臺灣博碩士論文加值系統

本研究目的以靜電噴霧(Electric Spraying)技術製備微膠囊，應用於精油包覆。本實驗以海藻酸鈉溶液為原料，經靜電噴霧法以15wt%氯化鈣水溶液進行交聯反應收集海藻酸鈉微膠囊，藉由調控不同實驗參數，參數如下，距離固定為5cm，至於電壓值變化則為15kV、18kV、21kV，流速為1mL/hr、3mL/hr、5mL/hr，並在靜電噴霧過程中，觀察不同濃度的海藻酸鈉、靜電噴霧的電壓及流速等因素，對海藻酸鈉微膠囊型態性質之探討。選出較佳實驗條件後，將海藻酸鈉微膠囊進行薰衣草精油包覆。樣品分別進行黏度分析、粒徑分析、包覆率及釋放性檢測。結果顯示，隨著海藻酸鈉溶液濃度的增加，其粘度也隨之增加，所製得微膠囊的粒徑也跟著變大，當其他參數固定的情況下微膠囊成型的粒徑大小會與電壓成反比與擠出速率成正比。海藻酸鈉溶液濃度為2wt %時為最佳的微膠囊成型濃度，濃度過高使粘度增大會影響到微膠囊成型的形狀不規則，濃度過低時則會造成粘度太低成型時的外形結構雜亂而不易成型。電壓21kV、海藻酸鈉濃度1wt %、擠出速率1mL/hr測得最小的平均粒徑，其微膠囊平均之粒徑大小約161.22μm±5.2μm。電壓18kV、海藻酸鈉濃度2wt %、擠出速率1mL/hr為最佳微膠囊成型條件，其平均之粒徑大小約200±5.2μm。電壓18kV、海藻酸鈉濃度2wt %包覆0.25g 精油、流速3ml/hr ，測得最小平均粒徑104.3μm，其包覆率82.45%。利用靜電噴霧法，將海藻酸鈉溶液與海藻酸鈉/薰衣草精油溶液製備成微膠囊，以15wt %氯化鈣水溶液為收集微膠囊之平台並且成功收集海藻酸鈉微膠囊應用於精油包覆。

This research presents an electrostatic spraying technique for the Sodium alginate microcapsules preparationand applied in coating essential oil. Sodium alginate is the basic material, we collect the sodium alginate microcapsules through the crosslinking reaction with calcium chloride solution by electrostatic spraying. Parameter of the distance fix in 5cm, the voltage adjuste to 15、18 and 21kV, the flow rate is 1、3 and 5ml/hr. We observe how the parameters (concentration、voltage and flow rate) effectSodium alginate microcapsules and discussed the quality. After choosing the better parameters, we further coated the lavender essential oil in the microcapsules and analyzed the viscosity, diameter, coating percentage and the releasing ability.
The results indicate that the increasing concentration of the sodium alginate will raising the viscosity and diameters. When other parameters are fixed, the diameter of the microcapsules will inversely with the voltage and proportional with the flow rate. Two percentage of the sodium alginate is the best concentration to forming the microcapsules. Higher concentration will increase the viscosity and lead to the irregular shape of the microcapsules contrarily the lower concentration will decrease the viscosity and difficult to form the microcapsules. With the 21kV voltage, 1% concentration of sodium alginate and the 1mL/hr flow rate forms the smallest average diameter about 161.22±5.2μm. 18kV, 2% concentration of sodium alginate and the flow rate 1mL/hr is the best parameter for forming the microcapsules with the average diameter 200±5.2μm. 18kV, 2% of sodium alginate with 0.25g essential oil coated and the flow rate 3mL/hr will get the smallest average diameter of 104.3μm and the covering rate is 82.45%.
By using electrostatic spraying and 15wt% calcium chloride as a fixation platform, we collect the spray and forms the lavender essential oil coated by sodium alginate microcapsules successfully.

致謝 ..................................................................Ⅰ
中文摘要 ............................................................. Ⅱ
英文摘要 ............................................................. Ⅲ
目錄 ................................................................. Ⅴ
表目錄 ............................................................... Ⅷ
圖目錄 ............................................................... Ⅰ
第一章 前言 ............................................................1
1-1 研究動機與重要性 ................................................1
1-2 研究目的 ........................................................2
1-3 微膠囊結構 ......................................................2
1-4 微膠囊包覆 ......................................................4
1-5 靜電紡絲技術 ....................................................9
第二章 文獻回顧 .......................................................10
2-1 芳香療法簡介 ...................................................10
2-1-1 芳香療法理論 ...............................................10
2-1-2 芳香療法歷史演進 ...........................................12
2-1-3 精油簡介 ...................................................14
2-1-4 海藻酸鈉 ...................................................15
2-2 微膠囊簡介 .....................................................19
2-2-1 微膠囊包覆技術 .............................................19
2-3 靜電紡絲簡介 ...................................................21
2-3-1 靜電噴霧之原理與特性 .......................................21
2-3-2 靜電紡絲的歷史 .............................................23
2-3-3 靜電噴霧設備與基本參數控制 .................................24
第三章 材料與方法 .....................................................30
3-1 實驗材料與儀器設備 .............................................30
3-1-1 實驗材料 ...................................................30
3-1-2 儀器設備 ...................................................31
3-2 實驗步驟 .......................................................32
3-3 實驗流程圖 .....................................................33
3-4 靜電噴霧微膠囊物性分析 .........................................34
3-4-1 黏度檢測 ...................................................34
3-4-2 粒徑分析 ...................................................34
3-4-3 熱重損失分析 ...............................................34
3-4-4 緩釋性測試 .................................................34
第四章 結果與討論 .....................................................35
4-1 海藻酸鈉濃度對於黏度及型態之影響 .............................36
4-2 電壓對於微膠囊型態及粒徑之影響 ...............................41
4-3 流速對於微膠囊型態及粒徑之影響 ...............................45
4-4 精油與微膠囊之包覆率分析......................................49
4-5 精油與微膠囊之釋放分析........................................50
第五章 結論 ...........................................................51
參考文獻 ..............................................................52

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