CONTENTS
ABSTRACT I
中文摘要 III
致謝 IV
CONTENTS V
LIST OF TABLES VII
LIST OF FIGURES VIII
NOMENCLATURE XI
ABBREVIATION XIV
Chapter 1 INTRODUCTION 1
1.1 Introduction to Peritoneal Dialysis 1
1.2 Continuous Ambulatory Peritoneal Dialysis 1
1.3 Mathematical Models for Peritoneal Dialysis 2
1.4 Peritoneal Dialysis Solutions 5
Chapter 2 THEORY OF THE MATHEMATICAL MODEL 10
2.1 Fluid and solute transport through semipermeable membranes for peritoneal dialysis 10
2.1.1 Thermodynamic model 10
2.1.2 Pore model 12
2.2 Membrane model 13
2.3 Three-pore model 15
2.3.1 Mathematical Models 15
2.3.2 The Simplicity of the Three-Pore Model 18
Chapter 3 PARAMETER SELECTION 22
3.1 Mass and osmolality spectrum of icodextrin 22
3.2 The transport parameter of the three-pore model 23
3.3 Program validation 24
Chapter 4 RESULTS AND DISCUSSION 30
4.1 Non-constant icodextrin concentration in blood 30
4.2 Effect of residual icodextrin concentrations in the plasma 30
4.3 Effects of increased direct lymphatic absorption 32
4.4 Effects of vascular surface area alterations 32
4.5 Discussion 33
Chapter 5 CONCLUSION 42
REFERENCES 44
BIOGRAPHY 48
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