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研究生(外文):Yu-Hsin Chen
論文名稱(外文):Studies on the bioactive compounds of bacteria derived from marine invertebrates
指導教授(外文):Ching-Feng WengPing-Jyun Sung
口試委員(外文):Tsong-Long HwangTzong-Huei LeeJimmy Kuo
外文關鍵詞:coral-derived bacteriasponge-derived bacteriamarine sediment bacteriaantibacterial activitycytotoxic activitysecondary metabolitePseudoalteromonasStreptomycetesBacillus
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第一章 緒論 1
第二章 實驗方法 57
第一節 樣本來源與採集 57
第二節 珊瑚衍生細菌分離培養 58
第三節 海水需求與含抗菌活性菌株之篩選 59
第四節 以16S rRNA序列鑑定細菌之分類地位 62
第五節 萃取物抗菌、細胞毒殺與抗發炎活性分析 67
第三章 結果與討論 81
第四章 結構解析與生物活性 121
第一節 海洋細菌Pseudoalteromonas sp. CGH2XX所含天然物之結構解析 121
第二節 Streptomycetes sp. GIC10-1所含天然物之結構解析 157
第三節 Bacillus amyloliquefaciens strain IA-LB所含天然物之結構解析 248
第四節 海洋細菌Streptomyces massaporeus AIAC1-21所含天然物之結構解析253
第五節 化合物實驗數據整理 260
第六節 生物活性數據 263
第五章 結論 269
1. ZoBell, C. E. Marine bacteriology. Annual Review of Biochemistry 1947, 16, 565–586.
2. Fenical, W.; Jensen, P. R. Developing a new resource for drug discovery: marine actinomycete bacteria. Nature Chemical Biology 2006, 2, 666–673.
3. Haefner, B. Drugs from the deep: marine natural products as drug candidates. Drug Discovery Today 2003, 8, 536–544.
4. Bergmann, W.; Feeney, R. J. Contributions to the study of marine products. XXXII. The nucleosides of sponges. I. The Journal of Organic Chemistry 1951, 16, 981–987.
5. Hu, G.-P.; Yuan, J.; Sun, L.; She, Z.-G.; Wu, J.-H.; Lan, X.-J.; Zhu, X.; Lin, Y.-C.; Chen, S.-P. Statistical research on marine natural products based on data obtained between 1985 and 2008. Marine Drugs 2011, 9, 514–525.
6. Osenbach, R.; Harvey, S. Neuraxial infusion in patients with chronic intractable cancer and noncancer pain. Current Pain and Headache Reports 2001, 5, 241–249.
7. Mittelman, A.; Chun, H. G.; Puccio, C.; Coombe, N.; Lansen, T.; Ahmed, T. Phase II clinical trial of didemnin B in patients with recurrent or refractory anaplastic astrocytoma or Glioblastoma multiforme (NSC 325319). Investigational New Drugs 1999, 17, 179–182.
8. Proksch, P.; Edrada, R. A.; Ebel, R. Drugs from the seas – current status and microbiological implications. Applied Microbiology and Biotechnology 2002, 59, 125–134.
9. Putz, A.; Proksch, P., Chemical defence in marine ecosystems. In Annual Plant Reviews Volume 39: Functions and Biotechnology of Plant Secondary Metabolites, Wiley-Blackwell: 2010; pp 162–213.
10. Carpenter, R. C. Partitioning herbivory and its effects on coral reef algal communities. Ecological Monographs 1986, 56, 345–363.
11. Lindquist, N.; Hay, M. E.; Fenical, W. Defense of ascidians and their conspicuous larvae: Adult vs. larval chemical defenses. Ecological Monographs 1992, 62, 547–568.
12. Faulkner, D. J. Marine pharmacology. Antonie van Leeuwenhoek 2000, 77, 135–145.
13. Valoti, G.; Nicoletti, M. I.; Pellegrino, A.; Jimeno, J.; Hendriks, H.; D'Incalci, M.; Faircloth, G.; Giavazzi, R. Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts. Clinical Cancer Research 1998, 4, 1977–1983.
14. Jimeno, J. M.; Faircloth, G.; Cameron, L.; Meely, K.; Vega, E.; Gomez, A.; Fernandez Sousa-Faro, J. M.; Rinehart, K. Progress in the acquisition of new marine-derived anticancer compounds: development of ecteinascidin-743 (ET-743). Drugs of the Future 1996, 21, 1155–1165.
15. Jin, S.; Gorfajn, B.; Faircloth, G.; Scotto, K. W. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. Proceedings of the National Academy of Sciences 2000, 97, 6775–6779.
16. Jimenez, J. T.; Šturdíková, M.; Šturdík, E. Natural products of marine origin and their perspectives in the discovery of new anticancer drugs. Acta Chimica Slovaca 2009, 2, 63–74.
17. Mendola, D., Aquacultural production of bryostatin 1 and ecteinascidin 743. In Drugs from the sea, Fusetani, N., Ed. Karger: Basel, 2000; pp 120–133.
18. Hart, J.; Lill, R.; Hickford, S.; Blunt, J.; Munro, M., The halichondrins: chemistry, biology, supply and delivery. In Drugs from the sea, Fusetani, N., Ed. Karger: Basel, 2000; pp 134–153.
19. Mutter, R.; Wills, M. Chemistry and clinical biology of the bryostatins. Bioorganic & Medicinal Chemistry 2000, 8, 1841–1860.
20. Wender, P. A.; Hardman, C. T.; Ho, S.; Jeffreys, M. S.; Maclaren, J. K.; Quiroz, R. V.; Ryckbosch, S. M.; Shimizu, A. J.; Sloane, J. L.; Stevens, M. C. Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV. Science 2017, 358, 218–223.
21. Vacelet, J.; Donadey, C. Electron microscope study of the association between some sponges and bacteria. Journal of Experimental Marine Biology and Ecology 1977, 30, 301–314.
22. Friedrich, A. B.; Merkert, H.; Fendert, T.; Hacker, J.; Proksch, P.; Hentschel, U. Microbial diversity in the marine sponge Aplysina cavernicola (formerly Verongia cavernicola) analyzed by fluorescence in situ hybridization (FISH). Marine Biology 1999, 134, 461–470.
23. Tachibana, K.; Scheuer, P. J.; Tsukitani, Y.; Kikuchi, H.; Van Engen, D.; Clardy, J.; Gopichand, Y.; Schmitz, F. J. Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. Journal of the American Chemical Society 1981, 103, 2469–2471.
24. Shimizu, Y., Microalgae as a drug source. In Drugs from the sea, Fusetani, N., Ed. Karger: Basel, 2000; pp 30–45.
25. Ikeda, Y.; Matsuki, H.; Ogawa, T.; Munakata, T. Safracins, new antitumor antibiotics. II. Physicochemical properties and chemical structures. The Journal of Antibiotics 1983, 36, 1284–1289.
26. Cuevas, C.; Pérez, M.; Martín, M. J.; Chicharro, J. L.; Fernández-Rivas, C.; Flores, M.; Francesch, A.; Gallego, P.; Zarzuelo, M.; de la Calle, F.; García, J.; Polanco, C.; Rodríguez, I.; Manzanares, I. Synthesis of ecteinascidin ET-743 and phthalascidin PT-650 from cyanosafracin B. Organic Letters 2000, 2, 2545–2548.
27. Davidson, S. K.; Allen, S. W.; Lim, G. E.; Anderson, C. M.; Haygood, M. G. Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the Bryozoan Bugula neritina. Applied and Environmental Microbiology 2001, 67, 4531–4537.
28. Monaghan, R. L.; Tkacz, J. S. Bioactive microbial products: Focus upon mechanism of action. Annual Review of Microbiology 1990, 44, 271–331.
29. Zobell, C. E. Marine microbiology. A monograph on hydrobacteriology. Chronica Botanica Co.: Waltham, Mass, 1946.
30. Rosenfeld, W. D.; Zobell, C. E. Antibiotic production by marine microorganisms. Journal of Bacteriology 1947, 54, 393–398.
31. Burkholder, P. R.; Pfister, R. M.; Leitz, F. H. Production of a pyrrole antibiotic by a marine bacterium. Applied and Environmental Microbiology 1966, 14, 649-653.
32. Blunt, J. W.; Copp, B. R.; Munro, M. H. G.; Northcote, P. T.; Prinsep, M. R. Marine natural products. Natural Product Reports 2011, 28, 196–268.
33. Kwon, H. C.; Kauffman, C. A.; Jensen, P. R.; Fenical, W. Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus Marinispora. The Journal of Organic Chemistry 2008, 74, 675–684.
34. Berrue, F.; Ierahim, A.; Boland, P.; Kerr, R. G. Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents. Pure and applied chemistry 2009, 81, 1027–1031.
35. Farnet, C. M.; Zazopoulos, E., Improving Drug Discovery From Microorganisms. In Natural Products, Zhang, L.; Demain, A. L., Eds. Humana Press: 2005; pp 95–106.
36. Bentis, C.; Kaufman, L.; Golubic, S. Endolithic fungi in reef-building corals (order: Scleractinia) are common, cosmopolitan, and potentially pathogenic. Biological Bulletin 2000, 198, 254–260.
37. Shashar, N.; Banaszak, A.; Lesser, M.; Amrami, D. Coral endolithic algae: Life in a protected environment. Pacific Science 1997, 51, 167–173.
38. Toller, W. W.; Rowan, R.; Knowlton, N. Zooxanthellae of the Montastraea annularis species complex: Patterns of distribution of four taxa of symbiodinium on different reefs and across depths. Biological Bulletin 2001, 201, 348–359.
39. Wegley, L.; Edwards, R.; Rodriguez-Brito, B.; Liu, H.; Rohwer, F. Metagenomic analysis of the microbial community associated with the coral Porites astreoides. Environmental Microbiology 2007, 9, 2707–2719.
40. Lesser, M. P.; Mazel, C. H.; Gorbunov, M. Y.; Falkowski, P. G. Discovery of symbiotic nitrogen-fixing cyanobacteria in corals. Science 2004, 305, 997–1000.
41. Nissimov, J.; Rosenberg, E.; Munn, C. B. Antimicrobial properties of resident coral mucus bacteria of Oculina patagonica. FEMS Microbiology Letters 2009, 292, 210–215.
42. Nithyanand, P.; Pandian, S. K. Phylogenetic characterization of culturable bacterial diversity associated with the mucus and tissue of the coral Acropora digitifera from the Gulf of Mannar. FEMS Microbiology Ecology 2009, 69, 384–394.
43. Rosenberg, E.; Koren, O.; Reshef, L.; Efrony, R.; Zilber-Rosenberg, I. The role of microorganisms in coral health, disease and evolution. Nature Reviews Microbiology 2007, 5, 355–362.
44. Ritchie, K. B.; Smith, G. W. Physiological comparison of bacterial communities from various species of scleractinian corals. Proceedings of the 8th International Coral Reef Symposium 1997, 1, 521–526.
45. Rohwer, F.; Breitbart, M.; Jara, J.; Azam, F.; Knowlton, N. Diversity of bacteria associated with the Caribbean coral Montastraea franksi. Coral Reefs 2001, 20, 85–95.
46. Rohwer, F.; Seguritan, V.; Azam, F.; Knowlton, N. Diversity and distribution of coral-associated bacteria. Marine Ecology Progress Series 2002, 243, 1–10.
47. Forest, R.; Victor, S.; Farooq, A.; Nancy, K. Diversity and distribution of coral-associated bacteria. Marine Ecology Progress Series 2002, 243, 1-10.
48. Gauthier, G.; Gauthier, M.; Christen, R. Phylogenetic analysis of the genera Alteromonas, Shewanella, and Moritella using genes coding for small-subunit rRNA sequences and division of the genus Alteromonas into two genera, Alteromonas (emended) and Pseudoalteromonas gen. nov., and proposal of twelve new species combinations. International Journal of Systematic and Evolutionary Microbiology 1995, 45, 755–761.
49. Gauthier, M. J.; Flatau, G. N. Antibacterial activity of marine violet-pigmented Alteromonas with special reference to the production of brominated compounds. Canadian Journal of Microbiology 1976, 22, 1612–1619.
50. Gerber, N. N.; Gauthier, M. J. New prodigiosin-like pigment from Alteromonas rubra. Applied and Environmental Microbiology 1979, 37, 1176–1179.
51. Sertan-de Guzman, A. A.; Predicala, R. Z.; Bernardo, E. B.; Neilan, B. A.; Elardo, S. P.; Mangalindan, G. C.; Tasdemir, D.; Ireland, C. M.; Barraquio, W. L.; Concepcion, G. P. Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS Microbiology Letters 2007, 277, 188–196.
52. Fehér, D.; Barlow, R.; McAtee, J.; Hemscheidt, T. K. Highly brominated antimicrobial metabolites from a marine Pseudoalteromonas sp. Journal of Natural Products 2010, 73, 1963–1966.
53. Burkholder, P. R.; Pfister, R. M.; Leitz, F. H. Production of a pyrrole antibiotic by a marine bacterium. Applied Microbiology 1966, 14, 649–653.
54. Andersen, R. J.; Wolfe, M. S.; Faulkner, D. J. Autotoxic antibiotic production by a marine Chromobacterium. Marine Biology 1974, 27, 281–285.
55. Isnansetyo, A.; Kamei, Y. MC21-A, a bactericidal antibiotic produced by a new marine bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30T, against methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2003, 47, 480–488.
56. Sonnenschein, E. C.; Stierhof, M.; Goralczyk, S.; Vabre, F. M.; Pellissier, L.; Hanssen, K. Ø.; de la Cruz, M.; Díaz, C.; de Witte, P.; Copmans, D.; Andersen, J. H.; Hansen, E.; Kristoffersen, V.; Tormo, J. R.; Ebel, R.; Milne, B. F.; Deng, H.; Gram, L.; Jaspars, M.; Tabudravu, J. N. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron 2017, 73, 2633–2637.
57. Shigemori, H.; Bae, M. A.; Yazawa, K.; Sasaki, T.; Kobayashi, J. Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai. The Journal of Organic Chemistry 1992, 57, 4317–4320.
58. Shiozawa, H.; Kagasaki, T.; Kinoshita, T.; Haruyama, H.; Domon, H.; Utsui, Y.; Kodama, K.; Takahashi, S. Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium. Fermentation, isolation, structure, and antimicrobial activity. The Journal of Antibiotics 1993, 46, 1834–1842.
59. Murphy, A. C.; Fukuda, D.; Song, Z.; Hothersall, J.; Cox, R. J.; Willis, C. L.; Thomas, C. M.; Simpson, T. J. Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390. Angewandte Chemie International Edition in English 2011, 50, 3271–3274.
60. Laatsch, H.; Thomson, R. H.; Cox, P. J. Spectroscopic properties of violacein and related compounds: crystal structure of tetramethylviolacein. Journal of the Chemical Society, Perkin Transactions 2 1984, 1331–1339.
61. Franks, A.; Haywood, P.; Holmstrom, C.; Egan, S.; Kjelleberg, S.; Kumar, N. Isolation and structure elucidation of a novel yellow pigment from the marine bacterium Pseudoalteromonas tunicata. Molecules 2005, 10, 1286–1291.
62. Shiozawa, H.; Kagasaki, T.; Torikata, A.; Tanaka, N.; Fujimoto, K.; Hata, T.; Furukawa, Y.; Takahashi, S. Thiomarinols B and C, new antimicrobial antibiotics produced by a marine bacterium. The Journal of Antibiotics 1995, 48, 907–909.
63. Shiozawa, H.; Shimada, A.; Takahashi, S. Thiomarinols D, E, F and G, new hybrid antimicrobial antibiotics produced by a marine bacterium; isolation, structure, and antimicrobial activity. The Journal of Antibiotics 1997, 50, 449–452.
64. Yoshikawa, K.; Takadera, T.; Adachi, K.; Nishijima, M.; Sano, H. Korormicin, a novel antibiotic specifically active against marine gram-negative bacteria, produced by a marine bacterium. The Journal of Antibiotics 1997, 50, 949–953.
65. Yoshikawa, K.; Adachi, K.; Nishida, F.; Mochida, K. Planar structure and antibacterial activity of korormicin derivatives isolated from Pseudoalteromonas sp. F-420. The Journal of Antibiotics 2003, 56, 866–870.
66. Speitling, M.; Smetanina, O. F.; Kuznetsova, T. A.; Laatsch, H. Bromoalterochromides A and A', unprecedented chromopeptides from a marine Pseudoalteromonas maricaloris strain KMM 636T. The Journal of Antibiotics 2007, 60, 36–42.
67. Feher, D.; Barlow, R. S.; Lorenzo, P. S.; Hemscheidt, T. K. A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra. Journal of Natural Products 2008, 71, 1970–1972.
68. Wang, Y.; Nakajima, A.; Hosokawa, K.; Soliev, A. B.; Osaka, I.; Arakawa, R.; Enomoto, K. Cytotoxic prodigiosin family pigments from Pseudoalteromonas sp. 1020R isolated from the Pacific coast of Japan. Bioscience, Biotechnology, and Biochemistry 2012, 76, 1229–1232.
69. Blasiak, L. C.; Clardy, J. Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression. Journal of the American Chemical Society 2010, 132, 926–927.
70. Zane, H. K.; Butler, A. Isolation, structure elucidation, and iron-binding properties of lystabactins, siderophores isolated from a marine Pseudoalteromonas sp. Journal of Natural Products 2013, 76, 648–654.
71. Tebben, J.; Motti, C.; Tapiolas, D.; Thomas-Hall, P.; Harder, T. A coralline algal-associated bacterium, Pseudoalteromonas strain J010, yields five new korormicins and a bromopyrrole. Marine Drugs 2014, 12, 2802–2815.
72. Seto, H.; Akao, H.; Furihata, K.; Ōtake, N. The structure of a new antibiotic, hygrolidin. Tetrahedron Letters 1982, 23, 2667–2670.
73. Werner, G.; Hagenmaier, H.; Albert, K.; Kohlshorn, H. The structure of the bafilomycins, a new group of macrolide antibiotics. Tetrahedron Letters 1983, 24, 5193–5196.
74. Ohta, E.; Kubota, N. K.; Ohta, S.; Suzuki, M.; Ogawa, T.; Yamasaki, A.; Ikegami, S. Micromonospolides A–C, new macrolides from Micromonospora sp. Tetrahedron 2001, 57, 8463–8467.
75. Kumagai, K.; Fukui, A.; Tanaka, S.; Ikemoto, M.; Moriguchi, K.; Nabeshima, S. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation. The Journal of Antibiotics 1993, 46, 1139–1144.
76. Moon, S. S.; Hwang, W. H.; Chung, Y. R.; Shin, J. New cytotoxic bafilomycin C1-amide produced by Kitasatospora cheerisanensis. The Journal of Antibiotics 2003, 56, 856–61.
77. Baker, G. H.; Brown, P. J.; Dorgan, R. J. J.; Everett, J. R.; Ley, S. V.; Slawin, A. M. Z.; Williams, D. J. A conformational study of bafilomycin A1 by x-ray crystallography and NMR techniques. Tetrahedron Letters 1987, 28, 5565–5568.
78. Zhang, D. J.; Wei, G.; Wang, Y.; Si, C. C.; Tian, L.; Tao, L. M.; Li, Y. G. Bafilomycin K, a new antifungal macrolide from Streptomyces flavotricini Y12-26. The Journal of Antibiotics 2011, 64, 391–393.
79. Carr, G.; Williams, D. E.; Díaz-Marrero, A. R.; Patrick, B. O.; Bottriell, H.; Balgi, A. D.; Donohue, E.; Roberge, M.; Andersen, R. J. Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy. Journal of Natural Products 2010, 73, 422–427.
80. Uyeda, M.; Kondo, K. I.; Ito, A.; Yokomizo, K.; Kido, Y. A new antiherpetic agent produced by Streptomyces sp. strain no. 758. The Journal of Antibiotics 1995, 48, 1234–1239.
81. Meyer, M.; Keller-Schierlein, W.; Drautz, H.; Blank, W.; Zähner, H. Isolation of bafilomycin-a1-21-O-(α-L-rhamnopyranoside). Structural determination by chemical correlation with bafilomycin A1 and leucanicidin (in German). Helvetica Chimica Acta 1985, 68, 83–94.
82. Laakso, J. A.; Mocek, U. M.; Van Dun, J.; Wouters, W.; Janicot, M. R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species. The Journal of Antibiotics 2003, 56, 909–916.
83. O'Shea, M. G.; Rickards, R. W.; Rothschild, J. M.; Lacey, E. Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups. Journal of Antibiotics 1997, 50, 1073–1077.
84. Kretschmer, A.; Dorgerloh, M.; Deeg, M.; Hagenmaier, H. The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin. Agricultural and Biological Chemistry 1985, 49, 2509–2511.
85. Tchize Ndejouong Ble, S.; Sattler, I.; Maier, A.; Kelter, G.; Menzel, K. D.; Fiebig, H. H.; Hertweck, C. Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis. The Journal of Antibiotics 2010, 63, 359–363.
86. Heinle, S.; Stunkel, K.; Zahner, H.; Drautz, H.; Bessler, W. G. Immunosuppressive effects of the macrolide antibiotic bafilomycin towards lymphocytes and lymphoid cell lines. Arzneimittelforschung 1988, 38, 1130–1133.
87. Lacey, E.; Gill, J. H.; Power, M. L.; Rickards, R. W.; O'Shea, M. G.; Rothschild, J. M. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes. International Journal for Parasitology 1995, 25, 349–357.
88. Lu, C.; Shen, Y. A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. The Journal of Antibiotics 2003, 56, 415–418.
89. Perez-Sayans, M.; Somoza-Martin, J. M.; Barros-Angueira, F.; Rey, J. M.; Garcia-Garcia, A. V-ATPase inhibitors and implication in cancer treatment. Cancer Treatment Reviews 2009, 35, 707–713.
90. Di Cristofori, A.; Ferrero, S.; Bertolini, I.; Gaudioso, G.; Russo, M. V.; Berno, V.; Vanini, M.; Locatelli, M.; Zavanone, M.; Rampini, P.; Vaccari, T.; Caroli, M.; Vaira, V. The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma. Oncotarget 2015, 6, 17514–17531.
91. Gagliardi, S.; Rees, M.; Farina, C. Chemistry and structure activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase. Current Medicinal Chemistry 1999, 6, 1197–212.
92. Li, L.-Q.; Xie, W.-J.; Pan, D.; Chen, H.; Zhang, L. Inhibition of autophagy by bafilomycin A1 promotes chemosensitivity of gastric cancer cells. Tumor Biology 2016, 37, 653–659.
93. Yan, Y.; Jiang, K.; Liu, P.; Zhang, X.; Dong, X.; Gao, J.; Liu, Q.; Barr, M. P.; Zhang, Q.; Hou, X.; Meng, S.; Gong, P. Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Scientific Reports 2016, 6, 37052.
94. Lolkema, J. S.; Chaban, Y.; Boekema, E. J. Subunit composition, structure, and distribution of bacterial V-type ATPases. Journal of Bioenergetics and Biomembranes 2003, 35, 323–335.
95. Bowman, B. J.; Bowman, E. J. Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. The Journal of Biological Chemistry 2002, 277, 3965–3972.
96. Gagliardi, S.; Gatti, P. A.; Belfiore, P.; Zocchetti, A.; Clarke, G. D.; Farina, C. Synthesis and Structure−Activity Relationships of Bafilomycin A1 Derivatives as Inhibitors of Vacuolar H+-ATPase. Journal of Medicinal Chemistry 1998, 41, 1883–1893.
97. Zhang, W.; Fortman, J. L.; Carlson, J. C.; Yan, J.; Liu, Y.; Bai, F.; Guan, W.; Jia, J.; Matainaho, T.; Sherman, D. H.; Li, S. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. Chembiochem 2013, 14, 301–306.
98. Nara, A.; Hashimoto, T.; Komatsu, M.; Nishiyama, M.; Kuzuyama, T.; Ikeda, H. Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms. The Journal of Antibiotics 2017, 70, 616–624.
99. Li, Z.; Du, L.; Zhang, W.; Zhang, X.; Jiang, Y.; Liu, K.; Men, P.; Xu, H.; Fortman, J. L.; Sherman, D. H.; Yu, B.; Gao, S.; Li, S. Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii. The Journal of Biological Chemistry 2017, 292, 7095–7104.
100. Kawada, M.; Usami, I.; Ohba, S.-I.; Someno, T.; Kim, J. W.; Hayakawa, Y.; Nose, K.; Ishizuka, M. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Biochemical and Biophysical Research Communications 2002, 298, 178–183.
101. Hensens, O. D.; Monaghan, R. L.; Huang, L.; Albers-Schonberg, G. Structure of the sodium and potassium ion activated adenosine triphosphatase inhibitor L-681,110. Journal of the American Chemical Society 1983, 105, 3672–3679.
102. Ding, N.; Jiang, Y.; Han, L.; Chen, X.; Ma, J.; Qu, X.; Mu, Y.; Liu, J.; Li, L.; Jiang, C.; Huang, X. Bafilomycins and odoriferous sesquiterpenoids from Streptomyces albolongus isolated from Elephas maximus feces. Journal of Natural Products 2016, 79, 799–805.
103. Yu, Z.; Zhao, L.-X.; Jiang, C.-L.; Duan, Y.; Wong, L.; Carver, K. C.; Schuler, L. A.; Shen, B. Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. The Journal of Antibiotics 2011, 64, 159–162.
104. Isogai, A.; Sakuda, S.; Matsumoto, S.; Ogura, M.; Furihata, K.; Seto, H.; Suzuki, A. The structure of leucanicidin, a novel insecticidal macrolide produced by Streptomyces halstedii. Agricultural and Biological Chemistry 1984, 48, 1379–1381.
105. Sakuda, S.; Isogai, A.; Matsumoto, S.; Ogura, M.; Furihata, K.; Seto, H.; Suzuki, A. Isolation and structure of isobutyrylleucanicidin produced by Streptomyces halstedii. Agricultural and Biological Chemistry 1987, 51, 2841–2842.
106. Sakuda, S.; Isogai, A.; Matsumoto, S.; Ogura, M.; Furihata, K.; Seto, H.; Suzuki, A. Isolation and structure of isobutyrylleucanicidin produced by Streptomyces halstedii. Agricultural and Biological Chemistry 2016, 51, 2841–2842.
107. Seto, H.; Tajima, I.; Akao, H.; Furihata, K.; Otake, N. The isolation and structures of hygrolidin amide and defumarylhygrolidin. The Journal of Antibiotics 1984, 37, 610–613.
108. Yu, Z.; Wang, L.; Yang, J.; Zhang, F.; Sun, Y.; Yu, M.; Yan, Y.; Ma, Y.-T.; Huang, S.-X. A new antifungal macrolide from Streptomyces sp. KIB-H869 and structure revision of halichomycin. Tetrahedron Letters 2016, 57, 1375–1378.
109. Supong, K.; Sripreechasak, P.; Tanasupawat, S.; Danwisetkanjana, K.; Rachtawee, P.; Pittayakhajonwut, P. Investigation on antimicrobial agents of the terrestrial Streptomyces sp. BCC71188. Applied Microbiology and Biotechnology 2017, 101, 533–543.
110. Supong, K.; Thawai, C.; Choowong, W.; Kittiwongwattana, C.; Thanaboripat, D.; Laosinwattana, C.; Koohakan, P.; Parinthawong, N.; Pittayakhajonwut, P. Antimicrobial compounds from endophytic Streptomyces sp. BCC72023 isolated from rice (Oryza sativa L.). Research in Microbiology 2016, 167, 290–298.
111. Kumagai, K.; Taya, K.; Fukui, A.; Fukasawa, M.; Fukui, M.; Nabeshima, S. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. I. Taxonomy, fermentation and biological activity. The Journal of Antibiotics 1993, 46, 972–978.
112. Ohta, E.; Ohta, S.; Kubota, N. K.; Suzuki, M.; Ogawa, T.; Yamasaki, A.; Ikegami, S. Micromonospolide A, a new macrolide from Micromonospora sp. Tetrahedron Letters 2001, 42, 4179–4181.
113. Lu, C.; Shen, Y. Two new macrolides produced by Streptomyces sp. CS. The Journal of Antibiotics 2004, 57, 597–600.
114. Li, J.; Lu, C.; Shen, Y. Macrolides of the bafilomycin family produced by Streptomyces sp. CS. The Journal of Antibiotics 2010, 63, 595–599.
115. Ueda, J. Y.; Hashimoto, J.; Yamamura, H.; Hayakawa, M.; Takagi, M.; Shin-ya, K. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. The Journal of Antibiotics 2010, 63, 627–629.
116. Kodani, S.; Murao, A.; Hidaki, M.; Sato, K.; Ogawa, N. Isolation and structural determination of a new macrolide, makinolide, from the newly isolated Streptomyces sp. MK-30. The Journal of Antibiotics 2012, 65, 331–334.
117. Molloy, E. M.; Tietz, J. I.; Blair, P. M.; Mitchell, D. A. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorganic & Medicinal Chemistry 2016, 24, 6276–6290.
118. Hidaki, M.; Yoshida, M.; Ogawa, N.; Kodani, S. Isolation and structural determination of makinolide B from Streptomyces sp. MK-19. Bioscience, Biotechnology, and Biochemistry 2013, 77, 1964–1966.
119. Kobayashi, K.; Fukuda, T.; Usui, T.; Kurihara, Y.; Kanamoto, A.; Tomoda, H. Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072. The Journal of Antibiotics 2015, 68, 126–132.
120. Werner, G.; Hagenmaier, H.; Drautz, H.; Baumgartner, A.; Zahner, H. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. Journal of Antibiotics 1984, 37, 110–117.
121. Arcamone, F. M.; Bertazzoli, C.; Ghione, M.; Scotti, T. Melanosporin and elaiophylin, new antibiotics from Streptomyces melanosporus (sive melonsporofaciens) n. sp. Giornale di Microbiologia 1959, 7, 207–216.
122. Ley, S. V.; Neuhaus, D.; Williams, D. J. A conformational study of elaiophylin by x-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect. Tetrahedron Letters 1982, 23, 1207–1210.
123. Hammann, P.; Kretzschmar, G.; Seibert, G. Secondary metabolites by chemical screening. 7. I. Elaiophylin derivatives and their biological activities. The Journal of Antibiotics 1990, 43, 1431–1440.
124. Wu, C.; Tan, Y.; Gan, M.; Wang, Y.; Guan, Y.; Hu, X.; Zhou, H.; Shang, X.; You, X.; Yang, Z.; Xiao, C. Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. Journal of Natural Products 2013, 76, 2153–2157.
125. Nair, M. G.; Chandra, A.; Thorogood, D. L.; Ammermann, E.; Walker, N.; Kiehs, K. Gopalamicin, an antifungal macrodiolide produced by soil actinomycetes. Journal of Agricultural and Food Chemistry 1994, 42, 2308–2310.
126. Lee, S.-Y.; Kim, H.-S.; Kim, Y.-H.; Han, S.-B.; Kim, H.-M.; Hong, S.-D.; Lee, J.-J. Immunosuppressive activity of elaiophylin. Journal of Microbiology and Biotechnology 1997, 7, 272–277.
127. Ritzau, M.; Heinze, S.; Fleck, W. F.; Dahse, H. M.; Grafe, U. New macrodiolide antibiotics, 11-O-monomethyl- and 11, 11'-O-dimethylelaiophylins, from Streptomyces sp. HKI-0113 and HKI-0114. Journal of Natural Products 1998, 61, 1337–1339.
128. Yamada, T.; Minoura, K.; Numata, A. Halichoblelide, a potent cytotoxic macrolide from a Streptomyces species separated from a marine fish. Tetrahedron Letters 2002, 43, 1721–1724.
129. Yamada, T.; Kikuchi, T.; Tanaka, R.; Numata, A. Halichoblelides B and C, potent cytotoxic macrolides from a Streptomyces species separated from a marine fish. Tetrahedron Letters 2012, 53, 2842–2846.
130. Lee, D.; Woo, J. K.; Kim, D.; Kim, M.; Cho, S. K.; Kim, J. H.; Park, S. P.; Lee, H. Y.; Riu, K. Z.; Lee, D. S. Antiviral activity of methylelaiophylin, an alpha-glucosidase inhibitor. Journal of Microbiology and Biotechnology 2011, 21, 263–266.
131. Nakakoshi, M.; Kimura, K.; Nakajima, N.; Yoshihama, M.; Uramoto, M. SNA-4606-1, a new member of elaiophylins with enzyme inhibition activity against testosterone 5 alpha-reductase. The Journal of Antibiotics 1999, 52, 175–177.
132. Han, Y.; Tian, E.; Xu, D.; Ma, M.; Deng, Z.; Hong, K. Halichoblelide D, a new elaiophylin derivative with potent cytotoxic activity from mangrove-derived Streptomyces sp. 219807. Molecules 2016, 21, 970:1–970:7.
133. Supong, K.; Sripreechasak, P.; Tanasupawat, S.; Danwisetkanjana, K.; Rachtawee, P.; Pittayakhajonwut, P. Investigation on antimicrobial agents of the terrestrial Streptomyces sp. BCC71188. Appl Microbiol Biotechnol 2017, 101, 533-543.
134. Lima, S. M.; Melo, J. G.; Militao, G. C.; Lima, G. M.; do Carmo, A. L. M.; Aguiar, J. S.; Araujo, R. M.; Braz-Filho, R.; Marchand, P.; Araujo, J. M.; Silva, T. G. Characterization of the biochemical, physiological, and medicinal properties of Streptomyces hygroscopicus ACTMS-9H isolated from the Amazon (Brazil). Applied Microbiology and Biotechnology 2017, 101, 711–723.
135. Klaus, F.; Hartwich, M.; Erwin, B.; Olga, S.; Anno, J.; Friedrich, B.; Martin, S. Manufacture of efomycin G, an antibiotic useful for promoting animal growth with Streptomyces. Jpn. Kokai, S62-234091 (C07H7/02), 1986.
136. Sheng, Y.; Lam, P. W.; Shahab, S.; Santosa, D. A.; Proteau, P. J.; Zabriskie, T. M.; Mahmud, T. Identification of elaiophylin skeletal variants from the indonesian Streptomyces sp. ICBB 9297. Journal of Natural Products 2015, 78, 2768–2775.
137. Stern, N. J.; Svetoch, E. A.; Eruslanov, B. V.; Perelygin, V. V.; Mitsevich, E. V.; Mitsevich, I. P.; Pokhilenko, V. D.; Levchuk, V. P.; Svetoch, O. E.; Seal, B. S. Isolation of a Lactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system. Antimicrobial Agents and Chemotherapy 2006, 50, 3111–3116.
138. Altschul, S. F.; Gish, W.; Miller, W.; Myers, E. W.; Lipman, D. J. Basic local alignment search tool. Journal of Molecular Biology 1990, 215, 403–410.
139. Cole, J. R.; Chai, B.; Farris, R. J.; Wang, Q.; Kulam, S. A.; McGarrell, D. M.; Garrity, G. M.; Tiedje, J. M. The ribosomal database project (RDP-II): sequences and tools for high-throughput rRNA analysis. Nucleic Acids Research 2005, 33, 294–296.
140. Wang, Q.; Garrity, G. M.; Tiedje, J. M.; Cole, J. R. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Applied and Environmental Microbiology 2007, 73, 5261–5267.
141. Kimura, M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. Journal of Molecular Evolution 1980, 16, 111–120.
142. Selders, G. S.; Fetz, A. E.; Radic, M. Z.; Bowlin, G. L. An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration. Regenerative Biomaterials 2017, 4, 55–68.
143. Segel, G. B.; Halterman, M. W.; Lichtman, M. A. The paradox of the neutrophil's role in tissue injury. Journal of Leukocyte Biology 2011, 89, 359–372.
144. Brown, K. A.; Brain, S. D.; Pearson, J. D.; Edgeworth, J. D.; Lewis, S. M.; Treacher, D. F. Neutrophils in development of multiple organ failure in sepsis. Lancet 2006, 368, 157–169.
145. Nathan, C. Neutrophils and immunity: challenges and opportunities. Nature Reviews Immunology 2006, 6, 173–182.
146. Hwang, T. L.; Li, G. L.; Lan, Y. H.; Chia, Y. C.; Hsieh, P. W.; Wu, Y. H.; Wu, Y. C. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radical Biology and Medicine 2009, 46, 520-528.
147. Hwang, T. L.; Su, Y. C.; Chang, H. L.; Leu, Y. L.; Chung, P. J.; Kuo, L. M.; Chang, Y. J. Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils. The Journal of Lipid Research 2009, 50, 1395–1408.
148. González, J. M.; Mayer, F.; Moran, M. A.; Hodson, R. E.; Whitman, W. B. Microbulbifer hydrolyticus gen. nov., sp. nov., and Marinobacterium georgiense gen. nov., sp. nov., two marine bacteria from a lignin-rich pulp mill waste enrichment community. International Journal of Systematic and Evolutionary Microbiology 1997, 47, 369–376.
149. Lafay, B.; Ruimy, R.; Rausch De Traubenberg, C.; Breittmayer, V.; Gauthier, M. J.; Christen, R. Roseobacter algicola sp. nov., a new marine bacterium Isolated from the phycosphere of the toxin-producing dinoflagellate Prorocentrum lima. International Journal of Systematic and Evolutionary Microbiology 1995, 45, 290–296.
150. Nedashkovskaya, O. I.; Suzuki, M.; Vysotskii, M. V.; Mikhailov, V. V. Reichenbachia agariperforans gen. nov., sp. nov., a novel marine bacterium in the phylum Cytophaga–Flavobacterium–Bacteroides. International Journal of Systematic and Evolutionary Microbiology 2003, 53, 81–85.
151. Koren, O.; Rosenberg, E. Bacteria associated with the bleached and cave coral Oculina patagonica. Microbial Ecology 2008, 55, 523–529.
152. Macleod, R. A. The question of the existence of specific marine bacterial. Bacteriological reviews 1965, 29, 9–24.
153. Shnit-Orland, M.; Kushmaro, A. Coral mucus-associated bacteria: a possible first line of defense. FEMS Microbiology Ecology 2009, 67, 371–380.
154. Kim, B. R. Regulation of microbial populations by coral surface mucus and mucus-associated bacteria. Marine Ecology Progress Series 2006, 322, 1–14.
155. Long, R. A.; Azam, F. Antagonistic interactions among marine pelagic bacteria. Applied and Environmental Microbiology 2001, 67, 4975–4983.
156. Nikaido, H. Multidrug efflux pumps of gram-negative bacteria. Journal of Bacteriology 1996, 178, 5853–5859.
157. Kushmaro, A.; Banin, E.; Loya, Y.; Stackebrandt, E.; Rosenberg, E. Vibrio shiloi sp. nov., the causative agent of bleaching of the coral Oculina patagonica. International Journal of Systematic and Evolutionary Microbiology 2001, 51, 1383–1388.
158. Chimetto, L. A.; Brocchi, M.; Thompson, C. C.; Martins, R. C. R.; Ramos, H. R.; Thompson, F. L. Vibrios dominate as culturable nitrogen-fixing bacteria of the Brazilian coral Mussismilia hispida. Systematic and Applied Microbiology 2008, 31, 312–319.
159. Weinstein, M. J.; Luedemann, G. M.; Oden, E. M.; Wagman, G. H. Gentamicin, a new broad-spectrum antibiotic complex. Antimicrob Agents Chemother 1963, 161, 1–7.
160. He, H.; Silo-Suh, L. A.; Handelsman, J.; Clardy, J. Zwittermicin A, an antifungal and plant protection agent from Bacillus cereus. Tetrahedron Letters 1994, 35, 2499–2502.
161. Yu, M.; Wang, J.; Tang, K.; Shi, X.; Wang, S.; Zhu, W. M.; Zhang, X. H. Purification and characterization of antibacterial compounds of Pseudoalteromonas flavipulchra JG1. Microbiology 2012, 158, 835–842.
162. Lucas-Elio, P.; Hernandez, P.; Sanchez-Amat, A.; Solano, F. Purification and partial characterization of marinocine, a new broad-spectrum antibacterial protein produced by Marinomonas mediterranea. Biochimica et Biophysica Acta 2005, 1721, 193–203.
163. Stackebrandt, E.; Goebel, B. M. Taxonomic note: A place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology. International Journal of Systematic and Evolutionary Microbiology 1994, 44, 846–849.
164. Rypien, K. L.; Ward, J. R.; Azam, F. Antagonistic interactions among coral-associated bacteria. Environmental Microbiology 2010, 12, 28–39.
165. Kurahashi, M.; Yokota, A. Tateyamaria omphalii gen. nov., sp. nov., an a-Proteobacterium isolated from a top shell Omphalius pfeifferi pfeifferi. Systematic and Applied Microbiology 2007, 30, 371–375.
166. Shieh, W. Y.; Lin, Y.-T.; Jean, W. D. Pseudovibrio denitrificans gen. nov., sp. nov., a marine, facultatively anaerobic, fermentative bacterium capable of denitrification. International Journal of Systematic and Evolutionary Microbiology 2004, 54, 2307–2312.
167. Prado, S.; Romalde, J. L.; Montes, J.; Barja, J. L. Pathogenic bacteria isolated from disease outbreaks in shellfish hatcheries. First description of Vibrio neptunius as an oyster pathogen. Diseases of Aquatic Organisms 2005, 67, 209–215.
168. Wietz, M.; Mansson, M.; Gotfredsen, C. H.; Larsen, T. O.; Gram, L. Antibacterial compounds from marine Vibrionaceae isolated on a global expedition. Marine Drugs 2010, 8, 2946–2960.
169. Xin, Q. S.; Zhu, X. Y. State resolved probe of an energetic surface reaction: Phosgene on silver. The Journal of Chemical Physics 1996, 104, 4274–4282.
170. Chen, I. H.; Kanai, M.; Shibasaki, M. Copper(I)−secondary diamine complex-catalyzed enantioselective conjugate boration of linear β,β-disubstituted enones. Organic Letters 2010, 12, 4098–4101.
171. Okamoto, S.; Yoshino, T.; Tsujiyama, H.; Sato, F. Highly efficient and general method for synthesis of tertiary allylic alcohols in a chiral form. Synthesis of arbaprostil. Tetrahedron Letters 1991, 32, 5793–5796.
172. Barnes, M. M.; Morton, R. A. Ubiquinone, plastoquinone and related substances. Proceedings of the Nutrition Society 2007, 21, 186-195.
173. Butenandt, A.; Karlson, P.; Zillig, W. Dioxo-piperazines from pupae of silkworm. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 1951, 288, 279–283.
174. Li, T.; Wang, G.-C.; Huang, X.-J. Whitmanoside a, a new α-pyrone glycoside from the leech Whitmania pigra. Heterocycles 2013, 87, 1537–1543.
175. Tatsuno, T.; Sato, M.; Kubota, Y.; Kubota, Y.; Tsunoda, H. Toxicological research of metabolic substances of Fusarium nivale. VIII. The fourth metabolic substance of F. nivale (in French). Chemical and Pharmaceutical Bulletin 1971, 19, 1498–1500.
176. Nalli, Y.; Gupta, S.; Khajuria, V.; Singh, V. P.; Sajgotra, M.; Ahmed, Z.; Thakur, N. L.; Ali, A. TNF-α and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp. Medicinal Chemistry Research 2017, 26, 93–100.
177. Marshall, J. A.; Adams, N. D. Total synthesis of bafilomycin V1:  A methanolysis product of the macrolide bafilomycin C2. The Journal of Organic Chemistry 2002, 67, 733–740.
178. Baker, G. H.; Brown, P. J.; Dorgan, R. J. J.; Everett, J. R. The conformational analysis of bafilomycin A1. Journal of the Chemical Society, Perkin Transactions 2 1989, 1073–1079.
179. Mayer, T.; Maier, M. E. Design and synthesis of a tag-free chemical probe for photoaffinity labeling. European Journal of Organic Chemistry 2007, 2007, 4711–4720.
180. Wu, Z.; Bai, L.; Wang, M.; Shen, Y. Structure–antibacterial relationship of nigericin derivatives. Chemistry of Natural Compounds 2009, 45, 333–337.
181. Harned, R. L.; Hidy, P. H.; Corum, C. J.; Jones, K. L. Nigericin a new crystalline antibiotic from an unidentified Streptomyces. Antibiotics and Chemotherapy (Northfield) 1951, 1, 594–596.
182. Steinrauf, L. K.; Pinkerton, M.; Chamberlin, J. W. The structure of nigericin. Biochemical and Biophysical Research Communications 1968, 33, 29–31.
183. Tang, J. S.; Gao, H.; Hong, K.; Yu, Y.; Jiang, M. M.; Lin, H. P.; Ye, W. C.; Yao, X. S. Complete assignments of 1H and 13C NMR spectral data of nine surfactin isomers. Magnetic Resonance in Chemistry 2007, 45, 792–796.
184. Waksman, S. A.; Woodruff, H. B. bacteriostatic and bactericidal substances produced by a soil Actinomyces. Proceedings of the Society for Experimental Biology and Medicine 1940, 45, 609–614.
185. Hollstein, U.; Breitmaier, E.; Jung, G. Carbon-13 nuclear magnetic resonance study of actinomycin D. Journal of the American Chemical Society 1974, 96, 8036–8040.
186. Teplova, V. V.; Tonshin, A. A.; Grigoriev, P. A.; Saris, N. E.; Salkinoja-Salonen, M. S. Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions. Journal of Bioenergetics and Biomembranes 2007, 39, 321–329.
187. Hollstein, U. Actinomycin. Chemistry and mechanism of action. Chemical Reviews 1974, 74, 625–652.
188. Jaffe, N.; Paed, D.; Traggis, D.; Salian, S.; Cassady, J. R. Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy. Cancer 1976, 38, 1925–1930.
189. Dhanarajan, G.; Rangarajan, V.; Sen, R. Dual gradient macroporous resin column chromatography for concurrent separation and purification of three families of marine bacterial lipopeptides from cell free broth. Separation and Purification Technology 2015, 143, 72–79.
190. Marshall, V. P.; McWethy, S. J.; Sirotti, J. M.; Cialdella, J. I. The effect of neutral resins on the fermentation production of rubradirin. Journal of Industrial Microbiology 1990, 5, 283–287.
191. Phillips, T.; Chase, M.; Wagner, S.; Renzi, C.; Powell, M.; DeAngelo, J.; Michels, P. Use of in situ solid-phase adsorption in microbial natural product fermentation development. Journal of Industrial Microbiology & Biotechnology 2013, 40, 411–425.
192. Jensen, P. R.; Gontang, E.; Mafnas, C.; Mincer, T. J.; Fenical, W. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environmental Microbiology 2005, 7, 1039–1048.
193. Ivanitskaia, L. P.; Singal, E. M.; Bibikova, M. V.; Vostrov, S. N. Directed isolation of Micromonospora generic cultures on a selective medium with gentamycin. Antibiotiki 1978, 23, 690–692.
194. Martin, J. P. Use of acid, rose bengal, and streptomycin in the plate method for estimating soil fungi. Soil Science 1950, 69, 215–232.
195. Dharmaraj, S.; Sumantha, A. Bioactive potential of Streptomyces associated with marine sponges. World Journal of Microbiology and Biotechnology 2009, 25, 1971–1979.
196. Zobell, C. E.; Conn, J. E. Studies on the thermal sensitivity of marine bacteria. Journal of Bacteriology 1940, 40, 223–238.
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