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研究生:莊雅如
研究生(外文):Chuang, Yalu
論文名稱:穿心蓮植物的功效探討
論文名稱(外文):Investigation of Effects of Andrographis paniculata
指導教授:張文騰張文騰引用關係
指導教授(外文):Chang, WenTeng
口試委員:楊昆霖薛聖芬
口試委員(外文):Yan, KunLinHsueh, ShengFen
口試日期:2013-01-21
學位類別:碩士
校院名稱:中華醫事科技大學
系所名稱:生物醫學研究所
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:42
中文關鍵詞:穿心蓮
外文關鍵詞:Andrographis paniculata
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穿心蓮(Andrographis paniculata)屬於爵床科植物,這是亞洲廣泛分佈的常見植物,在台灣也有廣泛培養作為經濟作物。傳統中醫典籍記載許多功效,如呼吸道感染、發燒、細菌痢疾、腹瀉、瘧疾、蛇咬傷、各式發炎與高血壓等,特別是在亞洲也做肝保護藥物。在台灣穿心蓮除用以治療疾病外,其萃取物也常被做為保健食品添加成分。穿心蓮含有需多化合物,包括穿心蓮內酯類、生物黃酮類、二帖類、維生素與礦物質等。近代科學研究探討穿心蓮萃取物或其特定化合物的功效,包含肝保護、糖尿病、抗瘧疾與神經保護等。我們為探討穿心蓮抗糖尿病的機制,選用成肌細胞C2C12 細胞株實驗模式,穿心蓮不影響C2C12 細胞生長,該細胞會表現發現葡萄糖轉運載體蛋白4,穿心蓮處理並不影響葡萄糖轉運載體蛋白4 的表現與葡萄糖的吸收。因此穿心蓮抗糖尿病的機制並不透過影響葡萄糖運輸。未來還需更深入探討穿心蓮的功效與其作用機制,可以讓穿心蓮的醫療保健功效更廣泛。
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目錄 i
致謝 iii
中文摘要 iv
英文摘要 v
第一章 穿心蓮植物介紹
第一節 穿心蓮植物的命名 1
第二節 穿心蓮植物的特徵 2
第三節 穿心蓮植物的分佈 4
第二章 穿心蓮成分分析
第一節 穿心蓮植物所含有的化學成分 5
第二節 含有能誘導quinone reductase的穿心蓮成分 11
第三章 穿心蓮的傳統醫療功效
第一節中草藥典籍所記載之功效 15
第四章 穿心蓮的近代研究報導
第一節 近代關於穿心蓮的報導 18
第二節 穿心蓮在特定疾病的研究 19
第五章 穿心蓮在糖尿病之細胞研究
第一節 C2C12細胞表現葡萄糖轉運蛋白 24
第二節 穿心蓮的細胞毒性 24
第三節 穿心蓮濃度對於葡萄糖轉運蛋白的影響 25
第四節 穿心蓮對於葡萄糖吸收的影響 25
第六章 結論 26
圖 27
參考文獻 30
附錄 38
作者簡歷 42

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