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研究生:林維安
研究生(外文):Wei-An Lin
論文名稱:輪班工作與攝護腺癌風險:系統性回顧與統合分析
論文名稱(外文):Shift work and prostate cancer risk: a systematic review and meta-analysis
指導教授:郭育良郭育良引用關係陳保中陳保中引用關係
指導教授(外文):Yue-Liang GuoPau-Chung Chen
口試委員:王榮德杜裕康
口試委員(外文):Jung-Der WangYu-Kang Tu
口試日期:2017-01-19
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:職業醫學與工業衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:英文
論文頁數:36
中文關鍵詞:輪班工作攝護腺癌統合分析職業流行病學
外文關鍵詞:shift workprostate cancermeta-analysisoccupational epidemiology
相關次數:
  • 被引用被引用:2
  • 點閱點閱:318
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:2
背景
雖然目前許多觀察性研究文獻顯示輪班工作與攝護腺癌風險相關,但不同研究結論仍不一致。本研究旨在針對過往無論有無針對輪班工作進行直接暴露評估之相關流行病學研究結果,進行系統性回顧及統合分析(meta-analysis),以釐清暴露輪班工作與攝護腺癌發生之相關性。
方法
於三個電子文獻資料庫搜尋並回顧2016年7月前發表之相關研究文獻及其參考資料。篩選研究結果以風險估計值(含95%信賴區間)呈現輪班工作及攝護腺癌相關性之文獻,並以隨機效應模式(random-effects model)計算統合風險估計值。
結果
統合分析總共納入26篇研究文獻,2785457名樣本,其中包含15655名攝護腺癌個案。針對輪班工作有直接進行暴露評估之研究,其攝護腺癌風險顯著上升(勝算比1.22,95%信賴區間1.08-1.36),以職業別間接進行輪班工作暴露評估之研究,攝護腺癌風險也顯著上升(勝算比1.17,95%信賴區間1.10-1.24),但皆存在顯著異質性。此相關性在多數次群組及敏感性分析下仍顯著存在。累積輪班工作暴露年數與攝護腺癌風險在非線性趨勢預測下未存在顯著劑量反應關係。在美國及歐洲總計可歸因於暴露輪班工作所造成之攝護腺癌死亡人數推估每年約達4906人。
結論
統合分析顯示輪班工作與攝護腺癌風險可能相關。未來流行病學研究宜針對輪班工作進行更細緻之暴露評估,以確認本研究結果並釐清可能之病生理機轉。
Background
Increasing numbers of observational studies suggest that shift work is associated with prostate cancer. However, the results remain controversial. We performed meta-analyses both of studies directly assessing shift work and those assessing shift work-related occupations, to clarify the suggested associations.

Methods
Relevant studies were identified by searching three databases to July 2016; the reference lists of the retrieved articles were also reviewed. We included observational studies that reported risk estimates with 95% confidence intervals (CIs) for the associations between shift work and the risk of prostate cancer. Random-effects models were used to calculate pooled risk estimates.

Results
A total of 26 studies with 2,785,457 participants involving 15,655 prostate cancer cases were included. A significantly increased risk of prostate cancer was evident in studies directly assessing shift work exposure (OR = 1.22, 95% CI 1.08–1.36) and those assessing shift work-related employment (OR = 1.17, 95% CI 1.10–1.24); however, substantial heterogeneities were apparent. The associations remained significant upon most subgroup and sensitivity analyses. Non-linear trend estimation revealed no significant dose-response relationship between cumulative exposure year of shift work and prostate cancer risk. The total number of prostate cancer deaths attributable to shift work is approximately 4,906 per year in the United States and Europe.

Conclusion
Our meta-analysis showed that shift work may be associated with an increased risk of prostate cancer. Further studies assessing different domains of shift work are warranted to confirm our findings and to clarify the biological mechanisms involved.
口試委員會審定書 i
誌謝 ii
中文摘要 iii
Abstract iv
Table of Contents vi
List of Figures and Tables viii
Chapter 1 Introduction 1
1.1 Background 1
1.2 Objective 2
Chapter 2 Materials and Methods 3
2.1 Search strategy 3
2.2 Inclusion criteria 3
2.3 Data extraction 4
2.4 Quality assessment 4
2.5 Statistical analysis 5
Chapter 3 Results 7
3.1 Study selection and characteristics 7
3.2 Association between shift work and prostate cancer 7
3.3 Subgroup analyses 7
3.4 Sensitivity analysis 8
3.5 Dose-response meta-analysis 9
3.6 Population attributable risk 9
3.7 Publication bias 9
Chapter 4 Discussion 11
4.1 Robustness and heterogeneity 11
4.2 Possible pathophysiological mechanism 12
4.3 Strength and limitation 12
Chapter 5 Conclusion 15
Reference 16
Appendix 35
1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359-E86 doi: 10.1002/ijc.29210[published Online First: Epub Date]|.
2. United States Department of Labor. Workers on flexible and shift schedules in May 2004. 2005. http://www.bls.gov/news.release/pdf/flex.pdf (accessed 23 Jun 2016)
3. Eurofond. Sixth European Working Conditions Survey. 2015. Secondary Sixth European Working Conditions Survey. http://www.eurofound.europa.eu/sites/default/files/ef_publication/field_ef_document/ef1568en.pdf (accessed 23 Jun 2016)
4. Straif K, Baan R, Grosse Y, et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol 2007;8(12):1065-66 doi: 10.1016/s1470-2045(07)70373-x[published Online First: Epub Date]|.
5. Megdal SP, Kroenke CH, Laden F, et al. Night work and breast cancer risk: a systematic review and meta-analysis. Eur J Cancer 2005;41(13):2023-32 doi: 10.1016/j.ejca.2005.05.010[published Online First: Epub Date]|.
6. Schernhammer ES, Laden F, Speizer FE, et al. Rotating night shifts and risk of breast cancer in women participating in the nurses'' health study. J Natl Cancer Inst 2001;93(20):1563-68
7. Costa G, Haus E, Stevens R. Shift work and cancer - considerations on rationale, mechanisms, and epidemiology. Scand J Work Environ Health 2010;36(2):163-79
8. Davis S, Mirick DK. Circadian disruption, shift work and the risk of cancer: A summary of the evidence and studies in Seattle. Cancer Causes Control 2006;17(4):539-45 doi: 10.1007/s10552-005-9010-9[published Online First: Epub Date]|.
9. Sigurdardottir LG, Valdimarsdottir UA, Fall K, et al. Circadian disruption, sleep Loss, and prostate cancer risk: a systematic review of epidemiologic studies. Cancer Epidemiol Biomarkers Prev 2012;21(7):1002-11 doi: 10.1158/1055-9965.epi-12-0116[published Online First: Epub Date]|.
10. Band PR, Le ND, Fang R, et al. Cohort study of air Canada pilots: mortality, cancer incidence, and leukemia risk. Am J Epidemiol 1996;143(2):137-43
11. Demers PA, Checkoway H, Vaughan TL, et al. Cancer incidence among firefighters in Seattle and Tacoma, Washington (United States). Cancer Causes Control 1994;5(2):129-35 doi: 10.1007/bf01830258[published Online First: Epub Date]|.
12. Lin S-Y, Lin C-L, Hsu W-H, et al. A comparison of cancer incidence among physician specialists and the general population: a Taiwanese cohort study. J Occup Health 2013;55(3):158-66
13. Rao D, Yu H, Bai Y, et al. Does night-shift work increase the risk of prostate cancer? a systematic review and meta-analysis. Onco Targets Ther 2015;8:2817-26 doi: 10.2147/ott.s89769[published Online First: Epub Date]|.
14. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009;6(7) doi: 10.1371/journal.pmed.1000100[published Online First: Epub Date]|.
15. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology - a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283(15):2008-12 doi: 10.1001/jama.283.15.2008[published Online First: Epub Date]|.
16. Wells G, Shea B, O''Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Health Research Institute, 2009.
17. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Cochrane Collabroration, 2011.
18. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 1992;135(11):1301-09
19. Orsini N, Li R, Wolk A, et al. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am J Epidemiol 2012;175(1):66-73 doi: 10.1093/aje/kwr265[published Online First: Epub Date]|.
20. Spiegelman D, Hertzmark E, Wand HC. Point and interval estimates of partial population attributable risks in cohort studies: examples and software. Cancer Causes Control 2007;18(5):571-79 doi: 10.1007/s10552-006-0090-y[published Online First: Epub Date]|.
21. Begg CB, Mazumdar M. Operating characteristics of a bank correlation test for publication bias. Biometrics 1994;50(4):1088-101 doi: 10.2307/2533446[published Online First: Epub Date]|.
22. Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34
23. Conlon M, Lightfoot N, Kreiger N. Rotating shift work and risk of prostate cancer. Epidemiol 2007;18(1):182-83 doi: 10.1097/01.ede.0000249519.33978.31[published Online First: Epub Date]|.
24. Gapstur SM, Diver WR, Stevens VL, et al. Work schedule, sleep duration, insomnia, and risk of fatal prostate cancer. Am J Prev Med 2014;46(3 Suppl 1):S26-33 doi: 10.1016/j.amepre.2013.10.033[published Online First: Epub Date]|.
25. Hammer GP, Emrich K, Nasterlack M, et al. Shift work and prostate cancer incidence in industrial workers a historical cohort study in a German chemical company. Dtsch Arztebl Int 2015;112(27-28):463-70 doi: 10.3238/arztebl.2015.0463[published Online First: Epub Date]|.
26. Kubo T, Oyama I, Nakamura T, et al. Industry-based retrospective cohort study of the risk of prostate cancer among rotating-shift workers. Int J Urol 2011;18(3):206-11 doi: 10.1111/j.1442-2042.2010.02714.x[published Online First: Epub Date]|.
27. Kubo T, Ozasa K, Mikami K, et al. Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am J Epidemiol 2006;164(6):549-55 doi: 10.1093/aje/kwj232[published Online First: Epub Date]|.
28. Papantoniou K, Castano-Vinyals G, Espinosa A, et al. Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study. Int J Cancer 2014 doi: 10.1002/ijc.29400[published Online First: Epub Date]|.
29. Parent ME, El-Zein M, Rousseau MC, et al. Night work and the risk of cancer among men. Am J Epidemiol 2012;176(9):751-9 doi: 10.1093/aje/kws318[published Online First: Epub Date]|.
30. Schwartzbaum J, Ahlbom A, Feychting M. Cohort study of cancer risk among male and female shift workers. Scand J Work Environ Health 2007;33(5):336-43 doi: 10.5271/sjweh.1150[published Online First: Epub Date]|.
31. Ahn Y-S, Jeong K-S, Kim K-S. Cancer morbidity of professional emergency responders in Korea. Am J Ind Med 2012;55(9):768-78 doi: 10.1002/ajim.22068[published Online First: Epub Date]|.
32. Bates MN. Registry-based case-control study of cancer in California firefighters. Am J Ind Med 2007;50(5):339-44 doi: 10.1002/ajim.20446[published Online First: Epub Date]|.
33. Bates MN, Fawcett J, Garrett N, et al. Is testicular cancer an occupational disease of fire fighters? Am J Ind Med 2001;40(3):263-70 doi: 10.1002/ajim.1097[published Online First: Epub Date]|.
34. Daniels RD, Kubale TL, Yiin JH, et al. Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009). Occup Environ Med 2014;71(6):388-97 doi: 10.1136/oemed-2013-101662[published Online First: Epub Date]|.
35. Eriksson M, Hardell L, Malker H, et al. Increased cancer incidence in physicians, dentists, and health care workers. Oncol Rep 1998;5(6):1413-18
36. Firth HM, Cooke KR, Herbison GP. Male cancer incidence by occupation: New Zealand, 1972-1984. Int J Epidemiol 1996;25(1):14-21 doi: 10.1093/ije/25.1.14[published Online First: Epub Date]|.
37. Gu JK CL, Burchfiel CM, Andrew ME, Violanti JM. Cancer incidence among police officers in a U.S. northeast region: 1976-2006. Int J Emerg Ment Health 2011;13(4):279-89
38. Haldorsen T, Reitan JB, Tveten U. Cancer incidence among Norwegian airline cabin attendants. Int J Epidemiol 2001;30(4):825-30 doi: 10.1093/ije/30.4.825[published Online First: Epub Date]|.
39. Hammer GP, Auvinen A, De Stavola BL, et al. Mortality from cancer and other causes in commercial airline crews: a joint analysis of cohorts from 10 countries. Occup Environ Med 2014;71(5):313-22 doi: 10.1136/oemed-2013-101395[published Online First: Epub Date]|.
40. Innos K, Rahu K, Baburin A, et al. Cancer incidence and cause-specific mortality in male and female physicians: a cohort study in Estonia. Scand J Public Health 2002;30(2):133-40 doi: 10.1080/14034940210133735[published Online First: Epub Date]|.
41. Kang D, Davis LK, Hunt P, et al. Cancer incidence among male Massachusetts firefighters, 1987-2003. Am J Ind Med 2008;51(5):329-35 doi: 10.1002/ajim.20549[published Online First: Epub Date]|.
42. Klein-Kremer A, Liphshitz I, Haklai Z, et al. Cancer incidence among physicians in Israel. Isr Med Assoc J 2014;16(7):412-17
43. Ma F, Fleming LE, Lee DJ, et al. Cancer incidence in Florida professional firefighters, 1981 to 1999. J Occup Environ Med 2006;48(9):883-88 doi: 10.1097/01.jom.000235862.12518.04[published Online First: Epub Date]|.
44. Pukkala E, Martinsen JI, Lynge E, et al. Occupation and cancer - follow-up of 15 million people in five Nordic countries. Acta Oncol 2009;48(5):646-790 doi: 10.1080/02841860902913546[published Online First: Epub Date]|.
45. Pukkala E, Martinsen JI, Weiderpass E, et al. Cancer incidence among firefighters: 45 years of follow-up in five Nordic countries. Occup Environ Med 2014;71(6):398-404 doi: 10.1136/oemed-2013-101803[published Online First: Epub Date]|.
46. Lee Y-S, Hsu C-C, Weng S-F, et al. Cancer Incidence in Physicians A Taiwan National Population-based Cohort Study. Med 2015;94(47) doi: 10.1097/md.0000000000002079[published Online First: Epub Date]|.
47. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2015. CA Cancer J Clin 2015;65(1):5-29 doi: 10.3322/caac.21254[published Online First: Epub Date]|.
48. Center MM, Jemal A, Lortet-Tieulent J, et al. International variation in prostate cancer incidence and mortality rates. Eur Urol 2012;61(6):1079-92 doi: 10.1016/j.eururo.2012.02.054[published Online First: Epub Date]|.
49. Wang F, Yeung KL, Chan WC, et al. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer. Ann Oncol 2013;24(11):2724-32 doi: 10.1093/annonc/mdt283[published Online First: Epub Date]|.
50. Moretti RM, Marelli MM, Maggi R, et al. Antiproliferative action of melatonin on human prostate cancer LNCaP cells. Oncol Rep 2000;7(2):347-51
51. Siu SWF, Lau KW, Tam PC, et al. Melatonin and prostate cancer cell proliferation: Interplay with castration, epidermal growth factor, and androgen sensitivity. Prostate 2002;52(2):106-22 doi: 10.1002/pros.10098[published Online First: Epub Date]|.
52. Martinez-Campa C, Alonso-Gonzalez C, Mediavilla MD, et al. Melatonin inhibits both ER alpha activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium. J Pineal Res 2006;40(4):291-96 doi: 10.1111/j.1600-079X.2006.00315.x[published Online First: Epub Date]|.
53. Tam CW, Shiu SYW. Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer. J Pineal Res 2011;51(3):297-312 doi: 10.1111/j.1600-079X.2011.00890.x[published Online First: Epub Date]|.
54. Hill SM, Frasch T, Xiang S, et al. Molecular Mechanisms of melatonin anticancer effects. Integr Cancer Ther 2009;8(4):337-46 doi: 10.1177/1534735409353332[published Online First: Epub Date]|.
55. Jung-Hynes B, Huang W, Reiter RJ, et al. Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells. J Pineal Res 2010;49(1):60-68 doi: 10.1111/j.1600-079X.2010.00767.x[published Online First: Epub Date]|.
56. Carrillo-Vico A, Guerrero JM, Lardone PJ, et al. A review of the multiple actions of melatonin on the immune system. Endocr 2005;27(2):189-200 doi: 10.1385/endo:27:2:189[published Online First: Epub Date]|.
57. Zhu Y, Stevens RG, Hoffman AE, et al. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res 2009;69(24):9315-22 doi: 10.1158/0008-5472.can-09-0648[published Online First: Epub Date]|.
58. Erren TC, Morfeld P. Computing chronodisruption: How to avoid potential chronobiological errors in epidemiological studies of shift work and cancer. Chronobiol Int 2014;31(4):589-99 doi: 10.3109/07420528.2013.877921[published Online First: Epub Date]|.
59. Stevens RG, Hansen J, Costa G, et al. Considerations of circadian impact for defining ''shift work'' in cancer studies: IARC Working Group Report. Occup Environ Med 2011;68(2):154-62 doi: 10.1136/oem.2009.053512[published Online First: Epub Date]|.
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