|
1.內政部戶政司網站, https://www.ris.gov.tw/app/portal. 2017. 2.世界衛生組織網站, https://www.who.int/. 2014. 3.衛生福利部國民健康署, https://www.hpa.gov.tw/Home/Index.aspx. 2007. 4.Foundation, N.O., https://www.nof.org/. 2014. 5.衛福部國健署, 2013-2015年國民營養健康狀況變遷. 6.趙育箴, et al., 偏遠社區老年女性骨質疏鬆症盛行率與相關危險因子之研究. 台灣家醫誌, 2010. 20: p. 64-73. 7.Boudin, E., et al., Genetic control of bone mass. Mol Cell Endocrinol, 2016. 432: p. 3-13. 8.SMITH, D.M., et al., Genetic Factors in Determining Bone Mass. The Journal of Clinical Investigation, 1973. 52: p. 2800-2808. 9.Krall, E.A. and B. Dawson-Hughes, Heritable and life-style determinants of bone mineral density. J Bone Miner Res, 1993. 8: p. 1-9. 10.Gueguen, R., Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res, 1995. 10: p. 2017-2022. 11.Slemenda, C., et al., The Genetics of Proximal Femur Geometry, Distribution of Bone Mass and Bone Mineral Density. Osteoporosis, 1996. 6: p. 178-182. 12.Liu, Y.J., et al., Genome-wide Association Studies for Osteoporosis: A 2013 Update. J Bone Metab, 2014. 21(2): p. 99-116. 13.Welter, D., et al., The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res, 2014. 42(Database issue): p. D1001-6. 14.Hart, A.B. and H.R. Kranzler, Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. Alcohol Clin Exp Res, 2015. 39(8): p. 1312-27. 15.Dole, N.S., Genetic Determinants of Skeletal Diseases: Role of microRNAs. Doctoral Dissertations, 2015: p. 763-911. 16.123RF, 123RF. 2018. 17.美國國家衛生研究院, https://www.nih.gov/. 2000. 18.洪立維, 認識骨質疏鬆症. 臺大醫院健康電子報, 2017. 117. 19.KANIS, J.A., et al., Risk of Hip Fracture According to the World HealthOrganization Criteria for Osteopenia and Osteoporosis. Bone, 2000. 27: p. 585-590. 20.KANIS, J.A., et al., The Diagnosis of Osteoporosis. JOURNAL OF BONE AND MINERAL RESEARCH, 1994. 9: p. 1137-1141. 21.WHO, Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser, 1994. 843: p. 1-129. 22.Hendrickx, G., E. Boudin, and W. Van Hul, A look behind the scenes: the risk and pathogenesis of primary osteoporosis. Nat Rev Rheumatol, 2015. 11(8): p. 462-74. 23.Chen, J.R., et al., Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther, 2008. 324(1): p. 50-9. 24.Chen, J.R., et al., A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res, 2010. 25(5): p. 1117-27. 25.Ronis, M.J., K. Mercer, and J.R. Chen, Effects of nutrition and alcohol consumption on bone loss. Curr Osteoporos Rep, 2011. 9(2): p. 53-9. 26.Maurel, D.B., et al., Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int, 2012. 23(1): p. 1-16. 27.Ward, K.D. and R.C. Klesges, A Meta-Analysis of the Effects of Cigarette Smoking on Bone Mineral Density. Calcif Tissue Int, 2001. 68: p. 259-270. 28.Yoon, V., N.M. Maalouf, and K. Sakhaee, The effects of smoking on bone metabolism. Osteoporos Int, 2012. 23(8): p. 2081-92. 29.Davis, S.R., Menopause - a new beginning. Climacteric, 2018. 21(4): p. 306-307. 30.Boyle, W.J., W.S. Simonet, and D.L. Lacey, Osteoclast differentiation and activation. NATURE, 2003. 423: p. 337-342. 31.Khosla, S., Pathogenesis of age-related bone loss in humans. J Gerontol A Biol Sci Med Sci, 2013. 68(10): p. 1226-35. 32.Tella, S.H. and J.C. Gallagher, Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol, 2014. 142: p. 155-70. 33.Finkelstein, J.S., et al., Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab, 2008. 93(3): p. 861-8. 34.Shuster, L.T., et al., Premature menopause or early menopause: long-term health consequences. Maturitas, 2010. 65(2): p. 161-6. 35.A, d.P., et al., Dietary calcium intake and serum vitamin D are major determinants of bone mass variations in women. A longitudinal study. Aging Clin Exp Res, 2002. 14: p. 382-388. 36.ME, T. and C. PM, Effect of Vitamin D Therapy on Bone Turnover Markers in Postmenopausal Women with Osteoporosis and Osteopenia. Endocr Pract, 2011. 17: p. 873-879. 37.Rizzoli, R., et al., Nutrition and bone health in women after the menopause. Womens Health, 2014. 10: p. 599-608. 38.Jin, H., et al., Polymorphisms in the 5' flank of COL1A1 gene and osteoporosis: meta-analysis of published studies. Osteoporos Int, 2011. 22(3): p. 911-21. 39.Chung, M., et al., Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med, 2011. 155: p. 827-838. 40.Richards, J.B., et al., Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture. Ann Intern Med, 2009. 151: p. 528-537. 41.Estrada, K., et al., Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet, 2012. 44(5): p. 491-501. 42.Qin, G., et al., Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies. Mol Biol Rep, 2013. 40(1): p. 497-506. 43.Haussler, M.R., et al., The vitamin D hormone and its nuclear receptor: molecular actions and disease states. Journal of Endocrinology, 1997. 154: p. 57-73. 44.Kato, S., The Function of Vitamin D Receptor in Vitamin D Action. J Biochem, 2000. 127: p. 717-722. 45.Bover, J., et al., Vitamin D, vitamin D receptor and the importance of its activation in patients with chronic kidney disease. Nefrologia, 2015. 35(1): p. 28-41. 46.Dabirnia, R., et al., The relationship between vitamin D receptor (VDR) polymorphism and the occurrence of osteoporosis in menopausal Iranian women. Clinical Cases in Mineral and Bone Metabolism, 2016. 13: p. 190-194. 47.WANG, Q.-x., et al., Lack of association between vitamin D receptor genes BsmI as well as ApaI polymorphisms and osteoporosis risk: A pooled analysis on Chinese individuals. International Journal of Rheumatic Diseases, 2018. 21: p. 967-974. 48.MORRISON, N.A., et al., Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin. Medical Sciences, 1992. 89: p. 6665-6669. 49.Ferrari, S., J.-P. Bonjour, and R. Rizzoli, The Vitamin D Receptor Gene and Calcium Metabolism. Elsevier Science, 1998. 9: p. 259-263. 50.Wang, D., et al., Vitamin D receptor Fok I polymorphism is associated with low bone mineral density in postmenopausal women: a meta-analysis focused on populations in Asian countries. Eur J Obstet Gynecol Reprod Biol, 2013. 169(2): p. 380-6. 51.He, W., et al., The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women. Dis Markers, 2015. 2015: p. 760313. 52.Zintzarasa, E., P. Rodopouloua, and G.N. Koukoulisb, BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: A meta-analysis. Disease Markers, 2006. 22: p. 317-326. 53.Yu, M., G.Q. Chen, and F. Yu, Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta-analysis. Kaohsiung J Med Sci, 2016. 32(12): p. 599-606. 54.DEFENG MENG, X.D., JIAOJIAO LAN, FANGLIANG PENG, WEIGUO ZHU, ZEYU CHENG, HAORUO JIA, HAO XU, CHENHUI SHI, LIJUAN PANG and WEI SHAN WANG, Association of vitamin D receptor ApaI gene polymorphism with osteoporosis susceptibility in postmenopausal Han Chinese women in Xinjiang. BIOMEDICAL REPORTS, 2018. 9: p. 483-490. 55.Medina-Gomez, C., et al., Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet, 2012. 8(7): p. e1002718. 56.Shen, H., J. Xie, and H. Lu, Vitamin D receptor gene and risk of fracture in postmenopausal women: a meta-analysis. Climacteric, 2014. 17(4): p. 319-24. 57.Thorlund, K., et al., User manual for Trial Sequential Analysis (TSA). 58.Perkel, J., SNP genotyping: six technologies that keyed arevolution. NATURE METHODS, 2008. 5: p. 447-454. 59.Rivadeneira, F., et al., Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet, 2009. 41(11): p. 1199-206. 60.Richards, J.B., et al., Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med, 2009. 151(8): p. 528-37. 61.Sterne, J.A., et al., Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ, 2011. 343: p. d4002. 62.Schwarzer, G., J.R. Carpenter, and G. Rücker, 2015. 63.Viechtbauer, W., Conducting Meta-Analyses in R with the metafor Package. Journal of Statistical Software, 2010. 36: p. 1-48. 64.Wacholder, S., Binomial regression in GLIM: estimating risk ratios and risk differences. Am J Epidemiol, 1986. 123(1): p. 174-84. 65.Ackert-Bicknell, C.L. and D. Karasik, Impact of the environment on the skeleton: Is it modulated by genetic factors? Current Osteoporosis Reports, 2013. 11(3): p. 219-228. 66.Ahn, J., et al., Genome-wide association study of circulating vitamin D levels. Human Molecular Genetics, 2010. 19(13): p. 2739-2745. 67.Al-Safi, Z.A. and N. Santoro, Menopausal hormone therapy and menopausal symptoms. Fertility and Sterility, 2014. 101(4): p. 905-915. 68.Baird, D., et al., Adult hip shape is influenced by variation in genes involved in endochondral bone formation: Findings from a genome-wide association study followed by meta-analysis. Journal of Bone and Mineral Research, 2017. 32: p. S175. 69.Ben-Avraham, D., et al., The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY), 2017. 9(1): p. 209-246. 70.Bernstein, C.N. and W.D. Leslie, Review article: Osteoporosis and inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 2004. 19(9): p. 941-952. 71.Bertoldo, F., The role of cholecalciferol on malignancy. Osteoporosis International, 2017. 28(1): p. S81. 72.Beyens, G., et al., Identification of sex-specific associations between polymorphisms of the Osteoprotegerin gene, TNFRSF11B, and Paget's disease of bone. Journal of Bone and Mineral Research, 2007. 22(7): p. 1062-1071. 73.Bhandari, B.M., H. Bayat, and K.D. Rothstein, Primary Biliary Cirrhosis. Gastroenterology Clinics of North America, 2011. 40(2): p. 373-386. 74.Brown, M.A., Genetic studies of osteoporosis - A rethink required. Calcified Tissue International, 2005. 76(5): p. 319-325. 75.Buvat, J., et al., Testosterone Deficiency in Men: Systematic Review and Standard Operating Procedures for Diagnosis and Treatment. Journal of Sexual Medicine, 2013. 10(1): p. 245-284. 76.Cartwright, R., et al., Genome wide association study in 8,997 women identifies novel genetic variants at five genomic loci associated with stress and urgency urinary incontinence. Neurourology and Urodynamics, 2014. 33(6): p. 1006-1007. 77.Challem, J., Medical journal watch: Context and applications. Alternative and Complementary Therapies, 2006. 12(2): p. 102-106. 78.Chen, J.H., et al., Association between Secreted Phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women. PLoS ONE, 2014. 9(5). 79.Cheung, C.L., et al., Meta-analysis of genome-wide association study identifies three loci influencing serum osteoprotegerin levels. Journal of Bone and Mineral Research, 2011. 26. 80.Cheung, C.L., et al., Genetic variants in grem2 are associated with bone mineral density in a southern Chinese population. Journal of Clinical Endocrinology and Metabolism, 2013. 98(9): p. E1557-E1561. 81.Cheung, C.L., et al., Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects. Osteoporos Int, 2012. 23(1): p. 131-42. 82.Chung, P.Y.J., et al., The majority of the genetic risk for Paget's disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes. Human Genetics, 2010. 128(6): p. 615-626. 83.Chung, P.Y.J., et al., Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone. Journal of Bone and Mineral Research, 2010. 25(12): p. 2316-2329. 84.Coviello, A.D., et al., A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 2012. 8(7). 85.Dang, Y.P., et al., Developments of anticoagulants and new agents with anti-coagulant effects in deep vein thrombosis. 86.Dang, Y.P., et al., Developments of anticoagulants and new agents with anti-coagulant effects in deep vein thrombosis. Mini-Reviews in Medicinal Chemistry, 2016. 16. 87.De Moor, M.H.M., et al., Genome-wide association study of exercise behavior in dutch and american adults. Medicine and Science in Sports and Exercise, 2009. 41(10): p. 1887-1895. 88.Degli Esposti, S. and D. Shah, Hepatitis B in Pregnancy: Challenges and Treatment. Gastroenterology Clinics of North America, 2011. 40(2): p. 355-372. 89.Efstathiadou, Z., A. Tsatsoulis, and J.P.A. Ioannidis, Association of collagen Iα 1 Sp1 polymorphism with the risk of prevalent fractures: A meta-analysis. Journal of Bone and Mineral Research, 2001. 16(9): p. 1586-1592. 90.El-Hajj Fuleihan, G., et al., Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range. Journal of Bone and Mineral Research, 2015. 30(7): p. 1119-1133. 91.Eriksson, J., et al., Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. 92.Estrada, K., et al., Meta-analysis of genome-wide association studies identifies 34 loci that regulate BMD with evidence of both site specific and generalized effects: The GEFOS consortium. Journal of Bone and Mineral Research, 2010. 25: p. S74. 93.Fang, Y., et al., Interaction of genome wide variants with dietary vitamin D intake on serum vitamin D concentration: The framingham osteoporosis study. Journal of Bone and Mineral Research, 2011. 26. 94.Felix, J.F., et al., Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet, 2016. 25(2): p. 389-403. 95.Ferrari, S., Osteoporosis genetics: From GWAS to functional studies. Osteoporosis International, 2012. 23(7): p. S741. 96.Ferrari, S., et al., Fracture prediction using a genetic markers algorithm compared to FRAX in three European cohorts. Annals of the Rheumatic Diseases, 2017. 76: p. 178. 97.Franconi, F., et al., The effect of sex/gender on cardiovascular pharmacology. Current Pharmaceutical Design, 2011. 17(11): p. 1095-1107. 98.Fratoni, V. and M.L. Brandi, B vitamins, Homocysteine and bone health. Nutrients, 2015. 7(4): p. 2176-2192. 99.Fu, X. and H.W. Deng, Several novel susceptibility loci identified in trans-ethnic genome-wide association for trabecular volumetric bone mineral density. Journal of Bone and Mineral Research, 2017. 31. 100.Gong, G., et al., The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos Int, 1999. 9(1): p. 55-64. 101.Greenbaum, J. and H.W. Deng, A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density. Journal of Bone and Mineral Research, 2017. 32(8): p. 1651-1658. 102.Greenbaum, J., et al., Increased detection of genetic loci associated with risk predictors of osteoporosis using a pleiotropic cFDR method. Journal of Bone and Mineral Research, 2017. 31. 103.Grundberg, E., et al., Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men. Osteoporosis International, 2008. 19(6): p. 829-837. 104.Guo, Y., et al., IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res, 2010. 25(5): p. 1042-8. 105.He, H., et al., Integrative analysis of GWASs, human protein interaction, and gene expression identified gene modules associated with BMDs. Journal of Clinical Endocrinology and Metabolism, 2014. 99(11): p. E2392-E2399. 106.Hocking, L.J., et al., Interaction between physical activity and a functional vitamin D receptor gene polymorphism affects bone mineral density. Bone, 2010. 47: p. S153-S154. 107.Holmes, D., Bone: Systems genetics links Bicc1 to bone development. Nature Reviews Endocrinology, 2014. 10(7): p. 380. 108.Hsu, Y., et al., An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis-related traits. PLoS Genetics, 2010. 6(6): p. 1-16. 109.Huang, Q.Y. and A.W.C. Kung, Genetics of osteoporosis. Molecular Genetics and Metabolism, 2006. 88(4): p. 295-306. 110.Hwang, J.Y., et al., Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture. J Med Genet, 2013. 50(4): p. 212-9. 111.Ioannidis, J.P.A., et al., Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. Journal of the American Medical Association, 2004. 292(17): p. 2105-2114. 112.Joehanes, R., et al., Epigenetic Signatures of Cigarette Smoking. Circulation: Cardiovascular Genetics, 2016. 9(5): p. 436-447. 113.Judson, R.N., et al., The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies. The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. 66(1): p. 130-135. 114.Justice, A.E., et al., Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 2017. 8. 115.Kamel, S., et al., Total cholesterol, low-density lipoprotein cholesterol, or high density lipoprotein and bone health: Systematic review and Mendelian randomization. Canadian Journal of Cardiology, 2015. 31(10): p. S304. 116.Kemp, J., et al., GWAS meta-analysis for total body BMD unveils 14 new BMD loci and variants exerting age-specific effects. Journal of Bone and Mineral Research, 2015. 30. 117.Kemp, J.P., et al., Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics, 2017. 49(10): p. 1468-1475. 118.Kemp, J.P., et al., Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research, 2014. 29(4): p. 1015-1024. 119.Kung, A.W.C., et al., Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies. American Journal of Human Genetics, 2010. 86(2): p. 229-239. 120.Langdahl, B.L., et al., Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: The GENOMOS study. Bone, 2008. 42(5): p. 969-981. 121.Lebel, M. and R.J. Monnat, Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. Ageing Research Reviews, 2018. 41: p. 82-97. 122.Lee, J.S. and M.A. Tucker, Making sense of puzzling genetic association studies: A team approach. Annals of Internal Medicine, 2006. 145(4): p. 302-304. 123.Lee, Y.H. and S.C. Bae, Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. Rheumatology International, 2016. 36(11): p. 1591-1599. 124.Leong, A., et al., The Causal Effect of Vitamin D Binding Protein (DBP) Levels on Calcemic and Cardiometabolic Diseases: A Mendelian Randomization Study. PLoS Medicine, 2014. 11(10). 125.Li, M., et al., Association of DDX6, CD247 and UBE2L3 polymorphism in Chinese patients with rheumatoid arthritis. International Journal of Rheumatic Diseases, 2012. 15: p. 11. 126.Li, M., et al., Association of PTPN2 (rs1893217) polymorphism in Chinese patients with rheumatoid arthritis. International Journal of Rheumatic Diseases, 2012. 15: p. 10-11. 127.Liu, D., et al., Can rheumatoid arthritis ever cease to exist: A review of various therapeutic modalities to maintain drug-free remission? American Journal of Translational Research, 2017. 9(8): p. 3758-3775. 128.Liu, J., et al., A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density. Journal of Bone and Mineral Research, 2012. 27(2): p. 331-341. 129.Liu, Y.J., et al., On genome-wide association studies and their meta-analyses: Lessons learned from osteoporosis studies. Journal of Clinical Endocrinology and Metabolism, 2013. 98(7): p. E1278-E1282. 130.Locke, A.E., et al., Genetic studies of body mass index yield new insights for obesity biology. Nature, 2015. 518(7538): p. 197-206. 131.Mafi Golchin, M., et al., Osteoporosis: A Silent Disease with Complex Genetic Contribution. Journal of Genetics and Genomics, 2016. 43(2): p. 49-61. 132.Mak, A., D.A. Isenberg, and C.S. Lau, Global trends, potential mechanisms and early detection of organ damage in SLE. Nature Reviews Rheumatology, 2013. 9(5): p. 301-310. 133.Manousaki, D., et al., Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. Am J Hum Genet, 2017. 101(2): p. 227-238. 134.Medina-Gomez, C., et al., Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. American Journal of Human Genetics, 2018. 102(1): p. 88-102. 135.Medina-Gomez, C., et al., Genome-wide association meta-analysis of skull bone mineral density identifies novel associations at four loci and replicates 57 known BMD loci. Calcified Tissue International, 2018. 102(1): p. S32-S33. 136.Meng, X.H., et al., Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions. Bone, 2018. 113: p. 41-48. 137.Moayyeri, A., et al., Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet, 2014. 23(11): p. 3054-68. 138.Mokry, L.E., et al., Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Medicine, 2015. 12(8). 139.Mokry, L.E., et al., Genetically decreased Vitamin D and risk of Alzheimer disease. 140.Mullin, B.H., et al., Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density. BMC Genomics, 2016. 17: p. 136. 141.Nielson, C., et al., Novel genetic variants are associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SCL1A3 and EPHB2. Journal of Bone and Mineral Research, 2017. 31. 142.Nielson, C.M., et al., Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. Journal of Bone and Mineral Research, 2016. 31(12): p. 2085-2097. 143.Niu, T., et al., Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies. J Bone Miner Res, 2016. 31(2): p. 358-68. 144.Niu, T., et al., Identification of new microrna binding site polymorphisms for bone mineral density in meta-analysis of genome-wide association studies. Journal of Bone and Mineral Research, 2012. 27. 145.Oei, L., et al., Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone, 2014. 59: p. 20-27. 146.Ohlsson, C. and R. Haring, Genetic determinants of serum testosterone concentrations in men. Endocrine Reviews, 2011. 32(3). 147.Ohlsson, C., et al., Genetic determinants of serum testosterone concentrations in men. PLoS Genet, 2011. 7(10): p. e1002313. 148.Ohlsson, C., et al., Genetic determinants of serum testosterone concentrations in men. Clinical Chemistry and Laboratory Medicine, 2011. 49: p. S424. 149.Okosieme, O.E., Thyroid hormone replacement: Current status and challenges. Expert Opinion on Pharmacotherapy, 2011. 12(15): p. 2315-2328. 150.Palmer, T.M., J.R. Thompson, and M.D. Tobin, Meta-analysis of Mendelian randomization studies incorporating all three genotypes. Statistics in medicine, 2008. 27(30): p. 6570-6582. 151.Paternoster, L., et al., Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure. PLoS Genetics, 2013. 9(2). 152.Paternoster, L., et al., Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone. PLoS Genetics, 2010. 6(11). 153.Paternoster, L., et al., OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. J Clin Endocrinol Metab, 2010. 95(8): p. 3940-8. 154.Pei, Y.F., et al., Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density. Bone, 2016. 91: p. 1-10. 155.Pei, Y.F., et al., Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density. Bone, 2018. 110: p. 378-385. 156.Pei, Y.F., et al., Genomic variants at 20p11 associated with body fat mass in the European population. Obesity (Silver Spring), 2017. 25(4): p. 757-764. 157.Peter, I., et al., Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis. Osteoporos Int, 2011. 22(4): p. 1199-209. 158.Pettersson-Kymmer, U., et al., Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk. Journal of Bone and Mineral Research, 2013. 28. 159.Porcu, E., et al., A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet, 2013. 9(2): p. e1003266. 160.Porter, K., et al., Causes,consequences and public health implications of low B-vitamin status in ageing. Nutrients, 2016. 8(11). 161.Qiu, C., H. Shen, and H. Deng, Identification of enhancer-SNPs associated with osteoporosis. Journal of Bone and Mineral Research, 2017. 32: p. S373. 162.Rabe, T., et al., Hormone replacement therapy - Risk and benefit. Journal fur Reproduktionsmedizin und Endokrinologie, 2004. 1(2): p. 77-81. 163.Ralston, S.H., Genetic control of susceptibility to osteoporosis. Journal of Clinical Endocrinology and Metabolism, 2002. 87(6): p. 2460-2466. 164.Ralston, S.H., Genetic determinants of osteoporosis. Current Opinion in Rheumatology, 2005. 17(4): p. 475-479. 165.Refsum, H., et al., The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants, and associations with disease. Journal of Nutrition, 2006. 136(6): p. 1731S-1740S. 166.Richards, J., et al., A systematic evaluation of 151 candidate genes for their association with osteoporosis and osteoporotic fracture in a meta-analysis of genome-wide association data. Bone, 2009. 44: p. S222-S223. 167.Roca-Ayats, N., et al., Exploring the FLJ42280 genomic region to identify genetic variants associated with osteoporosis. Journal of Bone and Mineral Research, 2015. 30. 168.Rozenberg, S., et al., Is it possible to predictwomen inwhom hormone replacement therapy (HRT),will not increase the risk for stroke? Maturitas, 2009. 63: p. S61. 169.Schrauwen, I., et al., COL1A1 association and otosclerosis: A meta-analysis. American Journal of Medical Genetics, Part A, 2012. 158 A(5): p. 1066-1070. 170.Shungin, D., et al., New genetic loci link adipose and insulin biology to body fat distribution. Nature, 2015. 518(7538): p. 187-196. 171.Sini, V., et al., Pharmacogenetics and aromatase inhibitor induced side effects in breast cancer patients. Pharmacogenomics, 2017. 18(8). 172.Song, J., et al., The relationship between IL-17 gene polymorphism and osteoporosis in postmenopausal women: A meta-analysis. Biomedical Research (India), 2017. 28(21): p. 9281-9285. 173.Starup-Linde, J., et al., Biochemical markers of bone turnover in diabetes patients - A meta-analysis, and a methodological study on the effects of glucose on bone markers. Osteoporosis International, 2014. 25(6): p. 1697-1708. 174.Steinberg, K., Duration/dose of HRT and risk of breast cancer in the unselected populations: Data from meta-analysis. Obstetrical and Gynecological Survey, 1998. 53(10 SUPPL.): p. S13-S16. 175.Strasser-Weippl, K. and P.E. Goss, Suitable trial designs and cohorts for preventive breast cancer agents. Nature Reviews Clinical Oncology, 2013. 10(12): p. 677-687. 176.Tan, L.J., et al., Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche. J Clin Endocrinol Metab, 2015. 100(11): p. E1457-66. 177.Tan, L.J., et al., Bivariate genome-wide association study implicates ATP6V1G1 as a novel pleiotropic locus underlying osteoporosis and age at menarche. 2015. p. E1457-E1466. 178.Taylor, K.C., et al., A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women. Bone Reports, 2016. 5: p. 233-242. 179.Teumer, A., et al., Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell, 2016. 15(5): p. 811-824. 180.Thakkinstian, A., C. D'Este, and J. Attia, Haplotype analysis of VDR gene polymorphisms: a meta-analysis. Osteoporos Int, 2004. 15(9): p. 729-34. 181.Tobias, J., et al., A genome-wide association meta-analysis and a mouse gene deletion model identify WNT16 as a potential regulator of cortical bone thickness. Osteoporosis International, 2012. 23: p. S534-S535. 182.Tural, Ş., N. Kara, and G. Alayli, Genetics of osteoporosis. Turk Osteoporoz Dergisi, 2011. 17(3): p. 100-109. 183.Uitterlinden, A.G., The latest news from the GENOMOS study. Clinical Cases in Mineral and Bone Metabolism, 2009. 6(1): p. 35-43. 184.Uitterlinden, A.G., et al., The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med, 2006. 145(4): p. 255-64. 185.Uitterlinden, A.G., et al., Identifying genetic risk factors for osteoporosis. Journal of Musculoskeletal Neuronal Interactions, 2006. 6(1): p. 16-26. 186.Urano, T. and S. Inoue, Recent genetic discoveries in osteoporosis, sarcopenia and obesity. Endocrine Journal, 2015. 62(6): p. 475-484. 187.Valero, C., et al., MTHFR C677T polymorphism and osteoporotic fractures. Horm Metab Res, 2007. 39(8): p. 543-7. 188.van Vliet, N.A., et al., Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study. Journal of Bone and Mineral Research, 2018. 33(7): p. 1318-1325. 189.Veldhuis-Vlug, A.G., et al., Association of polymorphisms in the beta-2 adrenergic receptor gene with fracture risk and bone mineral density. Osteoporos Int, 2015. 26(7): p. 2019-27. 190.Venegas, K.R., et al., Pharmacogenetics of osteoporosis: Towards novel theranostics for personalized medicine? OMICS A Journal of Integrative Biology, 2012. 16(12): p. 638-651. 191.Vermeire, S., G. Van Assche, and P. Rutgeerts, Long term treatment with infliximab in non-fistulising Crohn's disease. Acta Endoscopica, 2007. 37(3): p. 271-283. 192.Villalobos-Comparán, M., et al., A pilot genome-wide association study in postmenopausal Mexican-Mestizo women implicates the RMND1/CCDC170 locus is associated with bone mineral density. International Journal of Genomics, 2017. 2017. 193.Vimaleswaran, K.S., et al., Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol, 2014. 2(9): p. 719-29. 194.Wang, K.J., et al., Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis. Chin Med J (Engl), 2012. 125(14): p. 2589-97. 195.Wang, X., et al., A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Stroke, 2009. 40(3): p. 683-95. 196.Warner, S.C., et al., Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene. European Journal of Pain (United Kingdom), 2017. 21(7): p. 1277-1284. 197.Wen, Y., et al., Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporosis International, 2016. 27(3): p. 1041-1046. 198.Winkler, T.W., et al., The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet, 2015. 11(10): p. e1005378. 199.Xiao, S.M., et al., Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density. Human Molecular Genetics, 2012. 21(7): p. 1648-1657. 200.Xiao, S.M., et al., Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese. Journal of Clinical Endocrinology and Metabolism, 2013. 98(11): p. E1827-E1834. 201.Xiao, X., D. Roohani, and Q. Wu, Genetic profiling of decreased bone mineral density in an independent sample of caucasian women. Journal of Bone and Mineral Research, 2017. 32: p. S72-S73. 202.Xiong, D.H., et al., Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet, 2009. 84(3): p. 388-98. 203.Yan, L., et al., Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis. Genet Mol Res, 2015. 14(4): p. 19225-32. 204.Yang, B., et al., Geographical and ethnic distribution of MTHFR gene polymorphisms and their associations with diseases among Chinese population. Clinical Genetics, 2017. 92(3): p. 243-258. 205.Yang, Q., et al., Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. 206.Yang, Q., et al., Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: A Mendelian randomization study. European Journal of Clinical Nutrition, 2017. 71(8): p. 1008-1012. 207.Yao, S., et al., Integrating regulatory elements and gwass identifies novel susceptibility genes affecting bone mineral density. Osteoporosis International, 2017. 28: p. S410-S411. 208.Yao, S., et al., Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis. Human Genetics, 2017. 136(8): p. 963-974. 209.Yin, J.Y., et al., Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients. PLoS ONE, 2012. 7(6). 210.Yoshida, S., et al., An OPG polymorphism is a genetic risk factor for hip fracture in Japanese patients with rheumatoid arthritis. International Journal of Rheumatic Diseases, 2013. 16: p. 35. 211.Zemel, B., et al., Age effect on pediatric longitudinal BMD by multiple loci uncovered in adult BMD-related GWAS meta-analyses. Journal of Bone and Mineral Research, 2013. 28. 212.Zeng, Q., et al., Genome-wide association study of lncRNA polymorphisms with bone mineral density. Annals of Human Genetics, 2018. 82(5): p. 244-253. 213.Zhang, H., et al., Association between osteoprotegerin gene G1181C polymorphism and bone mineral density in postmenopausal women: A Meta-analysis. Chinese Journal of Tissue Engineering Research, 2013. 17(37): p. 6695-6700. 214.Zhang, L., et al., Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Human Molecular Genetics, 2013. 23(7): p. 1923-1933. 215.Zhang, L., et al., Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet, 2014. 23(7): p. 1923-33. 216.Zheng, H.F., et al., Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 2015. 526(7571): p. 112-117. 217.Zheng, H.F., et al., WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet, 2012. 8(7): p. e1002745. 218.Zhou, H., et al., Genetic risk score based on the lifetime prevalence of femoral fracture in 924 consecutive autopsies of Japanese males. Journal of Bone and Mineral Research, 2015. 30. 219.Zhu, W., et al., Comparative gene-based analysis for consecutive studies of GEFOS. Journal of Bone and Mineral Research, 2017. 31. 220.Zintzaras, E., Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. European Journal of Epidemiology, 2010. 25(8): p. 553-560. 221.Zintzaras, E., et al., Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: The CUMAGAS-OSTEOporosis information system. BMC Medicine, 2011. 9. 222.Mann, V., et al., A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. Journal of Clinical Investigation, 2001. 107(7): p. 899-907. 223.Mann, V. and S.H. Ralston, Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. Bone, 2003. 32(6): p. 711-7. 224.Thakkinstian, A., et al., Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res, 2004. 19(3): p. 419-28. 225.Fang, Y., et al., Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. Bone, 2006. 39(4): p. 938-45. 226.Riancho, J.A., C. Valero, and M.T. Zarrabeitia, MTHFR polymorphism and bone mineral density: Meta-analysis of published studies. Calcified Tissue International, 2006. 79(5): p. 289-293. 227.Zintzaras, E., P. Rodopoulou, and G.N. Koukoulis, BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis. Dis Markers, 2006. 22(5-6): p. 317-26. 228.Wang, C.L., et al., Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis. Osteoporos Int, 2007. 18(3): p. 295-305. 229.Tran, B.N., et al., Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis. BMC Med Genet, 2008. 9: p. 55. 230.Ji, G.R., et al., Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. J Int Med Res, 2009. 37(6): p. 1725-32. 231.Li, D. and J. Wu, Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women: A meta-analysis. Journal of Biomedical Research, 2010. 24(6): p. 417-423. 232.Li, Y., et al., Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women. Mol Biol Rep, 2012. 39(5): p. 5709-17. 233.Wang, H. and C. Liu, Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis. Osteoporos Int, 2012. 23(11): p. 2625-34. 234.Jia, F., et al., Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies. Genet Test Mol Biomarkers, 2013. 17(1): p. 30-4. 235.Guo, L., et al., Association between seven common OPG genetic polymorphisms and osteoporosis risk: a meta-analysis. DNA Cell Biol, 2014. 33(1): p. 29-39. 236.Luo, Y., et al., Significant associations between the A163G and G1181C polymorphisms of the osteoprotegerin gene and risk of osteoporosis, especially in postmenopausal women: a meta-analysis. Genet Test Mol Biomarkers, 2014. 18(3): p. 211-9. 237.Ma, C., et al., Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: A meta-analysis. Genetics and Molecular Research, 2014. 13(3): p. 7791-7799. 238.Ni, Y., et al., Association of IL-6 G-174C polymorphism with bone mineral density. J Bone Miner Metab, 2014. 32(2): p. 167-73. 239.Xu, G.Y., Y. Qiu, and H.J. Mao, Common polymorphism in the LRP5 gene may increase the risk of bone fracture and osteoporosis. Biomed Res Int, 2014. 2014: p. 290531. 240.Deng, W., et al., Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis. Genet Mol Res, 2015. 14(1): p. 1293-300. 241.Sun, J., et al., The transforming growth factor-beta1 (TGF-beta1) gene polymorphisms (TGF-beta1 T869C and TGF-beta1 T29C) and susceptibility to postmenopausal osteoporosis: a meta-analysis. Medicine (Baltimore), 2015. 94(4): p. e461. 242.Xie, P., et al., Association of COL1A1 polymorphisms with osteoporosis: A meta-analysis of clinical studies. International Journal of Clinical and Experimental Medicine, 2015. 8(9): p. 14764-14781. 243.Yu, K.H., et al., COL1A1 gene -1997G/T polymorphism and risk of osteoporosis in postmenopausal women: a meta-analysis. Genet Mol Res, 2015. 14(3): p. 10991-8. 244.Zhang, H., X. Tao, and J. Wu, Association of calcitonin receptor gene polymorphism with bone mineral density in postmenopausal Chinese women: a meta-analysis. Arch Gynecol Obstet, 2015. 291(1): p. 165-72. 245.Cong, Y., et al., A single nucleotide polymorphism in the TGF-beta1 gene (rs1982073 C>T) may contribute to increased risks of bone fracture, osteoporosis, and osteoarthritis: a meta-analysis. Clin Rheumatol, 2016. 35(4): p. 973-85. 246.Zhao, B., et al., Vitamin D receptor BsmI polymorphism and osteoporosis risk in post-menopausal women. Archives of Medical Science, 2016. 12(1): p. 25-30. 247.An, M., X.B. Song, and X.Y. Chen, Vitamin D receptor BsmI polymorphism may be associated with an decreased osteoporosis risk in South China. Cell Mol Biol (Noisy-le-grand), 2017. 63(5): p. 50-54. 248.Chen, Y.C., et al., Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk: A meta-analysis. Medicine (Baltimore), 2017. 96(51): p. e9231. 249.Fajar, J.K. and A. Azharuddin, The association between interleukin 6 −174 G/C gene polymorphism and the risk of osteoporosis: A meta-analysis. Journal of Taibah University Medical Sciences, 2017. 12(3): p. 212-220. 250.Li, S., H. Jiang, and N. Du, Association between osteoprotegerin gene T950C polymorphism and osteoporosis risk in the Chinese population: Evidence via meta-analysis. PLoS One, 2017. 12(12): p. e0189825. 251.Wu, J., M. Yu, and Y. Zhou, Association of collagen type I alpha 1 +1245G/T polymorphism and osteoporosis risk in post-menopausal women: a meta-analysis. Int J Rheum Dis, 2017. 20(7): p. 903-910. 252.Gao, S.T., et al., Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: A meta-analysis. BMC Musculoskeletal Disorders, 2018. 19(1). 253.Wang, Q.X., et al., Lack of association between vitamin D receptor genes BsmI as well as ApaI polymorphisms and osteoporosis risk: A pooled analysis on Chinese individuals. International Journal of Rheumatic Diseases, 2018. 21(5): p. 967-974. 254.Zhu, H., et al., Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: A systematic review and meta-analysis. BMC Endocrine Disorders, 2018. 18(1). 255.Luan Jun-wei, F.X.-h., Chen Zhan-wen, Correlation between Vitamin D receptor gene polymorphism and osteoporosis. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011. 15(50): p. 9486-9490. 256.pavel Marozik, I.M., Vidmantas alekna, ema Rudenko Heorhi Ramanau, Vaidilė Strazdienė, Volha samokhovec nikita Byshnev, alexander gonchar, Liubov Kundas, association Between polymorphisms of VDR, Col1a1, and lCt genes and Bone Mineral Density in Belarusian women with severe postmenopausal osteoporosis. Medicina (Kaunas), 2013. 49(4): p. 177-183. 257.Osvaldo D. Castelán-Martínez, N.V.-M., Edith Falcón-Ramírez, Margarita Valdés-Flores and Patricia Clark, Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women. Gac Med Mex, 2015. 151: p. 443-7. 258.Ahmad, I., et al., Association of vitamin D receptor gene polymorphism (TaqI and Apa1) with bone mineral density in North Indian postmenopausal women. Gene, 2018. 659: p. 123-127. 259.Chen Z, C.X., Wang D, Chen Y, Zhang H, Zhou Z, The study of the association between Apa I polymorphism of vitamin D receptor gene and osteoporosis. Chin J Osteoporos, 2007. 13: p. 402-5. 260.Duman, B.S., et al., Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Med Princ Pract, 2004. 13(5): p. 260-6. 261.Durusu Tanriover, M., et al., Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol, 2010. 29(11): p. 1285-93. 262.Ge JR, X.L., Chen K, Zeng XA, Lai YL, Li SQ, Association of genetic polymorphisms in several vitamin D receptor gene sites with bone mineral density and biochemical markers of bone turnover in postmenopausal women. J Clin Rehabil Tissue Eng Res, 2009. 13: p. 5593-6. 263.Gonzalez-Mercado, A., et al., Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women. Genet Mol Res, 2013. 12(3): p. 2755-63. 264.Kim, S.W., et al., Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD. Int J Chron Obstruct Pulmon Dis, 2015. 10: p. 1809-17. 265.Liang W, X.L., Liang Y, Yu B., The association between Vitamin D receptor gene polymorphism and osteoporosis. Acad J Sun Yat-Sen Univ Med Sci, 2002. 23: p. 47-9. 266.Marozik, P.M., et al., Association of Vitamin D Receptor Gene Variation With Osteoporosis Risk in Belarusian and Lithuanian Postmenopausal Women. Front Endocrinol (Lausanne), 2018. 9: p. 305. 267.Mitra S, D.M., Ikram Khatkhatay M, Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian women. Maturitas, 2006. 55: p. 27-35. 268.Mosaad, Y.M., et al., Vitamin D receptor gene polymorphism as possible risk factor in rheumatoid arthritis and rheumatoid related osteoporosis. Hum Immunol, 2014. 75(5): p. 452-61. 269.Sassi, R., et al., Polymorphisms in VDR gene in Tunisian postmenopausal women are associated with osteopenia phenotype. Climacteric, 2015. 18(4): p. 624-30. 270.Wu, J., et al., Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomed Rep, 2016. 5(2): p. 233-236. 271.Xie YM, H.S., Han H, Kou QA, Gao R, Du BJ, The relationship between VDR I, VDR II-1, VDR II-2 and bone mineral density in osteoporosis in Beijing, Wuhan and Fujian. Chin J Osteoporos, 2005. 11: p. 54-7. 272.Zhai M, L.L., Yang R, Association of vitamin D receptor gene polymorphism with osteoporosis in patients with diabetes mellitus. Zhong Guo Lin Chuang Kang Fu, 2005. 9: p. 177-9. 273.Susan R. Davis, I.L., Maryann Lumsden, Gita D. Mishra, Lubna Pal, Margaret Rees, Nanette Santoro & Tommaso Simoncini, Menopause. Nat Rev Dis Primers, 2015: p. 15004. 274.Nik Mohd Hatta NNK, L.M., Said N M, Daud A, Ibrahim M, Sharifudin MA, Deraman S, Fracture risk prediction in post-menopausal women with osteopenia and osteoporosis: preliminary findings. Enferm Clin, 2018: p. 232-235. 275.Hannan MT, F.D., Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, Kiel DP., Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res, 2000. 15(4): p. 710-720. 276.Ahn KS, K.C., Cho SB, Cho KH, Han KD, Park YG, Kim YH, Height Loss Was Associated With Osteoporosis in Korean Elderly Men, Not in Women: The Korea National Health and Nutrition Examination Survey 2008-2010. J Clin Densitom, 2019. 22(1): p. 59-66. 277.Coin A, S.G., Benincà P, Lupoli L, Cinti G, Ferrara L, Benedetti G, Tomasi G, Pisent C, Enzi G, Bone mineral density and body composition in underweight and normal elderly subjects. Osteoporos Int, 2000. 11(12): p. 1043-50. 278.Xiang J, C.Y., Wang Y, Su S, Wang X, Xie B, Zhang Q, Liu M, Lean Mass and Fat Mass as Mediators of the Relationship Between Physical Activity and Bone Mineral Density in Postmenopausal Women. J Womens Health (Larchmt), 2017. 26(5): p. 461-466. 279.Brazier M, K.S., Maamer M, Agbomson F, Elesper I, Garabedian M, Desmet G, Sebert JL, Markers of bone remodeling in the elderly subject: effects of vitamin D insufficiency and its correction. J Bone Miner Res, 1995. 10(11): p. 1753-61. 280.Tai, V., et al., Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ, 2015. 351: p. h4183. 281.Burger H, d.L.C., van Daele PL, Weel AE, Witteman JC, Hofman A, Pols HA, Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol, 1998. 147(9): p. 871-9. 282.Mazess RB, B.H., Bone density in premenopausal women: effects of age, dietary intake, physical activity, smoking, and birth-control pills. Am J Clin Nutr, 1991. 53(1): p. 132-42. 283.Yanmao Wang, J.D., Wanrun Zhong, Chengfang Hu, Shengdi Lu and Yimin Chai, Association between Serum Cholesterol Level and Osteoporotic Fractures. Front Endocrinol (Lausanne), 2018. 9(30). 284.Maghbooli Z, K.-N.L., Adabi E, Ramezani M, Asadollahpour E, Razi F, Rezanejad M, Negative correlation of high-density lipoprotein-cholesterol and bone mineral density in postmenopausal Iranian women with vitamin D deficiency. Menopause, 2018. 25(4): p. 458-464. 285.Park BK, Y.K., Kim SC, Joo JK, Lee KS, Choi OH, The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women. J Menopausal Med, 2017. 23(2): p. 96-101.
|