臺灣博碩士論文加值系統

本研究的目的為探討攝取麻油雞酒湯對母乳餵哺的影響。於臺北醫學大學萬芳醫院招募產後15天~3個月且對酒精無過敏的健康哺乳婦女共23位，以利用標準化配方統一製作的不含酒精的麻油雞湯(CS)和酒精含量為40 mg/mL的麻油雞酒湯(AS)為實驗材料。分別各進行1天實驗，中間間隔一星期，實驗前3天受試者避免攝取酒精性飲料或膳食，實驗進行前受試者以電動擠乳器排空乳汁，再分別依體重攝取8 mL/kg CS或AS。於攝取後的10, 20, 30, 40, 60, 90分鐘分別收集2 mL乳汁，於攝取後120分鐘，測量乳汁分泌時第一滴乳汁噴出時間和30分鐘的泌乳量；於實驗進行前後和攝取後的20, 40, 60, 90分鐘抽血。結果顯示，攝取AS後25±11分鐘血液中的酒精濃度達到最高，攝取AS後32±19分鐘母乳中的酒精濃度達到最高，於150分鐘時，大部分受試者的血液和母乳中酒精濃度趨近於基準值。攝取AS後，乳汁分泌時第一滴乳汁噴出時間顯著較攝取CS長。至於30分鐘泌乳量，攝取AS與CS相較，13人有顯著減少的情形，而10人有顯著增加的情形。綜合本實驗結果，攝取麻油雞酒湯對母乳餵哺的影響，主要為乳汁分泌時的噴乳反射時間延長，且亦得知攝取後2.5小時以上再行母乳餵哺應可避免或減少嬰兒經由乳汁攝入酒精所產生的健康風險。

The aim of present study was to investigate the effects of consuming sesame-oil chicken with rice wine on breastfeeding. Twenty-three healthy and non-alcohol sensitive lactating women were recruited from the Department of Obstetrics and Gynecology at Taipei Medical University Wan-Fang Hospital. Use standard materials and methods to prepare non-alcoholic sesame-oil chicken soup as control (CS) and sesame-oil chicken with rice wine soup (AS) which alcohol concentration was 40 mg/mL as experimental material. Each woman took 2 testing days that separated by 1 week, and they were instructed to refrain from drinking any alcoholic beverages or diets before the 3 days of the two testing days. Before experiment, each subject emptied both breast by using an electric breast pump, and then drank 8 mL/kg of body weight CS or AS. After 10, 20, 30, 40, 60, 90 min of CS or AS consumption, the subject collected 2 mL milk respectively. The amount of milk yield within 30 min and the time of the first droplet of milk to be ejected were measured after 120 min of CS or AS consumption. Blood samples were also collected before experiment and after 20, 40, 60, 90, 120 min of CS or AS consumption. The results show that, maximum blood and milk alcohol concentration were achieved after 25±11 and 32±19 min of AS consumption respectively. The blood and milk alcohol concentration of most subjects returned to the basal alcohol levels after 150 min of AS consumption. The time for the first droplet of milk to be ejected was significantly longer after consuming AS than CS. The milk yield within 30 min was significantly decreased in thirteen subjects and increased in ten subjects after consuming AS. In conclusion, the prolongation of milk ejection time was the main effects of consuming sesame-oil chicken with rice wine on breastfeeding. According to the present study, it recommends to breast-feed milk after 2.5 hours or more than 2.5 hours of consumption to avoid the risk on infants caused by alcohol exposure of breast milk.

中文摘要 I
英文摘要 II
致 謝 IV
總 目 錄 VI
表 目 錄 VIII
圖 目 錄 IX
附錄目錄 X
第一章 前 言 1
第二章 文獻回顧 2
第一節 母乳的分泌 2
第二節 影響乳汁分泌與成分之因素 3
第三節 酒精的吸收與代謝 7
第四節 影響酒精的吸收與代謝之因素 10
第五節 哺乳期間攝取酒精之影響 12
第三章 研究動機與目的 16
第四章 實驗材料與方法 18
第一節 實驗大綱 18
第二節 實驗材料 19
第三節 受試者 20
第四節 實驗設計與流程 21
第五節 實驗方法 23
第六節 統計分析 40
第五章 結 果 41
第一節 實驗材料成分與受試者基本資料 41
第二節 哺乳婦體內酒精之吸收代謝 46
第三節 攝取麻油雞酒湯對母乳餵哺之影響 55
第六章 討 論 61
第一節 實驗材料之控制與受試者順應性 61
第二節 哺乳婦體內酒精之吸收代謝 61
第三節 攝取麻油雞酒湯對母乳餵哺之影響 67
第七章 結 論 75
第八章 參考文獻 76
第九章 附 錄 82
表一 不同哺乳期階段中母乳成分之變化 6
表二 麻油雞湯與麻油雞酒湯之一般成分分析 42
表三 受試者基本資料 44
表四 受試者飲食攝取狀況 45
表五 受試者麻油雞湯和麻油雞酒湯攝取情形 48
表六 攝取麻油雞湯和麻油雞酒湯之血液生化分析結果 53
表七 攝取麻油雞湯和麻油雞酒湯對母乳分泌之影響 56
表八 受試者分組比較 57
表九 母乳成分分析結果 58
圖一 酒精代謝圖 9
圖二 麻油雞酒烹調過程中酒精濃度之變化 43
圖三 攝取麻油雞酒湯後血液的酒精濃度 49
圖四 攝取麻油雞酒湯後母乳中酒精濃度變化 50
圖五 攝取麻油雞酒湯後血液和母乳中酒精濃度之相關性 51
圖六 血液和母乳中乙醛含量之分析結果 54
圖七 攝取麻油雞湯和麻油雞酒湯前後母乳中之酪蛋白含量 59
圖八 母乳中酪蛋白之西方點墨法圖 60
附錄A 受試者參與計畫同意書 82
附錄B 受試者基本資料問卷 84
附錄C 人體試驗委員會審查通過之公文 86
附錄D 飲食紀錄表 87
附錄E SDS-PAGE與Western blotting使用試劑之配製 90

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