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研究生:施瑋泰
研究生(外文):Wei-Tai Shih
論文名稱:中藥小青龍湯的使用能降低小兒氣喘的住院率
論文名稱(外文):Xiao Qing Ling Tang use may reduce the risk of hospitalization in children with asthma
指導教授:陳保中陳保中引用關係
口試委員:李永寧吳清源顏宏融賴榮年
口試日期:2015-06-24
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:職業醫學與工業衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2015
畢業學年度:103
語文別:英文
論文頁數:32
中文關鍵詞:小青龍湯中藥氣喘小兒
外文關鍵詞:Xiao Qing Long Tang (XQLT)traditional Chinese medicine (TCM)asthmachildren
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Background:
Several animal studies have shown the therapeutic effect of Xiao Qing Long Tang (XQLT) in asthma. However, However, there is still no large clinical trial to prove the effect of XQLT in children with asthma. The purpose of this study was to investigate the association between XQLT use and asthma in children.
Methods:
We conducted a population-based cohort study by using the Taiwan National Health Insurance Research Database. A total of 21 415 children with asthma were included as the study cohort. A Cox proportional hazard regression was performed to evaluate the association between XQLT use and asthma admission risk.
Results:
The patients who recorded as XQLT users and nonusers were 2 281 and 19 134 in the unmatched cohort. In the matched cohort, a total of 2 197 users and 8 788 nonusers were included. After adjusted for the age, gender, severity, Allergic rhinitis, Atopic dermatitis, and urbanization, XQLT was independently associated with the decreased risk of admission for asthma with dose-response relationship. In the unmatched cohort, the hazard ratio(HRs) were 0.54 (95% confidence interval (CI) 0.36-0.81) in children who used XQLT 28 days or less and 0.34 (95% CI 0.21-0.55) in children who used XQLT more than 28 days, and were 0.53 (95% CI 0.34-0.82) and 0.34 (95% CI 0.21-0.56) in children who used XQLT 28 days or less and children who used XQLT more than 28 days in the matched cohort.
Conclusion:
In conclusion, XQLT use was associated with lower incidence of asthma admission in children with asthma. It may show the possible therapeutic application of XQLT in children with asthma. Further large-scale clinical study is needed.

口試委員會審定書……………………………………………………… i
中文摘…………………………………………………………………… ii
英文摘要………………………………………………………………… iv
引言……………………………………………………………………… 1
研究方法………………………………………………………………… 2
結果……………………………………………………………………… 7
討論……………………………………………………………………… 9
參考文獻………………………………………………………………… 14
附錄……………………………………………………………………… 17

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