臺灣博碩士論文加值系統

本研究目的為用定量式超音波評估一般民眾的生活習慣對骨質密度的影響，以預防骨折之發生率。受檢者共為937位，男性為312位，平均年齡66.8 ± 16.9歲；女性為625位，平均年齡60.3 ± 15.3歲。全部受檢者均接受定量式超音波測量慣用腳跟骨或未受傷腳的跟骨檢測，並填寫生活狀況之問卷，將檢測出的音波速度(speed of sound, SOS, m/s)、寬頻衰減值(broadband ultrasound attenuation, BUA, dB/cm)與定量超音波指數(quantitative ultrasound index, QUI)及問卷內容作相關性分析。研究顯示男性的SOS平均值為1528.7 ± 31.8 m/s較女性(1524.3 ± 32.8 m/s)為高(p=0.049)，男性的BUA平均值為69.5 ± 17.3 dB/cm；女性為63.2 ± 18.4 dB/cm (p<0.001)，男性的QUI平均值為84.4 ± 19.3；女性為79.5 ± 20.4 (p<0.001)，T-score男性為-1.1 ± 1.2；女性為-1.4 ± 1.3 (p=0.001)。從女性的結果中發現老年時期抽菸習慣的SOS (r=-0.141)、BUA (r=-0.131)及QUI (r=-0.150)均呈顯著的負相關(p<0.05)，但在全體女性一同分析時卻沒有此相關性；而全體女性中有喝茶及咖啡習慣的SOS (r=-0.115)、BUA (r=-0.111)及QUI (r=-0.106)皆有極顯著的負相關(p<0.01)，但在年齡分層中則沒有。另外在本研究中女性停經前SOS (r=-0.194)、BUA (r=-0.160)及QUI (r=-0.177)對長期性的藥物服用皆有顯著的負相關(p<0.05)，這和全體女性一同分析時的結果相同，但在年齡分層的統計中則沒有顯著相關。總結來探討，骨質密度除了在性別上具有顯著的差異外，在不同的年齡層及不同的生活習慣中亦會以不同的骨質密度結果。

The purpose of this study was to assess the impact of general population living habits of bone density by quantitative ultrasound to prevent the incidence of fractures. A total of 937 examinee, 312 men, mean age 66.8 ± 16.9 years; 625 women, mean age 60.3 ± 15.3 years. All examinee were accepted quantitative ultrasound measurement of the usual or not injured calcaneus, and fill out the questionnaire of living conditions. Then, the detected speed of sound (SOS)、broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) and the questionnaire for correlation analysis. In this study, the SOS average for male is 1528.7 ± 31.8 m/s; for female is 1524.3 ± 32.8 m/s (p=0.049), the BUA average for male is 69.5 ± 17.3 dB/cm; for females is 63.2 ± 18.4 dB/cm (p<0.001), the QUI average for male is 84.4 ± 19.3; for females is 79.5 ± 20.4 (p<0.001), the T-score average for male is -1.1 ± 1.2; for females is -1.4 ± 1.3 (p=0.001). From the results of which can be found in older women during the smoking habits of SOS (r=-0.141), BUA (r=-0.131) and QUI (r=-0.150) showed a significant negative correlation (p<0.05), but without this correlation analysis of all women; And all the women have tea and coffee habit SOS (r=-0.115), BUA (r=-0.111) and QUI (r=-0.106) are of extreme significant negative correlation (p<0.01), but in the age-stratified are not. In addition to this study, premenopausal women SOS (r=-0.194), BUA (r=-0.160) and QUI (r=-0.177) for long-term drug use has a significant negative correlation (p<0.05), and analysis of all women with the same result, but in the age-stratified is no significant correlation. In conclusion, bone density is significant differences in genders. At different age-stratified and different living habits also have the different bone density.

中文摘要 I
Abstract II
誌謝 III
目錄 IV
圖目錄 VI
表目錄 VII

第一章 緒論 1
1.1 研究背景 1
1.1.1 骨質疏鬆症的介紹 3
1.2 研究動機 8

第二章 研究材料與方法 11
2.1 超音波原理 11
2.2 定量式超音波原理 13
2.3 問卷內容 21
2.4 參與研究受檢者 21
2.5 統計方法 22
2.6 實驗架構 23

第三章 實驗結果 25
3.1受檢者的基本資料統計 25
3.2男性受檢者的骨質結構結果 32
3.2.1 男性骨質結構結果-年齡分層 33
3.3女性受檢者的骨質結構結果 37
3.3.1 女性骨質結構結果-年齡分層 38
3.3.2 女性骨質結構結果-停經與否 42

第四章 討論 46
4.1基本資料結果討論 48
4.2男性骨質結構結果討論 50
4.3女性骨質結構結果討論 51

第五章 結論 55

參考文獻 57

附錄一 骨密問卷調查表 64

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