臺灣博碩士論文加值系統

葡萄糖胺 (glucosamine) 與軟骨素 (chondroitin) 可經由代謝成為結締組織構成份。研究發現，葡萄糖胺與軟骨素對退化性關節炎病人之軟骨生長與症狀緩解有正面的效果，但近來許多研究者對此效果提出質疑。此外，目前並沒有針對經常發生軟骨損傷之舉重選手進行研究，因此本研究將探討葡萄糖胺與軟骨素對舉重選手運動表現、軟骨代謝及關節疼痛之影響。本實驗為期 12 週，對象為持續訓練之舉重選手。將 25 名受試者隨機分為補充劑組與安慰劑組，補充劑組每天投予 1800 mg 葡萄糖胺與 900 mg 軟骨素膠囊，安慰劑組則給予 2700 mg 澱粉膠囊。在生理情況方面，利用抓舉與挺舉成績評估選手運動表現。以血清中 C-propeptide of type II procollagen (CPII) 與 cartilage oligomeric matrix protein (COMP) 等生化值評估軟骨代謝情形。利用疼痛量表評估選手疼痛程度。研究結果發現，兩組選手之運動表現皆有上升的趨勢，且以補充劑組舉重選手成績增加較安慰劑組高。兩組之 CPII 濃度分別於第 0 週與第 12 週皆無顯著差異，但 COMP 在第 12 週則呈現補充劑組低於安慰劑組之趨勢。關節疼痛情況於第 0、8、12 週並沒有顯著差異。以本研究結果顯示，葡萄糖胺 1800 mg 與軟骨素 900 mg 補充 12 週，對舉重選手之運動表現、軟骨代謝與疼痛狀況，無顯著效果。

Glucosamine and chondroitin are the key components of connective tissue. Many researchers were confirmed the effect of glucosamine and chondroitin on osteoarthritis patients’ cartilage growth and the advantage for syndrome releasing. Some of the investigators were challenged the above results recently. However, no studies focused on weight lifters who often get cartilage damage. This study was researched into the effect of glucosamine and chondroitin on weight lifters’ exercise performance and cartilage metabolism. Twenty-five weight lifters were separated into two groups (supplement group and placebo group) randomly and they took training everyday for 12 weeks. The supplement group took 1800 mg glucosamine and 900 mg chondroitin capsules and the placebo group took 2700 mg starch capsules per day. In physiology, we measure exercise performance by the Snatch and the Clean and Jerk. We used serum C-propeptide of type II procollagen (CPII) and cartilage oligomeric matrix protein (COMP) to measure cartilage metabolism. We also measured athletes’ pain situation by pain score. We carried out that both group had trend to increase the total amount of exercise performance and the amount of supplement group was higher than placebo group. Serum CPII concentrations between two groups were no significant difference on week 0 and week 12. But COMP concentration in supplement group was lower than placebo group. And there were no benefits on joint pain score in 0, 8 and 12 week. In conclusion, the supplementation of 1800 mg glucosamine and 900 mg chondroitin was no effect on weight lifters’ exercise performance, cartilage metabolism and pain situation for 12 weeks intervention.

中文摘要 i
英文摘要 ii
目錄 iii
表目錄 vi
圖目錄 vii
第一章 緒論 1
一、人體關節 3
(一) 基本構造 3
(三) 身體關節分述 6
(四) 關節活動與健康 8
(五) 關節損傷之相關研究 9
1、軟骨代謝指標 11
2、疼痛評估 12
二、醣質營養素 14
(一) 代謝與功能 14
(二) 葡萄糖胺與軟骨素之相關研究 15
1、葡萄糖胺 16
2、軟骨素 17
三、運動與營養 20
(一) 運動員的營養需要 20
(二) 運動員的減重 22
第三章 材料與方法 23
一、實驗對象 23
二、實驗設計 24
(一) 補充劑成份與來源 24
(二) 完全隨機單盲試驗 24
三、實驗流程 25
四、實驗分析項目與分析方法 27
(一) 營養問卷 27
(二) 運動表現 27
(三) 血液生化值 27
(四) 疼痛評估 29
(五) 24 小時飲食紀錄 29
(六) 體脂肪測量 30
五、統計分析與方法 31
第四章 結果與討論 32
一、營養問卷 32
(一) 健康狀況 32
(二) 食物攝取狀況 33
(三) 補充劑使用狀況 33
(四) 體重控制狀況 33
二、運動表現 36
三、血液生化值 38
(一) CPII 38
(二) COMP 39
四、疼痛評估 41
五、24小時飲食紀錄 42
第五章 結論與建議 44
參考文獻 45
附錄一 人體肩關節構造 78
附錄二 人體肘關節構造 79
附錄三 人體腕關節構造 80
附錄四 人體髖關節構造 81
附錄五 人體膝關節構造 82
附錄六 人體踝關節構造 83
附錄七 社會組舉重比賽男女標準分級 84
附錄八 人體試驗委員會同意書 85
附錄九 受試者同意書 86
附錄十 葡萄糖胺製造流程 87
附錄十一 葡萄糖胺成份分析 88
附錄十二 軟骨素製造流程 89
附錄十三 軟骨素成份分析 90
附錄十四 舉重隊營養問卷 91
附錄十五 疼痛量表 94
附錄十六 二十四小時飲食紀錄 95
附錄十七 原始數據 96
附錄十八 體重分級之運動表現 97

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