臺灣博碩士論文加值系統

本研究系為了解茉莉精油在吸嗅之後對中樞神經之抑制效果。採用戊四氮
致痙動物模式，結果顯示預吸入茉莉精油能夠顯著地延遲第一級、第五級痙攣
誘發的時間（P<.05，P<.01）。人體實驗則研究在腦電波-ㄙi活動、血容積搏
動、心率變異（HRV：LF、HF、nLF、nHF、LF/HF、SDNN）、肌電位、皮膚
電導度、呼吸率、末稍溫度、痛閾值的變化情形。在吸嗅茉莉精油芳香分子後，
能夠顯著降低LF/HF值，調降呼吸率與皮膚電導度，並同時觀察到痛閾值及皮
膚末稍溫度有提升的趨勢（P<.05）。ㄙi活動、肌電位、低頻世!!!@#63841;強度、高頻
世!!!@#63841;強度與NN間期之標準差結果則在吸嗅茉莉精油後未達顯著變化。平均心
搏與血壓在芳香療法後無顯著改變。23%的受測者喜歡茉莉香氣，13%表示討
厭茉莉精油的味道，64%表示對茉莉香氣無特別的偏好與厭惡。茉莉香氣的偏
好與性別組成以男女比例方式分別為43:57（喜歡茉莉香氣）、1:1（討厭茉莉香
氣）、1:1（無特殊偏好）。根據受測者間的STAI分數與原始心搏數關聯性比較，
顯試受測者在受測者可能處於非壓力的情緒下。結論：所有的受測者在吸嗅完
I
茉莉香氣後其心率與血壓維持穩定，可知個體系處於非壓力的狀態。而根據放
鬆相關生理訊號的改變結果發現，吸嗅茉莉精油，或可利用抑制中樞神經的活
動使人們感到放鬆，而此抑制表現不受性別、年齡、氣味偏好之影響。吸嗅茉
莉精油具有與憂鬱表現相關的中樞神經抑制效果。茉莉精油的這些特質使其成
為添加於化粧品的潛力成份。未來或陳鉞讕悜[莉精油的吸嗅為一改善壓力
型美容問題的新方式。而此研究模式，亦提供未來研究人員另一快速、經濟篩
檢精油放鬆特質的平台。

This study was performed to evaluate the inhibitory effects of central nervous
system after inhalation of the essential oil from Jasmine. Animal model of
Pentylenetetrazole-induced convulsion has been adapted and the result shows
pre-inhalation of jasmine essential oil could significantly decreased the convulsion
level of the mice and delayed the appearance of the convulsion stage 1 & stage 5.
（P<.05，P<.01） Human model have been studied by using alpha activity in the
electroencephalogram（EEG）, blood vessel pulsation（BVP）, heart rate variability
（HRV：LF、HF、nLF、nHF、LF/HF、SDNN）, electromyography（EMG）,skin
conductance（SC）, respiratory rates, peripheral temperature and changes in pain
threshold. After inhalation of jasmine fragrance could significantly decrease the
LF/HF value, lower down the respiratory rates and skin conductance value, the
increased of the pain threshold and skin temperature have been observed.（P<.05）
The activity, EMG, LF power, HF power, SDNN show no significant change after
inhalation of the jasmine odor. The average heart beat and blood pressure show no
significantly change after aromatherapy. 23% of the objects like the odor of jasmine
essential oil, 13% has a dislike of the smell of jasmine odor, 64% objects show no
special preference of the jasmine odor.；the odor preference consist of the sex
III
distinction on male & female of 43:57（like the odor of jasmine）, 1:1（unlike the
odor of jasmine）and 1:1(no special preference). As a brief conclusion, according to
the correlation between scores of STAI and original heart beats between objects
shows total objects are under the same kind of non-stress level by distinguished
from the stable heart rate and blood pressure after inhalation of the jasmine odor.
According to the relaxing-like biological signals change, inhale the jasmine odor
might make people feel relax by inhibiting the CNS activity and the inhibitory
express won’t be affected by the age, sexual or the preference of the odor.
Inhalation of the fragrance oil from jasmine shows inhibitory activity of the CNS
related to decompression kind expression. These characteristics of jasmine essential
oil make it a potential cosmetic ingredient. It give us an idea that inhalation of
jasmine essential oil may help improving stress-induced skin problems in a new
way. We suggest this evaluation method as a fast and cost less way for researcher to
study the characteristics of essential oil.

目錄
中文摘要.............................................................................................................. I
英文摘要(Abstract).............................................................................................. III
誌謝...................................................................................................................... V
目錄...................................................................................................................... VI
表目錄.................................................................................................................. X
圖目錄.................................................................................................................. XI
英文縮寫表.......................................................................................................... XIII
第一章 文獻回顧
1-1 研究背景、動機及目的........................................................................ 1
1-2 壓力的探討
1-2-1 何謂壓力..................................................................................... 2
1-2-2 壓力的分類－壓力源................................................................. 4
1-2-3 壓力的偵測與量化..................................................................... 5
1-3 芳香療法
1-3-1 茉莉精油之化學組成................................................................. 8
1-3-2 精油之生理活性基礎................................................................. 11
1-4 壓力與美容問題.................................................................................... 15
VI
1-5 放鬆與生理變異
1-5-1 腦電波.......................................................................................... 18
1-5-2 血容量搏動................................................................................. 22
1-5-3 心率變異..................................................................................... 23
1-5-4 呼吸速率..................................................................................... 29
1-5-5 肌電位.......................................................................................... 30
1-5-6 體表溫度-末稍指溫.................................................................... 30
1-5-7 膚電位.......................................................................................... 31
1-5-8 痛閾.............................................................................................. 32
1-5-9 血壓.............................................................................................. 33
1-6 抗焦慮之動物實驗：戊四氮誘發痙攣小鼠模式............................... 33
第二章 研究材料、儀器與方法
2-1 人體實驗研究設計與架構
2-1-1 研究目標..................................................................................... 37
2-1-2 研究材料與工具......................................................................... 39
2-1-3 研究對象..................................................................................... 47
2-1-4 研究方法..................................................................................... 47
2-1-5 分析與統計方法......................................................................... 53
VII
2-2 戊四氮誘發痙攣小鼠模式實驗設計與架構
2-2-1 研究目標..................................................................................... 55
2-2-2 研究材料..................................................................................... 55
2-2-3 實驗動物..................................................................................... 56
2-2-4 研究方法..................................................................................... 56
2-2-5 統計與分析................................................................................. 59
第三章 研究結果
3-1 受測者香氣偏好與性別之關聯.......................................................... 60
3-2 狀態焦慮與焦慮特質分析.................................................................. 61
3-3 茉莉精油之人體放鬆效果.................................................................. 62
3-4 戊四氮誘發痙攣小鼠模式研究結果
3-4-1 茉莉精油吸嗅後於戊四氮致痙小鼠模式之抑制結果........... 66
3-4-2 陽性控制組琥珀酸與空白對照組之抑制效果比較............... 67
第四章 討論
4-1 茉莉精油之人體放鬆效果
4-1-1 STAI得分反映個體焦慮狀態....................................................70
4-1-2 心搏率於芳香療法前後之結果討論........................................70
4-1-3 HRV於芳香療法前後之結果討論.............................................71
4-1-4 末稍溫度於芳香療法前後之變異............................................72
VIII
IX
4-1-5 呼吸率於芳香療法前後之變異............................................... 73
4-1-6 皮膚導電度於芳香療法前後之變異....................................... 73
4-1-7 知覺痛閾於芳香療法前後之變異........................................... 74
4-1-8 放鬆指數變量之相關系數矩陣............................................... 75
4-2 茉莉精油於動物之中樞神經抑制研究結果...................................... 76
第五章 未來研究方向..................................................................................... 80
參考文獻............................................................................................................. 81
附件一（STAI量表） ........................................................................................ 88

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