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論文名稱(外文):Fabrication of Paper-based Microfluidics by One-step Hot Microembossing
指導教授(外文):Yi-Je Juang
外文關鍵詞:paper-based microfluidicsembossingwaxfilter paperheavy metal detection
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近年來,紙基微流體裝置(µPAD)得到相當多關注,因為其簡單、可攜帶以及可拋棄的特性,可用於低成本的化學、生物及環境檢測。再者,因為樣本與試劑不須使用機械或電子設備,單純以毛細現象即可進行輸送,降低了許多設備成本,而使其更容易作為檢測的裝置。目前已有各種不同製作紙基微流體裝置的方法問世,例如噴墨印刷法(ink jet printing)、紙張切割法(craft cutting),以及光微影法(photolithography)等。本研究將呈現如何以一步驟熱微壓印製備紙基微流體裝置,探討溫度、壓力及壓印時間等變數對於研究有何影響,並且將此微流體裝置用於重金屬離子之檢測。使用本研究方法將可在10秒以內完成紙基微流體裝置之製作。
In recent years, microfluidic paper-based analytical device (µPAD) has been receiving attention because it is simple, inexpensive and power-free for low-cost chemical, biological and environmental detection. Moreover, paper is lightweight, easy to stack, store and transport, biodegradable, biocompatible, good for colorimetric tests, flammable for easy disposal of used paper-based diagnostic devices by incineration, and can be chemically modified.
Different methods have been demonstrated to fabricate µPADs such as solid wax printing, craft cutting, photolithography, etc. In this study, we proposed and demonstrated one-step hot microembossing to fabricate µPADs. The processing parameters like temperature, embossing pressure and embossing time were systematically studied. The results showed that the temperature and embossing time played important roles in fabrication of µPADs. Heavy metal detection was conducted to verify the performance of µPADs as fabricated. Fabrication of µPADs can be completed within 10 seconds.
中文摘要 i
Extended Abstract ii
誌謝 xix
目錄 xx
圖目錄 xxiii
表目錄 xxviii
第一章 緒論 1
1.1 前言 1
1.2 研究動機與方法 1
第二章 文獻回顧 3
2.1 紙基微流體 3
2.2 紙基微流體的製作 5
2.2.1 Handcrafted 6
2.2.2 Mask 8
2.2.3 Printing 12
2.2.4 Cutting/Shaping 15
2.2.5 其它方法 18
2.3 紙基微流體之檢測方法 21
2.3.1 光度檢測法 21
2.3.2 螢光檢測法 22
2.3.3 電化學檢測法 23
2.4 紙基微流體之應用 24
2.4.1 臨床檢測 24
2.4.2 環境監控 25
2.4.3 食安分析 26
2.5 流體在濾紙中的流動行為 28
第三章 實驗材料及方法 30
3.1 實驗藥品與材料 30
3.2 實驗儀器 31
3.3 實驗步驟 36
3.3.1 製備紙基微流體裝置 36
3.3.2 重金屬檢測應用 37
第四章 結果與討論 39
4.1 流道隔絕層材料選擇 39
4.2 流道形成機制 41
4.3 製程變數之影響 43
4.3.1 壓印溫度 43
4.3.2 壓印壓力 44
4.3.3 壓印時間 47
4.3.4 不同濾紙之比較 48
4.4 流動現象與特徵 50
4.5 重金屬檢測 52
4.4.1 銅離子檢測 52
4.4.2 鐵離子檢測 55
第五章 結論 57
第六章 未來工作與展望 58
第七章 參考文獻 59
第八章 附錄 66
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