臺灣博碩士論文加值系統

　　本研究利用不同種類及重量之改質纖維素與生物可降解材料聚(癸二酸甘油酯) poly(glycerol sebacate) (PGS)進行反應，製備為PGS-co-纖維素之共聚彈性體，製程分為熱及光共聚(copolymerization)反應，並討論共聚物的性質與其相關應用。由傅立葉轉換紅外線光譜儀(FT-IR)可得知含雙鍵接枝單體確實接枝於Prepolymer使光共聚反應之彈性體順利成型。另利用熱重分析儀(TGA)及示差掃描熱分析儀(DSC)測試共聚彈性體之熱性質，得知彈性體摻入不同種類及比例之改質纖維素共聚反應後，熱及光共聚彈性體之熱裂解溫度、玻璃轉換溫度、熱熔融溫度、結晶溫度，皆有明顯差異。再由萬能材料拉力機測試共聚彈性體之機械性質，摻入不同種類及重量之改質纖維素，共聚彈性體的機械強度、伸長率、剛性，皆有所增減，加入改質纖維素可調控PGS應用所需之物性。

　　The copolymerization of modified cellulose with poly (glycerol sebacate) (PGS) was investigated in this study. Both the thermal and photo copolymerization methods were used to cure PGS-co-cellulose. The results of Fourier transform infrared spectroscopy (FT-IR) indicated that the modified PGS-co-cellulose could be photo cured when an unsaturated monomer was successfully grafted onto PGS-co-cellulose prepolymer. Thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC) were used to analyze the thermal properties of copolymer elastomers. It was obtained that the thermal degradation temperature, glass transition temperature, melting temperature, and crystallization temperature of the PGS-co-cellulose elastomers were significantly affected by the type and amount of the cellulose used. As a result, the corresponding tensile strength, elongation, and rigidity of the prepared elastomers were also changed. It is demonstrated that the physical properties of the PGS elastomer can be tuned by copolymerizing with the modified cellulose.

摘要 II
Abstract III
致謝 IV
目錄 V
圖目錄 IX
表目錄 XI
第1章 、緒論 12
1.1 前言 12
1.2 研究動機與方向 14
第2章 、文獻回顧 15
2.1 纖維素(Cellulose) 15
2.1.1 纖維素(Cellulose)之簡介 15
2.1.2 纖維素(Cellulose)之組成 16
2.1.3 纖維素(Cellulose)之性質 17
2.1.4 纖維素(Cellulose)之機械特性 17
2.1.5 纖維素(Cellulose)薄膜的應用 18
2.1.6 醋酸纖維素(Cellulose-acetate)之簡介 19
2.2 Poly(glycerol sebacate) (PGS)簡介 20
2.3 Poly(glycerol sebacate) (PGS)複合材料製作及調整方法 22
2.3.1 摻混(Blending) 22
2.3.2 共聚(Copolymerization) 22
2.3.3 微波輔助(Microwave-assisted) 24
2.3.4 靜電紡絲(Electro-spinning) 24
2.3.5 PGSA光引發聚合(Photopolymerization) 26
2.4 Poly(glycerol sebacate) (PGS)複合材料應用 27
2.4.1 組織再生支架 27
2.4.2 軟組織修補材料 28
2.4.3 手術密封膠 29
2.4.4 藥物載體 29
2.5 生物可降解聚合物 30
2.6 Poly(glycerol sebacate)(PGS)降解特性 31
2.6.1 體內降解 (In Vivo) 31
2.6.2 體外降解 (In Vitro) 32
2.7 生物相容性 33
2.7.1 材料結構與生物相容性間影響 33
2.7.2 間接細胞相容性 34
2.7.3 直接細胞相容性 34
2.8 TEMPO間接氧化法 (TEMPO-Mediated Oxidization) 36
2.8.1 TEMPO之簡介 36
2.8.2 TEMPO間接氧化原理 37
2.8.3 TEMPO氧化纖維素(TEMPO oxidized cellulose ) 38
第3章 、材料與實驗方法 40
3.1 實驗藥品 40
3.2 實驗設備 42
3.3 實驗步驟 44
3.3.1 纖維素(Cellulose)性質處理製備 44
3.3.2 Poly(glycerol sebacate) (PGS)之製備 47
3.3.3 PGS-co-(α-cellulose)彈性體熱固化製程與分析 51
3.3.4 PGS-co-(cellulose-acetate)彈性體熱固化製程與分析 54
3.3.5 PGS-co-(α-cellulose)彈性體光固化製程與分析 57
3.4 實驗儀器分析 60
3.4.1 凝膠滲透層析儀 （Gel Permeation Chromatography, GPC） 60
3.4.2 傅立葉轉換紅外光譜儀 (Fourier Transform Infrared Spectroscopy，FT-IR) 60
3.4.3 熱重分析(Thermogravimetric Analysis, TGA) 62
3.4.4 示差掃描熱分析儀（Differential Scanning Calorimetry, DSC） 62
3.4.5 機械性質測試（Universal Material Testing Machine） 66
第4章 、結果與討論 68
4.1 纖維素(Cellulose)材料鑑定分析 68
4.1.1 纖維素(Cellulose) FT-IR分析 68
4.1.2 纖維素(Cellulose) TGA分析 70
4.1.3 纖維素(Cellulose) DSC分析 73
4.2 Poly(glycerol sebacate) (PGS)彈性體鑑定分析 74
4.2.1 Poly(glycerol sebacate) (PGS)製程分析 74
4.2.2 Poly(glycerol sebacate) (PGS) FT-IR分析 74
4.2.3 Poly(glycerol sebacate) (PGS) GPC分析 76
4.2.4 Poly(glycerol sebacate) (PGS) TGA分析 77
4.2.5 Poly(glycerol sebacate) (PGS) 機械性質分析 78
4.3 PGS-co-Cellulose熱固化彈性體鑑定分析 79
4.3.1 PGS-co-Cellulose熱固化彈性體 ATR FT-IR分析 79
4.3.2 PGS-co-Cellulose熱固化彈性體 TGA分析 81
4.3.3 PGS-co-Cellulose熱固化彈性體 DSC分析 83
4.3.4 PGS-co-Cellulose熱固化彈性體 機械性質分析 86
4.4 PGS-co-(α-Cellulose) 光固化彈性體鑑定分析 90
4.4.1 Prepolymer-g-GMA 光固化彈性體 FT-IR分析 90
4.4.2 PGS-co-(α-Cellulose) 光固化彈性體 TGA分析 91
4.4.3 PGS-co-(α-Cellulose) 光固化彈性體 DSC分析 96
4.4.4 PGS-co-(α-Cellulose) 光固化彈性體 機械性質分析 98
第5章 、結論 101
5.1 結論 101
第6章 、參考文獻 103

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