臺灣博碩士論文加值系統

目前可能的性費洛蒙之主要成份為4，16-androstadien-3-one (AND)與estra-1，3，5(10)，16-tetraen-3-01 (EST)，屬於睪丸酮(testosterone)的衍生化合物。其中AND在男性的汗水中被發現，而EST在女性的尿液中發現。在先前的正子斷層造影研究發現男性受試者聞到EST時，在下視丘有明顯活化反應，女性受試者聞到AND時，在下視丘有明顯活化反應。在我們的研究中我們將利用功能性磁振造影比較兩種性費洛蒙在一般男性受試者與男性嗅覺喪失症患者腦中的活化機制。我們發現不只在EST刺激下兩組受試者不只在下視丘有活化而在一般嗅覺區也有活化這是與之前研究不一樣的地方。另外發現即使患者嗅覺路徑受到阻斷，下視丘的活化也不會受影響。這樣的結果顯示這兩種費洛蒙化合物在腦中的作用機制與一般氣味不同，推測是有一般嗅覺路徑之外的連接通往下視丘。

The testosterone derivative 4,16-androstadien-3-one (AND) and the estrogen-like steroid estra-1,3,5(10),16-tetraen-3-ol (EST) are candidate compounds for human pheromones. AND is detected primarily in male sweat, whereas EST has been found in female urine. A previous positron emission tomography study found that smelling AND and EST activated regions covering sexually dimorphic nuclei of the hypothalamus, and that this activation was differentiated with respect to sex and compound. In the present study, the pattern of activation induced by AND and EST was compared among normal men and the men suffered from anosmia with functional MRI. Our results was different from previous PET studies. We found EST was processed similarly in two groups of subjects and engaged not only the hypothalamus but also the olfactory area (amygdala, piriform, orbitofrontal, and insular cortex). Although olfactory pathway was blocked, this did not result in the action of the hypothalamus. These findings show that our brain reacts differently to the two putative pheromones compared with common odors, and suggest a link to hypothalamic neuronal processes without olfactory pathway.

圖表索引
中文摘要
英文摘要
一、 簡介(Introduction)
1.1、功能性磁振造影文獻
1.2、費洛蒙研究文獻
1.3、研究動機與目的
二、 材料與方法(material and method)
2.1、人腦嗅覺神經傳導路徑
2.2、實驗設計
2.3、取像方法
2.4、掃描程序
2.5、資料處理
三、結果(result)
四、討論(discussion)
參考文獻(references)

1. Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 1990;14:68-78
2. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 1990;87:9868-9872
3. Kwong KK, Belliveau JW, Chesler DA, et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 1992;89:5675-5679
4. Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS. Time course EPI of human brain function during task activation. Magn Reson Med 1992;25:390-397
5. Ogawa S, Tank DW, Menon R, et al. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 1992;89:5951-5955
6. Stark DD, Bradley W. Magnetic Resonance Imaging., 3rd ed. St. Lious Mosby, 1999
7. Karlson P, Luscher M. Pheromones': a new term for a class of biologically active substances. Nature 1959;183:55-56
8. Trotier D, Eloit C, Wassef M, et al. The vomeronasal cavity in adult humans. Chem Senses 2000;25:369-380
9. Smith TD, Bhatnagar KP. The human vomeronasal organ. Part II: prenatal development. J Anat 2000;197 Pt 3:421-436
10. Nixon A, Mallet AI, Gower DB. Simultaneous quantification of five odorous steroids (16-androstenes) in the axillary hair of men. J Steroid Biochem 1988;29:505-510
11. Monti-Bloch L, Grosser BI. Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium. J Steroid Biochem Mol Biol 1991;39:573-582
12. Thorne F, Neave N, Scholey A, Moss M, Fink B. Effects of putative male pheromones on female ratings of male attractiveness: influence of oral contraceptives and the menstrual cycle. Neuro Endocrinol Lett 2002;23:291-297
13. Savic I, Berglund H, Gulyas B, Roland P. Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 2001;31:661-668
14. Zelano C, Sobel N. Humans as an animal model for systems-level organization of olfaction. Neuron 2005;48:431-454
15. Gottfried JA, Deichmann R, Winston JS, Dolan RJ. Functional heterogeneity in human olfactory cortex: an event-related functional magnetic resonance imaging study. J Neurosci 2002;22:10819-10828
16. Rolls ET, Kringelbach ML, de Araujo IE. Different representations of pleasant and unpleasant odours in the human brain. Eur J Neurosci 2003;18:695-703
17. Small DM, Gregory MD, Mak YE, Gitelman D, Mesulam MM, Parrish T. Dissociation of neural representation of intensity and affective valuation in human gustation. Neuron 2003;39:701-711
18. Anderson AK, Christoff K, Stappen I, et al. Dissociated neural representations of intensity and valence in human olfaction. Nat Neurosci 2003;6:196-202
19. Sobel N, Prabhakaran V, Hartley CA, et al. Blind smell: brain activation induced by an undetected air-borne chemical. Brain 1999;122 ( Pt 2):209-217

20 Frackowiak RSJ, Friston KJ, Frith CD, Dolan RJ, Mazziotta JC.Human Brain Function. Chapter 2. Academic Press. 1997.