臺灣博碩士論文加值系統

現代人習慣在 3C 產品(電腦營幕、手機)上閱覽，因此經常暴露在高能 量的藍光環境中。目前有許多號稱護眼的過濾藍光產品隨之而出，然而過濾藍 光是否有利於或有損於閱覽時進行的眼動跳視的處理效率，此議題則未曾被探 討過。過去文獻指出，藍光會影響我們的晝夜節律、警覺性、執行功能、與動 態視力。近期的研究也顯示，和眼動及注意力導向相關的腦區，例如額葉眼動 區，會受到對藍光敏感的自發性感光視網膜神經節細胞的影響。本研究利用和 眼動反應與注意力相關的間隔效應派典來探討藍光是否影響跳視眼動與注意力 脫離。間隔效應是指對於視野周邊呈現之目標物的跳視眼動或手指按鍵反應， 會因為中央凝視點在目標物出現前消失(相對於凝視點持續存在以致於和目標 物的呈現時間重疊)而增快的現象。參與者在連續兩天的實驗中，暴露在藍光 或橘光的背景光源下，並針對視野周邊出現的目標物盡可能快速且正確的反 應。實驗一發現藍光會縮短在重疊情境的跳視潛時。實驗二發現只有當注意力 與眼動共同活動時，我們方能獲得穩定的藍光對於跳視潛時的增快效果。實驗 三發現了藍光會促進視覺醒目刺激的處理。總結而言，本研究顯示當注意力與 眼動系統為一體時，藍光會增快我們的跳視潛時，這樣的結果支持了注意力的 前運動理論。本研究提供了一個藍光有效提升眼動效率的方案，顯示在透過 3C 產品進行閱覽時，藍光的照射有利於跳視眼動。

People nowadays usually read or browse on 3C products (such as computer screen or cell phone) via saccades, hence exposing to high intensity of blue light very often. Recently, several products that claimed to filter blue light spring up, and yet whether filtering blue light is beneficial or detrimental to saccadic efficiency is unknown. It has been shown that exposure to blue light affects our circadian rhythm, alertness, executive functions, and dynamic visual acuity. Recent studies also showed that brain regions related to eye movements and attentional orientation such as frontal eye fields were activated by blue-light-sensitive intrinsically photosensitive retinal ganglion cells (ipRGCs). The current study adopted the gap effect paradigm to investigate whether saccadic eye movement and attentional disengagement would be affected by blue light. The gap effect refers to the phenomenon of facilitated saccadic or manual response to a peripherally presented target by extinguishing the fixation shortly before the target onset (compared to when the fixation remains on the screen and overlaps with the target presentation). Participants were exposed to blue (vs. orange) light in two consecutive days, and they were instructed to respond to peripherally presented targets as quickly and accurately as possible. Experiment 1 showed that blue light facilitated saccade latency in the overlap condition. Results from Experiment 2 indicated that only when attention and eye movements activated simultaneously would we obtain a stable blue-light facilitation effect. Experiment 3 further showed that blue light also facilitated the processing of a salient target. We conclude that when attention and oculomotor system operate together, blue light facilitates saccade latency, supporting the premotor theory of attention. Our findings provide evidence and suggest a way for facilitating the efficiency of saccade. When reading or browsing on 3C products, the exposure of blue light is beneficial to saccadic eye movement.

Introduction 1
Experiment 1 10
Methods 11
Results 17
Discussion 20
Experiment 2 24
Methods 26
Results 29
Discussion 34
Experiment 3 37
Methods 38
Results 40
Discussion 42
General Discussion 43
Blue-light effect on saccade latency and attentional disengagement 44
What is special about downward direction? 46
The gap effect modulated by blue light 47
Future studies and limitations 49
Importance of the current results 51
References 53

Abegg, M., Pianezzi, D., & Barton, J. (2015). A vertical asymmetry in saccades. Journal of Eye Movement Research, 8(5), 1-10.
Beaven, C. M., & Ekström, J. (2013). A comparison of blue light and caffeine effects on cognitive function and alertness in humans. PloS One, 8, e76707.
Cajochen, C., Munch, M., Kobialka, S., Krauchi, K., Steiner, R., Oelhafen, P., . . . Wirz-Justice, A. (2005). High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. The Journal of Clinical Endocrinology Metabolism, 90, 1311-1316.
Chen, H.-W., & Yeh, S.-L. (2019). Effects of blue light on dynamic vision. Frontiers in Psychology, 10.
Chun, M. M., Golomb, J. D., & Turk-Browne, N. B. (2011). A taxonomy of external and internal attention. Annual Review of Psychology, 62, 73-101.
Daneault, V., Dumont, M., Massé, É., Forcier, P., Boré, A., Lina, J.-M., . . . Carrier, J. (2018). Plasticity in the sensitivity to light in aging: Decreased non-visual impact of light on cognitive brain activity in older individuals but no impact of lens replacement. Frontiers in Physiology, 9, 1557.
Daneault, V., Dumont, M., Masse, E., Vandewalle, G., & Carrier, J. (2016). Light-sensitive brain pathways and aging. Journal of Physiological Anthropology, 35(1), 9.
Daneault, V., Hébert, M., Albouy, G., Doyon, J., Dumont, M., Carrier, J., & Vandewalle, G. (2014). Aging reduces the stimulating effect of blue light on cognitive brain functions. Sleep, 37, 85-96.
Deubel, H., & Schneider, W. X. (1996). Saccade target selection and object recognition: Evidence for a common attentional mechanism. Vision Research, 36, 1827-1837.
Dias, E. C., & Bruce, C. J. (1994). Physiological correlate of fixation disengagement in the primate''s frontal eye field. Journal of Neurophysiology, 72, 2532-2537.
Dorris, M. C., & Munoz, D. P. (1995). A neural correlate for the gap effect on saccadic reaction times in monkey. Journal of Neurophysiology, 73, 2558-2562.
Dorris, M. C., Pare, M., & Munoz, D. P. (1997). Neuronal activity in monkey superior colliculus related to the initiation of saccadic eye movements. Journal of Neuroscience, 17, 8566-8579.
Ecker, J. L., Dumitrescu, O. N., Wong, K. Y., Alam, N. M., Chen, S.-K., LeGates, T., . . . Hattar, S. (2010). Melanopsin-expressing retinal ganglion-cell photoreceptors: Cellular diversity and role in pattern vision. Neuron, 67(1), 49-60.
Fendrich, R., Demirel, S., & Danziger, S. (1999). The oculomotor gap effect without a foveal fixation point. Vision Research, 39, 833-841.
Funke, J. (2010). Complex problem solving: A case for complex cognition? Cognitive Processing, 11, 133-142.
Gandhi, N. J., & Katnani, H. A. (2011). Motor functions of the superior colliculus. Annual Review of Neuroscience, 34, 205-231.
Goffart, L., Hafed, Z. M., & Krauzlis, R. (2012). Visual fixation as equilibrium: Evidence from superior colliculus inactivation. Journal of Neuroscience, 32, 10627-10636.
Goldring, J., & Fischer, B. (1997). Reaction times of vertical prosaccades and antisaccades in gap and overlap tasks. Experimental Brain Research, 113, 88-103.
Hanifin, J. P., & Brainard, G. C. (2007). Photoreception for circadian, neuroendocrine, and neurobehavioral regulation. Journal of Physiological Anthropology, 26, 87-94.
He, S., Cavanagh, P., & Intriligator, J. (1996). Attentional resolution and the locus of visual awareness. Nature, 383, 334.
Hoffman, J. E., & Subramaniam, B. (1995). The role of visual attention in saccadic eye movements. Perception & Psychophysics, 57, 787-795.
Honda, H., & Findlay, J. (1992). Saccades to targets in three-dimensional space: Dependence of saccadic latency on target location. Perception & Psychophysics, 52, 167-174.
Hung, S.-M., Milea, D., Rukmini, A. V., Najjar, R. P., Tan, J. H., Viénot, F., . . . Hsieh, P.-J. (2017). Cerebral neural correlates of differential melanopic photic stimulation in humans. Neuroimage, 146, 763-769.
Jin, Z., & Reeves, A. (2009). Attentional release in the saccadic gap effect. Vision Research, 49, 2045-2055.
Machado, H., & Rafal, R. D. (2000). Strategic control over saccadic eye movements: Studies of the fixation offset effect. Perception & Psychophysics, 62, 1236-1242.
Newman, D. P., Lockley, S. W., Loughnane, G. M., Martins, A. C. P., Abe, R., Zoratti, M. T., . . . O’Connell, R. G. (2016). Ocular exposure to blue-enriched light has an asymmetric influence on neural activity and spatial attention. Scientific Reports, 6, 27754.
Nobre, A. C., Gitelman, D., Dias, E., & Mesulam, M.-M. (2000). Covert visual spatial orienting and saccades: Overlapping neural systems. Neuroimage, 11, 210-216.
Noda, H., Sugita, S., & Ikeda, Y. (1990). Afferent and efferent connections of the oculomotor region of the fastigial nucleus in the macaque monkey. Journal of Comparative Neurology, 302, 330-348.
Opris, I., Barborica, A., & Ferrera, V. P. (2001). On the gap effect for saccades evoked by electrical microstimulation of frontal eye fields in monkeys. Experimental Brain Research, 138, 1-7.
Panda, S., Nayak, S. K., Campo, B., Walker, J. R., Hogenesch, J. B., & Jegla, T. (2005). Illumination of the melanopsin signaling pathway. Science, 307, 600-604.
Parkhurst, D., Law, K., & Niebur, E. (2002). Modeling the role of salience in the allocation of overt visual attention. Vision Research, 42, 107-123.
Phipps-Nelson, J., Redman, J. R., Schlangen, L. J., & Rajaratnam, S. M. (2009). Blue light exposure reduces objective measures of sleepiness during prolonged nighttime performance testing. Chronobiology International, 26, 891-912.
Posner, M. I., Walker, J. A., Friedrich, F. J., & Rafal, R. D. (1984). Effects of parietal injury on covert orienting of attention. Journal of Neuroscience, 4, 1863-1874.
Pratt, J., Lajonchere, C. M., & Abrams, R. A. (2006). Attentional modulation of the gap effect. Vision Research, 46, 2602-2607.
Reuter-Lorenz, P. A., Hughes, H. C., & Fendrich, R. (1991). The reduction of saccadic latency by prior offset of the fixation point: An analysis of the gap effect. Perception & Psychophysics, 49, 167-175.
Rizzolatti, G., Riggio, L., Dascola, I., & Umiltá, C. (1987). Reorienting attention across the horizontal and vertical meridians: Evidence in favor of a premotor theory of attention. Neuropsychologia, 25, 31-40.
Rolfs, M., & Vitu, F. (2007). On the limited role of target onset in the gap task: Support for the motor-preparation hypothesis. Journal of Vision, 7(10), 1-20.
Saslow, M. (1967). Effects of components of displacement-step stimuli upon latency for saccadic eye movement. Journal of the Optical Society of America, 57, 1024-1029.
Schiller, P. H., & Tehovnik, E. (2005). Neural mechanisms underlying target selection with saccadic eye movements. Progress in Brain Research, 149, 157-171.
Schmidt, T. M., Chen, S.-K., & Hattar, S. (2011). Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions. Trends in Neurosciences, 34, 572-580.
Schmitt, L. M., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2014). Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem. Molecular Autism, 5, 47.
Sheliga, B., Riggio, L., & Rizzolatti, G. (1995). Spatial attention and eye movements. Experimental Brain Research, 105, 261-275.
Simola, J., Kuisma, J., Öörni, A., Uusitalo, L., & Hyönä, J. (2011). The impact of salient advertisements on reading and attention on web pages. Journal of Experimental Psychology: Applied, 17, 174.
Souman, J. L., Tinga, A. M., Te Pas, S. F., Van Ee, R., & Vlaskamp, B. N. (2018). Acute alerting effects of light: A systematic literature review. Behavioural Brain Research, 337, 228-239.
Sparks, D., Rohrer, W., & Zhang, Y. (2000). The role of the superior colliculus in saccade initiation: A study of express saccades and the gap effect. Vision Research, 40, 2763-2777.
Studer, P., Brucker, J. M., Haag, C., Van Doren, J., Moll, G. H., Heinrich, H., & Kratz, O. (2019). Effects of blue-and red-enriched light on attention and sleep in typically developing adolescents. Physiology & Behavior, 199, 11-19.
Tam, W. J., & Stelmach, L. B. (1993). Viewing behavior: ocular and attentional disengagement. Perception & Psychophysics, 54, 211-222.
Theeuwes, J., Atchley, P., & Kramer, A. F. (2000). On the time course of top-down and bottom-up control of visual attention. In S. Monsell & J. Driver (Eds.). Control of Cognitive Processes: Attention and Performance XVIII (pp. 105-124). Cambridge, MA: MIT Press.
Tinsley, C. J., & Everling, S. (2002). Contribution of the primate prefrontal cortex to the gap effect. Progress in Brain Research, 140, 61-72.
Treue, S. (2003). Visual attention: The where, what, how and why of saliency. Current Opinion in Neurobiology, 13, 428-432.
Tzelepi, A., Yang, Q., & Kapoula, Z. (2005). The effect of transcranial magnetic stimulation on the latencies of vertical saccades. Experimental Brain Research, 164, 67-77.
Ueda, H., Takahashi, K., & Watanabe, K. (2014). Influence of removal of invisible fixation on the saccadic and manual gap effect. Experimental Brain Research, 232, 329-336.
Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., . . . Dang-Vu, T. T. (2006). Daytime light exposure dynamically enhances brain responses. Current Biology, 16, 1616-1621.
Vandewalle, G., Collignon, O., Hull, J. T., Daneault, V., Albouy, G., Lepore, F., . . . Dumont, M. (2013). Blue light stimulates cognitive brain activity in visually blind individuals. Journal of Cognitive Neuroscience, 25, 2072-2085.
Vandewalle, G., Gais, S., Schabus, M., Balteau, E., Carrier, J., Darsaud, A., . . . Maquet, P. (2007). Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure. Cerebral Cortex, 17, 2788-2795.
Vandewalle, G., Maquet, P., & Dijk, D.-J. (2009). Light as a modulator of cognitive brain function. Trends in Cognitive Sciences, 13, 429-438.
Vernet, M., Yang, Q., Gruselle, M., Trams, M., & Kapoula, Z. (2009). Switching between gap and overlap pro-saccades: Cost or benefit? Experimental Brain Research, 197, 49.
Walker, R., Kentridge, R., & Findlay, J. (1995). Independent contributions of the orienting of attention, fixation offset and bilateral stimulation on human saccadic latencies. Experimental Brain Research, 103, 294-310.
Wong, K. Y. (2012). A retinal ganglion cell that can signal irradiance continuously for 10 hours. Journal of Neuroscience, 32, 11478-11485.
Yang, P.-L., Tsujimura, S.-i., Matsumoto, A., Yamashita, W., & Yeh, S.-L. (2018). Subjective time expansion with increased stimulation of intrinsically photosensitive retinal ganglion cells. Scientific Reports, 8, 11693.