臺灣博碩士論文加值系統

本研究將實際測量Varian Clinac 2100C/D醫用直線加速器開放照野的百分深度劑量曲線、劑量剖面曲線和照野輸出因子等資料，並和Varian標準射束資料作比對，然後將測量資料輸入Philips Pinnacle3放射治療計畫系統中，接著利用Varian標準射束資料製作出Philips Pinnacle3的參數射束模組，將它套用於實際測量Varian Clinac 2100C/D的射束模組中，比較測量資料和電腦計算資料的差異性。藉由使用Varian標準射束資料製作的射束模組參數，探討使用Varian標準射束資料於放射治療計畫系統之準確性和可行性。
在不同深度(5cm～20cm)和照野(6cm×6cm～20cm×20cm)，百分深度劑量曲線比對的誤差值在1％～1.47％以內。在兩種光子射束(6MV和10MV)不同的治療照野(4cm×4cm～20cm×20cm)，於深度5cm、10cm、15cm、20cm及最大深處劑量處劑量剖面曲線都有非常好的相似性。符合臨床可接受2％的誤差範圍。將Varian標準射束資料的射束模組參數套用於Varian Clinac 2100C/D實際測量曲線中，發現兩者誤差在1％以內。在輻射劑量驗證方面，在6MV，深度20cm，照野為20cm×20cm的條件下，Philips Pinnacle3放射治療計畫系統計算值與醫用直線加速器實際測量值之最大差異在3.19％。加入電子密度曲線做非均質物質的劑量修正，顯示最大誤差值為4.3％。誤差值都符合ICRU24報告5%的標準規範內。根據研究結果，藉由廠商所提供的Varian標準射束曲線所製作出的計算模組，應用於Philips Pinnacle3放射治療計畫系統中應是可行的。

Percentage depth dose curves(PDD curves), dose profile curves and field size output factors of Varian Clinac 2100C/D linear accelerator had been measured and compared with Varian Golden Beam Data(Varian GBD) in this study. Beam module parameters of Philips Pinnacle radiation treatment planning system had been configured by using Varian Golden Beam data. Then the computed data had been compared with measured data to find out the possibility and accurity of using Varian GBD in Pinnacle system.
According to these compared results, there were 1%~1.47% differences of PDD curves data in different depths (5cm ~ 20cm) and field sizes ( 6cm×6cm～20cm×20cm). There are good match of dose profile curves of two different photon beams (6MV and 10MV) in depth 5cm, 10cm, 15cm, 20cm and dmax in different field sizes (4cm×4cm～20cm×20cm). The criteria in clinical is 2% and the compared results are acceptable. The difference of measured curves and computed curves in Pinnacle system had been within 1% no matter what depths from dmax to 30cm. In dosimetry verified tests, the biggest difference between the calculated data and measured data was 3.19% in 6MV, 20cm depth and 20cm×20cm field size. The difference was 4.3% if electron density correction had been considered and these two situation were within 5% which was ICRU 24th report suggested.
Based on the conclusions of this study, it may be possible to use the beam module parameters configured by using Varian Golden Beam data in Philips Pinnacle system and the accuracy of calculations were acceptable.

論文指導教授推薦書與口試委員會審定書……………………………I
中文摘要………………………………………………………………III
英文摘要………………………………………………………………IV
致謝詞……………………………………………………………………V
目錄……………………………………………………………………VI
圖目錄………………………………………………………………VIII
表目錄…………………………………………………………………X
第一章 緒論……………………………………………………………1
1.1 研究背景………………………………………………………1
1.2 研究動機………………………………………………………2
1.3 研究目的………………………………………………………3
1.4 文獻回顧………………………………………………………4
第二章 理論基礎………………………………………………………6
2.1 放射治療計畫系統…………………………………………6
2.1.1 輸入直線加速器特性…………………………………7
2.1.2 射束模組參數…………………………………………7
2.1.3 劑量計算…………………………………………7
2.2 Varian標準射束資料…………………………………………8
第三章 研究步驟與方法…………………………………………9
3.1 射束資料收集…………………………………………………11
3.1.1 Varian標準射束資料………………………………11
3.1.2 Varian Clinac 2100C/D醫用直線加速器…………11
實際測量資料
3.1.2.1 劑量剖面曲線……………………………………12
3.1.2.2 照野輸出因子……………………………………12
3.2 比對Varian Clinac 2100C/D射束資料和Varian…………13
標準射束資料
3.3 Varian標準射束資料之射束運算模型製作………………13
3.4 套用Varian 標準射束資料的射束模組於Varian ………16
Clinac 2100C/D射束資料中
3.5 Varian Clinac 2100C/D醫用直線加速器的………………16
輻射劑量驗證
3.6 電腦斷層相對電子密度……………………………………17
第四章 結果與討論………………………………………………20
4.1 Varian Clinac 2100C/D醫用直線加速器與………………20
Varian標準射束資料之百分深度劑量比對結果
4.2 Varian Clinac 2100C/D醫用直線加速器與………………24
Varian標準射束資料劑量剖面曲線比對結果
4.3 Varian標準射束資料於Philips Pinnacle3放射…………35
治療計畫系統射束模組參數值
4.4 套用Varian 標準射束資料模組於Varian Clinac………39
2100C/D射束資料中之誤差結果
4.5 Varian標準射束資料之照野輸出因子與Varian Clinac…51
2100C/D射束資料照野輸出因子
4.6 Varian Clinac 2100C/D醫用直線加速器輻射劑…………53
量驗證結果
4.7 電腦斷層相對電子密度驗證結果…………………………55
第五章 結論…………………………………………………………59
參考文獻………………………………………………………………61

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