, Vadas MA: An oncogenic role of sphingosine kinase. Curr Biol 2000, 10:1527-1530.
12.Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S, Nakamura S: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem 2003, 278:46832-46839.
13.Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, et al: Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 2003, 278:40330-40336.
14.Lee MJ, Thangada S, Claffey KP, Ancellin N, Liu CH, Kluk M, Volpi M, Sha''afi RI, Hla T: Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 1999, 99:301-312.
15.Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, et al: FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 2007, 117:2408-2421.
16.Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, et al: FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 2008, 111:275-284.
17.Liu Q, Alinari L, Chen CS, Yan F, Dalton JT, Lapalombella R, Zhang X, Mani R, Lin T, Byrd JC, et al: FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clin Cancer Res 2010, 16:3182-3192.
18.Matsuoka Y, Nagahara Y, Ikekita M, Shinomiya T: A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. Br J Pharmacol 2003, 138:1303-1312.
19.Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, et al: FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 2005, 65:7478-7484.
20.Guneri P, Cankaya H, Yavuzer A, Guneri EA, Erisen L, Ozkul D, El SN, Karakaya S, Arican A, Boyacioglu H: Primary oral cancer in a Turkish population sample: association with sociodemographic features, smoking, alcohol, diet and dentition. Oral Oncol 2005, 41:1005-1012.
21.Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, et al: FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res 2007, 27:75-88.
22.Chua CW, Lee DT, Ling MT, Zhou C, Man K, Ho J, Chan FL, Wang X, Wong YC: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int J Cancer 2005, 117:1039-1048.
23.Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res 2003, 23:3183-3193.
24.Tanaka T, Takahara S, Hatori M, Suzuki K, Wang J, Ichimaru N, Suzuki S, Morozumi K, Okuyama A, Yamanaka H: A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine. Cancer Lett 2002, 181:165-171.
25.Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS: FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Res 2008, 68:1204-1212.
26.Sobel K, Menyhart K, Killer N, Renault B, Bauer Y, Studer R, Steiner B, Bolli MH, Nayler O, Gatfield J: Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem 2013, 288:14839-14851.
27.Omidbakhsh R, Rajabli B, Nasoohi S, Khallaghi B, Mohamed Z, Naidu M, Ahmadiani A, Dargahi L: Fingolimod affects gene expression profile associated with LPS-induced memory impairment. Exp Brain Res 2014, 232:3687-3696.
28.Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H: Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins. Am J Physiol Cell Physiol 2009, 297:C945-954.
29.Zhou C, Ling MT, Kin-Wah Lee T, Man K, Wang X, Wong YC: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett 2006, 233:36-47.
30.Permpongkosol S, Wang JD, Takahara S, Matsumiya K, Nonomura N, Nishimura K, Tsujimura A, Kongkanand A, Okuyama A: Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int J Cancer 2002, 98:167-172.
31.Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, et al: Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010, 362:402-415.
32.Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, et al: Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology 2011, 53:1943-1958.
33.Sobin LH: TNM: evolution and relation to other prognostic factors. Semin Surg Oncol 2003, 21:3-7.
34.Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC: Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995, 24:450-453.
35.Guha N, Boffetta P, Wunsch Filho V, Eluf Neto J, Shangina O, Zaridze D, Curado MP, Koifman S, Matos E, Menezes A, et al: Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol 2007, 166:1159-1173.
36.Gillison ML: Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck 2007, 29:779-792.
37.Neville BW, Day TA: Oral cancer and precancerous lesions. CA Cancer J Clin 2002, 52:195-215.
38.Poti Z, Mayer A: [Current methods of chemoradiotherapy for locally advanced cervical cancer. Options for reduction of side-effects]. Orv Hetil 2013, 154:803-809.
39.Mumme AM, Reitmeier F, Knecht R: [The current value of induction chemotherapy. ASCO Congress 2010]. Hno 2010, 58:1156, 1158, 1160-1152.
40.Lin JC, Jan JS, Hsu CY, Wong DY: High rate of clinical complete response to weekly outpatient neoadjuvant chemotherapy in oral carcinoma patients using a new regimen of cisplatin, 5-fluorouracil, and bleomycin alternating with methotrexate and epirubicin. Cancer 1999, 85:1430-1438.
41.Nakazawa M, Ohnishi T, Ohmae M, Chisoku H, Yui S, Iwai S, Sumi T, Fukuda Y, Kishino M, Yura Y: Phase II study of a novel oral formation of 5-fluorouracil in combination with low-dose cisplatin as preoperative chemotherapy of oral squamous cell carcinoma. Int J Clin Pharmacol Res 2005, 25:115-122.
42.Maiuri MC, Zalckvar E, Kimchi A, Kroemer G: Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007, 8:741-752.
43.Lockshin RA, Williams CM: PROGRAMMED CELL DEATH--I. CYTOLOGY OF DEGENERATION IN THE INTERSEGMENTAL MUSCLES OF THE PERNYI SILKMOTH. J Insect Physiol 1965, 11:123-133.
44.Ye X, Zhang C, Chen Y, Zhou T: Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell. J Cancer 2015, 6:48-53.
45.Kawahara R, Granato DC, Carnielli CM, Cervigne NK, Oliveria CE, Martinez CA, Yokoo S, Fonseca FP, Lopes M, Santos-Silva AR, et al: Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. PLoS One 2014, 9:e115004-115020.
46.Viet CT, Dang D, Achdjian S, Ye Y, Katz SG, Schmidt BL: Decitabine rescues cisplatin resistance in head and neck squamous cell carcinoma. PLoS One 2014, 9:e112880-112888.
47.Liang X, Tang J, Liang Y, Jin R, Cai X: Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci 2014, 4:10-21.
48.Taylor RC, Cullen SP, Martin SJ: Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008, 9:231-241.
49.Sun DY, Jiang S, Zheng LM, Ojcius DM, Young JD: Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation. J Exp Med 1994, 179:559-568.
50.Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 2007, 35:495-516.
51.McIlwain DR, Berger T, Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 2013, 5:a008656-008685.
52.Levine B, Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest 2005, 115:2679-2688.
53.Glick D, Barth S, Macleod KF: Autophagy: cellular and molecular mechanisms. J Pathol 2010, 221:3-12.
54.Tanida I, Ueno T, Kominami E: LC3 and Autophagy. Methods Mol Biol 2008, 445:77-88.
55.Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
56.Li X, Yan J, Wang L, Xiao F, Yang Y, Guo X, Wang H: Beclin1 inhibition promotes autophagy and decreases gemcitabine-induced apoptosis in Miapaca2 pancreatic cancer cells. Cancer Cell Int 2013, 13:26-35.
57.Lee JY, Oh TH, Yune TY: Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Endocrinology 2011, 152:2377-2386.
58.Atale N, Gupta S, Yadav UC, Rani V: Cell-death assessment by fluorescent and nonfluorescent cytosolic and nuclear staining techniques. J Microsc 2014, 255:7-19.
59.Oliveira T, Figueiredo CA, Brito C: Effect of Allium cepa L. on Lipopolysaccharide-Stimulated Osteoclast Precursor Cell Viability, Count, and Morphology Using 4'',6-Diamidino-2-phenylindole-Staining. 2014, 2014:535789-535796.
60.Wu JC, Lai CS, Badmaev V, Nagabhushanam K, Ho CT, Pan MH: Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol Nutr Food Res 2011, 55:1646-1654.
61.Kajstura M, Halicka HD, Pryjma J, Darzynkiewicz Z: Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms. Cytometry A 2007, 71:125-131.
62.Wu YC, Wu WK, Li Y, Yu L, Li ZJ, Wong CC, Li HT, Sung JJ, Cho CH: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem Biophys Res Commun 2009, 382:451-456.
63.Makarevic J, Rutz J, Juengel E, Kaulfuss S, Reiter M, Tsaur I, Bartsch G, Haferkamp A, Blaheta RA: Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2. PLoS One 2014, 9:e105590-105599.
64.Aries IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML: EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Leukemia 2014, 28:1828-1837.
65.Zhou X, Yuan L, Zhao X, Hou C, Ma W, Yu H, Xiao R: Genistein antagonizes inflammatory damage induced by beta-amyloid peptide in microglia through TLR4 and NF-kappaB. Nutrition 2014, 30:90-95.
66.Acheva A, Ghita M, Patel G, Prise KM, Schettino G: Mechanisms of DNA damage response to targeted irradiation in organotypic 3D skin cultures. PLoS One 2014, 9:e86092-86105.
67.Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, et al: Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev 2014, 28:1957-1975.
68.Xie X, Xiao H, Ding F, Zhong H, Zhu J, Ma N, Mei J: Over-expression of prolyl hydroxylase-1 blocks NF-kappaB-mediated cyclin D1 expression and proliferation in lung carcinoma cells. Cancer Genet 2014, 207:188-194.
69.Yang RC, Chang CC, Sheen JM, Wu HT, Pang JH, Huang ST: Davallia bilabiata Inhibits TNF-alpha-Induced Adhesion Molecules and Chemokines by Suppressing IKK/NF-kappa B Pathway in Vascular Endothelial Cells. Am J Chin Med 2014:1-19.
70.Kumar N, Gangappa D, Gupta G, Karnati R: Chebulagic acid from Terminalia chebula causes G1 arrest, inhibits NFkappaB and induces apoptosis in retinoblastoma cells. BMC Complement Altern Med 2014, 14:319-329.
71.Hafeez A, Elmadhoun O, Peng C, Ding JY, Geng X, Guthikonda M, Ding Y: Reduced Apoptosis by Ethanol and Its Association with PKC-delta and Akt Signaling in Ischemic Stroke. Aging Dis 2014, 5:366-372.
72.Lv H, Liu R, Fu J, Yang Q, Shi J, Chen P, Ji M, Shi B, Hou P: Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway. Cell Cycle 2014, 13:2962-2974.
73.Song G, Ouyang G, Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005, 9:59-71.
74.Johnson GL, Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1192.
75.Cagnol S, Chambard JC: ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence. Febs j 2010, 277:2-21.
76.Yang XL, Lin FJ, Guo YJ, Shao ZM, Ou ZL: Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways. Onco Targets Ther 2014, 7:1033-1042.
77.Mitter S, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn Jr WA, Ding J, et al: Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy 2014:1989-2005.
78.Moller P, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Klingberg H, Jensen DM, Christophersen DV, Hemmingsen JG, Cao Y, Loft S: Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles. Mutat Res Rev Mutat Res 2014, 762c:133-166.
79.Perillo B, Di Santi A, Cernera G, Ombra MN, Castoria G, Migliaccio A: Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS. Nucleus 2014, 5:482-491.
80.Su M, Mei Y, Sinha S: Role of the Crosstalk between Autophagy and Apoptosis in Cancer. J Oncol 2013, 2013:102735-102749.
81.Gump JM, Thorburn A: Autophagy and apoptosis: what is the connection? Trends Cell Biol 2011, 21:387-392.
82.Kim KR, Park KK, Chung WY, Hwang YS: The Inhibitory Effect of Buddlejasaponin IV on the Growth of YD-10B Human Oral Squamous Cell Carcinoma Cells. J Cancer Prev 2013, 18:330-336.
83.Shao Y, Qu Y, Dang S, Yao B, Ji M: MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6. Cancer Cell Int 2013, 13:51-60.
84.Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, et al: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. Anticancer Res 2009, 29:4503-4511.
85.Falck Miniotis M, Mukwaya A, Gjorloff Wingren A: Digital holographic microscopy for non-invasive monitoring of cell cycle arrest in L929 cells. PLoS One 2014, 9:e106546-106552.
86.Liao AJ, Hu R, Li YC, Yao K, Wang HH, Zhang R, Yang W, Liu ZG: [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266]. Zhonghua Xue Ye Xue Za Zhi 2011, 32:664-667.
87.Lu Z, Wang J, Zheng T, Liang Y, Yin D, Song R, Pei T, Pan S, Jiang H, Liu L: FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. BMC Cancer 2014, 14:783-794.
88.Al-Halabi R, Bou Chedid M, Abou Merhi R, El-Hajj H, Zahr H, Schneider-Stock R, Bazarbachi A, Gali-Muhtasib H: Gallotannin inhibits NFkB signaling and growth of human colon cancer xenografts. Cancer Biol Ther 2011, 12:59-68.
89.Sholler GS, Currier EA, Dutta A, Slavik MA, Illenye SA, Mendonca MC, Dragon J, Roberts SS, Bond JP: PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma. J Cancer Ther Res 2013, 2:21-42.
90.Harhaji-Trajkovic L, Arsikin K, Kravic-Stevovic T, Petricevic S, Tovilovic G, Pantovic A, Zogovic N, Ristic B, Janjetovic K, Bumbasirevic V, Trajkovic V: Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation. Pharm Res 2012, 29:2249-2263.
91.Castino R, Bellio N, Follo C, Murphy D, Isidoro C: Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells. Toxicol Sci 2010, 117:152-162.
92.Takatsuka C, Inoue Y, Matsuoka K, Moriyasu Y: 3-methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions. Plant Cell Physiol 2004, 45:265-274.
93.Seglen PO, Gordon PB: 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 1982, 79:1889-1892.
94.Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y: Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998, 23:33-42.
|