臺灣博碩士論文加值系統

內源性憂鬱症（ endogenous depression ）是一種嚴重的精神症狀，包括情緒低落、失歡現象、睡眠障礙、精神運動及體重異常等。抗憂鬱藥物（如三環抗憂鬱劑）對此症有相當程度的治療效果，但也有相當嚴重的副作用（如思睡）。 在中國傳統醫學上，自明代以來，逍遙散即廣被應用於治療〝鬱證〞。此實驗用內源性憂鬱症動物模型來探測此傳統藥物的治療效果。根據 Vogel 發展出來的內源性憂鬱症動物模型，我們選用 Sprague-Dawley 種系老鼠，在第 8 至 21 天大時，控制組給生理食鹽水(1 ㏄/kg, bid)，實驗組則給予Clomipramine (15mg/kg, bid) 作誘導；到第 5 個月大時，以隨機方式將實驗組分成四組，各組連續 14 天給予不同的治療：即西藥組Amitriptyline(10mg/kg,qd)，中藥組逍遙散低濃度 (1.0g/kg, qd)、高濃度(2.5g/kg,qd)，及生理食鹽水 (1 ㏄ /kg,qd)。在治療期間，進行各組間之體重、荷爾蒙及行為等項目測試。經變異數分析方法進行統計各組之均值，結果顯示：在生理指標：體重，逍遙散有顯著增進作用；在病理指標：與憂鬱症相關之荷爾蒙的探討，逍遙散與 Amitriptyline 有相似的調整效果；在行為指標上：a. 開放空間：逍遙散增進了活動量，但 Amitriptyline 組的活動量卻顯著下降。 b. 糖耗試驗：逍遙散與 Amitriptyline 對享樂效應（ hedonic effect ）皆有顯著增進作用。
我們的結論是：逍遙散有可以與 Amitriptyline 比較的治療效果，但無其鎮靜之副作用，是一種有潛力控制內源性憂鬱病狀的方劑。此研究尚屬初報，可進一步做臨床試驗來評估其對內源性憂鬱症之療效。

Endogenous depression is a severe psychotic disorder, including the following symptoms: depressed mood, sleep disturbance, psychomotor and body weight abnormalities, ect. Antidepressants (eg. tricyclic antidepressants) have some effects on depression, but they also have some side effects (eg. drowsiness). In Chinese traditional medicine, Hsiao-Yao-Shan (HYS) had been popularly used to treat "depression" since Ming dynasty. The purpose of this experiment is to evaluate the antidepressant effect of Hsiao-Yao-Shan via the animal model of endogenous depression. According to the animal model of depression proposed by Vogel, neonatal clomipramine (15mg/kg, bid) injection to Sprague-Dawley rats when 8 to 21 day-old for the experimental group, while normal saline (1cc/kg), bid) injection for control group. At the 5 month of age, experimental group was divided randomly into 4 subgroup and with the different treatments: amitriptyline (AMI; 10mg/kg qd), low concentration of HYS (1g/kg), and normal saline (1cc/kg). We check body weight, hormone and behavior change during the treatment course. By using ANOVA to compare the mean values of parameter for five group, and it shows: 1.HYS has significant effect for body weight increment. 2.HYS has the same regulation effect of hormone compared to AMI. 3.HYS increased motor acivity in the open field, while AMI decreased. 4.Both HYS and AMI increased hedonic effect in the sucrose consumption test.