跳到主要內容

臺灣博碩士論文加值系統

(44.201.97.0) 您好!臺灣時間:2024/04/16 09:33
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:許瑜芳
研究生(外文):Hsu, Yu-Fang
論文名稱:高血壓之胰島素和類胰島素生長因子-1調節血管功能-探討長期運動和低蛋胺酸介入之影響
論文名稱(外文):Insulin-mediated and IGF-1-mediated Vascular Function in Hypertension - Long-term Intervention of Exercise and Low Methionine Diet
指導教授:楊艾倫楊艾倫引用關係
指導教授(外文):Yang, Ai-Lun
口試日期:2016-06-29
學位類別:碩士
校院名稱:臺北市立大學
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
論文頁數:69
中文關鍵詞:高血壓低蛋胺酸運動胰島素類胰島素生長因子-1
外文關鍵詞:HypertensionLow methionine dietExerciseInsulinInsulin-like growth factor-1 (IGF-1)
相關次數:
  • 被引用被引用:0
  • 點閱點閱:245
  • 評分評分:
  • 下載下載:20
  • 收藏至我的研究室書目清單書目收藏:0
背景與目的: 根據世界衛生組織(World Health Organization, WHO)數據統計,全球每年罹患高血壓人口日益劇增,且超過三分之一人口伴隨其他心血管疾病。高血壓是一種慢性疾病,目前除了藥物治療、飲食控制、和運動外,素食飲食被認為和血壓控制有關聯性。有文獻指出減少動物性蛋白或蛋胺酸之攝取,可以降低心血管疾病之發生率,但其生理機制仍有待釐清。因此,本研究主要利用長期低蛋胺酸飲食與運動訓練介入,探討並比較兩者對於高血壓心血管功能的成效及其生理機制。方法: 本研究使用自發性高血壓大鼠(spontaneously hypertensive rat, SHR),隨機分為正常飲食組(CON)、低蛋胺酸飲食組(MET)、運動訓練組(EX)、及低蛋胺酸合併運動訓練組(MET+EX),低蛋胺酸飲食組每天給予0.172%低蛋胺酸飼料,而運動訓練組給予跑步訓練(60分/天,一週五天),分別進行二十四週的介入,最後測量胰島素和類胰島素生長因子-1調控之心血管功能與蛋白質表現等參數,以 SPSS統計軟體進行四組統計分析比較。結果:本研究發現經長期低蛋胺酸飲食及其運動介入後: 一、MET組、EX組和MET+EX組胰島素及類胰島素生長因子-1所調節之血管舒張反應皆顯著高於CON組(P<0.05);二、四組個別加入抑制劑L-NAME與Wortmannin後,對於單一濃度胰島素及類胰島素生長因子-1(IGF-1)所調節之血管舒張反應皆受到抑制而顯著下降(P<0.05),且四組間無顯著差異;三、MET組、EX組和MET+EX組之內皮型一氧化氮合成酶、胰島素受器及類胰島素生長因子-1(IGF-1)受器之蛋白表現量皆顯著高於CON組(P<0.05)。結論:長期低蛋胺酸飲食及運動訓練,顯著改善高血壓之胰島素和類胰島素生長因子-1調控之血管功能。
Purpose: According to the World Health Organization (WHO), the global population suffering from hypertension is increasing annually, and over one third of this population would accompany with other cardiovascular diseases. Hypertension is one of chronic diseases, and vegetarian diet is considered to be significantly related to blood pressure control, in addition to medication, diet control, and exercise. Literatures show that reduced animal protein or methionine intake may reduce the incidence of cardiovascular disease, but physiological mechanisms remain to be clarified. Therefore, the aim of this study was to investigate the effects of the low methionine diet and exercise training on cardiovascular function and physiological mechanisms in hypertension. Methods: Male spontaneously hypertensive rats (SHR) were used and randomly divided into 4 groups: the sedentary control (CON), low methionine diet (MET), exercise training (EX), and combined low methionine diet and exercise training (MET+EX) groups. Low methionine diet was administered by the diet containing 0.172% methionine for 24 weeks. Also, exercise training was conducted by the treadmill running (60 minutes/day, five days a week) for 24 weeks. After the intervention, the insulin- and IGF-1-mediated vascular function and its protein expression were evaluated. All of data were analyzed by the SPSS software. Results: Our results showed that 1) the insulin- and IGF-1-mediated vasorelaxant responses were significantly higher in MET, EX, and MET+EX groups than those in the CON group; 2) after the pre-treatment with L-NAME or wortmannin, the vasorelaxant responses were significantly inhibited and comparable in all groups; 3) compared with the CON group, the vascular proteins of endothelial nitric oxide synthase (eNOS), insulin receptor (IR), and IGF-1 receptor (IGF-1R) were significantly enhanced in MET, EX, and MET+EX groups. Conclusions: Twenty-four-weeks low methionine diet and exercise training significantly ameliorated parts of the insulin- and IGF-1-mediated vascular function in hypertension.
授權書 ii
學位考試審定書 iii
摘要 iv
Abstract vi
謝誌 viii
目錄 ix
第壹章 緒論 1
第一節 研究背景 1
第二節 研究目的 2
第三節 研究問題 2
第四節 研究假設 2
第貳章 文獻探討 3
第一節 高血壓之病生理成因 3
第二節 低蛋胺酸對心血管功能的影響 6
第三節 胰島素調節與心血管功能 12
第四節 類胰島素生長因子-1調節與心血管功能 14
第五節 運動介入對心血管功能的影響 16
第參章 材料與方法 20
第一節 實驗動物與組別 20
第二節 長期低蛋胺酸飲食與運動訓練計畫 20
第三節 血管舒張反應之測量 22
第四節 西方墨點法 25
第五節 統計分析 27
第四章 結果 29
第一節 胰島素和類胰島素生長因子-1調節之血管舒張反應 29
第二節 血管功能相關之蛋白表現量 31
第伍章 討論與結論 33
參考文獻 42

Aarestrup, F. M., & Seyfarth, A. M. (2000). Effect of intervention on the occurrence of antimicrobial resistance. Acta Vet Scand Suppl, 93, 99-102; discussion 102-103, 111-107.
Ahmed, H. M., Blaha, M. J., Nasir, K., Rivera, J. J., & Blumenthal, R. S. (2012). Effects of physical activity on cardiovascular disease. Am J Cardiol, 109(2), 288-295. doi: 10.1016/j.amjcard.2011.08.042
Alissa, E. M., & Ferns, G. A. (2015). Dietary Fruits and Vegetables and Cardiovascular Diseases Risk. Crit Rev Food Sci Nutr. doi: 10.1080/10408398.2015.1040487
Arturo A. Arce-Esquivel, A. K. B., Catherine R. Mikus and M. (2013). Insulin Resistance and Endothelial Dysfunction: Macro and Microangiopathy, Type 2 Diabetes. intechopen(2013). ISBN: 978-953-51-1171-9, doi: 10.5772/56475
Balch, J. F. B. P. A. (2006). 《營養治療的處方百科》(Prescription for Nutritional Healing). 世潮出版股份有限公司 2006[民95],ISBN:9577767478.
Barbosa Neto, O., Abate, D. T., Marocolo Junior, M., Mota, G. R., Orsatti, F. L., Rossi e Silva, R. C., da Silva, V. J. (2013). Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats. J Sports Sci Med, 12(1), 52-59.
Barzilai, N., & Rossetti, L. (1995). Relationship between changes in body composition and insulin responsiveness in models of the aging rat. Am J Physiol, 269(3 Pt 1), E591-597.
Blumenthal, J. A., Babyak, M. A., Hinderliter, A., Watkins, L. L., Craighead, L., Lin, P. H., Sherwood, A. (2010). Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Arch Intern Med, 170(2), 126-135. doi: 10.1001/archinternmed.2009.470
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012). Lack of exercise is a major cause of chronic diseases. Compr Physiol, 2(2), 1143-1211. doi: 10.1002/cphy.c110025
Bosse, J. D., Lin, H. Y., Sloan, C., Zhang, Q. J., Abel, E. D., Pereira, T. J., Jalili, T. (2013). A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol, 304(12), H1733-1742. doi: 10.1152/ajpheart.00631.2012
Brattstrom, L. E., Israelsson, B., Jeppsson, J. O., & Hultberg, B. L. (1988). Folic acid--an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest, 48(3), 215-221. doi: 10.3109/00365518809167487
Bruce, C. R., & Hawley, J. A. (2004). Improvements in insulin resistance with aerobic exercise training: a lipocentric approach. Med Sci Sports Exerc, 36(7), 1196-1201.
BruceBlaus. ( 2014). Hypertension (High Blood Pressure). Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762.
Cacicedo, J. M., Gauthier, M. S., Lebrasseur, N. K., Jasuja, R., Ruderman, N. B., & Ido, Y. (2011). Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol, 301(4), H1255-1265. doi: 10.1152/ajpheart.01279.2010
Cano-Montoya, J., Ramirez-Campillo, R., Martinez, C., Sade-Calles, F., Salas-Parada, A., & Alvarez, C. (2016). [Interaction between antihypertensive therapy and exercise training therapy requires drug regulation in hypertensive patients]. Rev Med Chil, 144(2), 152-161. doi: 10.4067/S0034-98872016000200002
Caponi, P. W., Lehnen, A. M., Pinto, G. H., Borges, J., Markoski, M., Machado, U. F., & Schaan, B. D. (2013). Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes. Clinics (Sao Paulo), 68(7), 1010-1017. doi: 10.6061/clinics/2013(07)20
Carretero, O. A., & Oparil, S. (2000). Essential hypertension. Part I: definition and etiology. Circulation, 101(3), 329-335.
Chang-Claude, J., Hermann, S., Eilber, U., & Steindorf, K. (2005). Lifestyle determinants and mortality in German vegetarians and health-conscious persons: results of a 21-year follow-up. Cancer Epidemiol Biomarkers Prev, 14(4), 963-968. doi: 10.1158/1055-9965.EPI-04-0696
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jr., National High Blood Pressure Education Program Coordinating, C. (2003). Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, 42(6), 1206-1252. doi: 10.1161/01.HYP.0000107251.49515.c2
Clemmons, D. R. (2012). Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinol Metab Clin North Am, 41(2), 425-443, vii-viii. doi: 10.1016/j.ecl.2012.04.017
Colao, A. (2008). The GH-IGF-I axis and the cardiovascular system: clinical implications. Clin Endocrinol (Oxf), 69(3), 347-358. doi: 10.1111/j.1365-2265.2008.03292.x
Cornelissen, V. A., & Fagard, R. H. (2005). Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension, 46(4), 667-675. doi: 10.1161/01.HYP.0000184225.05629.51
Craig, W. J., Mangels, A. R., & American Dietetic, A. (2009). Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc, 109(7), 1266-1282.
Crichton, G., Elias, M., Alkerwi, A., & Buckley, J. (2015). Intake of Lutein-Rich Vegetables Is Associated with Higher Levels of Physical Activity. Nutrients, 7(9), 8058-8071. doi: 10.3390/nu7095378
Crissey, J. M., Jenkins, N. T., Lansford, K. A., Thorne, P. K., Bayless, D. S., Vieira-Potter, V. J., Padilla, J. (2014). Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats. Am J Physiol Regul Integr Comp Physiol, 306(8), R596-606. doi: 10.1152/ajpregu.00493.2013
Crowe, F. L., Skeaff, C. M., Green, T. J., & Gray, A. R. (2006). Serum fatty acids as biomarkers of fat intake predict serum cholesterol concentrations in a population-based survey of New Zealand adolescents and adults. Am J Clin Nutr, 83(4), 887-894.
Dauchet, L., Amouyel, P., & Dallongeville, J. (2009). Fruits, vegetables and coronary heart disease. Nat Rev Cardiol, 6(9), 599-608. doi: 10.1038/nrcardio.2009.131
Dauchet, L., Amouyel, P., Hercberg, S., & Dallongeville, J. (2006). Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr, 136(10), 2588-2593.
Del Turco, S., Gaggini, M., Daniele, G., Basta, G., Folli, F., Sicari, R., & Gastaldelli, A. (2013). Insulin resistance and endothelial dysfunction: a mutual relationship in cardiometabolic risk. Curr Pharm Des, 19(13), 2420-2431.
Elshorbagy, A. K., Valdivia-Garcia, M., Mattocks, D. A., Plummer, J. D., Smith, A. D., Drevon, C. A., Perrone, C. E. (2011). Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res, 52(1), 104-112. doi: 10.1194/jlr.M010215
Enkhmaa, B., Surampudi, P., Anuurad, E., & Berglund, L. (2000). Lifestyle Changes: Effect of Diet, Exercise, Functional Food, and Obesity Treatment, on Lipids and Lipoproteins. In L. J. De Groot, P. Beck-Peccoz, G. Chrousos, K. Dungan, A. Grossman, J. M. Hershman, C. Koch, R. McLachlan, M. New, R. Rebar, F. Singer, A. Vinik & M. O. Weickert (Eds.), Endotext. South Dartmouth (MA).
Farshid, G., & Rush, G. (2004). Assessment of 142 stellate lesions with imaging features suggestive of radial scar discovered during population-based screening for breast cancer. Am J Surg Pathol, 28(12), 1626-1631.
Faulx, M. D., Wright, A. T., & Hoit, B. D. (2003). Detection of endothelial dysfunction with brachial artery ultrasound scanning. Am Heart J, 145(6), 943-951. doi: 10.1016/S0002-8703(03)00097-8
Fernandez, M. L. (2001). Soluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk. Curr Opin Lipidol, 12(1), 35-40.
Feyh, A., Bracero, L., Lakhani, H. V., Santhanam, P., Shapiro, J. I., Khitan, Z., & Sodhi, K. (2016). Role of Dietary Components in Modulating Hypertension. J Clin Exp Cardiolog, 7(4). doi: 10.4172/2155-9880.1000433
Finkelstein, J. D. (1990). Methionine metabolism in mammals. J Nutr Biochem, 1(5), 228-237.
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008). Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell, 7(5), 681-687.
Foo, S. Y., Heller, E. R., Wykrzykowska, J., Sullivan, C. J., Manning-Tobin, J. J., Moore, K. J., Rosenzweig, A. (2009). Vascular effects of a low-carbohydrate high-protein diet. Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15418-15423. doi: 10.1073/pnas.0907995106
Frederich, R. C., Hamann, A., Anderson, S., Lollmann, B., Lowell, B. B., & Flier, J. S. (1995). Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med, 1(12), 1311-1314.
Frystyk, J. (2007). Utility of free IGF-I measurements. Pituitary, 10(2), 181-187. doi: 10.1007/s11102-007-0025-y
Gan, Y., Tong, X., Li, L., Cao, S., Yin, X., Gao, C., Lu, Z. (2015). Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies. Int J Cardiol, 183, 129-137. doi: 10.1016/j.ijcard.2015.01.077
Graham, D. A., & Rush, J. W. (2004). Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol (1985), 96(6), 2088-2096. doi: 10.1152/japplphysiol.01252.2003
Grant, R., Bilgin, A., Zeuschner, C., Guy, T., Pearce, R., Hokin, B., & Ashton, J. (2008). The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents. Asia Pac J Clin Nutr, 17(1), 107-115.
Gunaydin, Z. Y., Ozer, F. F., Karagoz, A., Bektas, O., Karatas, M. B., Vural, A., Yaman, M. (2016). Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment. J Geriatr Cardiol, 13(1), 75-80. doi: 10.11909/j.issn.1671-5411.2016.01.003
Guo, H. Y., Xu, F. K., Lv, H. T., Liu, L. B., Ji, Z., Zhai, X. Y., Chi, J. F. (2014). Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice. J Geriatr Cardiol, 11(1), 74-78. doi: 10.3969/j.issn.1671-5411.2014.01.013
Hasek, B. E., Stewart, L. K., Henagan, T. M., Boudreau, A., Lenard, N. R., Black, C., Gettys, T. W. (2010). Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Regul Integr Comp Physiol, 299(3), R728-739. doi: 10.1152/ajpregu.00837.2009
Hens, J. R., Sinha, I., Perodin, F., Cooper, T., Sinha, R., Plummer, J., Orentreich, D. (2016). Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer, 16(1), 349. doi: 10.1186/s12885-016-2367-1
Higashi, Y., Quevedo, H. C., Tiwari, S., Sukhanov, S., Shai, S. Y., Anwar, A., & Delafontaine, P. (2014). Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging. Front Horm Res, 43, 107-124. doi: 10.1159/000360571
Horikawa, Y., Uehara, D., Matsuda, K., S, F. S., & Tamaki, N. (2008). Modulation of maltose preference by selection from dextrin, maltose and glucose diets in zinc-deficient rats. J Nutr Sci Vitaminol (Tokyo), 54(3), 203-209.
Huang, T. H., Lewis, J. L., Lin, H. S., Kuo, L. T., Mao, S. W., Tai, Y. S., Yang, R. S. (2014). A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats. J Nutr, 144(5), 621-630. doi: 10.3945/jn.113.187922
Imrie, H., Abbas, A., & Kearney, M. (2010). Insulin resistance, lipotoxicity and endothelial dysfunction. Biochim Biophys Acta, 1801(3), 320-326. doi: 10.1016/j.bbalip.2009.09.025
International Consortium for Blood Pressure Genome-Wide Association, S., Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Johnson, T. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. doi: 10.1038/nature10405
James, E. L., Stacey, F. G., Chapman, K., Boyes, A. W., Burrows, T., Girgis, A., Lubans, D. R. (2015). Impact of a nutrition and physical activity intervention (ENRICH: Exercise and Nutrition Routine Improving Cancer Health) on health behaviors of cancer survivors and carers: a pragmatic randomized controlled trial. BMC Cancer, 15, 710. doi: 10.1186/s12885-015-1775-y
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Ortiz, E. (2014). 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA, 311(5), 507-520. doi: 10.1001/jama.2013.284427
Jasperse, J. L., & Laughlin, M. H. (2006). Endothelial function and exercise training: evidence from studies using animal models. Med Sci Sports Exerc, 38(3), 445-454. doi: 10.1249/01.mss.0000191187.24525.f2
Jeanplong, F., Osepchook, C. C., Falconer, S. J., Smith, H. K., Bass, J. J., McMahon, C. D., & Oldham, J. M. (2015). Undernutrition regulates the expression of a novel splice variant of myostatin and insulin-like growth factor 1 in ovine skeletal muscle. Domest Anim Endocrinol, 52, 17-24. doi: 10.1016/j.domaniend.2015.01.002
Jin, Z. G., Wong, C., Wu, J., & Berk, B. C. (2005). Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem, 280(13), 12305-12309. doi: 10.1074/jbc.M500294200
Kahleova, H., Matoulek, M., Bratova, M., Malinska, H., Kazdova, L., Hill, M., & Pelikanova, T. (2013). Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Nutr Diabetes, 3, e75. doi: 10.1038/nutd.2013.12
Kazlauskiene, L., Butnoriene, J., & Norkus, A. (2015). Metabolic syndrome related to cardiovascular events in a 10-year prospective study. Diabetol Metab Syndr, 7, 102. doi: 10.1186/s13098-015-0096-2
Knights, A. J., Funnell, A. P., Pearson, R. C., Crossley, M., & Bell-Anderson, K. S. (2014). Adipokines and insulin action: A sensitive issue. Adipocyte, 3(2), 88-96. doi: 10.4161/adip.27552
Kobayashi, T., & Kamata, K. (2002). Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats. Am J Physiol Heart Circ Physiol, 283(5), H1761-1768. doi: 10.1152/ajpheart.00248.2002
Korsager Larsen, M., & Matchkov, V. V. (2016). Hypertension and physical exercise: The role of oxidative stress. Medicina (Kaunas), 52(1), 19-27. doi: 10.1016/j.medici.2016.01.005
Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Kadowaki, T. (2011). Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab, 13(3), 294-307. doi: 10.1016/j.cmet.2011.01.018
Lagiou, P., Sandin, S., Lof, M., Trichopoulos, D., Adami, H. O., & Weiderpass, E. (2012). Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study. BMJ, 344, e4026. doi: 10.1136/bmj.e4026
Laughlin, M. H., & Roseguini, B. (2008). Mechanisms for exercise training-induced increases in skeletal muscle blood flow capacity: differences with interval sprint training versus aerobic endurance training. J Physiol Pharmacol, 59 Suppl 7, 71-88.
Lee, B. R., Ko, Y. M., Cho, M. H., Yoon, Y. R., Kye, S. H., & Park, Y. K. (2016). Effects of 12-week Vegetarian Diet on the Nutritional Status, Stress Status and Bowel Habits in Middle School Students and Teachers. Clin Nutr Res, 5(2), 102-111. doi: 10.7762/cnr.2016.5.2.102
Lin, Y. Y., Lee, S. D., Su, C. T., Cheng, T. L., & Yang, A. L. (2015). Long-term treadmill training ameliorates endothelium-dependent vasorelaxation mediated by insulin and insulin-like growth factor-1 in hypertension. J Appl Physiol (1985), 119(6), 663-669. doi: 10.1152/japplphysiol.01062.2014
Liu, B., Ma, S., Wang, T., Zhao, C., Li, Y., Yin, J., Jia, R. (2016). A novel rat model of heart failure induced by high methionine diet showing evidence of association between hyperhomocysteinemia and activation of NF-kappaB. Am J Transl Res, 8(1), 117-124.
Luft, F. C. (1998). Molecular genetics of human hypertension. J Hypertens, 16(12 Pt 2), 1871-1878.
Luna-Vazquez, F. J., Ibarra-Alvarado, C., Rojas-Molina, A., Rojas-Molina, J. I., Yahia, E. M., Rivera-Pastrana, D. M., Zavala-Sanchez, M. A. (2013). Nutraceutical value of black cherry Prunus serotina Ehrh. fruits: antioxidant and antihypertensive properties. Molecules, 18(12), 14597-14612. doi: 10.3390/molecules181214597
Malloy, V. L., Krajcik, R. A., Bailey, S. J., Hristopoulos, G., Plummer, J. D., & Orentreich, N. (2006). Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell, 5(4), 305-314. doi: 10.1111/j.1474-9726.2006.00220.x
Marsh, S. A., & Davidoff, A. J. (2012). Heart smart insulin-like growth factor 1. Hypertension, 59(3), 550-551. doi: 10.1161/HYPERTENSIONAHA.111.188441
Marwick, T. H., Hordern, M. D., Miller, T., Chyun, D. A., Bertoni, A. G., Blumenthal, R. S., Outcomes, R. (2009). Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation, 119(25), 3244-3262. doi: 10.1161/CIRCULATIONAHA.109.192521
Materson, B. J. (2013). JNC 8 transmogrified. J Clin Hypertens (Greenwich), 15(10), 704. doi: 10.1111/jch.12174
Mather, K. J., Steinberg, H. O., & Baron, A. D. (2013). Insulin resistance in the vasculature. J Clin Invest, 123(3), 1003-1004. doi: 10.1172/JCI67166
McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009). The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses, 72(2), 125-128. doi: 10.1016/j.mehy.2008.07.044
Mikus, C. R., Rector, R. S., Arce-Esquivel, A. A., Libla, J. L., Booth, F. W., Ibdah, J. A., Thyfault, J. P. (2010). Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats. J Appl Physiol (1985), 109(4), 1203-1210. doi: 10.1152/japplphysiol.00064.2010
Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., & Smith-Wheelock, M. (2005). Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell, 4(3), 119-125. doi: 10.1111/j.1474-9726.2005.00152.x
Moskovitz, J., Bar-Noy, S., Williams, W. M., Requena, J., Berlett, B. S., & Stadtman, E. R. (2001). Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proceedings of the National Academy of Sciences of the United States of America, 98(23), 12920-12925. doi: 10.1073/pnas.231472998
Muniyappa, R., Montagnani, M., Koh, K. K., & Quon, M. J. (2007). Cardiovascular actions of insulin. Endocr Rev, 28(5), 463-491. doi: 10.1210/er.2007-0006
Novotny, T. E. (2006). US Department of Health and Human Services: a need for global health leadership in preparedness and health diplomacy. Am J Public Health, 96(1), 11-13. doi: 10.2105/AJPH.2005.076885
Obarzanek, E., Sacks, F. M., Vollmer, W. M., Bray, G. A., Miller, E. R., 3rd, Lin, P. H., Group, D. R. (2001). Effects on blood lipids of a blood pressure-lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr, 74(1), 80-89.
Oldewage-Theron, W., & Egal, A. (2013). The effect of consumption of soy foods on the blood lipid profile of women: a pilot study from Qwa-Qwa. J Nutr Sci Vitaminol (Tokyo), 59(5), 431-436.
Olson, B. H., Anderson, S. M., Becker, M. P., Anderson, J. W., Hunninghake, D. B., Jenkins, D. J., Fulgoni, V. L., 3rd. (1997). Psyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results of a meta-analysis. J Nutr, 127(10), 1973-1980.
Orentreich, N., Matias, J. R., DeFelice, A., & Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr, 123(2), 269-274.
Orgeron, M. L., Stone, K. P., Wanders, D., Cortez, C. C., Van, N. T., & Gettys, T. W. (2014). The impact of dietary methionine restriction on biomarkers of metabolic health. Prog Mol Biol Transl Sci, 121, 351-376. doi: 10.1016/B978-0-12-800101-1.00011-9
Palmeiro, C. R., Anand, R., Dardi, I. K., Balasubramaniyam, N., Schwarcz, M. D., & Weiss, I. A. (2012). Growth hormone and the cardiovascular system. Cardiol Rev, 20(4), 197-207. doi: 10.1097/CRD.0b013e318248a3e1
Pettersen, B. J., Anousheh, R., Fan, J., Jaceldo-Siegl, K., & Fraser, G. E. (2012). Vegetarian diets and blood pressure among white subjects: results from the Adventist Health Study-2 (AHS-2). Public Health Nutr, 15(10), 1909-1916. doi: 10.1017/S1368980011003454
Rask-Madsen, C., & Kahn, C. R. (2012). Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol, 32(9), 2052-2059. doi: 10.1161/ATVBAHA.111.241919
Reaven, G. M. (1993). Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med, 44, 121-131. doi: 10.1146/annurev.me.44.020193.001005
Riccioni, G., Sblendorio, V., Gemello, E., Di Bello, B., Scotti, L., Cusenza, S., & D'Orazio, N. (2012). Dietary fibers and cardiometabolic diseases. Int J Mol Sci, 13(2), 1524-1540. doi: 10.3390/ijms13021524
Roque, F. R., Briones, A. M., Garcia-Redondo, A. B., Galan, M., Martinez-Revelles, S., Avendano, M. S., Salaices, M. (2013). Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension. Br J Pharmacol, 168(3), 686-703. doi: 10.1111/j.1476-5381.2012.02224.x
Salehi-Abargouei, A., Maghsoudi, Z., Shirani, F., & Azadbakht, L. (2013). Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases--incidence: a systematic review and meta-analysis on observational prospective studies. Nutrition, 29(4), 611-618. doi: 10.1016/j.nut.2012.12.018
Schuler, G., Adams, V., & Goto, Y. (2013). Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J, 34(24), 1790-1799. doi: 10.1093/eurheartj/eht111
Schutte, A. E., Volpe, M., Tocci, G., & Conti, E. (2014). Revisiting the relationship between blood pressure and insulin-like growth factor-1. Hypertension, 63(5), 1070-1077. doi: 10.1161/HYPERTENSIONAHA.113.03057
Sofi, F., Dinu, M., Pagliai, G., Cesari, F., Marcucci, R., & Casini, A. (2016). Mediterranean versus vegetarian diet for cardiovascular disease prevention (the CARDIVEG study): study protocol for a randomized controlled trial. Trials, 17(1), 233. doi: 10.1186/s13063-016-1353-x
Sousa, N., Mendes, R., Abrantes, C., Sampaio, J., & Oliveira, J. (2013). A randomized 9-month study of blood pressure and body fat responses to aerobic training versus combined aerobic and resistance training in older men. Exp Gerontol, 48(8), 727-733. doi: 10.1016/j.exger.2013.04.008
Steed, M. M., & Tyagi, S. C. (2011). Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxid Redox Signal, 15(7), 1927-1943. doi: 10.1089/ars.2010.3721
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N., & Baron, A. D. (1994). Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest, 94(3), 1172-1179. doi: 10.1172/JCI117433
Sukhanov, S., Higashi, Y., Shai, S. Y., Blackstock, C., Galvez, S., Vaughn, C., Delafontaine, P. (2011). Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effects. FEBS Lett, 585(19), 3065-3072. doi: 10.1016/j.febslet.2011.08.029
Tanaka, S., Yoshimura, Y., Kamada, C., Tanaka, S., Horikawa, C., Okumura, R., Japan Diabetes Complications Study, G. (2013). Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type 2 diabetes. Diabetes Care, 36(12), 3916-3922. doi: 10.2337/dc13-0654
Tao, L., Bei, Y., Zhang, H., Xiao, J., & Li, X. (2015). Exercise for the heart: signaling pathways. Oncotarget, 6(25), 20773-20784.
Tektonidis, T. G., Akesson, A., Gigante, B., Wolk, A., & Larsson, S. C. (2015). A Mediterranean diet and risk of myocardial infarction, heart failure and stroke: A population-based cohort study. Atherosclerosis, 243(1), 93-98. doi: 10.1016/j.atherosclerosis.2015.08.039
Torricelli, F. C., Marchini, G. S., Colombo, J. R., Jr., Coelho, R. F., Nahas, W. C., & Srougi, M. (2015). Nephron-sparing surgery for treatment of reninoma: a rare renin secreting tumor causing secondary hypertension. Int Braz J Urol, 41(1), 172-176. doi: 10.1590/S1677-5538.IBJU.2015.01.23
Tuttle, K. R., Milton, J. E., Packard, D. P., Shuler, L. A., & Short, R. A. (2012). Dietary amino acids and blood pressure: a cohort study of patients with cardiovascular disease. Am J Kidney Dis, 59(6), 803-809. doi: 10.1053/j.ajkd.2011.12.026
Tuttle, K. R., Shuler, L. A., Packard, D. P., Milton, J. E., Daratha, K. B., Bibus, D. M., & Short, R. A. (2008). Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol, 101(11), 1523-1530. doi: 10.1016/j.amjcard.2008.01.038
Viera, A. J., & Neutze, D. M. (2010). Diagnosis of secondary hypertension: an age-based approach. Am Fam Physician, 82(12), 1471-1478.
Vizzardi, E., Bonadei, I., Zanini, G., Frattini, S., Fiorina, C., Raddino, R., & Dei Cas, L. (2009). Homocysteine and heart failure: an overview. Recent Pat Cardiovasc Drug Discov, 4(1), 15-21.
Walsh, M. F., Barazi, M., Pete, G., Muniyappa, R., Dunbar, J. C., & Sowers, J. R. (1996). Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. Endocrinology, 137(5), 1798-1803. doi: 10.1210/endo.137.5.8612517
WHO. (2013). A global brief on Hypertension.
Widmer, R. J., Flammer, A. J., Lerman, L. O., & Lerman, A. (2015). The Mediterranean diet, its components, and cardiovascular disease. Am J Med, 128(3), 229-238. doi: 10.1016/j.amjmed.2014.10.014
Williams, C. M., Lovegrove, J. A., & Griffin, B. A. (2013). Dietary patterns and cardiovascular disease. Proc Nutr Soc, 72(4), 407-411. doi: 10.1017/S0029665113002048
Woodside, J. V., McGrath, A. J., Lyner, N., & McKinley, M. C. (2015). Carotenoids and health in older people. Maturitas, 80(1), 63-68. doi: 10.1016/j.maturitas.2014.10.012
Yang, A. L., Lo, C. W., Lee, J. T., & Su, C. T. (2011). Enhancement of vasorelaxation in hypertension following high-intensity exercise. Chin J Physiol, 54(2), 87-95.
Yang, A. L., Su, C. T., Lin, K. L., Chao, J. I., You, H. P., & Lee, S. D. (2006). Exercise training improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation in rat aortas. Life Sci, 79(21), 2017-2021. doi: 10.1016/j.lfs.2006.06.037
Yavari, A., Javadi, M., Mirmiran, P., & Bahadoran, Z. (2015). Exercise-induced oxidative stress and dietary antioxidants. Asian J Sports Med, 6(1), e24898. doi: 10.5812/asjsm.24898
Zeng, G., & Quon, M. J. (1996). Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest, 98(4), 894-898. doi: 10.1172/JCI118871
Zhang, Q. J., Li, Q. X., Zhang, H. F., Zhang, K. R., Guo, W. Y., Wang, H. C., Gao, F. (2007). Swim training sensitizes myocardial response to insulin: role of Akt-dependent eNOS activation. Cardiovasc Res, 75(2), 369-380. doi: 10.1016/j.cardiores.2007.04.015
Zheng, H. Q., Zhang, L. Y., Luo, J., Li, L. L., Li, M., Zhang, Q., & Hu, X. Q. (2014). Physical exercise promotes recovery of neurological function after ischemic stroke in rats. Int J Mol Sci, 15(6), 10974-10988. doi: 10.3390/ijms150610974
Zhou, P., Zhang, L., Li, J., Luo, Y., Zhang, B., Xing, S., . . . Zhou, G. (2015). Effects of Dietary Crude Protein Levels and Cysteamine Supplementation on Protein Synthetic and Degradative Signaling in Skeletal Muscle of Finishing Pigs. PLoS One, 10(9), e0139393. doi: 10.1371/journal.pone.0139393
Zhu, L., Yu, J., Jia, B., Zhao, F., Tang, M., Hu, L., & Lin, F. (2015). Effect of losartan with folic acid on plasma homocysteine and vascular ultrastructural changes in spontaneously hypertensive rats. Int J Clin Exp Pathol, 8(10), 12908-12914.
Zulli, A., Widdop, R. E., Hare, D. L., Buxton, B. F., & Black, M. J. (2003). High methionine and cholesterol diet abolishes endothelial relaxation. Arterioscler Thromb Vasc Biol, 23(8), 1358-1363. doi: 10.1161/01.ATV.0000080686.39871.54
蔡慧君、蔡儀冠. (2013). 營養新星-蔬果植化物. 行政院農委會水產試驗所電子報 第83期, http://www.tfrin.gov.tw/friweb/frienews/enews0083/p0084.html.
衛生福利部國民健康署. (2013). 素食飲食指標手冊. 衛生福利部食品藥物管理署.

連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關期刊