臺灣博碩士論文加值系統

鈦及其合金目前用做為植入性材料，具有良好的機械性能，高耐腐蝕性和優良的生物相容性，陽極氧化處理可使鈦及其合金提高生物相容性，於表面製備氧化鈦可使表面具有生物活性及良好骨鍵結能力。本研究添加Na2SO4-、CA與Ca-GP作為電解液，將Ti6Al4V置於電解液中，使用陽極氧化處理法（Anodic oxidation, AO）進行表面處理，改變Ti6Al4V表面形成緻密的多孔性氧化層，藉此能增加表面粗糙度與骨組織之親和力，以達具備生醫植體之目的。將陽極氧化處理後之Ti6Al4V，浸泡於人體模擬體液（SBF）後，表面成功誘導氫氧基磷灰石生長，利用掃描式電子顯微鏡（SEM）及能量散射光譜儀（EDS）觀察其結構和元素、以X光繞射儀（XRD）鑑定其晶體結構、X光光電子光譜儀（XPS）分析其表面之成分分析與鍵結型態。
本研究結果發現，Ti6Al4V於Na2SO4¬、CA與Ca-GP電解液中，進行陽極氧化處理後，浸泡人體模擬體液（SBF），可成功誘導氫氧基磷灰石的生成。隨著電解液Na2SO4濃度越高，其誘導氫氧基磷灰石能力越好。Ti6Al4V進行陽極氧化處理時，隨著Na2SO4¬濃度提高，溶解與成長速率隨著提升，孔洞數量隨著增加，孔洞尺寸則越小，孔洞平均直徑介於80nm～160nm。電解液中含有Na2SO4溶液條件下，其表面形成的孔洞比未添加Na2SO4數量多及小，表示添加Na2SO4溶液，其氧化能力較未添加Na2SO4佳。當浸泡人體模擬體液（SBF）後，含有Na2SO4溶液條件下，浸泡人體模擬體液後，短時間內可誘導氫氧基磷灰石於表面生長，而未添加Na2SO4需浸泡較長時間才會誘導氫氧基磷灰石生長，浸泡人體模擬體液（SBF）14天，氫氧基磷灰石達厚度5.78μm。因此，於Na2SO4、CA和Ca-GP電解液中，進行陽極氧化處理，可成功製備出具生物活性之Ti6Al4V。

Titanium and its alloys are currently used as implant materials due to their good mechanical properties, high corrosion resistance and excellent biocompatibility. In this study, anodic oxidation in a Na2SO4¬, CA and Ca-GP solution has been employed to modify the structure and bioactivity of the biomedical Ti6Al4V alloy. The electrolyte solution allows for the production of bioactive titanium films to enhance its bone-forming function，hence increasing the efficacy of the orthopedic implant. After being treated with anodic oxidation treatment and soaked in simulated body fluid (SBF), the Ti6Al4V alloy was able to induce the formation of apatite on its surface. The films were investigated by means of scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), XRD and X-ray photoelectron spectrometer (XPS) to determine morphology and chemical composition of the surface layer and characterize structure, surface bonding and atomic composition before and after being soaked in SBF .
The results showed that anodic oxidation in a Na2SO4, CA and Ca-GP solution can be employed to produce crystalline titanium films on Ti6Al4V surfaces. which will then induce the formation of hydroxyapatite in simulated body fluid (SBF). Additionally, the hydroxyapatite-forming ability of the films obtained through anodic oxidation has been shown to increase with the increase of the concentration of Na2SO4 in the solution. The same increase resulted in an increase of porosity and number of pores and a decrease of their size. The average diameter of the pores is within 80nm～160nm. The electrolyte solution used was made of Na2SO4 and allowed for the formation of more and smaller holes, if compared with the solution without Na2SO4. As a consequence, the oxidation capacity of the solution with Na2SO4 resulted better than that of the solution without Na2SO4. After soaking the alloy in simulated body fluid (SBF), the presence of Na2SO4 in the solution was shown to induce a faster growth of hydroxyl-apatite on its surface. On the other hand, more time is required to induce the growth of hydroxyl-apatite if the solution does not contain Na2SO4. The hydroxyapatite film formed after soaking the alloy in SBF for 14 days was 5.78 μm thick. To conclude, the anodic oxidation in a Na2SO4¬, CA and Ca-GP solution can be seen as an effective way to prepare a bioactive Ti6Al4V alloy.

摘要 I
Abstract III
誌 謝 V
目錄 VI
表目錄 VIII
圖目錄 IX
第一章 前言 1
1-1 生物醫用材料產業 1
1-2生物醫用材料市場 1
第二章 理論基礎與文獻回顧 5
2-1生醫材料 5
2-1-1生醫材料簡介 5
2-1-2生醫材料分類 6
2-2生物相容性（Biocompatibility） 6
2-3鈦合金特性介紹 7
2-4表面處理介紹 10
2-5陽極處理 13
2-5-1不同電解液陽極處理之應用 14
2-5-2不同合金製備具有生物活性氧化膜之應用 17
2-5-3複合式陽極處理之應用 19
第三章 實驗步驟 54
3-1實驗材料 54
3-2實驗方法 54
3-2-1實驗項目 54
3-2-2實驗流程 55
3-3試片製備 55
3-4陽極氧化處理（Anodic oxidation, AO） 55
3-4-1配出所需粉末重量，以下是求出需多少 粉末的公式： 56
3-5表面性能分析 56
3-5-1接觸角測定（Contact angle） 56
3-5-2生物活性測定（Simulated body fluid, SBF） 56
3-6掃描式電子顯微鏡（SEM）與能量散射光譜儀（EDS）分析 58
3-7 X光繞射儀（XRD） 59
3-8 X光光電子光譜儀（XPS） 59
第四章 結果與討論 62
4-1添加不同濃度Na2SO4之電解液分析 62
4-2不同濃度之陽極處理表面接觸角 64
4-3 Na2SO4電解液濃度對表面形貌之影響 65
4-4氫氧基磷灰石生長機制 66
4-5不同Na2SO4濃度對氫氧基磷灰石生長之影響 69
4-6不同Na2SO4濃度對厚度之影響 69
4-7表面元素鍵結分析 70
第五章 結論 104
第六章 未來工作 106
參考文獻 107

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