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研究生:洪柏江
研究生(外文):Bo-Jiang Hong
論文名稱:無介面活性劑製備 介孔生物活性玻璃之藥物載體
論文名稱(外文):Surfactant-free synthesis of mesoporous bioactive glass for drug delivery
指導教授:施劭儒
指導教授(外文):Shao-Ju Shih
口試委員:顏怡文段維新陳錦毅
口試委員(外文):Yee-wen YenWei-Hsing TuanChin-Yi Chen
口試日期:2018-07-24
學位類別:碩士
校院名稱:國立臺灣科技大學
系所名稱:材料科學與工程系
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2018
畢業學年度:106
語文別:中文
論文頁數:95
中文關鍵詞:介孔生物玻璃藥物載體雙氧水噴霧熱裂解法
外文關鍵詞:Mesoporous bioactive glassHydrogen peroxideDrug carrierSpray pyrolysis
相關次數:
  • 被引用被引用:0
  • 點閱點閱:243
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  • 下載下載:14
  • 收藏至我的研究室書目清單書目收藏:0
開放式骨折的發生常伴隨著複雜的治療流程,而在開放式骨折的治療初期,常常需施加抗生素以預防感染的風險。此外,抗生素的施加,常常為了達到有效的治療效果,需要定時定量的植入於人體中,而藥物載體的應用能夠有效控制藥物的釋放亦能減少藥物植入人體的次數。在老年人的骨折事件中,老年人的骨骼修復能力較為不佳。而生物活性玻璃(BG)是一個具有優異生物活性的骨植入物以及藥物載體,其在浸入模擬體液後會於表面上形成氫氧基磷灰石層能夠有效幫助骨骼的修復。而在藥物載體的研究中,提高比表面積與孔體積能夠有效影響材料的載藥量,而具有高比表面積介孔生物活性玻璃(MBG)亦為目前的主流材料。此外,溶膠-凝膠法、噴霧熱解法(Spray pyrolysis , SP)是兩種常見的製備MBG方法,雖然SP相較於溶膠-凝膠法具有低成本且快速製造時間的優勢,但是於SP的製程中使用介面活性劑時會因為燒結時間短,而導致有碳殘留的問題,且介面活性劑因缺乏高度有序的微粒結構易產生團聚現象,導致MBG的比表面積減少。為了克服上述問題,在本研究中分別添加0、25、40、50以及69 vol% 雙氧水以合成MBG。而在本實驗結果顯示具有高比表面積以及具有較高孔徑大小的樣品具有較高的藥物釋放情況。
The occurrence of the open fractures is often accompanied by complex treatment procedures. In the early stages of treatment for the open fracture, antibiotics are often required to prevent the risk of infection. In addition, in order to achieve an effective therapeutic effect, antibiotics require regular quantitative implantation for the human body. The application of the drug carrier can effectively control the release of the drug and also reduce the number of times to implant the drug into the human body. In the bone fractures of the elderly, the skeletal reparability of the elderly is relatively poor. Bioactive glass is a potential biomaterial for bone implants and drug carriers because it has excellent bioactivity and forms a hydroxyl apatite (HA) layer when immersed in body fluid. In the research of drug carriers, increasing the specific surface area and pore volume can effectively affect the drug loading of the material. One product of these studies is mesoporous bioactive glass (MBG), which has a high specific surface. The common pore-forming agents of MBG are surfactants; however, surfactants present the serious problems of micelle aggregation and carbon contamination.
To overcome these problems, hydrogen peroxide (H2O2) has been used as a pore-forming agent to replace the traditional surfactants, such as P123, and F127. In this study, 0, 25, 40, 50, and 69 vol% H2O2-treated MBG powders were synthesized using spray pyrolysis (SP). The corresponding formation mechanisms are also discussed. The results shows that samples with high specific surface area and high pore size have higher drug release.
摘要 I
Abstract II
致謝 III
目錄 IV
圖目錄 VIII
表目錄 XII
第一章、 緒論 1
1.1 研究背景 1
1.2 研究動機與目的 3
第二章、文獻回顧 4
2.1骨折 4
2.1.1人體骨骼 4
2.1.2骨折的成因 7
2.1.3 開放式骨折 9
2.2 藥物釋放 12
2.2.1藥物傳輸系統 14
2.2.2藥物載體 16
2.2.3 抗生素藥物載體 18
2.2.3.1 聚甲基丙烯酸甲酯 18
2.2.3.2 生物可降解高分子材料 19
2.2.3.4氫氧基磷灰石 21
2.3 生物活性玻璃 22
2.3.1 生物活性之機制 24
2.3.2 影響生物活性的因素 26
2.3.2.1 提升材料的比表面積 26
2.3.2.2 改變材料的化學組成 26
2.3.3 介孔生物活性玻璃 30
2.4 介孔生物活性玻璃製程方式 34
2.4.1 溶膠凝膠法 34
2.4.2 噴霧熱裂解法 38
第三章、實驗目的與方法 41
3.1 實驗設計及其目的 41
3.2 實驗原料 43
3.3 實驗儀器設備 44
3.4介孔生物活性玻璃粉體之製備與收集 45
3.5 樣品性質及分析方法 46
3.5.1 X光繞射儀 46
3.5.2場發射掃描式電子顯微鏡 48
3.5.3場發射穿透式電子顯微鏡 49
3.5.4傅立葉轉換紅外線光譜儀 50
3.5.5氮氣吸/脫附分析儀 51
3.6體外生物活性評估 52
3.7藥物釋放 53
第四章、實驗結果 54
4.1 介孔生物活性玻璃之晶體結構及形貌 54
4.1.1 X光繞射分析 54
4.1.2場發射掃描式電子顯微鏡 55
4.1.3穿透式電子顯微鏡 58
4.2介孔生物活性玻璃之比表面積及生物活性 60
4.2.1氮氣吸/脫附分析 60
4.2.2傅立葉氏轉換紅外線光譜儀分析 62
4.3藥物載體分析 65
第五章、結果討論 67
5.1介孔生物活性玻璃之成型機制探討 67
5.2介孔生物活性玻璃之比表面積與孔徑探討 69
5.3介孔生物活性玻璃之比表面積與生物活性探討 70
5.4介孔生物活性玻璃之表面積與藥物釋放探討 71
第六章、結論 74
第七章、未來工作 76
參考文獻 77
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